Article
Public, Environmental & Occupational Health
Binur Orazumbekova, Alpamys Issanov, Kuralay Atageldiyeva, Salim Berkinbayev, Gulnara Junusbekova, Laura Danyarova, Zhanmedet Shyman, Akmaral Tashmanova, Antonio Sarria-Santamera
Summary: This study aimed to estimate the prevalence of impaired fasting glucose (IFG), undiagnosed, and prior-diagnosed Type 2 diabetes mellitus (T2DM) in Kazakhstan. The results showed a high prevalence of IFG and a significant proportion of newly diagnosed T2DM in Kazakhstan. The identified risk factors can be used to strengthen the identification of undiagnosed patients and provide preventive or therapeutic interventions to reduce the incidence of T2DM and its complications.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Clinical Neurology
Yuhan Karida Liu, Susan Ling, Leanna M. W. Lui, Felicia Ceban, Maj Vinberg, Lars Vedel Kessing, Roger C. Ho, Taeho Greg Rhee, Hartej Gill, Bing Cao, Rodrigo B. Mansur, Yena Lee, Joshua Rosenblat, Kayla M. Teopiz, Roger S. McIntyre
Summary: This study assessed the prevalence of type 2 diabetes, impaired fasting glucose, general obesity, and abdominal obesity in patients with bipolar disorder. The findings showed that patients with bipolar disorder had a higher prevalence of these conditions compared to the control group.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Tina Kalbitzer, Kristina Lobenhofer, Silke Martin, Markus Beck Erlach, Werner Kremer, Hans Robert Kalbitzer
Summary: Type 2 diabetes and its borderline states, impaired fasting glucose and/or glucose tolerance, are associated with dyslipoproteinemia. This study uses NMR spectroscopy to analyze the lipoprotein subclass patterns of patients with different stages of diabetes and investigates the changes in lipoprotein patterns over time. The study found that the lipoprotein subclass distributions were altered in diabetic patients, but the total concentrations of lipoprotein particles produced by the liver were not significantly changed.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Amelia Betson, Pamela G. Rufus-Membere, James Gaston, Adolfo Diez-Perez, Mark A. Kotowicz, Julie A. Pasco
Summary: This study found that in men, individuals with T2DM had lower bone material strength index (BMSi) compared to those without T2DM, independent of T2DM, while bone mineral density (BMD) and trabecular bone score (TBS) measured by DXA were higher. These results suggest that measures reflecting bone material properties and microarchitecture may be better than BMD in identifying individuals with T2DM at risk of fracture.
Article
Cardiac & Cardiovascular Systems
Ayuba Issaka, Adrian J. Cameron, Yin Paradies, Jean B. Kiwallo, William K. Bosu, Yessito Corine N. Houehanou, Chea S. Wesseh, Dismand S. Houinato, Diarra J. P. Nazoum, Christopher Stevenson
Summary: The study found that waist-to-height ratio (WHtR) and waist circumference are the obesity indices most strongly associated with type 2 Diabetes Mellitus (T2DM) and impaired fasting glucose (IFG) among adults from West African countries. Due to its simplicity, waist circumference may be the most useful metric for conveying the risk of T2DM in this population.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Oak-Kee Hong, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Summary: The status of metabolic abnormalities, including impaired fasting glucose (IFG), can change over time. Using data from the Korean National Health Insurance system, the study found that cumulative exposure to IFG was associated with a higher risk of type 2 diabetes mellitus in a dose-response fashion.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Xiao Tong Teong, Kai Liu, Andrew D. Vincent, Julien Bensalem, Bo Liu, Kathryn J. Hattersley, Lijun Zhao, Christine Feinle-Bisset, Timothy J. Sargeant, Gary A. Wittert, Amy T. Hutchison, Leonie K. Heilbronn
Summary: Intermittent fasting plus early time-restricted eating (iTRE) is an effective approach to improve glucose metabolism in adults at increased risk of developing type 2 diabetes, with greater improvements seen in the short term compared to continuous calorie restriction (CR).
Article
Medicine, General & Internal
Eraj Abbas, Iftikhar Ahmed Siddiqui, Muhammad Saeed Khan, Kahkashan Perveen, Anum Butt, Asher Fawwad
Summary: This study analyzed fasting glucagon levels in Pakistani patients with type 2 diabetes and impaired glucose tolerance, finding positive correlations with 2-hour plasma glucose, systolic blood pressure, diastolic blood pressure, BMI, hip and waist circumference, and hip-to-waist ratio in the diabetic group.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Shuting Chen, Jiale Wang, Juping Wang, Qian Gao, Xiaotian Zhao, Hongwei Guan, Tong Wang
Summary: The association between sleep-disordered breathing and impaired fasting glucose and type 2 diabetes can be explained by the mediating effect of obesity, especially central obesity.
