Article
Biochemistry & Molecular Biology
Teppei Okabe, Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Masayuki Umemura, Yuki Suzuki, Yoshihiko Sugita, Yoshikazu Naiki, Yoshiaki Hasegawa, Jun-ichiro Hayashi, Shotaro Kawamura, Noritaka Sawada, Yuhei Takayanagi, Takeki Fujimura, Naoya Higuchi, Akio Mitani
Summary: This study found that the culture supernatant of Porphyromonas gingivalis accelerated inflammation in the lungs of Streptococcus pneumoniae-infected mice, and increased inflammatory cell infiltration. Compared to S. pneumoniae infection alone, PgSup synergistically increased TNF-alpha and IL-17 expression/production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Cecilia Bacali, Rahela Carpa, Smaranda Buduru, Mirela L. Moldovan, Ioana Baldea, Annemarie Constantin, Marioara Moldovan, Doina Prodan, Laura Monica Dascalu (Rusu), Ondine Lucaciu, Florinela Catoi, Mariana Constantiniuc, Mandra Badea
Summary: This study showed that the use of polymethyl methacrylate resin enhanced with graphene silver nanoparticles and extra oral photodynamic therapy can effectively inhibit bacteria associated with halitosis in denture wearers, providing a safer and more efficient alternative for preventing bad breath and oral infections.
Article
Dentistry, Oral Surgery & Medicine
Yasuo Takeuchi, Takashi Nemoto, Yutaro Kitanaka, Akira Aoki, Yuichi Izumi, Takanori Iwata, Shinichi Arakawa
Summary: This study aimed to evaluate the in vitro antibacterial effects of lysozyme-chitosan oligosaccharide conjugates (LYZOX) against Streptococcus gordonii and Porphyromonas gingivalis. The results showed that LYZOX exhibited concentration-dependent antibacterial activity. Conclusion: LYZOX has antibacterial activity against two periodontal bacteria and may be a promising plaque control agent.
Article
Microbiology
Fengjiao Li, Chuandong Wang, Jing Xu, Xiaoyu Wang, Meng Cao, Shuhua Wang, Tingting Zhang, Yanyong Xu, Jing Wang, Shaobin Pan, Wei Hu
Summary: The antimicrobial activity of Elsholtzia ciliate essential oil (ECO) against halitosis-causing bacteria was investigated. ECO showed comparable activities to chlorhexidine and significantly reduced the production of volatile sulfur compounds (VSCs). The major chemical components of ECO, carvacrol, p-cymene, and phellandrene, exhibited inhibitory effects on the bacteria.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Lena Katharina Mueller-Heupt, Anja Eckelt, John Eckelt, Jonathan Gross, Till Opatz, Nadine Kommerein
Summary: Periodontitis, caused by bacterial dysbiosis, is a common global disease associated with anaerobic bacterial colonization. A study investigated the potential of calcium peroxide (CaO2) as an antimicrobial agent for treating periodontitis. It was found that CaO2 selectively inhibited the growth and viability of Porphyromonas gingivalis but had little effect on Streptococcus oralis, indicating its potential for selectively affecting both planktonic bacteria and mono-species biofilms of P. gingivalis.
Article
Immunology
Bing-Yan Wang, Tom Lu, Qiuyin Cai, Meng-Hsuan Ho, Sally Sheng, Hsiu-Wan Meng, Laura Arsto, Jianming Hong, Hua Xie
Summary: This study on periodontitis patients of different ethnic backgrounds revealed that Caucasian Americans had higher median incomes compared to African Americans and Hispanic Americans. The distribution of total bacteria and Porphyromonas gingivalis varied among the groups, and the ratio of Streptococcus cristatus to P. gingivalis was significantly higher in Caucasians. Higher levels of P. gingivalis and lower ratios of S. cristatus to P. gingivalis may contribute to periodontal health disparities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Kaori Takeda, Eiji Nishinaga, Ken-ichiro Shibasaki, Seiji Morishima
Summary: The diversity of oral microbiome in 18-month-old infants was significantly lower than that in parents, and the composition of microbiome differed significantly between infants and parents. Additionally, the microbiome of infants was more similar to that of their mothers, indicating that parents' oral microbiome influences that of children under 18 months of age.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Min Wang, Lili Li, Jun Qian, Nannan Wang, Jun Bao, Jiangyue Lu, Faming Chen, Yanfen Li, Yangheng Zhang, Fuhua Yan
Summary: In this study, the salivary microbiota from patients with periodontitis was transferred to obese mice induced by high-fat diet to investigate the influence on gut microbiome and liver metabolism. The results showed that periodontitis salivary microbiota altered gut microbiota composition and exacerbated intestinal barrier dysfunction, leading to activation of toll-like receptor 4 signaling and release of pro-inflammatory factors in the liver. Moreover, the upregulation of the tryptophan-kynurenine-AhR signal axis in the liver was associated with aggravated hepatic steatosis and dysregulation of glucolipid metabolism during NAFLD development. This study suggests that periodontitis salivary microbiota may worsen the pathological progression of NAFLD in the context of obesity, with the tryptophan-AhR pathway potentially playing a key role.
