Article
Radiology, Nuclear Medicine & Medical Imaging
Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian, Azeez Farooki
Summary: Bone mineral density measurement and FRAX assessment tools can help evaluate fracture risk and guide decisions for osteoporosis pharmacologic treatment. Specific populations like postmenopausal women and men over 50 should receive pharmacologic treatment according to guidelines. Monitoring BMD regularly and considering secondary causes or non-compliance is important during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Anna Darelid, Robert Rudang, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
Summary: This prospective cohort study aimed to evaluate the association between the bone material strength index (BMSi) and the risk of incident fracture in older women. The study found that increasing BMSi was associated with a greater risk of fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Genetics & Heredity
Anthony L. Guerrerio, Allyson Mateja, Marjohn Rasooly, Samara Levin, Alaina Magnani, Caeden Dempsey, Gretchen MacCarrick, Harry C. Dietz, Erica Brittain, Alison M. Boyce, Pamela A. Frischmeyer-Guerrerio
Summary: Loeys-Dietz syndrome (LDS) patients commonly have reduced bone density and increased risk of fractures, possibly due to increased bone resorption. Certain clinical features can predict a subgroup of patients at highest risk of low bone density and fractures.
GENETICS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Aamir Kadri, Neil Binkley, Scott D. Daffner, Paul A. Anderson
Summary: Among vertebral fracture patients with normal bone mineral density (BMD), there is a high prevalence of clinical fracture risk factors and a significant risk of fracture. Besides BMD, other important risk factors may indicate poor bone health, highlighting the need for further evaluation.
Article
Medicine, Research & Experimental
Qing Wu, Jongyun Jung
Summary: This study introduces a novel genome-wide polygenic score (GPS) to quantify inherited susceptibility to osteoporosis and osteoporotic fracture, providing new opportunities for clinical prevention and risk assessment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Victoria L. Bland, Jennifer W. Bea, Robert M. Blew, Denise J. Roe, Vinson R. Lee, Janet L. Funk, Scott B. Going
Summary: The study indicates that changes in total body lean mass and fat mass during adolescence are associated with bone outcomes. Total body lean mass has a greater influence on bone development than total body fat mass, with lean mass being the predominant predictor of bone outcomes.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Miroslav Vujasinovic, Lorena Nezirevic Dobrijevic, Ebba Asplund, Wiktor Rutkowski, Ana Dugic, Mashroor Kahn, Ingrid Dahlman, Maria Saaf, Hannes Hagstrom, Johannes-Matthias Lohr
Summary: This study found that only 23% of patients with CP underwent DXA examination, with 53.4% of patients having low BMD. The fracture rate was significantly higher in patients with low BMD compared to those with normal BMD.
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Allergy
Ayelet Makovoz, Jing Wang, Gloria Oshegbo, Young Hwan Park, Jonathan J. Lyons, A. Robin Eisch, Linda M. Scott, James C. Reynolds, Ana M. Ortega-Villa, Dean D. Metcalfe, Hirsh D. Komarow
Summary: This study investigated fracture prevalence and risk predictors in North American patients with systemic mastocytosis (SM), finding a 74% fracture history rate among the cohort. Factors such as age, body mass index, bone density, and alkaline phosphatase levels were consistent with European studies on individuals with SM and bone disease. The study also developed a predictive model for fracture risk based on DXA spine T-scores, alkaline phosphatase, and age.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Environmental Sciences
Seyed Rohallah Mousavibaygei, Amir Bisadi, Fariba ZareSakhvidi
Summary: This study systematically reviewed the evidence on the association between exposure to air pollution and osteoporosis-related outcomes. The findings suggest that PM2.5, PM10, and nitrogen dioxide may be associated with decreased bone density, osteoporotic fractures, and osteoporosis. However, due to limitations in the number of studies, heterogeneity, and publication bias, caution should be exercised in interpreting the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Jedidah S. Yong, Benjamin K. Weeks, Belinda R. Beck
