Article
Medicine, General & Internal
Yuta Seko, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura
Summary: In this study, the prognostic impact of new-onset or improved anemia after discharge from ADHF was investigated. The results showed that persistent and new-onset anemia at 6-month visit were associated with a higher risk for all-cause death or HF hospitalization in patients with ADHF, highlighting the importance of detecting anemia during follow-up.
Article
Cardiac & Cardiovascular Systems
P. B. Jayagopal, Sridhar L. Sastry, Veena Nanjappa, Jabir Abdullakutty, Johny Joseph, P. R. Vaidyanathan, Nitin Kabra, P. Manokar, Soma Sekhar Ghanta, Vinod Sharma, Trinath Kumar Mishra, Narendra Jathappa, Vikas Singh, S. N. Routray, Subroto Mandal, Neeraj Bhalla, Prabhakar Dorairaj, Nihar Mehta, Dayanand Kumbla, Abhijit Ramdas Rane, Tapan Kumar Matia, Dharmendra Jain, Gautam Rege, Sunil Modi, V. K. Chopra, P. P. Mohanan, A. Geevar Zachariah, K. S. Ravindranath, Rabin Chakraborty, B. C. Srinivas, T. R. Raghu, C. N. Manjunath
Summary: Acute decompensated heart failure (ADHF) is becoming increasingly prevalent in India, but there is a lack of data on ADHF in the country. A study of 5269 ADHF patients found that they were younger and predominantly male. The usage of guideline-based medical therapy (GDMT) was low, and the in-hospital and 30-day outcomes were poor.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tomomi Ide, Hidetaka Kaku, Shouji Matsushima, Takeshi Tohyama, Nobuyuki Enzan, Kouta Funakoshi, Yoko Sumita, Michikazu Nakai, Kunihiro Nishimura, Yoshihiro Miyamoto, Miyuki Tsuchihashi-Makaya, Masaru Hatano, Issei Komuro, Hiroyuki Tsutsui
Summary: The JROADHF study in Japan revealed that hospitalized HF patients were elderly, with a high prevalence of HFpEF, and their prognosis remained poor.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Teng-Yao Yang, Meng-shu Tsai, Jeng-Yu Jan, Jung-Jung Chang, Chang-Ming Chung, Ming-Shyan Lin, Hui-Ming Chen, Yu-Sheng Lin
Summary: Ivabradine is effective in controlling heart rate when initiated in patients with acute heart failure, but it does not seem to provide significant benefits in reducing heart failure hospitalization, all-cause hospitalization, and mortality after one year.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
P. Christian Schulze, Juergen Bogoviku, Julian Westphal, Pawel Aftanski, Franz Haertel, Sissy Grund, Stephan von Haehling, Ulrike Schumacher, Sven Moebius-Winkler, Martin Busch
Summary: This study suggests that early addition of empagliflozin to standard diuretic therapy can increase urine output in patients with acute decompensated heart failure without affecting renal function.
