Article
Microbiology
Yunguang Wang, Xinxin He, Danna Zheng, Qiang He, Lifang Sun, Juan Jin
Summary: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that increase the risk of each other. However, the molecular mechanism underlying the susceptibility of patients with DM to PTB infection remains unclear. This study identified key genes and signaling pathways related to PTB complicated by DM through integrated metabolomics and transcriptomics analysis. In addition, peripheral metabolite levels may serve as biomarkers for PTB management in patients with DM.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Min Kyung Jung, Sang Young Lee, Jeong Min Ko, Soo-Ah Im
Summary: The aim of this study was to determine whether the glycemic control status influenced radiological manifestations in patients with pulmonary tuberculosis (PTB), particularly in terms of bronchial erosive changes. The study found that the uncontrolled diabetes mellitus (DM) group displayed a higher frequency of cavitation and bronchial erosion, whereas the controlled DM group showed similar frequencies to the non-DM group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Minmin Li, Tao Chen, Zhongqiu Hua, Hong Yan, Duolao Wang, Zhaoqing Li, Yijun Kang, Ni Zhu, Chao Li
Summary: The study estimated the prevalence of diabetes mellitus in a population with pulmonary tuberculosis using various research methods, revealing that this comorbidity is prevalent globally with high prevalence rates.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Medicine, General & Internal
Min Yang, Pei Li, Han Liu, Xiaojie Zhu, Guofeng Zhu, Peize Zhang, Guofang Deng
Summary: The co-occurrence of tuberculosis and diabetes presents a significant obstacle to TB eradication. The study confirms an association between diabetes and pulmonary cavitation in TB patients. The study also suggests that different immunological mechanisms may be employed in TB patients with IGRA positivity compared to TB patients with IGRA negativity.
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Liangliang Ma, Xuelin Chen, Maolong Gao
Summary: This study aimed to explore the risk factors of malnutrition in PTB-T2DM patients and provide a clinical research basis for identifying and preventing malnutrition. The results showed that drinking, divorced, low weight, low BMI, high scores, low hemoglobin and albumin levels, and abnormal lung function parameters were independent risk factors for malnutrition in PTB-T2DM patients.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Medicine, General & Internal
Qian Wu, Yang Liu, Yu-Bo Ma, Kui Liu, Song-Hua Chen
Summary: This meta-analysis aimed to estimate the global incidence and prevalence of pulmonary tuberculosis (PTB) among patients with type 2 diabetes mellitus (T2DM). The results showed a high incidence and prevalence of T2DM-PTB, particularly in Asia and countries with a high TB burden. This study highlights the need for more preventive interventions among T2DM patients, especially in high TB burden countries.
ANNALS OF MEDICINE
(2022)
Article
Infectious Diseases
Qi Yu, Wujin Weng, Hong Luo, Jisong Yan, Xin Zhao
Summary: This study aimed to explore the predictive value of monocyte to high-density lipoprotein cholesterol ratio (MHR), neutrophils to high-density lipoprotein cholesterol ratio (NHR), C-reactive protein-to-lymphocyte ratio (CLR), and C-reactive protein-to-albumin ratio (CAR) for type 2 diabetes mellitus (T2DM) in patients with active pulmonary tuberculosis (APTB). The study found that MHR, NHR, CLR, and CAR are simple and practicable inflammatory parameters that could be used for assessing T2DM in APTB.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Biotechnology & Applied Microbiology
Hongmei Zhao, Lian Shi, Xiaohong Wang, Xiuli Yu, Danfeng Wang
Summary: Patients with Type 2 diabetes mellitus are more susceptible to tuberculosis, and the downregulation of PTEN may exacerbate the condition, while the regulation of SP1 may affect lung injury and inflammation through the Akt signaling pathway.
Article
Endocrinology & Metabolism
Shengnan Chen, Weisong Zhang, Zhenquan Zheng, Xiaolong Shao, Peng Yang, Xiaobin Yang, Kai Nan
Summary: This study utilized Mendelian randomization to uncover the genetic causality between type 2 diabetes mellitus (T2DM) and pulmonary tuberculosis (PTB) in the East Asian population, confirming that individuals with T2DM are genetically more susceptible to developing PTB. These findings provide a crucial basis for the joint management of concurrent T2DM and PTB in clinical practice.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Chemistry, Multidisciplinary
Ummey Jannatun Nahar, Istvan Toth, Mariusz Skwarczynski
Summary: This article discusses the use of adjuvants and vaccine delivery systems to enhance vaccine efficacy. It focuses on the role of mannose receptors in antigen recognition by antigen presenting cells (APCs). The production strategies and effectiveness of mannosylated vaccines are examined, considering factors such as mannose valency, density, and routes of administration. The advantages, disadvantages, and future directions of mannosylation strategy are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Public, Environmental & Occupational Health
Qian Wu, Min Wang, Yu Zhang, Wei Wang, Teng-Fei Ye, Kui Liu, Song-Hua Chen
Summary: This study aimed to evaluate the status of diabetes mellitus (DM) and drug resistance in tuberculosis (TB) patients. The results showed that there was no significant association between DM and TB drug resistance. However, untreated TB patients without DM were more likely to develop poly-drug resistant tuberculosis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes
Summary: This study highlights the potential of sRAGE as an attractive treatment for preventing diabetes. The research showed efficacy and reproducibility of sRAGE at multiple research centers and in human T cells. The study found that sRAGE increased regulatory T cells and improved pancreatic islet function, providing protection against diabetes.
