Editorial Material
Clinical Neurology
Juliana H. VanderPluym
Summary: Migraine is a common neurologic disease characterized by attacks of headache and nonheadache symptoms. It has the highest prevalence in women aged 18-44 and is the leading cause of disability for them. Pregnancy is a major life event for women in this age group, and some may avoid it due to concerns about the potential worsen of migraine during pregnancy, difficulty in pregnancy, and negative effects on their child.
Review
Chemistry, Inorganic & Nuclear
Mariola Koszytkowska-Stawinska, Wlodzimierz Buchowicz
Summary: The bioorganometallic chemistry of ferrocene is increasingly important, as demonstrated by the significant biological properties of ferrocene-triazole conjugates. These conjugates are synthesized via azide-alkyne cycloaddition reactions and have been shown to exhibit various activities such as anticancer, antibacterial and/or antifungal, antiprotozoal, and other effects. The role of the ferrocene core in the biological activity of these conjugates is still not fully understood, but the redox properties of ferrocene have been proposed to be important in some cases.
DALTON TRANSACTIONS
(2023)
Editorial Material
Business
Justin Paul, Altaf Merchant, Yogesh K. Dwivedi, Gregory Rose
Summary: Classic literature reviews play a crucial role in advancing a subject area. Framework-based reviews and reviews that develop classic theories are often more impactful. Successful review articles not only identify research gaps but also establish future research agenda.
JOURNAL OF BUSINESS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Darren C. Holland, Anthony R. Carroll
Summary: This article presents a meta-analysis of the biological activities of 2048 marine indole alkaloids (MIAs) and highlights the underexplored bioactivity potentials of most published MIAs. Despite the majority of MIAs not exhibiting cytotoxic or antimicrobial activity, there is still a focus on evaluating structurally related analogues using these assays. Cheminformatics analyses reveal that some MIAs possess potent and diverse activities, and many analogues that were previously only tested in cellular toxicity assays could be better utilized to generate structure-activity relationships for the treatment of emerging diseases. Shifting the focus to non-toxic disease targets could maximize the potential of MIAs for drug discovery.
NATURAL PRODUCT REPORTS
(2023)
Review
Allergy
Natalya Maltseva, Elena Borzova, Daria Fomina, Mojca Bizjak, Dorothea Terhorst-Molawi, Mitja Kosnik, Kanokvalai Kulthanan, Raisa Meshkova, Simon Francis Thomsen, Marcus Maurer
Summary: Cold urticaria is a chronic condition characterized by allergic reactions to cold, with mechanisms involving autoallergens and proinflammatory mediators. Diagnosis relies on patient history and cold stimulation testing, while treatment includes cold avoidance and medication use. Many questions regarding ColdU remain unanswered, highlighting the need for further research to improve management strategies.
Review
Chemistry, Multidisciplinary
Mahendra Rai, Avinash P. Ingle, Joanna Trzcinska-Wencel, Magdalena Wypij, Shital Bonde, Alka Yadav, Gabriela Kratosova, Patrycja Golinska
Summary: Nanobiotechnology is a rapidly emerging field with significant potential, and biogenically synthesized silver nanoparticles exhibit unique physicochemical properties that enable a wide range of applications in medicine, food, agriculture, and industries.