Article
Multidisciplinary Sciences
Anastasios Karydis, Indra Sandal, Jiwen Luo, Amanda Prislovsky, Amanda Gamboa, Edward F. Rosloniec, David D. Brand
Summary: The study found that carrying the shared epitope and inoculation with Porphyromonas gingivalis increased the percentage of Th17 cells, significantly increased bone loss, and allowed for the generation of CCP2 ACPAs not found in C57BL/6 or DBA/1 arthritic mouse serum.
Review
Microbiology
Qizhao Ma, Qiong Zhang, Yang Chen, Shuxing Yu, Jun Huang, Yaqi Liu, Tao Gong, Yuqing Li, Jing Zou
Summary: Oral bacteria have complex and variable environments in the oral cavity. They rely on post-translational modifications (PTMs) to regulate their metabolic processes in response to external stimuli. Different PTMs such as phosphorylation, acetylation, glycosylation, citrullination, succinylation, and glutathionylation occur in oral bacteria, altering protein functions and playing roles in physiological processes and regulatory networks.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Banndith Cheat, Coralie Torrens, Asmaa Foda, Brigitte Baroukh, Jeremy Sadoine, Lotfi Slimani, Veronique Witko-Sarsat, Olivier Huck, Marjolaine Gosset, Jerome Bouchet
Summary: Our study investigates the role of NLRP3 in periodontitis, demonstrating its ambiguous role in neutrophils and its interaction with Porphyromonas gingivalis. The study reveals that NLRP3 is involved in regulatory pathways that limit periodontitis in mouse models, but its protective effect is diminished in the presence of P. gingivalis. Overexpression of NLRP3 in connective tissue leads to increased production of mature IL-1 beta and mobilization of neutrophils, while NLRP3 deficiency results in lower IL-1 beta expression and almost no neutrophil mobilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed Hamarsha, Kumarendran Balachandran, Ahmad Tarmidi Sailan, Nurrul Shaqinah Nasruddin
Summary: The aim of this study was to investigate the relationship between P. gingivalis and AD, and explore the role of genes and molecular targets. Through gene expression analysis, 10 common genes associated with both diseases were identified, and molecular simulations were conducted. The findings of this study revealed novel genes related to P. gingivalis-associated AD that require further validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Gina R. Lewin, Kendall S. Stocke, Richard J. Lamont, Marvin Whiteley
Summary: This study characterizes the behavior and virulence of the periodontal pathogen Porphyromonas gingivalis during human infection. It reveals that P. gingivalis is highly expressed in diseased samples, with genes related to virulence factors and growth/matabolism being actively expressed. The study also shows that the gene expression of P. gingivalis during periodontitis is highly conserved with logarithmic laboratory growth, suggesting that simple test tube growth can be used as a model for studying P. gingivalis biology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Seonhwa Park, Kiryeon Park, Hee Sam Na, Jin Chung, Haesik Yang
Summary: An electrochemical biosensor for sensitive detection of Porphyromonas gingivalis in saliva was developed without the need for washing and separation steps. This biosensor can be used as an initial diagnosis method to distinguish between healthy people and patients with periodontal diseases.
ANALYTICAL CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Caroline C. Tonon, Beatriz H. D. Panariello, Denise M. P. Spolidorio, Ana G. Gossweiler, Simone Duarte
Summary: The study evaluated the antimicrobial effect of ozonized physiological saline solution in different concentrations against oral biofilms developed on titanium surface, showing that ozone has antibiofilm activity against peri-implant diseases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)