Article
Infectious Diseases
Panyachot Buasroung, Tananchai Petnak, Prapaipim Liwtanakitpipat, Sasisopin Kiertiburanakul
Summary: The prevalence of diabetes mellitus (DM) among tuberculosis (TB) patients was unexpectedly high in this study, and TB patients with DM had unfavorable outcomes compared to those without DM.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Respiratory System
Xunliang Tong, Dingyi Wang, He Wang, Yixuan Liao, Yimeng Song, Yuanchun Li, Yue Zhang, Guohui Fan, Xuefeng Zhong, Yang Ju, Yanming Li
Summary: This study found that the clinical features of TB-DM patients are associated with cavities in CT scan, rather than DST results. This may help recognize confounding variables and influence treatment strategy and outcomes for TB-DM patients.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Medicine, General & Internal
Cassandra L. R. van Doorn, Clare Eckold, Katharina Ronacher, Rovina Ruslami, Suzanne van Veen, Ji-Sook Lee, Vinod Kumar, Sarah Kerry-Barnard, Stephanus T. Malherbe, Leanie Kleynhans, Kim Stanley, Philip C. Hill, Simone A. Joosten, Reinout van Crevel, Cisca Wijmenga, Julia A. Critchley, Gerhard Walzl, Bachti Alisjahbana, Marielle C. Haks, Hazel M. Dockrell, Tom H. M. Ottenhoff, Eleonora Vianello, Jacqueline M. Cliff
Summary: The study found that the analysis of patients' whole blood transcriptional profiles can predict treatment failure or success in tuberculosis, even in patients with diabetes mellitus.
Correction
Cell Biology
Heidi G. Rodriguez-Ramirez, Mario C. Salinas-Carmona, Oralia Barboza-Quintana, Americo Melo-de la Garza, Luis Angel Cecenas-Falcon, Lilia M. Rangel-Martinez, Adrian G. Rosas-Taraco
MEDIATORS OF INFLAMMATION
(2020)
Article
Infectious Diseases
Mario C. Salinas-Carmona, Ossian Longoria-Lozano, Humberto R. Garza-Esquivel, Juan Lopez-Ulloa, Jorge Reyes-Carrillo, Anna Velia Vazquez-Marmolejo
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Carlos A. Lopez-Acevo, Erick Arrendondo-Loza, Mario C. Salinas-Carmona, Adrian Rendon, Azalia M. Martinez-Castilla, Anna V. Vazquez-Marmolejo, Gerardo Munoz-Maldonado, Adrian G. Rosas-Taraco
Summary: In patients infected with IBV, higher levels of Th1, Th17, and IL-10 cytokines were observed, while leukocyte and neutrophil counts were negatively correlated with viral load. Perceived stress had a negative impact on monocyte and systemic cytokine production in IBV infected patients.
Article
Rheumatology
David Vega-Morales, Mario A. Garza-Elizondo, Leendert A. Trouw, Karina I. Gonzalez-Torres, Ernesto Torres-Lopez, Miryam Eguia-Bernal, Salvador A. Loredo-Alanis, Tayde S. Gracia-Arechiga, Brenda R. Vazquez-Fuentes, Diana D. Castaneda-Martinez, Martha M. Castaneda-Martinez, Cesar V. Elizondo-Solis, Andres Mendiola-Jimenez, Mario C. Salinas-Carmona, Pablo Herrera-Sandate, Jesus A. Cardenas-de la Garza, Gerardo E. Rodriguez-Sanchez, Dionicio A. Galarza-Delgado
Summary: In Mexican Hispanics with established rheumatoid arthritis, the presence of anti-CarP IgG antibodies does not show a significant association with disease activity. Over time, the clinical value of measuring anti-CarP antibodies in RA diminishes.
MODERN RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
D. Vega-Morales, M. A. Garza Elizondol, L. A. Trouw, K. I. Gonzalez Marquez, E. Torres-Lopez, M. Eguia Bernal, S. A. Loredo Alanis, S. Gracia-Arechigal, B. R. Vazquez Fuentes, D. D. Castaneda Martinez, M. M. Castaneda-Martinezl, C. V. Solis, A. Mendiola-Jimenezl, M. C. Salinas-Carmona, P. Herrera-Sandatel, A. Cardenas, G. E. Rodriguez-Sanchez, D. A. Galarza-Delgadol
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Pediatrics
Jose Fernando de-la-Garza-Salazar, Julieta Rodriguez-de-Ita, Barbara M. Garza-Ornelas, Jorge A. Martinez-Cardona
Summary: This study evaluated the performance of a new physical examination tool (the pronation manoeuvre) as a screening tool for developmental dysplasia of the hip (DDH) in newborns. The new manoeuvre showed higher sensitivity and specificity compared to the traditional Ortolani and Barlow manoeuvres. These findings have important implications for the diagnosis and prognosis of DDH patients.
