Article
Andrology
Lorenzo Romano, Raffaele Pellegrino, Carmine Sciorio, Biagio Barone, Antonietta Gerarda Gravina, Antonio Santonastaso, Caterina Mucherino, Silvia Astretto, Luigi Napolitano, Achille Aveta, Savio Domenico Pandolfo, Davide Loizzo, Francesco Del Giudice, Matteo Ferro, Ciro Imbimbo, Marco Romano, Felice Crocetto
Summary: The study found that sexual dysfunction is prevalent in celiac disease patients. Early age at diagnosis and high body mass index appear to be predictors of sexual dysfunction. The assessment of sexual function should be included in the initial evaluation of celiac disease patients for prompt diagnosis and treatment.
Article
Urology & Nephrology
Joana Carvalho, Priscila Campos, Mariana Carrito, Catarina Moura, Ana Quinta-Gomes, Ines Tavares, Pedro Nobre
Summary: This study found that psychological adjustment during lockdown plays an important mediating role in the sexual functioning domain, having a greater impact on men than women. While confinement levels are not directly related to sexual functioning, psychological adjustment during lockdown predicts lower sexual functioning in both genders.
JOURNAL OF SEXUAL MEDICINE
(2021)
Article
Medicine, General & Internal
Paraskevi Sotiropoulou, Fotini Ferenidou, Dimitra Owens, Ioulia Kokka, Eirini Minopoulou, Evangelia Koumantanou, Iliana Pavlopoulou, Panagiotis Apotsos, Maria Karvouni, Elli Koumantarou, Iraklis Mourikis, Nikos Vaidakis, Charalambos Papageorgiou
Summary: During the national quarantine imposed by the Greek government, sexual function and relationship quality of couples did not appear to be negatively impacted. Living with a partner and being in a steady relationship may enhance satisfaction with sexual activity and emotional security.
Article
Surgery
Mohamed D. Sarhan, Mohammed Khattab, Mai D. Sarhan, Karim K. Maurice, Haitham Hassan
Summary: The study found that bariatric surgery has a significant long-term improvement on male sexual function, leading to increased IIEF scores and serum testosterone levels. Weight and BMI affect IIEF scores, while weight, BMI, and age impact serum testosterone levels.
Review
Health Care Sciences & Services
Effrosyni Nikolaidou, Evangelia Antoniou, Angeliki Sarella, Maria Iliadou, Eirini Orovou, Maria Dagla
Summary: Female sexual function is influenced by multiple factors, including physiological structures, hormonal fluctuations postpartum, and psychological adjustment. This review systematically appraised existing data and found that the mode of delivery does not appear to have a significant effect on female sexual function, while moderating factors may indirectly influence this relationship. Healthcare professionals should educate expectant mothers and be aware of the potential impact of delivery method on sexual function.
Article
Psychiatry
Alireza Khabbazi, Ali Reza Shafiee-Kandjani, Hadise Kavandi, Morteza Asadi, Maryam Panahzadeh
Summary: This study found that BD has significant effects on sexual function in females, with a high prevalence of sexual dysfunction. Sexual dysfunction is an important issue for patients with BD.
IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES
(2022)
Article
Medicine, General & Internal
Sahar A. Ismail, Nagwa E. Abdel-Azim, Medhat A. Saleh, Ahmed A. Mohamed, Ali H. Yosef, Ahmad M. Abbas
Summary: This study established a new grading system that accurately classified female sexual dysfunction and found varying degrees of FSD among the sample population. It showed a linear trend of reduction in desire scores with increasing severity of FSD, which was statistically significant.
AFRICAN HEALTH SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Laura Mateu Arrom, Montserrat Girabent-Farres, Monica Gonzalez, Joan Palou, Carlos Errando-Smet, Ines Ramirez-Garcia
Summary: A 6-item Spanish version of the FSFI was developed through a focus group and IRT analysis, showing good reliability in a group of Spanish women.
