Article
Nutrition & Dietetics
Jesus F. Garcia-Gavilan, Indira Paz-Graniel, Nancy Babio, Dora Romaguera, Jose Alfredo Martinez, Vicente Martin, Maria Angeles Martinez, Jadwiga Konieczna, Miguel Ruiz-Canela, Jose Antonio de Paz Fernandez, Albert Goday, Miguel Angel Martinez-Gonzalez, Monica Bullo, Jordi Salas-Salvado
Summary: This study found that a high pro-inflammatory diet, as measured by the M-DIS, is associated with lower bone mineral density in a senior Mediterranean population with metabolic syndrome.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Food Science & Technology
Weili Feng, Xiaoping Wang, Daoqiang Huang, Anqi Lu
Summary: This study used an umbrella review and meta-analysis to summarize the association between dietary factors and the incidence of osteoporosis in adults. The findings suggest that dietary factors have an impact on osteoporosis, and consuming appropriate amounts of dairy products, vegetables, fruits, and micronutrients, while reducing alcohol and coffee intake, can help reduce the risk of osteoporosis.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Alejandro Martinez-Rodriguez, Javier Sanchez-Sanchez, Maria Martinez-Olcina, Manuel Vicente-Martinez, Laura Miralles-Amoros, Juan Antonio Sanchez-Saez
Summary: The study found that older and trained players have better physical fitness; higher weight and BMI have a negative impact on power, agility, speed, and endurance; adherence to the Mediterranean diet is moderate, and beach handball seems to have a beneficial influence on bone condition.
Review
Endocrinology & Metabolism
Vincenzo Garofalo, Federica Barbagallo, Rossella Cannarella, Aldo Eugenio Calogero, Sandro La Vignera, Rosita Angela Condorelli
Summary: This systematic review found no significant effect of different types of ketogenic diet on bone health, including bone mass density, bone formation, and overall bone turnover. Only in female subjects after a 10% weight loss, an increase in bone resorption and a decrease in new bone synthesis were observed, without increasing the risk of osteoporosis. Additionally, ketogenic diet was associated with weight loss, increased vitamin D levels, and reduced parathyroid hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Syed Danish Hussain, Abdullah M. Alnaami, Naji Aljohani, Shaun Sabico
Summary: Osteoporosis is a significant public health concern in Saudi Arabia, particularly among the aging population. This study examined the association between dietary calcium intake and osteoporosis risk in Saudi adults. Results showed that the overall mean calcium intake was very low and that certain dietary factors, such as tea intake and consumption of fish and eggs, were associated with a lower risk of osteoporosis.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Yi Zheng, Jiacheng Wang, Yawen Wang, Kelin Xu, Xingdong Chen
Summary: This study aimed to investigate the association between three plant-based diet indexes and bone loss. The results showed that higher hPDI and PDI were associated with increased risk of bone loss, while higher uPDI was associated with increased risk of osteoporosis. Several sensitivity analyses were conducted to ensure the robustness of results. The study demonstrates the deleterious effects of a plant-based diet on bone health and emphasizes the importance of a balanced diet.
Review
Nutrition & Dietetics
Abdulbaqi Al-Toma, Amin Herman, Willem F. Lems, Chris J. J. Mulder
Summary: Impaired bone mineral density is a common complication of adult-onset celiac disease. It is mainly caused by malabsorption of nutrients, changes in bone metabolism associated with inflammation, and decreased overall physical health and mobility. However, research on the surveillance, prevention, and treatment of bone disease in celiac disease is limited. A proper diet and sufficient intake of calcium and vitamin D are essential for reducing fracture risk in adult patients. Individualized approaches should be taken for patients with low bone mineral density or fragility fractures.
