Review
Biochemistry & Molecular Biology
Sara Assadiasl, Nuala Mooney, Mohammad Hossein Nicknam
Summary: Cytokines play crucial roles in autoimmune, allergic, and infectious diseases, as well as allograft rejection. Recent advances in novel anti-cytokine agents and gene therapy for immunomodulatory cytokines have shown significant improvements in managing dysregulated cytokine secretion and overexpression.
Article
Cardiac & Cardiovascular Systems
Matthew R. Alexander, Samuel Hank, Bethany L. Dale, Lauren Himmel, Xue Zhong, Charles D. Smart, Daniel J. Fehrenbach, Yuhan Chen, Nitin Prabakaran, Brian Tirado, Megan Centrella, Mingfang Ao, Liping Du, Yu Shyr, Daniel Levy, Meena S. Madhur
Summary: Research suggests that the Trp encoding allele of rs3184504 may be causal for hypertension and renal dysfunction, in part due to the loss of SH2B3-mediated repression of T cell IL-12 signaling leading to enhanced IFNg production.
CIRCULATION RESEARCH
(2022)
Article
Urology & Nephrology
Wei Zhu, Xin Zhang, Zhen Zhou, Yin Sun, Guangyuan Zhang, Xiaolu Duan, Zhicong Huang, Guoyao Ai, Yang Liu, Zhijian Zhao, Wen Zhong, Guohua Zeng
Summary: This study found a significant association between single nucleotide polymorphisms (SNPs) and kidney stone recurrence, and SNPs can provide prognostic value in addition to traditional clinical risk factors. A predictive model combining clinical and genetic variables shows potential as an assessment tool for evaluating the recurrence risk of kidney stones.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Peng Li, Xi Liang, Shan Xu, Ye Xiong, Jianrong Huang
Summary: This study aimed to evaluate the impact of artificial liver support system (ALSS) treatment before liver transplantation (LT), and assess the predictive values of current ACLF prognostic models for short-term prognosis after LT. The results showed that ALSS treatment combined with LT improved short-term survival rates in patients with HBV-related ACLF, and ALSS treatment pre-LT was identified as an independent protective factor affecting the 4-week survival rate after LT.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sola Lee, Nam-Joon Yi, Eui Soo Han, Su Young Hong, Jeong-Moo Lee, Suk Kyun Hong, YoungRok Choi, Hyun-Young Kim, Joong Kee Youn, Dayoung Ko, Jae Sung Ko, Jin Soo Moon, Seong Mi Yang, Kwang-Woong Lee, Kyung-Suk Suh
Summary: Pediatric acute liver failure (PALF) patients have poorer post-liver transplantation survival rates compared to patients with biliary atresia (BA). PALF patients have higher rates of renal replacement therapy (RRT) and hepatic artery complications post-transplantation. Survival outcomes in PALF patients are associated with lower body weight, hepatic artery complications, and post-transplant RRT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Francois Vileret, Fanny Lebosse, Sylvie Radenne, Didier Samuel, Bruno Roche, Jean-Yves Mabrut, Vincent Leroy, Georges-Philippe Pageaux, Rodolphe Anty, Sylvie Thevenon, Sinafa Si Ahmed, Aaron Hamilton, Marintha Heil, Caroline Scholtes, Massimo Levrero, Barbara Testoni, Fabien Zoulim, ECOGREFFE Study Grp
Summary: This study found that viral recurrence can occur rapidly after liver transplantation, despite prophylaxis with nucleos(t)ide analogues (NUCs) and hepatitis B immunoglobulin (HBIG). The majority of patients had at least one HBV marker detected in either serum or the liver 12 months after transplantation. Optimal patient compliance to antiviral prophylaxis is crucial to prevent viral rebound.
Article
Gastroenterology & Hepatology
Li-Ping Sheng, Jun-Chang Zhang, Zhi-Qiang Zhong, Xue-Han Sheng, Jing Ren, Gui-Qiang Wang
Summary: The optimal prophylactic regimen for preventing hepatitis B virus (HBV) recurrence after liver transplantation (LT) in HBV-infected patients is uncertain. New evidence suggests that an HBIG-free approach may be feasible when combined with high-potency nucleos(t)ide analogues (HPNAs). This study provides robust estimates for long-term survival and HBV recurrence in patients receiving different HBV-prophylaxis strategies after LT.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Hongmei Jiang, Hui Guo, Bo Yang, Yuanyuan Zhao, Lai Wei, Zhishui Chen, Dong Chen
Summary: This case series explores the characteristics and outcomes of acute AMR in liver transplant recipients with autoimmune liver disease (ALD). The incidence of acute AMR in ALD patients was higher compared to non-ALD recipients. Individualized therapies based on clinical manifestations resulted in good prognoses for most patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsien-Jen Chiang, Ming-Chung Chou, Yi-Hsuan Chuang, Chun-Wei Li, Chih-Che Lin, Hock-Liew Eng, Chao-Long Chen, Yu-Fan Cheng
Summary: The objective of this study is to evaluate the diagnostic performance of BOLD MRI in patients with ACR post-liver transplant and to monitor treatment response.
EUROPEAN RADIOLOGY
(2022)
Article
Immunology
Yi Chen, Wenmin Zhang, Hui Bao, Wubing He, Lihong Chen
Summary: The study found that HMGB1 expression is upregulated in liver allografts during acute rejection, leading to increased inflammatory cell infiltration and DC maturation, ultimately promoting T cell proliferation and differentiation. Inhibition of HMGB1 with glycyrrhizic acid during liver preservation was shown to reduce inflammation, hepatocyte damage, and prolong allograft survival time, suggesting a potential therapeutic target to prevent acute rejection in liver transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuan Chang, Xiangjie Li, Qi Cheng, Yiqing Hu, Xiao Chen, Xiumeng Hua, Xuexin Fan, Menghao Tao, Jiangping Song, Shengshou Hu
Summary: Acute rejection (AR) is a significant contributor to graft failure post-heart transplantation, and the regulation of immune metabolism, particularly the increased glucose metabolism of cardiac macrophages in AR patients, has become a new focus for immunosuppressive drug development. Through single-cell RNA sequencing, it was found that during AR, cardiac resident macrophages were replaced by monocytes and proinflammatory macrophages, which exhibited higher antigen presentation and inflammatory recruitment capabilities, as well as glycolysis. The increase in glycolysis in monocytes/macrophages was primarily regulated by HIF1A, and inhibition of HIF1A could reduce inflammatory cells infiltration in AR.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Oncology
Zhongyi Jiang, Qianwei Jiang, Xu Fang, Pusen Wang, Weitao Que, Hao Li, Yang Yu, Xueni Liu, Chunguang Wang, Lin Zhong
Summary: The recipient C7 rs9292795 gene polymorphism is associated with HCC recurrence after orthotopic liver transplantation, serving as a potential prognostic marker for HCC patients undergoing OLT.
Review
Immunology
Yanyao Liu, Ping Yan, Yue Bin, Xiaoyan Qin, Zhongjun Wu
Summary: NETs play an important role in liver transplantation complications, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. Therefore, NETs have the potential to be a target for liver transplantation therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha
Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Oncology
Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An, Jianxin Lyu
Summary: This study identified for the first time an association between genetic variations in SOAT1 and the occurrence of HCC, indicating a potential role of SOAT1 in the development of HCC that requires further investigation.
Article
Medicine, Research & Experimental
Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela
Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.
ARCHIVES OF MEDICAL RESEARCH
(2024)