Article
Cell Biology
Qi Chen, Nan Gao, Fu-Shin Yu
Summary: IL-36 cytokines have different roles in mediating immune and inflammatory response. This study showed that IL-36R signaling plays a role in corneal epithelial wound healing and IL-36R deficiency accelerates the healing process. The expression of certain proinflammatory cytokines and antimicrobial peptides were affected by IL-36R deficiency. IL-36Ra could be a potential therapeutic agent for wound healing and ulcer reduction.
Article
Multidisciplinary Sciences
Ying Hon Sze, Qian Zhao, Jimmy Ka Wai Cheung, King Kit Li, Dennis Yan Yin Tse, Chi Ho To, Thomas Chuen Lam
Summary: This study utilized high-throughput mass spectrometry technology to identify a large number of proteins in the mouse retina and constructed a comprehensive spectral library. This will help to provide a more comprehensive understanding of the proteins in retinal tissue and their role in biological signaling pathways.
Article
Orthopedics
Monideepa Chatterjee, Ashley Acosta, Peter J. Taub, Nelly Andarawis-Puri
Summary: The study found that MRL mice exhibited enhanced healing in the repair of supraspinatus tendons compared to B6 mice. They showed improved zonal architecture and bone structure recovery, as well as a temporal balance of collagen levels. The initial gait deficits observed in MRL mice may have provided a protective loading environment that ultimately contributed to better healing.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Orthopedics
Tyler J. Vovos, Bridgette D. Furman, Janet L. Huebner, Kelly A. Kimmerling, Gangadhar M. Utturkar, Cynthia L. Green, Virginia B. Kraus, Farshid Guilak, Steven A. Olson
Summary: Posttraumatic arthritis (PTA) commonly occurs after articular fracture due to joint surface incongruity. MRL/MpJ (MRL) super-healer mice have protection against PTA compared to C57BL/6 (B6) mice. Joint incongruity measured by in vivo micro-computed tomography (microCT) in mice may not predict the severity of subsequent PTA, indicating a unique biologic response in MRL mice.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Immunology
Tim Bleul, Xinyu Zhuang, Antonia Hildebrand, Clemens Lange, Daniel Boehringer, Guenther Schlunck, Thomas Reinhard, Thabo Lapp
Summary: The study investigated immunological differences and the role of CD38+/F4/80 + M1 macrophages in C57BL/6J and BALB/c recipient mouse corneal transplantation models. It was found that both strains of mice exhibited rejection of allogeneic corneal transplants, with more pronounced tissue alterations in C57BL/6J recipients. Following syngeneic transplantation, C57BL/6J recipients showed persistent graft swelling with increased numbers of CD38+/F4/80 + M1 macrophages in the grafted tissue, in contrast to BALB/c recipients. The results suggest that strain-dependent differences lead to different innate immune responses in BALB/c and C57BL/6J strains, and careful consideration of both donor and recipient mouse lines is essential for murine keratoplasty experiments. C57BL/6J-recipient mice may be particularly suited for studying corneal graft rejection in high-risk clinical settings.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Zgutka, Katarzyna Piotrowska, Mateusz Bosiacki, Andrzej Pawlik, Maciej Tarnowski
Summary: This study found that every-other day feeding affects the levels of trace elements in the bones of mice, but is not influenced by the activity of bone cells.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Behavioral Sciences
Melanie P. Leussis, Jessica M. Thanos, Alex Powers, Emalee Peterson, Joshua P. Head, Nathan J. McGovern, Francis J. Malarkey, Anna Drake
Summary: The study showed that prenatal exposure to fluoxetine affects neurodevelopment, mood, social, and repetitive behaviors in mice. High doses of fluoxetine resulted in increased repetitive behaviors and decreased sucrose preference in adult offspring.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Collin M. Bantle, C. Tenley French, Jason E. Cummings, Shankar Sadasivan, Kevin Tran, Richard A. Slayden, Richard J. Smeyne, Ronald B. Tjalkens
Summary: Exposure to elevated levels of manganese during juvenile development could sensitize glial cells to more severe neuro-immune responses to influenza infection later in life through persistent epigenetic changes.
