Article
Cell Biology
Yiping Huang, Hao Liu, Runzhi Guo, Yineng Han, Yuhui Yang, Yi Zhao, Yunfei Zheng, Lingfei Jia, Weiran Li
Summary: Orthodontic tooth movement involves periodontal tissue remodeling triggered by mechanical force, with autophagy playing a significant role in preventing damage. The study highlights the importance of lncRNA FER1L4 in regulating autophagy in PDLSCs during orthodontic treatment. FER1L4 inhibits AKT phosphorylation and promotes FOXO3 nuclear translocation, mediating autophagic cascades under compressive strain.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia Brockhaus, Rogerio B. Craveiro, Irma Azraq, Christian Niederau, Sarah K. Schroder, Ralf Weiskirchen, Joachim Jankowski, Michael Wolf
Summary: The study reveals that human Periodontal Ligament Fibroblasts undergo changes in morphology, cell number, and cell cycle under mechanical compression during orthodontic tooth movement. However, these cells can recover and regain homeostasis after adapting to environmental changes, impacting the reorganization of the periodontium.
Article
Chemistry, Multidisciplinary
Shai Yona, Oded Medina, Rachel Sarig, Nir Shvalb
Summary: Orthodontic tooth movement is a topic of interest for both medical and engineering communities. Previous studies focused on stress distribution and remodeling processes, but lacked a practical clinical decision support platform. This paper presents a simplified numerical model that bridges this gap and provides accurate clinical results, as demonstrated by comparison with real-world cases.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Erika Calvano Kuechler, Agnes Schroeder, Gerrit Spanier, Geraldo Thedei Jr, Maria Beatriz Carvalho Ribeiro de Oliveira, Maria Angelica Hueb de Menezes-Oliveira, Peter Proff, Christian Kirschneck
Summary: This study investigated the association between single-nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and gene expression in human periodontal ligament (hPDL) fibroblasts under simulated orthodontic compressive force. The results showed that the different genotypes of SNPs in the VDR gene did not have a statistically significant impact on gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Changyun Sun, Mila Janjic Rankovic, Matthias Folwaczny, Thomas Stocker, Sven Otto, Andrea Wichelhaus, Uwe Baumert
Summary: This study investigated the effects of different magnitudes and durations of static tensile strain on human periodontal ligament cells. The results showed that lower magnitudes of strain promoted osteogenesis and caused less inflammation, while higher magnitudes inhibited osteogenesis and enhanced inflammation. Among all magnitudes, 10% generally caused a lower level of inflammation with a higher level of osteogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Erika Calvano Kuechler, Agnes Schroeder, Vinicius Broska Teodoro, Ute Nazet, Rafaela Scariot, Gerrit Spanier, Peter Proff, Christian Kirschneck
Summary: The study found that simulated orthodontic compressive strain affects the expression of RANKL, RANKL:OPG ratio, COX-2, IL-6, DHCR7, CYP2R1, and AMDHD1 in hPDL fibroblasts. Additionally, physiological concentrations of vitamin D3 and single nucleotide polymorphisms in the VDR gene also regulate the expression of these genes.
Article
Physiology
Yukun Jiang, Yuzhe Guan, Yuanchen Lan, Shuo Chen, Tiancheng Li, Shujuan Zou, Zhiai Hu, Qingsong Ye
Summary: The Piezo1 channel plays a critical role in mediating bone formation and osteoclastic activities during orthodontic tooth movement, particularly on the tension side. Inhibition of Piezo1 function leads to reduced expression of osteogenesis-associated transcription factors and disruptions in bone remodeling processes.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Fabian Weissinger, Marco Aoqi Rausch, Oleh Andrukhov, Erwin Jonke
Summary: The systematic review revealed that orthodontic forces induce increased expression levels of MMPs and TIMPs in the PDL during orthodontic tooth movement. However, the exact effect may vary depending on intervention and sample parameters as well as subject characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yue Zhou, Aki Nishiura, Hidetoshi Morikuni, Wenqi Deng, Toru Tsujibayashi, Yoshihiro Momota, Yuki Azetsu, Masamichi Takami, Yoshitomo Honda, Naoyuki Matsumoto
