Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Ravy K. Vajravelu, Jordan M. Shapiro, Josephine Ni, Shivani U. Thanawala, James D. Lewis, Hashem B. El-Serag
Summary: Individuals concurrently exposed to antibiotics and bowel purgative had slightly higher rates of surrogate IBS outcomes compared with matched controls who did not receive antibiotics concurrently with bowel purgative.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Zarina Mamieva, Elena Poluektova, Valery Svistushkin, Vasily Sobolev, Oleg Shifrin, Francisco Guarner, Vladimir Ivashkin
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with incompletely understood etiology. Dysbiosis of the gut microbiota and antibiotic use are closely associated with the development of IBS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: Isotretinoin does not increase the risk of Crohn's disease, but it may be associated with a slight and temporary increase in the risk of ulcerative colitis. However, it can lower the risk of irritable bowel syndrome.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Article
Multidisciplinary Sciences
A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: Alterations in the gut mycobiome were found to be significantly different between patients with Irritable Bowel Syndrome (IBS) and control subjects, but not among clinical subtypes of IBS. The mycobiome changes were significantly associated with alterations in the bacteriome and metabolome, but did not show a link with dietary habits. Despite co-variation with bacterial components, the mycobiome presents limited therapeutic and diagnostic potential for IBS.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Qi Su, Hein M. Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis K. L. Chan, Siew C. Ng
Summary: This study examined the association between gut microbiota and Irritable bowel syndrome (IBS) subtypes, and found that there are distinct differences in microbiota composition among different IBS subtypes. The microbial diversity is significantly reduced in IBS-D and IBS-U, but not in IBS-C. The study also identified microbial signatures associated with depression in IBS patients. Factors such as gender, age, and dietary patterns have significant effects on gut microbiota in different IBS subtypes. These findings emphasize the importance of personalized gut microbiome modulation approaches for optimal therapeutic effects in different subtypes of IBS.
Review
Immunology
Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji, Tao Wu
Summary: "Application of Metabolomics in Irritable Bowel Syndrome: A Review" provides an updated overview of metabolomics studies related to irritable bowel syndrome (IBS) in the past 5 years, including clinical studies, animal studies, and traditional Chinese medicine interventions. The review highlights the potential of metabolomics in the diagnosis and treatment of IBS, as well as the role of traditional Chinese medicine in improving IBS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Robin Spiller
Summary: IBS is strongly influenced by diet, but identifying specific food intolerances is difficult due to the complexities of diet. Rapidly fermented carbohydrates and gut-specific mast cell activation may cause symptoms in IBS patients. More research is needed to fully understand the mechanisms of food intolerances and improve personalized medicine approaches to diet in IBS.
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Marcelina Radziszewska, Joanna Smarkusz-Zarzecka, Lucyna Ostrowska
Summary: Irritable Bowel Syndrome (IBS) is a chronic digestive disorder that is diagnosed based on the Rome IV criteria. People with IBS often associate their symptoms with the food they eat, leading to dietary restrictions. The FODMAP diet is currently recommended for IBS patients, but it may not work for everyone. Other unconventional diets lack research support and may worsen nutritional status. Physical activity and supplementation, such as probiotics and vitamin D, can be beneficial for managing IBS symptoms. This review aims to analyze the impact of various food items, physical activity, and dietary supplementation on the course of IBS.
Review
Obstetrics & Gynecology
Sarvee Moosavi, Yang Won Min, Melissa Wong, Ali Rezaie
Summary: Gastroparesis is a functional gastrointestinal disorder that primarily affects women during childbearing age, but there is a lack of data and guidelines for managing it during pregnancy. Despite the absence of approved therapies, healthcare providers must navigate the challenge of counseling and managing gastroparesis patients. This systematic review aims to fill the knowledge gaps regarding the impact of pregnancy on gastroparesis and vice versa, while highlighting the available therapies and safe dietary approaches during pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: With the rise in aging population and chronic diseases, the use and abuse of opioids have increased worldwide, leading to an increase in opioid-related adverse events, specifically opioid-induced bowel dysfunction. This calls for a rational clinical management strategy.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mahban Rahimifard, Maryam Baeeri, Taraneh Mousavi, Asaad Azarnezhad, Hamed Haghi-Aminjan, Mohammad Abdollahi
Summary: Gastric cancer is a medical dilemma with a high economic and global burden. Conventional chemotherapy regimens containing cisplatin have limited effectiveness and cause adverse drug reactions. This study tested the biological efficacy of the cisplatin-resveratrol combination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Mahmood Alizadeh Sani, Gholamreza Jahed-Khaniki, Ali Ehsani, Nabi Shariatifar, Mohammad Hadi Dehghani, Mohammad Hashemi, Hedayat Hosseini, Mohammad Abdollahi, Shokoufeh Hassani, Zahra Bayrami, David Julian McClements
Summary: A simple, label-free, and ultra-sensitive fluorescent platform based on a metal-organic framework (MOF) was developed to detect melamine in milk powder. The fluorescence sensor was fabricated from sensitized terbium (Tb)@NH2-MIL-253 (Al) MOF using a hydrothermal method. It showed high accuracy, sensitivity, and reproducibility compared to the high-performance liquid chromatography (HPLC) method. The sensor had a linear range and lower limit of detection (LLOD) much lower than the maximum residual level (MRL) for melamine detection in infant formula and other foods/feeds.