Article
Nutrition & Dietetics
Dawson B. H. Livingston, Allison Sweet, Alexane Rodrigue, Lalit Kishore, Julia Loftus, Farida Ghali, Salma Mahmoodianfard, Colleen Celton, Farah Hosseinian, Krista A. Power
Summary: The gut-brain axis is crucial for mental health and mood disorders, and flaxseed can attenuate inflammation by modulating the gut microbiota.
Article
Endocrinology & Metabolism
Emma Laporte, Silke De Vriendt, Julie Hoekx, Hugo Vankelecom
Summary: Interleukin-6 (IL-6) is important for stem cell activation in the pituitary, but dispensable for normal development and homeostasis. However, IL-6 is needed for the acute stem cell response to local damage in the pituitary.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Derek P. D. Bornath, Greg L. McKie, Seth F. McCarthy, Luke W. Vanderheyden, Greg J. Howe, Philip J. Medeiros, Tom J. Hazell
Summary: This study examined the role of IL-6 on exercise-induced appetite regulation and found that IL-6 was not associated with appetite suppression. Although individuals with obesity had a blunted appetite response to moderate-intensity continuous training (MICT), normal weight participants experienced decreased hunger after exercise, and there were no significant differences in appetite perceptions between the control and exercise groups or between the normal weight and obesity groups.
Article
Neurosciences
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov, David Fazylov, Richard J. Bodnar
Summary: The present study found that C57BL/6 mice showed higher sensitivity to different drug interventions in the acquisition and expression of fat conditioned flavor preferences. There were also differences in the acquisition and expression of fat and sugar conditioned flavor preferences in these mice.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Orthopedics
Martine T. Dolan, Natalie A. Lowenstein, Jamie E. Collins, Elizabeth G. Matzkin
Summary: This study investigated the percentage of patients with rotator cuff tears undergoing repair surgery who reported preoperative sleep disturbances, as well as the changes in reported sleep disturbances during postoperative follow-up. The results showed that a majority of patients reported sleep disturbances before surgery and in the early postoperative period, with older patients (>65 years) more likely to report resolution of sleep disturbances compared to younger patients (<65 years).
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Orthopedics
Martine T. Dolan, Natalie A. Lowenstein, Jamie E. Collins, Elizabeth G. Matzkin
Summary: This study aimed to determine the percentage of patients undergoing rotator cuff repair (RCR) who reported preoperative sleep disturbances and to observe the resolution of sleep disturbances at different postoperative time intervals. The results showed that 89% of patients reported preoperative sleep disturbances, 77% reported resolution of sleep disturbances within 6 months postoperatively, and 81% reported resolution of sleep disturbances within 2 years postoperatively.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Biochemical Research Methods
Jing Zhang, Jun-qing Yang, Ying Luo, Jian-sha Li, Tao Gong, Su-qiong Huang, Yan Xiong, Xin-hui Jiang
Summary: This study explores and optimizes a method for the simultaneous determination of 23 amino acids in the bone marrow fluid and hippocampus of C57BL/6 mice with cerebral ischemia-reperfusion injury, providing insights into the changes in analyte content in this model.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Gastroenterology & Hepatology
Timothy J. Keane, Jenna Dziki, Eric Sobieski, Adam Smoulder, Arthur Castleton, Neill Turner, Lisa J. White, Stephen F. Badylak
JOURNAL OF CROHNS & COLITIS
(2017)
Article
Engineering, Biomedical
Neill J. Turner, Scott A. Johnson, Leslie J. R. Foster, Stephen F. Badylak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Correction