Summary: In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy. This study demonstrates that mechanical stress-induced senescent cells aggravate apical root resorption and can be prevented by administering senolytics. These findings offer a new therapeutic target to prevent root resorption during orthodontic tooth movement.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Su-Young Lee, Jung-Sun Moon, Dong-Wook Yang, Hong-Il Yoo, Ji-Yeon Jung, Ok-Su Kim, Min-Seok Kim, Jeong-Tae Koh, Hyun-Ju Chung, Sun-Hun Kim
Summary: The study highlights the role of SLPI in maintaining periodontal tissue homeostasis during tooth movement, suggesting SLPI or its inhibitors as potential target molecules for therapeutic interventions in modulating bone remodeling.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Medicine, Research & Experimental
Yiqiang Yang, Qi Liu, Xun Lu, Jing Ma, Donglan Mei, Qi Chen, Tian Zhao, Jia Chen
Summary: This study aimed to investigate the mechanism of Sanhuang decoction (SHD) in orthodontic tooth movement (OTM) treatment. The results showed that SHD can inhibit autophagy of periodontal ligament (PDL) fibroblasts by activating the PI3K-Akt-mTOR pathway and suppressing oxidative stress. These findings suggest that SHD could be a valuable treatment for managing complications in OTM therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Xie, Q. Tang, S. Yu, W. Zheng, G. Chen, X. Huang, L. Chen
Summary: BMAL1 in PDLCs plays a crucial role in sensing and transmitting biomechanical signals during orthodontic tooth movement. Upregulation of BMAL1 expression by orthodontic force can enhance secretion of CCL2 and RANKL, ultimately promoting osteoclast recruitment. Inhibition of ERK/AP1/BMAL1 signaling can effectively reduce osteoclastic activity and slow down orthodontic tooth movement.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yoo-Sung Nam, Dong-Wook Yang, Jung-Sun Moon, Jee-Hae Kang, Jin-Hyoung Cho, Ok-Su Kim, Min-Seok Kim, Jeong-Tae Koh, Young-Jun Kim, Sun-Hun Kim
Summary: Sclerostin in periodontal ligament (PDL) may play a crucial role as a homeostatic regulator in the periodontium and can be a potential target for therapeutic modulation of biophysical-force-induced tooth movement (BFTM).
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Multidisciplinary Sciences
Torkan Gholamalizadeh, Sune Darkner, Peter Lempel Sondergaard, Kenny Erleben
Summary: This study investigates the force systems used for tooth position correction in orthodontic treatments by studying different types of tooth movements and the effect of couple force direction on the position of the center of rotation (CRot). Results show that similar patterns can be obtained for CRot positions of different patients and teeth under the same load conditions, but changes in force and couple directions can cause misalignment of CRot trajectories.
Review
Cell Biology
Lanzhi Deng, Yilin Chen, Jiusi Guo, Xianglong Han, Yongwen Guo
Summary: YAP/TAZ are crucial transcriptional coactivators involved in the mechanical-biochemical signal transduction, playing a central role in regulating cellular responses and tissue remodeling during orthodontic tooth movement.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Ziqi Gan, Yifan Zhao, Yeke Wu, Wei Yang, Zhihe Zhao, Lixing Zhao
Summary: Temporomandibular disorder (TMD) is a clinical challenge with limited therapeutic methods. We developed a biomimetic scaffold with optimal reinforcement, demonstrating its superior properties and potential for complex tissue regeneration in animal models.
ACTA BIOMATERIALIA
(2022)
Correction
Cell Biology
Fang Pei, Jialing Liu, Lan Zhang, Xuefeng Pan, Wei Huang, Xiao Cen, Shishu Huang, Ying Jin, Zhihe Zhao
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Yingke Liu, Xingying Qi, Yashi Wang, Man Li, Quan Yuan, Zhihe Zhao
Summary: Oral mucositis (OM) is a common complication of cancer chemotherapy, and its treatment is challenging. In this study, we developed nanomicelles that target inflammation and loaded them with the anti-inflammatory drug cannabidiol (CBD). These nanomicelles showed improved accumulation and retention of CBD, and demonstrated better anti-inflammatory effects compared to free CBD in both local and systemic administration. They also accelerated healing and inhibited inflammatory cell infiltration and transcription. Overall, CBD-loaded nanomicelles show promise for OM treatment.