Review
Biochemistry & Molecular Biology
Adriana Volna, Martin Bartas, Petr Pecinka, Vladimir Spunda, Jiri Cerven
Summary: This paper reviews the current understanding of miRNAs in spring barley, discussing their roles in plant development, homeostasis, and immune processes, and proposing future research directions and unresolved questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zeina Alraawi, Nayan Banerjee, Srujana Mohanty, Thallapuranam Krishnaswamy Suresh Kumar
Summary: The study of protein aggregation, especially amyloidosis, has attracted considerable interest. Despite the abundance of research articles, the understanding of these aggregates is still limited. This review provides a comprehensive overview of amyloid proteins, including their discovery, structure, formation mechanisms, and the influence of specific proteins and the biophysical and cellular environment. Additionally, it discusses the therapeutic strategies and drug failure rates in clinical trials for neurodegenerative diseases, as well as the potential impact of COVID-19 on triggering early-onset amyloidosis. The review also briefly explores the applications of amyloid proteins as biomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Immunology
Linda Abou Chacra, Florence Fenollar, Khoudia Diop
Summary: The vaginal microbiome is an important part of the human microbiome, characterized by unique conditions. Increased diversity in the microbiota can lead to dysbiosis such as bacterial vaginosis, with significant health consequences. Diagnosis and treatment methods are evolving, and research on this topic is becoming increasingly important.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Aline A. Zuma, Wanderley de Souza
Summary: Chagas disease is a Neglected Tropical Disease affecting around 6-7 million people worldwide, predominantly in Latin America. Current treatments, benznidazole and nifurtimox, have limited effectiveness and can cause side effects, especially in the chronic phase. Studies have shown potential new drugs with equivalent or superior efficacy to benznidazole, highlighting the need for further research to improve treatment options.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Peripheral Vascular Disease
Dixitha Anugula, Rhanderson Cardoso, Gowtham R. Grandhi, Ron Blankstein, Khurram Nasir, Mouaz Al-Mallah, Dipan J. Shah, Miguel Cainzos-Achirica
Summary: The coronary artery calcium score is a useful tool for further risk stratification in the primary prevention of atherosclerotic cardiovascular disease. In addition to detecting coronary artery calcium, non-contrast scans also allow visualization of calcifications in the thoracic aorta and heart valves. Recent studies have evaluated the clinical value of measuring thoracic aortic calcification, aortic valve calcification, and mitral annulus calcification. Although their added value has traditionally been considered modest, some studies suggest that severe thoracic aortic calcification and aortic valve calcifications may have prognostic implications, particularly in younger individuals. Further research is needed to fully understand their potential role in risk assessment.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Hamid-Reza Mohammadi-Motlagh, Mona Sadeghalvad, Niloofar Yavari, Rosita Primavera, Setareh Soltani, Shashank Chetty, Abantika Ganguly, Shobha Regmi, Tina Floyel, Simranjeet Kaur, Aashiq H. H. Mirza, Avnesh S. S. Thakor, Flemming Pociot, Reza Yarani
Summary: Pancreatic beta cells play a crucial role in regulating blood sugar levels through insulin production. Research has shown that autophagy, the process of recycling cell components, is vital for beta cell function and survival. Impaired autophagy leads to loss of beta cell function, apoptosis, and the development of diabetes. Factors such as endoplasmic reticulum stress, inflammation, and high metabolic demands can affect autophagy, thereby impacting beta cell function and insulin synthesis. This review highlights the importance of autophagy in determining the fate of beta cells in diabetes and discusses the role of intrinsic and extrinsic factors in modulating autophagy and cellular failure.
Review
Pharmacology & Pharmacy
Javid Sadri Nahand, Nikta Rabiei, Reza Fathazam, Mohammad Taghizadieh, Mohammad Saeid Ebrahimi, Maryam Mahjoubin-Tehran, Hossein Bannazadeh Baghi, AliReza Khatami, Mohammad Abbasi-Kolli, Hamid Reza Mirzaei, Neda Rahimian, Maryam Darvish, Hamed Mirzaei