Article
Cardiac & Cardiovascular Systems
Koichi Washida, Takao Kato, Neiko Ozasa, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Yuta Seko, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura
Summary: Factors influencing discharge destination in acute decompensated heart failure patients include prehospital social background, age, body mass index, low self-care ability, events during hospitalization (worsening heart failure, stroke, etc), functional decline, and length of hospital stay. The prognosis of nonhome discharge patients is worse than that of home discharge patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Charu Gandotra, Motahar Basam, Ankit Mahajan, Julius Ngwa, Gezzer Ortega, Daniel Tran, Terrence M. Fullum, Zaki A. Sherif
Summary: The study aimed to describe the preoperative clinical characteristics of African American obese hypertensive patients and identify predictors of hypertension resolution one year after Roux-en-Y Gastric Bypass (RYGB) surgery. Results showed that older age, a higher prevalence of diabetes mellitus, and dyslipidemia were associated with a lower likelihood of hypertension resolution after surgery.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Anthony P. Carnicelli, Robert Clare, Paul Hofmann, Karen Chiswell, Adam D. DeVore, Sreekanth Vemulapalli, G. Michael Felker, Phil Sarocco, Robert J. Mentz
Summary: WHF events are common in patients with HFrEF and are associated with more advanced disease, leading to higher rates of death and hospitalization.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Kai Zhao, Qun Zheng, Jiang Zhou, Qi Zhang, Xiaoli Gao, Yinghua Liu, Senlin Li, Weichao Shan, Li Liu, Nan Guo, Hongsen Tian, Qingmin Wei, Xitian Hu, Yingkai Cui, Xue Geng, Qian Wang, Wei Cui
Summary: This study investigates the association between serum electrolyte and adverse short-term prognosis in Chinese patients with ADHF. The findings suggest that deviations from normal potassium levels, lower sodium levels, hypochloremia, and the number of electrolyte abnormalities are associated with poorer short-term prognosis in ADHF patients.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Juan Esteban Gomez-Mesa, Juliana Maria Gutierrez-Posso, Manuela Escalante-Forero, Brayan Daniel Cordoba-Melo, Paula Andrea Cardenas-Marin, Eduardo R. Perna, Madelyn Raquel Valle-Ramos, German Camilo Giraldo-Gonzalez, Noel Alberto Florez-Alarcon, Ida Fabiola Rodriguez-Caballero, Cristian Nunez-Carrizo, Luz Teresa Cabral-Gueyraud, Sarah Raquel Marte-Arias, Elizabeth Ashley Hardin, Amada Alvarez-Sangabriel, Maria Eugenia Menjivar-De Ramos, Kwame van der Hilst, Licurgo Jacob Cruz-Diaz, Sergio Roberto Ovando, Luis Arturo Rodriguez, Juan Pablo Escalante, Gabriela Ormaechea-Gorricho, Norberto Raul Bornancini, Maria Juliana Rodriguez-Gonzalez, Sebastian Campbell-Quintero, Raquel E. Gonzalez-Hormostay, Guillermo Oviedo-Pereira, Guillermo Trout-Guardiola, Juan Justiniano Encina, Ana Margarita Jerez-Castro, Mark Drazner, Daniel Quesada-Chaves, Alexander Romero-Guerra, Victor Alejandro Rossel-Mariangel, Mario Speranza
Summary: The AMERICCAASS registry aims to describe the characteristics and pharmacological management of patients with ambulatory or acutely decompensated heart failure in America. The findings suggest that a significant number of patients are not receiving optimal medical therapy.
CLINICAL CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Midori Yukino, Yuji Nagatomo, Ayumi Goda, Takashi Kohno, Makoto Takei, Yosuke Nishihata, Mike Saji, Yuichi Toyosaki, Shintaro Nakano, Yukinori Ikegami, Yasuyuki Shiraishi, Shun Kohsaka, Takeshi Adachi, Tsutomu Yoshikawa
Summary: The study found that the use of NPPV is associated with a lower rate of endotracheal intubation in patients with acute decompensated heart failure, but may result in longer length of hospital stay. Stratified analysis showed that patients with ischemic etiology, high systolic blood pressure, and better nutritional status may benefit from NPPV use, while patients with non-ischemic etiology, low systolic blood pressure, and poorer nutritional status may experience longer hospital stays.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michael Abiragi, Tahli Singer-Englar, Robert M. M. Cole, Dominic Emerson, Fardad Esmailian, Dominick Megna, Jaime Moriguchi, Jon A. A. Kobashigawa, Michelle M. M. Kittleson
Summary: Patients with cardiogenic shock may require temporary mechanical circulatory support (tMCS) to assess candidacy for definitive therapy or maintain stability. This study compares the outcomes of patients who received intra-aortic balloon pump (IABP) vs. Impella support at a high-volume advanced heart failure center. Despite the worse condition of patients who received Impella support, a high proportion of them were successfully stabilized. These findings highlight the heterogeneity of the cardiogenic shock patient population and may guide future trials on different tMCS devices.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ali Vazir, Chris J. Kapelios, Elif Agaoglu, Marco Metra, Yury Lopatin, Petar Seferovic, Wilfred Mullens, Gerasimos Filippatos, Giuseppe Rosano, Andrew J. S. Coats, Ovidiu Chioncel
Summary: There is significant variability in the management of acute decompensated heart failure (ADHF) among physicians and between cardiologists and non-cardiologists. This includes differences in the use of diuretics, assessment of congestion, treatment goals, and response evaluation. Cardiologists tend to have different strategies and targets compared to non-cardiologists.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Sarli Issa, Silvia Moreira Ayub-Ferreira, Matthew Schroyens, Paulo Roberto Chizzola, Paulo Rogerio Soares, Silvia Helena Gelas Lage, Edimar Alcides Bocchi
Summary: This study aimed to analyze the clinical presentation and prognosis of patients with Chagas cardiomyopathy and decompensated heart failure, comparing with other causes. The study found that patients with Chagas cardiomyopathy presented distinct clinical features and had a worse prognosis compared with patients of other etiologies.