Article
Medicine, General & Internal
Alicia R. Jones, Koen Simons, Susan Harvey, Vivian Grill
Summary: Individuals with primary hyperparathyroidism have reduced cortical bone mineral density, but relatively preserved trabecular bone density. However, their fracture risk is still increased. Trabecular bone score may provide a more accurate assessment of bone quality and fracture risk. This study compared the effectiveness of bone mineral density and trabecular bone score in describing bone quality in patients with primary hyperparathyroidism, and also evaluated changes in trabecular bone score following parathyroidectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Maria Grau-Perez, Tamara Garcia-Barrera, Sara Ramirez-Acosta, Jose L. Gomez-Ariza, Beatriz Perez-Gomez, Inaki Galan-Labaca, Ana Navas-Acien, Josep Redon, Laisa S. Briongos-Figuero, Antonio Duenas-Laita, Jose Luis Perez-Castrillon, Maria Tellez-Plaza, Juan Carlos Martin-Escudero
Summary: The study evaluated the association between arsenic, cadmium, and selenium biomarkers with bone mineral density. Results showed that selenium was associated with BMD-related disease, while arsenic and cadmium were not. The non-linear association of selenium with BMD-related disease included a strong positive association with osteoporosis-related bone fractures risk at higher selenium exposure levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Toxicology
A. Saad-Hussein, M. M. Taha, N. N. Fadl, A-H Awad, H. Mahdy-Abdallah, G. Moubarz, H. Aziz, K. A. El-Shamy
HUMAN & EXPERIMENTAL TOXICOLOGY
(2016)
Article
Toxicology
A. Saad-Husseini, E. H. Thabet, M. M. Taha, E. M. Shahy, H. Mahdy-Abdallahl
HUMAN & EXPERIMENTAL TOXICOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Amal Saad-Hussein, Magda Noshy, Mona Taha, Haidan El-Shorbagy, Eman Shahy, Ebtesam A. Abdel-Shafy
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2017)
Article
Oncology
Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El Bastawisy, Shereen Hamdy Abd Elaziz, Mirhane Mohamed Hassan, Amal Saad-Hussein
Article
Public, Environmental & Occupational Health
Amira Roess, Sally Lahm, Ibrahim Kabbash, Amal Saad-Hussein, Ashraf Shaalan, Ossama Rasslan, Mohamed Mohamed
ANNALS OF GLOBAL HEALTH
(2018)
Article
Biotechnology & Applied Microbiology
Amal Saad-Hussein, Safia Beshir, Mona M. Taha, Eman M. Shahy, Weam Shaheen, Ebtesam A. Abdel-Shafy, Eman Thabet
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2019)
Article
Biology
Nadia Y. S. Morcos, Amal Saad-Hussein, Khadiga S. Ibrahim, Sanaa R. Abou-ElMakarem, Naglaa Abd El-Zaher, Gehan Moubarz
Article
Environmental Sciences
Elmahdy M. Elmahdy, Mohamed N. F. Shaheen, Neveen M. Rizk, Amal Saad-Hussein
FOOD AND ENVIRONMENTAL VIROLOGY
(2020)
Article
Environmental Sciences
Amal Saad-Hussein, Eman M. Shahy, Weam Shaheen, Khadiga S. Ibrahim, Heba Mahdy-Abdallah, Mona M. Taha, Salwa F. Hafez
Summary: The study found that furniture workers exposed to wood dust had significantly higher levels of AFB1/albumin, AST, ALT, MDA, and GPx, while CAT was significantly reduced compared to controls. A significant correlation was observed between AFB1/albumin levels and liver enzymes. CAT was inversely correlated with AFB1/albumin and liver enzymes, while GPx was inversely correlated with AST in workers.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2021)
Article
Rheumatology
Manar A. Helmy, Amal Saad-Hussein, Heba Allah Abd E. Rahman, Rasha S. Shemies, Mona Elhelaly, Asmaa F. Enein, Mona A. Helmy
Summary: The detected OCs p,p'-DDE and HCB are associated with increased risk of SLE in Egyptian patients and correlate to the manifestations of disease severity.
Article
Environmental Sciences
Amal Saad-Hussein, Mona Adel Helmy, Lamia Samir Ellaithy, Ali Wheida, Mostafa El Nazeer, Stephane C. Alfaro, Guillaume Siour, Agnes Borbon, Mohamed Magdy Abdel Wahab, Amira N. Mostafa
Summary: This study aimed to investigate the relationship between diarrhea morbidity rates and meteorological changes in several representative Egyptian governorates. The results showed that some meteorological parameters could serve as predictors for diarrhea morbidity rates in certain provinces, while the temporal trend and the relationship with meteorology were not significant in other provinces. The study concluded that the predictive power of meteorological data for diarrhea morbidity rates depends on the geographical location and infrastructures of the target area.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Amal Saad-Hussein, Wafaa Ghoneim Shousha, Sara Yahya Mohamed Al-Sadek, Shimaa Shawki Ramadan
Summary: This study investigated the role of MTHFR C677T and MTHFR A1298C gene polymorphisms on oxidative stress and homocysteine levels in wastewater treatment plant (WWTP) workers exposed to high lead concentrations. Workers with the TT polymorphism showed higher lead, homocysteine, and malondialdehyde (MDA) levels, and lower total antioxidant capacity (TAC) compared to other polymorphisms. Similar results were found among workers with the CC polymorphism. These gene polymorphisms can be used to predict the susceptibility to kidney impairments caused by high lead exposure among WWTP workers in the sludge departments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Amal Saad-Hussein, Haidi Karam-Allah Ramadan, Ashraf Bareedy, Reda Elwakil
Summary: This review discusses the impact of climate change on the distribution and severity of hepatic diseases and the mechanisms involved. It found that climate change can lead to outbreaks and re-emergence of hepatic diseases, as well as changes in chemical concentrations that affect the health pattern of hepatic toxicity and liver cancer. This review provides important information for health decision-makers.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Article
Meteorology & Atmospheric Sciences
Amira N. Mostafa, Ali Wheida, Mostafa El Nazer, Mona Adel, Lamia El Leithy, Guillaume Siour, Adriana Coman, Agnes Borbon, Abel Wahab Magdy, Mohamed Omar, Amal Saad-Hussein, Stephane C. Alfaro
WEATHER AND CLIMATE EXTREMES
(2019)
Article
Genetics & Heredity
Nada Ezzeldin, Dalia Ei-Lebedy, Amira Darwish, Ahmed El-Bastawisy, Mirhane Hassan, Shereen Abd El-Aziz, Mohamed Abdel-Hamid, Amal Saad-Hussein
GENES AND ENVIRONMENT
(2017)