Summary: Chemoresistance is a major factor in cancer treatment failure, highlighting the need to understand molecular pathways and develop new therapies. Viruses have been linked to metastatic tumor masses, and viral infections can dominate the development of cancer cell chemoresistance.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Clemence Lacroix, Isabelle Alleman-Brimault, Arnaud Zalta, Frank Rouby, Catherine Casse-Perrot, Elisabeth Jouve, Laurence Attolini, Romain Guilhaumou, Joelle Micallef, Olivier Blin
Summary: Medical cannabis has shown potential in treating neurological disorders, but clinical studies have produced inconsistent results. Patients' perspectives highlight the practical use of cannabis for symptom relief. However, the use of medical cannabis also poses safety risks and requires medical supervision.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Nagma Dalvi, Ruth A. Kleinerman, Sidnei Epelman, David H. Abramson, Ira J. Dunkel
Summary: Survivors of hereditary retinoblastoma with RB1 gene mutations may have an increased risk for developing low-grade glioma, as shown by a retrospective review of databases from Memorial Sloan Kettering Cancer Center and the NCI.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Lucy V. Cobbs, Jasmine H. Francis, Ira J. Dunkel, Y. Pierre Gobin, Scott E. Brodie, David H. Abramson
Summary: This study aimed to identify best practices for treating 13q deletion syndrome patients with retinoblastoma using super-selective ophthalmic artery chemosurgery and intravitreal injection therapy. The majority of patients treated with these regimens had good ocular survival rates, but there were increased risks of systemic complications. Despite toxicities, the majority of patients had good outcomes with acceptable toxicity levels.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Joanne F. Chou, Jennifer S. Ford, Ruth A. Kleinerman, David H. Abramson, Jasmine H. Francis, Charles A. Sklar, Kevin C. Oeffinger, Leslie L. Robison, Ira J. Dunkel, Danielle Novetsky Friedman
Summary: The study found that most Rb survivors adhere to cancer screening recommendations and the rates are not significantly different from non-Rb controls. Among female Rb survivors, utilization of Pap smear for cervical cancer screening is associated with older age, overweight/obesity, and lack of recent contact with medical personnel. Future research is needed to further explore these associations for potential intervention.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Jasmine H. Francis, Allison L. Richards, Diana L. Mandelker, Michael F. Berger, Michael F. Walsh, Ira J. Dunkel, Mark T. A. Donoghue, David H. Abramson
Summary: By sequencing enucleated retinoblastoma specimens, this study found correlations between vitreous seeding and copy number variations, as well as between BCOR mutations and propensity for metastasis. Additionally, a portion of patients were found to have additional germline mutations in other cancer-related genes.
Article
Ophthalmology
Shuk Kei Cheng, Anika Michael, Allison E. Rizzuti
Summary: We report a rare case of severe phlyctenular keratoconjunctivitis associated with pachydermoperiostosis (PDP). To our knowledge, this is the first case of PDP to initially present with vision loss.
Article
Oncology
Ira J. Dunkel, Jin Piao, Guillermo L. Chantada, Anuradha Banerjee, Sherif Abouelnaga, Jeffrey C. Buchsbaum, Thomas E. Merchant, Meaghan M. Granger, Rima F. Jubran, Joanna L. Weinstein, Lauren Saguilig, David H. Abramson, Mark D. Krailo, Carlos Rodriguez-Galindo, Murali M. Chintagumpala
Summary: Intensive multimodality therapy is highly effective for patients with regional extraocular retinoblastoma and stage IVa metastatic retinoblastoma. However, more effective therapy is still required for patients with CNS involvement.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Sameer Farouk Sait, Mauricio Rendon Bernot, Elizabeth Klein, David H. Abramson, Jasmine H. Francis, Stephen Gilheeney, Matthias A. Karajannis, Barbara Spitzer, Suzanne Wolden, Ira J. Dunkel, Nancy A. Kernan
Summary: Stage 4a metastatic RB patients treated with ASCT achieved similar overall survival regardless of pretransplant chemotherapy response. Furthermore, the administration of IFRT did not seem necessary for controlling bony disease and increased the risk of osteosarcoma.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Genetics & Heredity
Priya H. Marathe, Ira J. Dunkel, Jasmine H. Francis, Zoltan Antal, Y. Pierre Gobin, David H. Abramson, Danielle N. Friedman
Summary: This study assesses ovarian function in pubertal female survivors of retinoblastoma treated with melphalan-based OAC, and provides initial evidence that ovarian function remains intact.