Review
Gastroenterology & Hepatology
Theodoros Vichos, Ali Rezaie, Petros Vichos, Brooks Cash, Mark Pimentel
Summary: This study aimed to systematically assess the occurrence of colorectal cancer (CRC) and colorectal polyps (CRP) in irritable bowel syndrome (IBS) patients. The analysis revealed a significantly decreased prevalence of CRP in IBS subjects and a lower prevalence of CRC, although it did not reach statistical significance.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Jane Lim, Ali Rezaie
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Engineering, Environmental
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Summary: Environmental toxicants can regulate gene expression through epigenetic mechanisms. This article discusses the impact of three epigenetic modifications on seven important categories of diseases and the influence of eleven main environmental factors on epigenetic modifications. These epigenetic-related mechanisms play a crucial role in the development of common diseases, aiding in diagnosis and treatment, as well as predicting transgenerational and intergenerational effects. However, more well-designed research is needed to determine the precise role of environmentally-induced epigenetic alterations in disease etiology.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Health Care Sciences & Services
Neha Durgam, Ankur A. Dashputre, Olga Moshkovich, Ali Rezaie, Nicholas Martinez, Pedram Enayati, James Stansbury, George Joseph
Summary: The purpose of this study was to develop and validate a new PRO instrument, the SIBO Symptom Measure (SSM) daily diary. The SSM assesses symptom severity in SIBO patients, aiming to provide a PRO tool for endpoint measurement.
QUALITY OF LIFE RESEARCH
(2023)
Article
Toxicology
Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, Mohammad Abdollahi
Summary: In this study, the protective effects of Levosimendan (LEVO) on pancreatic islets exposed to sodium arsenite (NaAsO2) were investigated. The results showed that LEVO improved the viability and functionality of pancreatic islets and modulated oxidative stress and inflammatory biomarkers.
Letter
Gastroenterology & Hepatology
Will Takakura, Ali Rezaie
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Toxicology
Nader Rahimi Kakavandi, Taraneh Mousavi, Tayebeh Asadi, Ayda Moradi, Mahta Esmaeili, Ahmad Habibian Sezavar, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study conducted a systematic review and dose-response meta-analysis on the association between arsenic exposure and the risk of type 2 diabetes. The results showed that arsenic in drinking water and urine were significantly associated with the risk of type 2 diabetes.
TOXICOLOGY LETTERS
(2023)
Review
Endocrinology & Metabolism
Marzieh Daniali, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study compares diabetes management between pediatric and adult patients and identifies treatment challenges and gaps. Research shows children have lower insulin sensitivity, clearance, and beta cell function than adults. Personalized and precise approaches are crucial in managing diabetes in pediatrics, and more research is necessary to assess the safety and efficacy of different antidiabetic drugs and improve diabetes treatment for children and adolescents.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychiatry
Ali Amirkafi, Faezeh Mohammadi, Arash Tehrani-Banihashemi, Maziar Moradi-Lakeh, Christopher J. L. Murray, Mohsen Naghavi, Ali H. Mokdad
Summary: The study investigates drug use disorders as a significant contributor to Disability Adjusted Life Years (DALYs) in the Eastern Mediterranean Region (EMR). The findings reveal a significant increase in the prevalence of drug use disorders since 1990, with opioid use being the most prevalent disorder. United Arab Emirates, Libya, and Iran are among the countries most affected by drug use disorders in the region.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Amrit K. Kamboj, Yin Chan, Jason Nasser, Jane E. Lim, Bianca W. Chang, Ali Rezaie
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