Summary: The MEDEX-OP trial compared high-intensity resistance training (HiRIT) with low-intensity exercise control (BB) in postmenopausal women with low bone mass, finding that HiRIT significantly improved LS BMD and functional performance. Exercise compliance was good and both programs were well tolerated.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Emergency Medicine
Sabrina Sandriesser, Stefan Foerch, Edgar Mayr, Falk Schroedl, Christian von Rueden, Peter Augat
Summary: This study compared the stabilizing effects of supplemental cable cerclage and solitary plate fixation in distal tibial spiral fractures. The results showed that supplemental cable cerclage significantly increased fixation stiffness and reduced interfragmentary movements, allowing immediate mobilization without weight-bearing restrictions from a biomechanical perspective.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Andreas Brand, Christian von Ruden, Carina Probst, Lisa Wenzel, Peter Augat, Mario Perl
Summary: Patients with surgically treated acetabular fractures using the less invasive anatomical pararectus approach did not show significant differences in lower extremity biomechanics during walking and stair climbing. However, reductions in vertical ground reaction force, knee and hip extension moments were observed during walking.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Orthopedics
Shabnam Samsami, Robert Patzold, Tim Neuy, Markus Greinwald, Peter E. Muller, Yan Chevalier, Klaus Puschel, Peter Augat
Summary: This study compared the effects of two different double locked plating techniques on bicondylar tibial plateau fractures. The results showed that the location of the medial locking plate can affect the direction of movement for the fracture segments.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Emergency Medicine
Lisa Wenzel, Sabrina Sandriesser, Claudio Glowalla, Boyko Gueorguiev, Mario Perl, Fabian M. Stuby, Peter Augat, Sven Hungerer
Summary: The purpose of this study was to compare the stabilization of anterior column acetabular fractures fixed with a cranial socket revision cup with flange and iliac peg or with a suprapectineal plate osteosynthesis combined with an additional revision cup. Results showed that both surgical approaches showed comparable fracture reduction in terms of initial construct stiffness and interfragmentary movement. The potential benefit of the less-invasive cranial socket revision cup needs further investigation in clinical studies.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Neurosciences
Inga Kroeger, Janina Muessig, Andreas Brand, Robert Paetzold, Hannes Wackerle, Isabella Kloepfer-Kraemer, Peter Augat
Summary: Patients with surgically treated tibial shaft fractures show functional deficits during gait and squat performance even six months post surgery, with incomplete recovery in knee kinematics and kinetics when compared to healthy controls, explaining the reported functional limitations.
Article
Orthopedics
Sabrina Sandriesser, Katarina Ruehlicke, Peter Augat, Daniel Hensler
Summary: This study compares the effects of three different graft fixation positions on knee mobility and joint functionality in PCL reconstruction surgery. The results indicate that a lower graft fixation position within the femoral footprint of the PCL can restore knee stability and mobility.
Article
Veterinary Sciences
Johannes Maximilian Schmutterer, Peter Augat, Markus Greinwald, Andrea Meyer-Lindenberg
Summary: The study aimed to investigate changes in the stifle after a tibial plateau levelling osteotomy with different postoperative tibia plateau angles. Results showed that TPLO restored stifle kinematics and reduced the force acting on both menisci significantly after a 1-degree TPLO.
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2022)
Article
Orthopedics
Marianne Hollensteiner, Sabrina Sandriesser, Hilmar Krauss, Markus Greinwald, Fabian Stuby, Peter Augat
Summary: A common agreement for the surgical treatment of osteoporotic ankle fractures has not been defined yet. This study evaluated the mechanical stability of locked and conventional plates on osteoporotic Danis-Weber-B-fibula fracture models. The results showed that although no overall mechanical superiority was found, the locking plate groups exhibited higher shear and rotational stability compared to the neutralization plate group.