OPHTHALMIC GENETICS
(2022)
Article
Multidisciplinary Sciences
David H. Abramson, Diana L. Mandelker, A. Rose Brannon, Ira J. Dunkel, Ryma Benayed, Michael F. Berger, Maria E. Arcila, Marc Ladanyi, Danielle Novetsky Friedman, Gowtham Jayakumaran, Monica S. Diosdado, Melissa A. Robbins, Dianna Haggag-Lindgren, Neerav Shukla, Michael F. Walsh, Prachi Kothari, Dana W. Y. Tsui, Jasmine H. Francis
Summary: Cell free DNA (cfDNA) and circulating tumor cell free DNA (ctDNA) from blood (plasma) are increasingly used in oncology for various purposes. In this study, ctDNA was investigated in retinoblastoma patients at different stages of treatment, and it was found that the levels of ctDNA RB1 significantly decreased after optic nerve transection.
Article
Ophthalmology
David H. Abramson, Diana Mandelker, A. Rose Brannon, Michael F. Berger, Melissa Robbins, Ira J. Dunkel, Jasmine H. Francis
Summary: The study aims to determine if RB1 ctDNA can be detected in the blood of patients with pseudoretinoblastoma, potentially aiding clinicians in the diagnosis of retinoblastoma.
BMJ OPEN OPHTHALMOLOGY
(2022)
Article
Oncology
Ira J. Dunkel, Francois Doz, Nicholas K. Foreman, Darren Hargrave, Alvaro Lassaletta, Nicolas Andre, Jordan R. Hansford, Tim Hassall, Matthias Eyrich, Sridharan Gururangan, Ute Bartels, Amar Gajjar, Lisa Howell, Deepti Warad, Misena Pacius, Rachel Tam, Yu Wang, Li Zhu, Kenneth Cohen
Summary: The CheckMate 908 study evaluated the use of NIVO and NIVO + IPI in pediatric patients with high-grade CNS malignancies. The results showed that these treatments did not provide significant clinical benefits compared to historical data, but they had manageable safety profiles.
Article
Oncology
Sameer Farouk Sait, Cheryl Fischer, Zoltan Antal, Krisoula Spatz, Daniel E. Prince, Katarzyna Ibanez, Gerald G. Behr, Ira J. Dunkel, Matthias A. Karajannis
Summary: Off label use of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) in pediatrics is increasing. Limited long-term safety data and specific toxicities in pediatrics may arise. A retrospective analysis of patients under 18 years old with recurrent/refractory FGFR altered gliomas treated with FGFR TKIs at MSKCC (n = 7) showed slipped capital femoral epiphyses in three of seven patients along with increased linear growth velocity. Clinicians should closely monitor bone health and be aware of the potential for serious orthopedic complications, such as slipped capital femoral epiphyses, in pediatric patients receiving FGFR TKI treatment.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Hematology
James A. Whitlock, Birgit Geoerger, Ira J. Dunkel, Michael Roughton, Jeea Choi, Lisa Osterloh, Mark Russo, Darren Hargrave
Summary: Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder primarily affecting children, and BRAF mutations are common in LCH patients. Dabrafenib, either alone or in combination with trametinib, has shown clinical efficacy and manageable toxicity in relapsed/refractory BRAF V600-mutant pediatric LCH. These findings suggest that dabrafenib-based therapies could be a potential treatment option for this patient group.
Article
Oncology
Murali Chintagumpala, Jin Piao, Dan Gombos, Patricia Chevez-Barrios, Lindsay Brock, Ira J. Dunkel, Rima Jubran, Ann M. Leahey, Jonathan Kim, Joan O'Brien, Carol L. Shields, Carlos Rodriguez-Galindo
Summary: This study examined the feasibility of delivering melphalan directly into the ophthalmic artery for the treatment of retinoblastoma. The results showed that the treatment did not meet the feasibility goals, with a certain failure rate. The study suggests that centers planning to use this treatment should undergo training or refer patients to centers with expertise.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Melanie D. Degliuomini, Katherine Armstrong, Audrey Mauguen, Emily K. Slotkin, Stephen S. Roberts, Ira J. Dunkel, Mary Clouser, Michael Ortiz, Gerald A. Soff
Summary: This single-institution study examined the impact of chemotherapy-induced thrombocytopenia (CIT) on pediatric solid tumor cohorts. The results showed that CIT increased platelet transfusion burden and led to treatment reduction and delay.
PEDIATRIC BLOOD & CANCER
(2022)