Article
Endocrinology & Metabolism
Dian Jing, Zexi Chen, Yi Men, Yating Yi, Yuhong Wang, Jun Wang, Jianru Yi, Lingyun Wan, Bo Shen, Jian Q. Feng, Zhihe Zhao, Hu Zhao, Chaoyuan Li
Summary: Normal development of craniofacial sutures is essential for cranial and facial growth. Suture stem cells (SuSCs) play a crucial role in maintaining homeostasis, repairing damage, and balancing stress. Mechanical forces stimulate suture and bone remodeling, with the Wnt signaling pathway playing a key role in this process.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. Y. Yang, S. H. Li, J. L. Liu, X. Q. Sun, Y. Y. Cen, R. Y. Ren, S. C. Ying, Y. Chen, Z. H. Zhao, W. Liao
Summary: This study developed a deep learning model to assist pathologists in diagnosing oral squamous cell carcinoma (OSCC), demonstrating improved diagnostic accuracy and speed in both junior and senior pathologists.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruyi Wang, Li Mei, Shuai Wang, Yu Li
Summary: Impaction of multiple maxillary anterior teeth is a rare but significant issue that affects patients' chewing function and esthetics. This case report presents a successful treatment of an 11-year-old girl with surgical exposure and orthodontic traction, resulting in proper alignment of impacted teeth and healing of the surrounding dentigerous cyst.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Immunology
YiFan Wang, GuanYin Zhu, Fang Pei, ZhiHe Zhao
Summary: This study found that SNHG15 plays an important regulatory role in osteoclast differentiation by competitively binding to miR-381-3p to promote the expression of NEK2, thereby promoting cell proliferation, migration, and differentiation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Yingke Liu, Zhihe Zhao, Man Li
Summary: Cell penetrating peptides (CPPs), a class of short peptides capable of translocating drugs across cell membranes, have shown significant potential in drug delivery, particularly in the treatment of cancer, myocardial ischemia, ocular posterior segment disorders, etc. Recent research has focused on CPP-functionalized nano-drug delivery systems, highlighting their promising clinical translation.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Yuan Tao, Yingke Liu, Ziyan Dong, Xiaoxiao Chen, Yashi Wang, Ting Li, Jiaxin Li, Shuya Zang, Xuan He, Dong Chen, Zhihe Zhao, Man Li
Summary: This study developed dandelion-like size-shrinkable nanoparticles for tumor-targeted delivery of hypoxia regulator resveratrol and photodynamic agent chlorine e6, which enhanced the therapeutic effects of photodynamic therapy in oral squamous cell carcinoma by elevating oxygen content in tumor cells and inducing autophagic cell death and apoptosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Yu Shen, Dian Jing, Zhihe Zhao
Summary: Extracellular matrix (ECM) stiffness plays a crucial role in the differentiation of human bone marrow mesenchymal stem cells (hBMSCs). This study reveals that the phosphoinositide 3-kinase (PI3K)-AKT pathway is highly correlated with ECM stiffness. AKT phosphorylation influences the subcellular localization and activation of Yes-associated protein (YAP).
CELLULAR SIGNALLING
(2022)
Article
Cell & Tissue Engineering
Yifan Wang, Guanyin Zhu, Fang Pei, Yigan Wang, Jun Liu, Caixia Lu, Zhihe Zhao
Summary: Using RNA-seq, this study investigated the differential expression of miRNAs in dental, periodontal, and alveolar bone tissue of orthodontic tree shrews under tension. The results showed that miR-149 could modulate osteoblast differentiation under orthodontic mechanical tension through targeting ASAP3.
STEM CELLS INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruyi Wang, Hui Qiao, Yuran Qian, Gehua Zhen, Zhihe Zhao, Yu Li
Summary: This study investigates the effects of TPTD and ABL on adolescent mandibular growth. The results show that both drugs have promotive effects on mandibular growth, but the effects are attenuated when combined with mandibular advancement (MA). In addition, in vitro experiments demonstrate that both drugs can enhance mandibular chondrocyte proliferation and extracellular matrix synthesis, as well as regulate the expression of related genes.
EUROPEAN JOURNAL OF ORTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Qi, Y. Zhang, L. Xu, X. Zheng, Y. Li, Q. Wei, Y. Lie, Z. Zhao, J. Fang
Summary: This study reveals the molecular function of RAP2A as a mechanotransduction molecule in TMJOA progression, playing a critical role in chondrocyte phenotype and matrix synthesis function.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lin Xu, Yuan Li, Li Mei, Hexu Qi, Jie Fang, Yu Li
Summary: The local injection of abaloparatide can promote mandibular condyle lengthening in adolescent rats by enhancing chondrogenesis in the mandibular condylar cartilage and ossification in the subchondral bone. Additionally, abaloparatide can also promote the proliferation of chondrocytes and enhance the osteogenic differentiation of pre-osteoblasts.
JOURNAL OF ORAL REHABILITATION
(2023)
Proceedings Paper
Computer Science, Information Systems
Xian Shuai, Yulin Shen, Siyang Jiang, Zhihe Zhao, Zhenyu Yan, Guoliang Xing
Summary: In this paper, a federated learning framework called BalanceFL is proposed to address the challenge of long-tailed data distribution. By designing a novel local update scheme, BalanceFL can handle both global and local data imbalance issues. Experimental results demonstrate that BalanceFL outperforms state-of-the-art federated learning approaches on three datasets.
2022 21ST ACM/IEEE INTERNATIONAL CONFERENCE ON INFORMATION PROCESSING IN SENSOR NETWORKS (IPSN 2022)
(2022)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)