Article
Neurosciences
Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Fotini Boufidou, Manolis Markianos
Summary: Cholesterol levels may be associated with disease characteristics in multiple sclerosis, particularly with demyelination and immune response. This study found lower levels of plasma and cerebrospinal fluid cholesterol in patients with multiple sclerosis. Patients with positive oligoclonal bands had even lower cerebrospinal fluid cholesterol levels, which may be related to disease progression and enhanced humoral immune response.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Mariola Swiderek-Matysiak, Magdalena Oset, Malgorzata Domowicz, Grazyna Galazka, Magdalena Namiecinska, Mariusz Stasiolek
Summary: A study analyzed 242 cerebrospinal fluid samples from patients with T2-hyperintensive lesions on brain MRI. The levels of IL-6, osteopontin, and neurofilaments light chain were found to be significantly different among groups, but their diagnostic power for differentiating multiple sclerosis from other inflammatory CNS disorders was weak.
Article
Biochemistry & Molecular Biology
Mario Stampanoni Bassi, Tommaso Nuzzo, Luana Gilio, Mattia Miroballo, Alessia Casamassa, Fabio Buttari, Paolo Bellantonio, Roberta Fantozzi, Giovanni Galifi, Roberto Furlan, Annamaria Finardi, Arianna De Rosa, Anna Di Maio, Francesco Errico, Diego Centonze, Alessandro Usiello
Summary: The study found that levels of cerebrospinal fluid L-glutamate (L-Glu) were slightly reduced in patients with multiple sclerosis, and were correlated with disability progression and inflammatory molecules like interleukin. Abnormal expression of L-Glu was associated with disability progression, oxidative stress, and inflammation.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Xingwei Fang, Yaxin Lu, Yongmei Fu, Zifeng Liu, Allan G. Kermode, Wei Qiu, Li Ling, Chunxin Liu
Summary: This study investigated the association between routine cerebrospinal fluid (CSF) findings, especially CSF chloride, at the time of the first lumbar puncture and the relapse risk and disability progression of relapsing-remitting multiple sclerosis (RRMS). The study found that elevated CSF chloride levels were associated with a higher risk of MS relapse.
Article
Clinical Neurology
Simone Hjaeresen, Tobias Sejbaek, Marcus Axelsson, Helle Vinslov-Jensen, Sif Klovedal Mortensen, Gorm Pihl-Jensen, Lenka Novakova, Julie Damgaard Rosgaard Christensen, Christian Bonde Pedersen, Bo Halle, Frantz Rom Poulsen, Jette Lautrup Frederiksen, Mengliang Zhang, Eirikur Benedikz, Jan Lycke, Zsolt Illes, Asa Fex Svenningsen
Summary: This study found that levels of HTRA1 in cerebrospinal fluid significantly increased in multiple sclerosis patients, and disease modifying therapies were able to decrease these levels. ROC analysis showed that HTRA1 levels could distinguish healthy controls from MS patients, demonstrating potential biomarker value.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Christian Barro, Brian C. Healy, Yanqing Liu, Shrishti Saxena, Anu Paul, Mariann Polgar-Turcsanyi, Charles R. G. Guttmann, Rohit Bakshi, Harald Kropshofer, Howard L. Weiner, Tanuja Chitnis
Summary: Neurodegeneration and astrocytic activation are characteristic pathological features of progressive MS. sNfL and sGFAP can be used as tools to stratify patients based on progression and disease activity status.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Yoshimitsu Kuwabara, Shuichi Ono, Akira Katayama, Sachiko Kurihara, Yumiko Oishi, Toshiyuki Takeshita
Summary: This study evaluated the concentrations of osteopontin (OPN) in blood and follicular fluid (FF) during the ovarian cycle, and found that the plasma OPN concentration may serve as a novel clinical marker for predicting the risk of ovarian hyperstimulation syndrome (OHSS). A positive correlation was observed between OPN concentrations in FF and plasma samples, as well as between plasma OPN and FF VEGF concentrations, irrespective of the blood-sampling period.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Shinji Ashida, Takayuki Kondo, Chihiro Fujii, Mio Hamatani, Toshiki Mizuno, Hirofumi Ochi
Summary: This study found that the inflammatory profile in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is associated with magnetic resonance imaging (MRI) findings. This suggests that combined CSF and MRI analysis may help identify different MS phenotypes related to the heterogeneity of underlying immune processes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Genetics & Heredity
Emily Eckman, Jon D. Laman, Kael F. Fischer, Bert Lopansri, Tom B. Martins, Harry R. Hill, John D. Kriesel