Article
Public, Environmental & Occupational Health
Ana-Maria Cristina Daescu, Liana Dehelean, Dan-Bogdan Navolan, Gheorghe Nicusor Pop, Dana Liana Stoian
Summary: This study examined the psychometric reliability and validity of the Romanian Version of the Female Sexual Function Index (FSFI-RO). The results showed that FSFI-RO had high reliability and validity, making it a reliable and valid instrument for use in Romanian-speaking women.
Article
Surgery
Adel M. Wilson, Amr A. Zaki
Summary: The study focused on the treatment of female genital mutilation through clitoral reconstruction and coverage with sensate labial flaps, showing significant improvements in sexual function, clitoral sensation, genital aesthetics, and self-esteem among patients.
AESTHETIC SURGERY JOURNAL
(2022)
Review
Medicine, Research & Experimental
Hanan Khaled Sleiman, Jeane Maria de Oliveira, Guilherme Barroso Langoni de Freitas
Summary: Isoflavones are a group of plant compounds that have similar structures to endogenous hormones and may affect the development and functioning of the reproductive system. They have both beneficial and harmful effects, which can be influenced by factors such as type and exposure period.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Soumita Mandal, Pradip Mukhopadhyay, Sujoy Ghosh
Summary: The study found that sexual dysfunction is very common, affecting 90% of subjects with Sheehan syndrome. Patients with Sheehan syndrome had significantly lower sexual function scores compared to healthy controls, particularly in the areas of desire, arousal, lubrication, orgasm, and satisfaction.
ENDOCRINE PRACTICE
(2021)
Article
Obstetrics & Gynecology
Ozgur Ozer, Esra Keles, Hasan Huseyin Eker, Ifrah Abdi Nor, Kursad Nuri Baydili
Summary: This study aimed to evaluate the impact of the COVID-19 pandemic on female sexual function in women with female genital mutilation (FGM) in Somalia. The results showed a decline in female sexual functioning during the COVID-19 pandemic. This is a major public health concern that requires urgent attention in Somalia.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Geriatrics & Gerontology
Rui Ju, Xiangyan Ruan, Yu Yang, Xin Xu, Jiaojiao Cheng, Yongtao Bai, Yanhong Shi, Xingzi Yang, Ruiling Li, Alfred O. Mueck
Summary: This study investigated the factors affecting the sex lives of postmenopausal Chinese women, focusing on body weight, climacteric symptoms, and androgens. The results showed that climacteric symptoms and sociodemographic factors had a notable effect on sexual function. It is necessary to provide more attention to and intervention for these symptoms to improve the quality of life of postmenopausal women.
Article
Medicine, General & Internal
Tony Chen, Hriday P. Bhambhvani, Alex M. Kasman, Michael L. Eisenberg
Summary: The study found that there were no significant changes in overall male sexual function during the COVID-19 pandemic in the United States, but there was an increase in sexual frequency. For those who reported a decrease in sexual function, it was significantly associated with higher depression scores. Therefore, interventions aimed at promoting male sexual health during the COVID-19 pandemic should focus on mental health.
Review
Cell Biology
Ammad Ahmad Farooqi, Humaira Naureen, Rukset Attar
Summary: Groundbreaking discoveries in molecular oncology have advanced our understanding to a new level. The discovery of circular RNAs has added complexity to cell signaling pathways and opened up new areas of research. This review summarizes the recent advancements in the interplay between circular RNAs and microRNAs in regulating various cancer-related pathways.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Ammad Ahmad Farooqi, Rukset Attar, Ishmuratova Margarita Yulaevna, Rossana Berardi
Summary: Advancements in single-cell RNA sequencing technologies have allowed us to understand the heterogeneity of the immune system and identify different subsets of immune cells in disease and health. The discovery of non-coding RNAs has provided new insights into the regulatory roles of cell signaling pathways in immunology and oncology. The delivery of non-coding RNAs through exosomes to recipient cells has shown promising potential for rewiring pathways and protein networks. A broader understanding of the regulation in this system could lead to the development of clinically effective therapeutics.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ghazala Butt, Ulku Ozbey, Durr-e-shahwar Malik, Rukset Attar, Lara Youssef, Ammad Ahmad Farooqi