Article
Cardiac & Cardiovascular Systems
Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizua, Daishi Nakagawa, Kimi Sato, Tomoko Machino-Ohtsuka, Isao Nishi, Yoshie Hamada-Harimura, Seika Sai, Akinori Sugano, Masako Baba, Haruhiko Higuchi, Kazutaka Aonuma, Nobuyuki Ohte, Masaki Ieda
Summary: This study showed that sST2 can predict cardiovascular events in patients with heart failure, especially in those with preserved ejection fraction. Other biomarkers such as PTX3, Gal-3, and high-sensitivity troponin T did not demonstrate significant predictive value after adjustment for clinical variables.
JOURNAL OF CARDIAC FAILURE
(2021)
Review
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Aymen Ahmed, Stephen J. Greene, Mona Fiuzat, Michelle M. Kittleson, Javed Butler, George L. Bakris, Gregg C. Fonarow
Summary: Heart failure and end-stage kidney disease often coexist and worsen each other's prognosis. Patients on dialysis are at high risk, but they have been excluded from major clinical trials on heart failure, resulting in a lack of data and reliance on observational evidence. In clinical practice, heart failure treatment is often reduced or discontinued in patients with end-stage kidney disease undergoing dialysis due to safety concerns. This review discusses the available evidence, challenges, and future directions for optimizing heart failure management in these high-risk patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Eric D. Peterson, Neil Keshvani, Dharam J. Kumbhani, Clyde W. Yancy, Alanna A. Morris, Larry A. Allen, Saket Girotra, Gregg C. Fonarow, Randall C. Starling, Paulino Alvarez, Milind Y. Desai, Peter Cram, Ambarish Pandey
Summary: This study found that using race-specific risk adjustment models can more accurately represent hospital performance for patients of Black and other races in terms of heart failure hospitalization and 30-day risk-standardized readmission rate and risk-standardized mortality rate.
