Article
Ophthalmology
Kafayat A. Oyemade, Timothy T. Xu, Johanny Lopez Dominguez, Mihai G. Dumbrava, David O. Hodge, Launia J. White, Lauren A. Dalvin
Summary: The incidence of intraocular tumors in Olmsted County, Minnesota was determined in this population-based study. Most intraocular tumors were benign melanocytic lesions, while malignant tumors were rare. It is important to monitor these tumors appropriately to prevent vision loss and potentially life-threatening malignancies.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Juliana H. VanderPluym, Kartik Mangipudi, Amir Abdallah Mbonde, David Gritsch, Edoardo Caronna, Rashmi B. Halker B. Singh, Richard J. Butterfield, Jonathan H. Smith
Summary: This study aims to determine the incidence, recurrence rate, and clinical associations of status migrainosus (SM) in care-seeking residents of Olmsted County, Minnesota. Between 2012 and 2017, 237 incident cases of SM were identified, with a majority being female. Aberrant sleep patterns were identified as a potentially modifiable risk factor for 1-year SM recurrence.
Article
Medicine, General & Internal
Ann M. Rusk, Rachel E. Giblon, Alanna M. Chamberlain, Christi A. Patten, Jamie R. Felzer, Yvonne T. Bui, Chung-Il Wi, Christopher C. Destephano, Barbara A. Abbott, Cassie C. Kennedy
Summary: The smoking prevalence and pharmaceutical cessation aid uptake were higher in the Indigenous cohort, but the relapse rate after achieving cessation was more than three times higher compared to the non-Indigenous cohort.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Clinical Neurology
Mahboubeh Fereidan-Esfahani, Paul A. Decker, Jeanette E. Eckel Passow, Claudia F. Lucchinetti, Eoin Patrick Flanagan, William Oliver Tobin
Summary: Tumefactive demyelination (TD) is a rare condition, but should be suspected in patients presenting with subacutely progressive neurological deficits associated with MRI findings and CSF analysis.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
June Tome, Kanika Sehgal, Amrit K. Kamboj, William S. Harmsen, Patricia P. Kammer, Edward V. Loftus, William J. Tremaine, Sahil Khanna, Darrell S. Pardi
Summary: The study found that the incidence of MC and its subtypes remained stable between 2011 and 2019, but the prevalence was higher than in previous periods. The incidence of MC continues to be associated with increasing age and female sex.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Clinical Neurology
Enrico Giordan, Christopher S. Graffeo, Alejandro A. Rabinstein, Robert D. Brown Jr, Walter A. Rocca, Alanna M. Chamberlain, Giuseppe Lanzino
Summary: A decrease in the incidence and 30-day case-fatality rate of aSAH was observed in Olmsted County, Minnesota from 1996 to 2016, with an accelerated decline in the fatality rate from 2006 to 2016. These trends align with previous studies and coincide with a significant reduction in smoking rates in the population.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Gina R. Chacon Osorio, Saranya P. Wyles, Nneka I. Comfere, Paul Y. Takahashi, Jennifer M. Manggaard, Karen M. Fischer, Heather N. Jett, Abhinav Singla, Nahid Y. Vidal
Summary: Malignant skin tumors in chronic leg ulcers are often underdiagnosed, leading to treatment delay and poor outcomes. This study aimed to determine the incidence and characteristics of skin cancers in leg ulcers in a specific population from 1995 to 2020. Electronic medical records were analyzed and revealed 37 individuals with skin cancers in nonhealing ulcers. The most common types of skin cancer were basal cell carcinoma and squamous cell carcinoma.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Catielen Paula Pavi, Isabella Dai Pra, Rafael Dorighello Cadamuro, Isamu Kanzaki, Jhuly Wellen Ferreira Lacerda, Louis Pergaud Sandjo, Roberto Messias Bezerra, Jorge Federico Orellana Segovia, Gislaine Fongaro, Izabella Thais Silva
Summary: This study evaluated the activity of seventeen extracts derived from eight Amazonian medicinal plants against herpes simplex virus and chikungunya virus. Four extracts exhibited significant activity against both viruses, including the drug-resistant strains. Virucidal tests showed a higher level of virucidal activity compared to antiviral activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Marzena Lenart, Edyta Dzialo, Anna Kluczewska, Kazimierz Weglarczyk, Anna Szaflarska, Magdalena Rutkowska-Zapala, Marcin Surmiak, Marek Sanak, Anna Pituch-Noworolska, Maciej Siedlar
Summary: The study identified upregulated expression of four miRNAs in patients with severe and/or recurrent HSV infection, which, when inhibited, affected NK cell antiviral response. Furthermore, these miRNAs were found to regulate genes involved in antiviral response pathways and impact NK cell intracellular protein expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Geffen Kleinstern, Dirk R. Larson, Cristine Allmer, Aaron D. Norman, Grace Muntifering, Jason Sinnwell, Alissa Visram, Vincent Rajkumar, Angela Dispenzieri, Robert A. Kyle, Susan L. Slager, Shaji Kumar, Celine M. Vachon
Summary: High body mass index is a prognostic factor for the progression of MGUS, and this association may be stronger among females.
BLOOD CANCER JOURNAL
(2022)
Review
Immunology
Divya Sharma, Supriya Sharma, Natasha Akojwar, Ayusha Dondulkar, Nikhil Yenorkar, Deepti Pandita, Satyendra K. K. Prasad, Mahaveer Dhobi
Summary: This review summarizes the history, life cycle, current treatment methods, and limitations of two herpes viruses. It also discusses vaccine strategies and nanotechnological approaches for oral and genital herpes infections. The article provides insight for researchers and the healthcare sector on challenges and upcoming solutions in the treatment and vaccine development against HSV infections.
Article
Immunology
Daniel C. DeSimone, Brian D. Lahr, Nandan S. Anavekar, Muhammad R. Sohail, Imad M. Tleyjeh, Walter R. Wilson, Larry M. Baddour
Summary: The incidence of infective endocarditis (IE) in Olmsted County, Minnesota increased over time, particularly enterococcal IE, while Staphylococcus aureus IE showed seasonal dependence. There was no statistically significant difference in the incidence of viridans group streptococci (VGS) IE before and after the publication of the 2007 AHA IE prevention guidelines.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Ji Xiao, Miaomiao Cai, Yifei Wang, Ping Ding
Summary: The iridoid compounds in traditional Chinese medicine have significant antiviral effects. This study identified seven new iridoid compounds from the aerial parts of Morinda officinalis, with officinaloside C showing significant anti-HSV-1 activity.
Article
Medicine, General & Internal
Elliott H. Campbell, Jacob P. Reinhart, Olivia M. Crum, Sydney L. Proffer, Amy Weaver, Lawrence E. Gibson, Jerry D. Brewer, Addison M. Demer
Summary: This study aimed to investigate the changes in the incidence and mortality of cutaneous melanoma in the fastest-growing segment of the US population, middle-aged adults. The results showed a significant increase in the incidence of melanoma since 1970, particularly among female patients. In the past 15 years, the incidence has continued to rise in women, while it has stabilized in men.
MAYO CLINIC PROCEEDINGS
(2023)