Journal
ARCHIVES OF MEDICAL SCIENCE
Volume 6, Issue 4, Pages 513-518Publisher
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/aoms.2010.14461
Keywords
aging; glutathione peroxidase; hypertension; oxidative stress; superoxide dismutase
Categories
Ask authors/readers for more resources
Introduction: An increase in oxidative stress is strongly documented in hypertensive patients In blood vessels, oxidative stress increases the production of superoxide anion O-2(center dot-) that reacts with nitric oxide (NO) and impairs the ability of endothelium to relax Many reports indicate a beneficial effect of coenzyme Q10 (CoQ) in hypertension Coenzyme Q10 therapy may lower O-2(center dot-) and thus decrease the complications associated with hypertension The aim of our study was to evaluate the effects of CoQ supplementation on antioxidative enzyme activities and lipid peroxidation in elderly hypertensive patients Material and methods: We determined the activities of superoxide dismutase (SOD-1) and glutathione peroxidase (GSH-Px) and the concentration of malondialdehyde (MDA) in erythrocytes of 27 elderly (mean age 72 +/- 6 1 year) hypertensive patients treated with indapamide at baseline and after 12 weeks of CoQ supplementation (60 mg twice a day) in comparison with 30 healthy elderly volunteers (mean age 76 +/- 8.5 year) Results: Decrease of SOD-1 (p < 0.001) and insignificant reduction of GSH-Px activities and increase of MDA (p < 0.001) level were observed in hypertensive patients in comparison to healthy volunteers before supplementation Coenzyme Q10 administration resulted in a significant increase only in SOD-1 activity (p < 0.001) Conclusions: The present study indicates that CoQ improves the most important component of the antioxidant defence system SOD-1, which is responsible for O-2(center dot-) scavenging Coenzyme Q10 may be used as an additional therapeutic agent for prophylaxis and treatment of hypertension in elderly patients
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available