PAEDIATRICS & CHILD HEALTH
(2022)
Article
Immunology
Armando S. Flores-Torres, Adrian Rendon, Mario C. Salinas-Carmona, Eva Salinas, Adrian G. Rosas-Taraco
Summary: Human eosinophils were found to express sialic acid residues targeted against influenza virus, significantly reducing viral titers and demonstrating antiviral activity through upregulation of RIG-I mRNA expression post-infection. Additionally, high concentrations of IL-8 were observed in eosinophil cultures exposed to the virus.
Letter
Public, Environmental & Occupational Health
Julieta Rodriguez-de Ita, Fabiola Castorena-Torres, Barbara Mariel Garza-Ornelas
SALUD PUBLICA DE MEXICO
(2021)
Article
Parasitology
Mayra A. Rodriguez-Serrato, Angel F. Gonzalez-Mireles, Alberto Y. Limon-Flores, Mario C. Salinas-Carmona
Summary: Cutaneous leishmaniasis is the most common form of leishmaniasis in humans, and UVB radiation may play an important role in this disease by suppressing immune responses and promoting lesion progression.
Article
Medicine, Research & Experimental
Jorge A. Gonzalez-Chapa, Victor M. Pena-Martinez, Jose F. Vilchez-Cavazos, Mario C. Salinas-Carmona, Adrian G. Rosas-Taraco
Summary: This study investigates the cytokine profiles in patients with septic arthritis (SA) and their association with disease severity and prognosis. The findings show that SA patients have a systemic and local proinflammatory cytokine profile, with significantly elevated levels of IL-6 and HMGB1. Systemic IL-6 is negatively correlated with general mental health and predicts higher osteoarthritis index after one year. HMGB1 in synovial fluid is associated with osteochondral damage. TNF-alpha in synovial fluid is negatively correlated with SF-36 questionnaire scores (role limitation, body pain, general mental health) after one year.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Oncology
Adriana G. Quiroz-Reyes, Carlos A. Gonzalez-Villarreal, Herminia Martinez-Rodriguez, Salvador Said-Fernandez, Mario Cesar Salinas-Carmona, Alberto Y. Limon-Flores, Adolfo Soto-Dominguez, Gerardo Padilla-Rivas, Roberto Montes De Oca-Luna, Jose F. Islas, Elsa N. Garza-Trevino
Summary: Translation: As our understanding of cancer improves, mesenchymal stem cells (MSCs) have been proposed as a promising and effective therapy. In this study, it was found that mice implanted with genetically engineered MSCs carrying soluble TRAIL and IFN-beta genes demonstrated significant anti-tumor effects against lymphoma, reducing tumor size, delaying growth, or achieving tumor clearance.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Multidisciplinary Sciences
Daniela Leon Rojas, Fabiola Castorena Torres, Barbara Garza Ornelas, Julieta Rodriguez-de-Ita
Summary: The COVID-19 pandemic has had a significant impact on the mental health of female physicians, with high prevalence rates of depression, anxiety, sleep disturbances, and PTSD symptoms. Risk factors associated with these symptoms include previous mental health disorders, younger age, and being on the frontline of COVID-19 attention.
Article
Pediatrics
Leslie Uribe-Ortiz, Barbara M. Garza-Ornelas, Ana C. Vazquez-Fernandez, Fabiola Castorena-Torres, Julieta Rodriguez-De-Ita
Summary: The study revealed that although parents and caregivers in Mexico have some knowledge of childhood cancer, there are certain concepts that need to be reinforced to enhance their understanding of this disease. They play a crucial role in seeking medical attention for children, therefore, education and health promotion are essential in low- and middle-income countries.
Article
Infectious Diseases
Carlos Eduardo Medina-De la Garza, Maria de los Angeles Castro-Corona, Mario Cesar Salinas-Carmona
Summary: The study highlights the reliance of some health care providers on the traditional ELISA-Western blot diagnostic algorithm for HIV infection diagnosis. It emphasizes the necessity of updating and training healthcare providers to improve the accuracy and sensitivity of HIV diagnosis.
Article
Microbiology
Anna V. Vazquez-Marmolejo, Nallely Lopez-Lopez, Jorge A. Ascacio-Martinez, Jose G. Valadez-Calderon, Pablo E. Espinoza-Martinez, Mario C. Salinas-Carmona
Summary: Mycetoma is a chronic infectious disease that causes severe deformation in the lower extremities, with etiological agents including fungi and bacteria. Nitric oxide plays a significant role in the development of actinomycetoma by affecting inflammation and T cell proliferation.
FEMS MICROBIOLOGY LETTERS
(2021)
Article
Medicine, Research & Experimental
Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela
Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.
ARCHIVES OF MEDICAL RESEARCH
(2024)