Editorial Material
Cardiac & Cardiovascular Systems
Javed Butler, Khawaja M. Talha, Gregg C. Fonarow
Editorial Material
Cardiac & Cardiovascular Systems
Brian R. Lindman, Gregg C. Fonarow, Gary Myers, Heather M. Alger, Christine Rutan, Katie Troll, Angeline Aringo, Melanie Shahriary, Mariell Jessup, Suzanne V. Arnold, Pinak B. Shah, Wilson Y. Szeto, Clyde W. Yancy, Catherine M. Otto
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Harriette G. C. Van Spall, James L. Januzzi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Shariq Usman, Tariq Jamal Siddiqi, Stefan D. Anker, George L. Bakris, Deepak L. Bhatt, Gerasimos Filippatos, Gregg C. Fonarow, Stephen J. Greene, James L. Januzzi, Muhammad Shahzeb Khan, Mikhail N. Kosiborod, Darren K. McGuire, Ileana L. Pina, Julio Rosenstock, Muthiah Vaduganathan, Subodh Verma, Shelley Zieroth, Javed Butler
Summary: SGLT2 inhibitors can reduce the risk of heart failure events and cardiovascular death in patients with type 2 diabetes, heart failure, and chronic kidney disease, and the effects are consistent in patients with different combinations of these diseases.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Stephen J. Greene
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Jie-Lena Sun, Gregg C. Fonarow, Stephen B. Heitner, Punag H. Divanji, Gary Binder, Larry A. Allen, Brooke Alhanti, Clyde W. Yancy, Nancy M. Albert, Adam D. DeVore, G. Michael Felker, Stephen J. Greene
Summary: This study investigated the clinical profile and healthcare costs of US patients with heart failure who do not meet the threshold for advanced therapies. The majority of these patients have severely reduced ejection fraction (≤30%) and face increased risk of death and heart failure hospitalization despite receiving guideline-directed medical therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Boshu Ru, Xi Tan, Yu Liu, Kartik Kannapur, Dheepan Ramanan, Garin Kessler, Dominik Lautsch, Gregg Fonarow
Summary: This study aimed to compare different machine learning prediction models and feature construction methods to predict readmissions and worsening heart failure events (WHFEs) in patients with heart failure with reduced ejection fraction (HFrEF). The results showed that the XGBoost model with the frequency of clinical codes as features had the best discriminative ability for predicting these events.
JMIR FORMATIVE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Neil Keshvani, Vinayak Subramanian, Christopher A. Wrobel, Nicole Solomon, Brooke Alhanti, Stephen J. Greene, Adam D. DeVore, Clyde W. Yancy, Larry A. Allen, Gregg C. Fonarow, Ambarish Pandey
Summary: This study aimed to investigate the referral and participation rates in cardiac rehabilitation (CR) among patients with heart failure with reduced ejection fraction and evaluate the impact on survival and readmission. The results showed that referral rates have increased from 2010 to 2020, but only one in four patients were referred to CR. The participation rate in CR was low. Patients referred to CR had a lower risk of 1-year death compared to those not referred.
CIRCULATION-HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Reza Mohebi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohamed B. Jalloh, Tauben Averbuch, Prashanth Kulkarni, Christopher B. Granger, James L. Januzzi, Faiez Zannad, Robert W. Yeh, Clyde W. Yancy, Gregg C. Fonarow, Khadijah Breathett, Michael Gibson, Harriette G. C. Van Spall
Summary: Heart failure is a leading cause of death and disability in older adults, but the implementation of guideline-directed medical therapies to reduce the burden of the disease has been suboptimal. This review discusses interventions that increase the uptake of these therapies, barriers and facilitators of implementation, conceptual frameworks in implementation science, and trial design suggestions. An evidence-to-care conceptual model is proposed to generate evidence and promote long-term implementation. By applying principles of implementation science, policymakers, researchers, and clinicians can help alleviate the burden of heart failure worldwide.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Harsh Patolia, Muhammad Shahzeb Khan, Gregg C. Fonarow, Javed Butler, Stephen J. Greene
Summary: Despite the availability of effective medical therapy for heart failure with reduced ejection fraction, there are major gaps in its utilization. This review discusses various strategies for improving the use of these therapies and emphasizes the urgent need for better provision of appropriate treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Congyi Zheng, Jiayuan Qiu, Gregg C. Fonarow, Gregory Y. H. Lip, Yingqing Feng, Zengwu Wang
Summary: The burden of heart failure (HF) in China is expected to increase due to population ageing. However, there is limited knowledge about the prevalence of HF stages in China. Therefore, this study aimed to evaluate the prevalence of HF stages in the general Chinese population and the specific prevalence by age, sex, and urbanity. The study found that both pre-clinical and clinical HF burdens are high in China and vary by age, sex, and urbanity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: In a large cohort of adults with type 2 diabetes, the study found a significant association between cardiac autonomic neuropathy (CAN) and the risk of silent myocardial infarction (SMI). Low heart rate variability was significantly associated with an increased risk of incident SMI. Participants with CAN had a 1.9-fold greater risk of SMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)