Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Article
Oncology
Yu Peng, Fubin Liu, Yating Qiao, Peng Wang, Han Du, Changyu Si, Xixuan Wang, Kexin Chen, Fangfang Song
Summary: This study found that higher levels of plasma AGEs and AGEs/sRAGE-ratio were associated with an increased risk of breast cancer, but sRAGE levels were negatively associated with breast cancer risk. The study emphasized the potential of the AGE-RAGE axis as a new biomarker of breast cancer.
Article
Biochemistry & Molecular Biology
Olivia May, Laure Yatime, Nicolas S. Merle, Florian Delguste, Mike Howsam, Marie Daugan, Charles Paul-Constant, Muriel Billamboz, Alina Ghinet, Steve Lancel, Jordan D. Dimitrov, Eric Boulanger, Lubka T. Roumenina, Marie Frimat
Summary: The interaction between RAGE and heme with micromolar affinity could potentially promote proinflammatory and prothrombotic signaling in vivo. This suggests that this interaction may play a role in heme-overload conditions.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Gastroenterology & Hepatology
Armando Rojas, Cristian Lindner, Ivan Schneider, Ileana Gonzalez, Miguel Angel Morales
Summary: Compelling evidence from clinical and experimental research shows that activation of the receptor for advanced glycation end products (RAGE) axis is crucial in the development of neoplasms, including gastric cancer (GC). RAGE plays a significant role in establishing an inflammatory environment that supports tumor growth and dissemination, and acts as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori infection. This review highlights the contribution of RAGE axis overexpression and activation to the proliferation, survival, and invasive phenotypes of GC cells, as well as the potential role of RAGE gene polymorphisms in susceptibility and prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Geriatrics & Gerontology
Shou-En Wu, Yi-Lin Chiu, Tung-Wei Kao, Wei-Liang Chen
Summary: The soluble receptor for advanced glycation end products (sRAGE) level is positively associated with sarcopenia, especially in female groups, possibly attributed to the loss of protection from estrogen in postmenopausal women. Using sRAGE level as a prospective marker for sarcopenia warrants further investigation in future studies.
Review
Gastroenterology & Hepatology
Armando Rojas, Ivan Schneider, Cristian Lindner, Ileana Gonzalez, Miguel Angel Morales
Summary: In patients with inflammatory bowel disease (IBD) infected with SARS-CoV-2, the activation of the RAGE axis and the cross-talk with the renin-angiotensin system are dampened by the high expression of soluble forms of both RAGE and angiotensin-converting enzyme (ACE) 2, which helps to mitigate the inflammatory response.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Endocrinology & Metabolism
Andrea Garza-Campos, Jose Roberto Prieto-Correa, Jose Alfredo Dominguez-Rosales, Zamira Helena Hernandez-Nazara
Summary: Obesity and type 2 diabetes mellitus (T2DM) are chronic diseases that have a high incidence globally. They have shared pathological mechanisms that can lead to the development of cancer. The review focuses on the role of the receptor for advanced glycation end products (RAGE) in obesity, T2DM, and cancer, aiming to understand the intracellular signaling mechanisms involved in cancer initiation and to develop diagnostic and therapeutic strategies to reduce the morbidity and mortality associated with these diseases.
WORLD JOURNAL OF DIABETES
(2023)
Review
Biochemistry & Molecular Biology
Klaudia Gutowska, Krzysztof Czajkowski, Alina Kurylowicz
Summary: Advanced glycation end products (AGEs) play a crucial role in cellular dysfunction caused by hyperglycemia, and their accumulation in the extracellular matrix is a key factor in obesity-related adipose tissue dysfunction. By binding to their receptor (RAGE), AGEs affect various intracellular pathways, leading to impaired adipocyte differentiation, metabolism, and secretory activity. Inhibiting AGE production and accumulation, as well as interfering with the activated metabolic pathways, may be a promising therapeutic strategy for restoring normal adipose tissue function and combating obesity-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Julie Toby Thomas, Betsy Joseph, Timo Sorsa, Matti Mauramo, Sukumaran Anil, Tuomas Waltimo
Summary: The systematic review aims to compare the levels of advanced glycation end products (AGEs) and RAGE expression in diabetic periodontitis patients with non-diabetic periodontitis patients and to identify the relationship of AGE and RAGE levels with periodontal disease severity.