Summary: A panel of 10 IgG enzyme-linked immunosorbent assays (ELISAs) were developed to detect anti-microbial immune responses in the cerebrospinal fluid (CSF) of patients with demyelinating diseases. CSF reactivity against certain bacterial lysates was significantly higher in demyelination patients compared to controls, indicating potential intrathecal antibody production. This study supports the hypothesis that specific MS candidate microbes may contribute to demyelination in some patients.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Immunology
Xiang Zhang, Hongjun Hao, Tao Jin, Wei Qiu, Huan Yang, Qun Xue, Jian Yin, Ziyan Shi, Hai Yu, Xiaopei Ji, Xiaobo Sun, Qiuming Zeng, Xiaoni Liu, Jingguo Wang, Huining Li, Xiaoyan He, Jing Yang, Yarong Li, Shuangshuang Liu, Alexander Y. Lau, Feng Gao, Shimin Hu, Shuguang Chu, Ding Ding, Hongyu Zhou, Haifeng Li, Xiangjun Chen
Summary: The nationwide prevalence of cerebrospinal fluid oligoclonal band (CSF-OCB) in Chinese multiple sclerosis (MS) patients is 76.4%, and it demonstrates a good diagnostic performance in differentiating MS from other CNS diseases. The CSF-OCB prevalence in Chinese MS patients is correlated with high latitude and altitude.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ilaria Callegari, Mika Schneider, Vera Aebischer, Margarete M. M. Voortman, Undine Proschmann, Tjalf Ziemssen, Raija Lindberg, Bettina Fischer-Barnicol, Michael Khalil, Ludwig Kappos, Jens Kuhle, Nicholas S. R. Sanderson, Tobias Derfuss
Summary: This study found that natalizumab can diffuse in different anatomical compartments, including cerebrospinal fluid and milk. By developing a flow-cytometry-based assay and applying it to quantify natalizumab in body fluids, including cerebrospinal fluid, breastmilk, and serum, a better understanding of the safety of therapeutic antibody administration during pregnancy and lactation can be achieved.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Francesco Errico, Luana Gilio, Andrea Mancini, Tommaso Nuzzo, Mario Stampanoni Bassi, Laura Bellingacci, Fabio Buttari, Ettore Dolcetti, Antonio Bruno, Giovanni Galifi, Roberto Furlan, Annamaria Finardi, Anna Di Maio, Massimiliano Di Filippo, Diego Centonze, Alessandro Usiello
Summary: The neuroinflammatory process in multiple sclerosis (MS) is associated with changes in synaptic transmission and levels of excitatory amino acids. This study found that levels of L-aspartate (L-Asp) were reduced in the cortex and spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), a model for MS. Additionally, CSF levels of L-Asp were decreased in MS patients and showed a positive correlation with inflammatory biomarkers.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Immunology
Marco Puthenparampil, Tommaso Torresin, Silvia Franciotta, Annachiara Marin, Federica De Napoli, Valentina Annamaria Mauceri, Silvia Miante, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo
Summary: This study found an association between retinal hyper-reflecting foci (HRF) and cerebrospinal fluid (CSF) cytokines and MRI parameters in relapsing-remitting MS (RRMS). The results suggest that HRF may serve as markers of activated microglia in MS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Ruturaj Masvekar, Jonathan Phillips, Mika Komori, Tianxia Wu, Bibiana Bielekova
Summary: Multiple sclerosis (MS)-related inflammation can be categorized into lesional and non-lesional activity, with IL12p40 and CHI3L1 identified as the best CSF biomarkers for measuring MS lesional activity. The study aims to develop a CSF-biomarker-based molecular surrogate for MS lesional activity.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Harald Hegen, Klaus Berek, Gabriel Bsteh, Michael Auer, Patrick Altmann, Franziska Di Pauli, Astrid Grams, Dejan Milosavljevic, Markus Ponleitner, Paulina Poskaite, Christine Schnabl, Sebastian Wurth, Anne Zinganell, Thomas Berger, Janette Walde, Florian Deisenhammer
Summary: This study aimed to investigate the additional predictive value of x-FLC index and sNfL Z score for MS disease activity. The results showed that both x-FLC index and sNfL Z score independently predicted the time to second clinical attack. The chance of relapse within 12 months was 2% for patients with high levels of x-FLC index (>100) and high sNfL Z score (>3), 30% for patients with high x-FLC index (>100) and lower sNfL Z score (<= 3), 70% for patients with lower x-FLC index (<= 100) but high sNfL Z score (>3), and 90% for patients with lower levels of x-FLC index (<= 100) and sNfL Z score (<= 3).