FOOT AND ANKLE SURGERY
(2022)
Article
Engineering, Biomedical
Andreas Brand, Inga Kroeger, Isabella Kloepfer-Kraemer, Hannes Wackerle, Janina Anna Muessig, Andrea Dietrich, Moritz Boettger, Leander Gaul, Johannes Gabel, Peter Augat
Summary: This study investigated the biomechanical and morphological adaptations of the gastrocnemius muscle after unilateral calcaneal fracture. The results showed that patients had an increase in muscle fascicle length and a decrease in the shortening of the serial elastic element. Compared to healthy controls, patients had differences in fascicle lengthening and pennation angle increase. Even at twelve months after surgery, there were still restrictions in the shortening behavior of the serial elastic element and muscle-tendon unit. This suggests that the dynamic morphological behavior of the medial gastrocnemius is not fully restored in patients with calcaneal fracture.
CLINICAL BIOMECHANICS
(2022)
Article
Engineering, Biomedical
Thomas Thurner, Benjamin Esterer, David Fuerst, Marianne Hollensteiner, Sabrina Sandriesser, Peter Augat, Roland Pruckner, Daniela Wirthl, Martin Kaltenbrunner, Andreas Mueller, Gerhard Foerster, Claus Pototschnig, Andreas Schrempf
Summary: Surgical simulators are evolving educational tools for developing surgical skills, with virtual and hybrid simulators being preferred. A Smart Artificial Soft Tissue is presented to accelerate the revolution of hybrid simulators, providing objective positional feedback for haptically correct artificial soft tissue. The development of a laryngeal phantom demonstrates the capabilities of the simulator, which also uses a tablet computer for virtual representation and additional information display.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Critical Care Medicine
Dirk Stengel, Peter Augat, Peter V. Giannoudis
Summary: During the past decade, there has been an increase in large-scale pragmatic clinical trials in orthopedic trauma surgery. However, the precision of outcome measurement depends not only on sample size but also on the homogeneity of the studied population. There is currently a lively and controversial debate about the role of randomized controlled trials in the era of stratified medicine and the use of artificial intelligence in data analysis.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Critical Care Medicine
Christian von Rueden, Julia Rehme-Roehr, Peter Augat, Jan Friederichs, Simon Hackl, Fabian Stuby, Oliver Trapp
Summary: This review article summarizes the currently available evidence on the treatment of clavicle fractures. Classifications, indications, and treatment options for different fracture patterns of the medial, mid-shaft, and lateral clavicles are presented and discussed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Medicine, General & Internal
Mischa Muehling, Sabrina Sandriesser, Claudio Glowalla, Sven Herrmann, Peter Augat, Sven Hungerer
Summary: Ipsilateral revision surgeries for total hip or knee arthroplasties are increasing due to aging population, and the risk of interprosthetic fractures depends on the distance between adjacent implants. This study investigated the strain within the femoral shaft between two implants using a physical model and finite element model. Results showed that a smaller interprosthetic distance and thinner cortices increased strain peaks, while a minimum interprosthetic distance of 10 mm seemed crucial to avoiding strain accumulation. Interprosthetic fracture management is especially important for patients with reduced bone quality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Xiaowei Huang, Andreas K. Nussler, Marie K. Reumann, Peter Augat, Maximilian M. Menger, Ahmed Ghallab, Jan G. Hengstler, Tina Histing, Sabrina Ehnert
Summary: The present study established and validated a finite element model (FEM) to predict the mechanical properties of mice tibiae. The FEM showed good correlation with biomechanical data obtained from bending tests. By reducing the need for animal experiments, the FEM can contribute to reducing the number of research animals in bone biomechanics studies.
BIOENGINEERING-BASEL
(2022)
Article
Emergency Medicine
Simon Hackl, Katharina Trenkwalder, Matthias Militz, Peter Augat, Fabian M. Stuby, Christian von Rueden
Summary: A retrospective study found that many patients with femoral shaft nonunion, initially classified as aseptic, actually had bacterial infections. Therefore, two-stage surgical nonunion revision with microbiological diagnosis is recommended for patients with indications of a possible infectious event.