SLEEP AND BREATHING
(2023)
Article
Biochemistry & Molecular Biology
Robert Wagner, Martin Heni, Adam G. Tabak, Juergen Machann, Fritz Schick, Elko Randrianarisoa, Martin Hrabe de Angelis, Andreas L. Birkenfeld, Norbert Stefan, Andreas Peter, Hans-Ulrich Haering, Andreas Fritsche
Summary: Analysis of high-risk individuals revealed six distinct subphenotypes of type 2 diabetes, among which three had elevated glycemia levels, with clusters 3 and 5 having imminent diabetes risks.
Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Giuliana Valerio, Maria R. Licenziati, Giuseppina Campana, Emanuele M. del Giudice, Anna Di Sessa, Anita Morandi, Claudio Maffeis, Claudio Chiesa, Lucia Pacifico, Marco G. Baroni, Melania Manco
Summary: The study revealed a significant association between uric acid levels and markers of prediabetes, insulin resistance, and insulin sensitivity in overweight/obese youth. Higher uric acid levels were correlated with elevated markers of impaired glucose metabolism, particularly post-challenge conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Shuaiming Jiang, Aijie Liu, Wenyao Ma, Xinlei Liu, Pengfei Luo, Meng Zhan, Xiaoli Zhou, Lihao Chen, Jiachao Zhang
Summary: This study evaluated the therapeutic efficacy of Lactobacillus gasseri CKCC1913, a potential probiotic strain, in high-fat diet-induced insulin-resistant diabetes using a mouse model. The results revealed that L. gasseri CKCC1913 improved glucose tolerance, reduced fasting blood glucose levels, and decreased pro-inflammatory cytokine expression. Additionally, it alleviated oxidative stress damage, improved insulin resistance, and positively influenced lipid metabolism and glucose control. The study highlights the potential of probiotics, specifically L. gasseri CKCC1913, as a therapeutic approach for diabetes and metabolic disorders.
Article
Biochemistry & Molecular Biology
Shuaiming Jiang, Aijie Liu, Wenyao Ma, Xinlei Liu, Pengfei Luo, Meng Zhan, Xiaoli Zhou, Lihao Chen, Jiachao Zhang
Summary: This study evaluated the therapeutic efficacy of Lactobacillus gasseri CKCC1913, a potential probiotic strain, in high-fat diet-induced insulin-resistant diabetes using a mouse model. The results showed that L. gasseri CKCC1913 improved glucose tolerance, decreased fasting blood glucose levels, reduced inflammation, alleviated oxidative stress, and improved lipid metabolism and glucose control in diabetic mice. The potential mechanism involved an increase in beneficial bacteria and the production of short-chain fatty acids, as well as the influence on local bacterial metabolism pathways.
Article
Medicine, General & Internal
Michael Sampson, Allan Clark, Max Bachmann, Nikki Garner, Lisa Irvine, Amanda Howe, Colin Greaves, Sara Auckland, Jane Smith, Jeremy Turner, Dave Rea, Gerry Rayman, Ketan Dhatariya, W. Garry John, Garry Barton, Rebecca Usher, Clare Ferns, Melanie Pascale
Summary: The study found that group-based lifestyle interventions reduced the risk of progression to type 2 diabetes in populations with a high-risk glycemic category. Participants in the intervention arms had significantly lower odds of developing type 2 diabetes. However, enhancing the intervention with support from diabetes prevention mentors did not further reduce the risk of diabetes.
JAMA INTERNAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Norbert J. Tripolt, Sebastian J. Hofer, Peter N. Pferschy, Faisal Aziz, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathasan, Mara Waltenstorfer, Tobias Eisenberg, Anna M. A. Obermayer, Regina Riedl, Harald Kojzar, Othmar Moser, Caren Sourij, Heiko Bugger, Abderrahim Oulhaj, Thomas R. Pieber, Matthias Zanker, Guido Kroemer, Frank Madeo, Harald Sourij
Summary: The effects of fasting on glucose metabolism were examined in non-obese and obese participants and people with type 2 diabetes. The results showed that after 36 hours of fasting, glucose, insulin, and C-peptide levels were significantly decreased. Non-obese participants had higher glucose levels but lower insulin levels after 36 hours of fasting, while no significant differences were observed in obese participants or people with diabetes. Insulin sensitivity improved in all cohorts after 36 hours of fasting. Metabolomics analysis revealed subtle baseline differences and attenuated metabolic response to fasting in obese participants and people with diabetes.
Article
Medicine, Research & Experimental
Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela
Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.
ARCHIVES OF MEDICAL RESEARCH
(2024)