Cell & Tissue Engineering
B. M. Sicari, V Agrawal, B. F. Siu, C. J. Medberry, C. L. Dearth, N. J. Turner, S. F. Badylak
TISSUE ENGINEERING PART A
(2018)
Article
Cell & Tissue Engineering
Lindsey T. Saldin, Shil Patel, Li Zhang, Luai Huleihel, George S. Hussey, David G. Nascari, Lina M. Quijano, Xue Li, Divya Raghu, Anant K. Bajwa, Nicholas G. Smith, Christopher C. Chung, Ashten N. Omstead, Juliann E. Kosovec, Blair A. Jobe, Neill J. Turner, Ali H. Zaidi, Stephen F. Badylak
TISSUE ENGINEERING PART A
(2019)
Article
Cell & Tissue Engineering
Catalina Pineda Molina, George S. Hussey, Jonas Eriksson, Michael A. Shulock, Laura L. Cardenas Bonilla, Ross M. Giglio, Riddhi M. Gandhi, Brian M. Sicari, Derek Wang, Ricardo Londono, Denver M. Faulk, Neill J. Turner, Stephen F. Badylak
TISSUE ENGINEERING PART A
(2019)
Article
Chemistry, Multidisciplinary
Shayla Goller, Neill J. Turner
APPLIED SCIENCES-BASEL
(2020)
Article
Cell & Tissue Engineering
Lina M. Quijano, Juan D. Naranjo, Salma O. El-Mossier, Neill J. Turner, Catalina Pineda Molina, Joseph Bartolacci, Li Zhang, Lisa White, Hui Li, Stephen F. Badylak
TISSUE ENGINEERING PART C-METHODS
(2020)
Editorial Material
Chemistry, Multidisciplinary
Neill J. Turner
Summary: This Special Issue explores the various applications of extracellular matrix (ECM) in regenerative medicine, including manufacturing scaffold materials, understanding the impact of changes in ECM composition on disease development, and utilizing decellularization techniques to develop tissue-derived ECM scaffolds. Overall, the articles in this issue cover a wide range of research and applications of ECM in the field of regenerative medicine.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell & Tissue Engineering
Neill J. J. Turner, Lina M. M. Quijano, George S. S. Hussey, Peng Jiang, Stephen F. F. Badylak
Summary: Recent studies have found an extracellular vesicle population that is tightly anchored within the extracellular matrix until released by matrix turnover events. These vesicles contain tissue-specific proteins and microRNA cargo, and play an important role in regulating tissue homeostasis.
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
G. Lorenz, L. Saldin, D. Nascari, A. Omstead, L. Quijano, M. Lebaudy, A. Gorbunova, P. Joseph, X. Li, J. G. Bartolacci, J. Naranjo, A. Abo-Zed, S. Ayazi, K. Newhams, Y. Komatsu, K. Hall, G. Hussey, N. J. Turner, B. Jobe, A. H. Zaidi, S. F. Badylak
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
N. J. Turner, L. M. Quijano, G. S. Hussey, P. Jiang, S. F. Badylak, S. F. Badylak
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Lindsey T. Saldin, David G. Nascari, Xue Li, Ashten N. Omstead, Lina M. Quijano, Anastasia Gorbunova, Li Zhang, Paul Joseph, Blair A. Jobe, Vera S. Donnenberg, Neill J. Turner, Ali H. Zaidi, Stephen F. Badylak
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Lindsey T. Saldin, Shil Patel, Li Zhang, Luai Huleihel, Lina M. Quijano, Anant Bajwa, Divya Raghu, David Nascari, Chris Chung, Nicholas Smith, George Hussey, Ashten N. Omstead, Juliann E. Kosovec, Daisuki Matsui, Neill Turner, Ali H. Zaidi, Stephen F. Badylak, Blair A. Jobe
Meeting Abstract
Cell & Tissue Engineering
L. J. White, T. J. Keane, A. Smoulder, L. Zhang, J. Reing, N. J. Turner, S. F. Badylak
TISSUE ENGINEERING PART A
(2017)
Article
Cell & Tissue Engineering
Neill J. J. Turner, Lina M. M. Quijano, George S. S. Hussey, Peng Jiang, Stephen F. F. Badylak
Summary: Recent studies have identified a population of matrix-bound nanovesicles (MBVs) tightly anchored within the extracellular matrix (ECM) of tissues and organs, which contain tissue-specific protein and microRNA cargo. These MBVs may play an important role in regulating tissue homeostasis.
TISSUE ENGINEERING PART A
(2022)