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Vincenzo Falco, Guruprasad P. Aithal, Naaventhan Palaniyappan, Yusuf Yilmaz, Jerome Boursier, Christophe Cassinotto, Victor de Ledinghen, Wah Kheong Chan, Sanjiv Mahadeva, Peter Eddowes, Philip Newsome, Thomas Karlas, Johannes Wiegand, Vincent Wai-Sun Wong, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Monica Lupsor-Platon, Jeremy F. L. Cobbold, Jian-Gao Fan, Feng Shen, Katharina Staufer, Michael Trauner, Rudolf Stauber, Atsushi Nakajima, Masato Yoneda, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Ming-Hua Zheng, Calogero Camma, Quentin M. Anstee, Ferenc E. Mozes, Michael Pavlides, Salvatore Petta
Summary: This study evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The results showed that liver stiffness measurement (LSM) and AGILE 3+ were better at determining advanced fibrosis compared to serum tests. The evaluation of diagnostic methods for NAFLD with T2D is clinically significant.
Article
Gastroenterology & Hepatology
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gomez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Summary: This study aimed to determine if there was a need to change the nomenclature and definition of NAFLD and NASH. Through a Delphi process involving content experts and patient advocates, a consensus was reached to replace NAFLD with metabolic dysfunction-associated steatotic liver disease (MetALD) and modify the diagnostic criteria. The new nomenclature and criteria are widely supported, nonstigmatizing, and can improve awareness and patient identification.
Article
Gastroenterology & Hepatology
Quentin M. Anstee, Kathryn J. Lucas, Sven Francque, Manal F. Abdelmalek, Arun J. Sanyal, Vlad Ratziu, Adrian C. Gadano, Mary Rinella, Michael Charlton, Rohit Loomba, Edward Mena, Joern M. Schattenberg, Mazen Noureddin, Donald Lazas, George B. B. Goh, Shiv K. Sarin, Yusuf Yilmaz, Miljen Martic, Rowan Stringer, Jossy Kochuparampil, Li Chen, Gerardo Rodriguez-Araujo, Elaine Chng, Nikolai V. Naoumov, Clifford Brass, Marcos C. Pedrosa
Summary: This study assessed the safety and efficacy of the combined treatment of tropifexor and cenicriviroc for NASH, compared to monotherapy. The combination treatment did not show substantial incremental efficacy compared to monotherapy.
Article
Gastroenterology & Hepatology
Virendra Singh, Arka De, Rohit Mehtani, Paolo Angeli, Rakhi Maiwall, Sanjaya Satapathy, Ashwini K. Singal, Anoop Saraya, B. C. Sharma, C. E. Eapen, P. N. Rao, Akash Shukla, Shalimar, Narendra S. Choudhary, Diana Alcantara-Payawal, Vinod Arora, Guru Aithal, Anand Kulkarni, Akash Roy, Ananta Shrestha, Mamun al Mahtab, Madunil A. Niriella, Tan Soek Siam, Chun-Qing Zhang, Lee Guan Huei, Ming-Lung Yu, Stuart K. Roberts, Cheng-Yuan Peng, Tao Chen, Jacob George, Vincent Wong, Yusuf Yilmaz, Sombat Treeprasertsuk, Juferdy Kurniawan, Seung Up Kim, Zobair M. Younossi, Shiv Kumar Sarin
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Hannes Hagstrom, Terry T. -K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Veronica Miller, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jorn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: This study aimed to develop a research agenda for fatty liver disease, and 28 priorities were identified to address the individual and societal harms caused by this disease. Adopting this agenda can accelerate global efforts to respond to this public health threat.
JOURNAL OF HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Federica Verme, Alessandra Scarpa, Giorgia Varallo, Paolo Pitera, Paolo Capodaglio, Jacopo Maria Fontana
Summary: Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease among people over 50, characterized by musculoskeletal pain and stiffness. Current treatment with corticosteroids has adverse effects, necessitating the search for alternatives. This case report highlights the effectiveness of whole-body cryostimulation (WBC) on a 74-year-old woman with PMR, showing improvements in disease impact, fatigue, pain, sleep quality, and daily drug intake reduction. Considering the increasing prevalence of PMR and drug treatment side effects, WBC could be a valuable and well-tolerated alternative for treating PMR.
Meeting Abstract
Gastroenterology & Hepatology
Zobair M. Younossi, Yusuf Yilmaz, Ming-Lung Yu, Vincent Wai-Sun Wong, Marlen Ivon Castellanos Fernandez, Vasily A. Isakov, Ajay K. Duseja, Nahum Mendez-Sanchez, Yuichiro Eguchi, Elisabetta Bugianesi, Patrizia Burra, Jacob George, Jian-Gao Fan, George V. Papatheodoridis, Maria Buti, Wah Kheong Chan, Khalid Aida Alswat, Saeed S. Hamid, Ashwani K. Singal, Manuel Romero-Gomez, Stuart C. Gordon, Stuart Roberts, Mohamed El Kassas, Gamal Esmat, Marcelo Kugelmas, Janus Ong, Brian P. Lam, Issah Younossi, Andrei Racila, Linda Henry, Maria Stepanova, Saleh Alqahtani
Article
Gastroenterology & Hepatology
Jeffrey Lazarus, Laurent Castera, Henry E. Mark, Alina M. Allen, Leon A. Adams, Quentin M. Anstee, Marco Arrese, Saleh A. Alqahtani, Elisabetta Bugianesi, Massimo Colombo, Kenneth Cusi, Hannes Hagstrom, Rohit Loomba, Manuel Romero-Gomez, Jorn M. Schattenberg, Maja Thiele, Luca Valenti, Vincent Wai-Sun Wong, Yusuf Yilmaz, Zobair M. Younossi, Sven M. Francque, Emmanuel A. Tsochatzis
Summary: Non-invasive tests (NITs) provide a practical solution for advanced fibrosis identification in non-alcoholic fatty liver disease (NAFLD). However, the study found variations in the cut-offs used for the same NITs by different clinicians, highlighting the importance of establishing consistent guidelines in NAFLD management.
Article
Gastroenterology & Hepatology
Ilkay Ergenc, Busra Gozaydinoglu, Caglayan Keklikkiran, Yusuf Yilmaz
Summary: This study investigated the risk of developing primary biliary cholangitis (PBC) in individuals incidentally identified as having positive antimitochondrial antibodies (AMA)-M2. Results showed that two-thirds of the positive individuals developed typical features of PBC after a certain period of time. Therefore, close follow-up is recommended for positive individuals to detect the development of PBC.
Article
Gastroenterology & Hepatology
Ezgi Ersoy Yesil, Yusuf Yilmaz, Atakan Yesil, Meral Mese, Eda Kaya, Elif Ari Bakir
Summary: This study evaluated the prevalence of MAFLD among kidney transplant recipients (KTRs) and found that the prevalence of MAFLD in KTRs was not significantly higher compared to the control group. Larger populations are needed to confirm these results.
Article
Gastroenterology & Hepatology
Tansu Eris, Moomen Hassan, Yousra Hikal, Enas Sawah, Fatemeh Daneshgar, Ayse Gulsen Teker, Furkan Ozel, Nimet Emel Luleci, Eda Kaya, Yusuf Yilmaz
Summary: This study retrospectively evaluated the demographic characteristics, etiologies of chronic liver disease, and FibroScan (R) parameters of patients referred to a tertiary care center between 2013 and 2021. The results showed that nonalcoholic fatty liver disease was the most common indication for referral, followed by hepatitis B and hepatitis C.
Article
Biochemistry & Molecular Biology
Jacopo Maria Fontana, Angelo Alito, Paolo Pitera, Federica Verme, Stefania Cattaldo, Mauro Cornacchia, Stefania Mai, Amelia Brunani, Paolo Capodaglio
Summary: This study examined a multidisciplinary rehabilitation protocol for patients with obesity and post-COVID symptoms, and found that the program, including WBC, was safe and effective in improving physical and psychological well-being.
Article
Gastroenterology & Hepatology
Ayse Sakalli Kani, Ahmet Ozercan, Haluk Tarik Kani, Fatih Eren, Kemal Sayar, Yusuf Yilmaz
Summary: This study aimed to investigate the variations in chronotype, night-eating patterns, and sleep quality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and analyze their correlation with disease severity and fibrosis. The results showed that patients with non-morningness chronotype had poorer sleep quality and a higher prevalence of night-eating behavior. In addition, age and poor sleep quality significantly impacted the presence of advanced fibrosis.
Meeting Abstract
Gastroenterology & Hepatology
Zobair M. Younossi, Marlen Castellanos Fernandez, Yusuf Yilmaz, Ming-Lung Yu, Mohamed El-Kassas, Gamal Esmat, Vasily Isakov, Vincent Wong, Yuichiro Eguchi, Khalid Alswat, Nahum Mendez-Sanchez, Ajay Duseja, Maria Buti, George Papatheodoridis, Saeed S. Hamid, Jacob George, Elisabetta Bugianesi, Wah-Kheong Chan, Ashwani K. Singal, Stuart C. Gordon, Jian Gao Fan, Manuel Romero-Gomez, Stuart K. Roberts, Janus Ong, Brian P. Lam, Marcelo Kugelmas, Issah M. Younossi, Fatema Nader, Andrei Racila, Maria Stepanova, Saleh A. Alqahtani