Summary: Natural products have been historically invaluable as a source of therapeutic agents, and recent advancements in research have shed light on the diversity of proteins targeted by these products. Wogonin, an O-methylated flavone, has shown pharmacological targeting abilities in different cancers and potential in preventing carcinogenesis and metastasis. Further research is needed to understand the pleiotropic role of wogonin and its regulation of non-coding RNAs for a comprehensive understanding of its chemopreventive properties.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiukun Lin, Rukset Attar, Iqra Mobeen, Ishmuratova Margarita Yulaevna, Aliye Aras, Ghazala Butt, Ammad Ahmad Farooqi
Summary: The field of molecular oncology has seen exponential growth, leading to a better understanding of the therapeutic challenges of cancer and solving many mysteries surrounding cancer. Our evolving knowledge of deregulated oncogenic signaling pathways has attracted significant attention in pharmacological targeting. Natural product research, specifically with substances like schisandrin, is gaining momentum due to their potential in cancer treatment, with a need for further detailed research on their regulatory mechanisms.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rukset Attar, Tahira Panah, Mirna Azalea Romero, Ishmuratova Margarita Yulaevna, Maria Gazouli, Rossana Berardi, Edyta Wieczorek, Ammad Ahmad Farooqi
Summary: The wealth of information has transformed our understanding of the genetics and functional genomics of ovarian cancer, potentially leading to long-term survival. The motility and invasive properties of ovarian cancer cells are driven by signaling cascades, many of which play crucial roles in metastasis.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ammad Ahmad Farooqi, Humaira Naureen, Rabbia Zahid, Lara Youssef, Rukset Attar, Baojun Xu
Summary: This review summarizes the regulatory effects of Fisetin in different cancers, including modulation of multiple oncogenic signaling pathways, inhibition of tumor cell metastasis, and promotion of autophagy. Fisetin has shown promising therapeutic effects in clinical trials.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Iqra Mobeen, Mirna Azalea Romero, Ishmuratova Margarita Yulaevna, Rukset Attar, Saima Jabeen, Sundas Fayyaz
Summary: This article summarizes the regulation of different oncogenic pathways in carcinogenesis and metastasis by genistein, as well as its modulation of non-coding RNAs. It also includes a discussion on clinical trials related to genistein for cancer prevention/inhibition. The article points out potential hints of a pro-metastatic role of genistein, highlighting the need for rational testing in a broader context.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ammad Ahmad Farooqi, Ru Wen, Rukset Attar, Simona Taverna, Ghazala Butt, Baojun Xu
Summary: This article reviews the modulation mechanism of natural product berbamine in different cancers and oncogenic cell-signaling pathways. It also analyzes the activation of the TGF/SMAD pathway by berbamine and nanotechnological strategies for efficient delivery. Furthermore, berbamine demonstrates potent anti-cancer and anti-metastatic effects in tumor-bearing mice. However, the regulatory role of berbamine in non-coding RNAs remains insufficiently studied, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Emre Murat Altinkilic, Selami Bayrakdar, Gulcan Seymen Karabulut, Belma Haliloglu, Rukset Attar
Summary: This study investigated the effects of circulating miRNAs on leptin resistance in obese children by targeting the SOCS3 pathway. The results showed that miR-218-5p might be involved in leptin resistance in obese children.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2022)
Review
Oncology
Ammad Ahmad Farooqi, Rabbia Zahid, Humaira Naureen, Rukset Attar, Maria Gazouli, Rossana Berardi, Jolanta Szelachowska, Rafal Matkowski, Edyta Pawlak
Summary: Recent breakthroughs in high-throughput technologies have provided insights into the regulatory role of rho-associated protein kinases (ROCKs) in cancer through long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). These findings highlight the pleiotropic modulation of ROCK1/2 by lncRNAs and circRNAs in multistep cancer progression.
Review
Biochemistry & Molecular Biology
Ammad Ahmad Farooqi, Rukset Attar, Baojun Xu
Summary: Cancer is a life-threatening disease that has been extensively studied in the past three decades. Thymoquinone, a natural product, has shown promising potential in cancer chemoprevention through its multifunctionality. Further research is needed to transition thymoquinone from preclinical studies to clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Durr-E-Shahwar Malik, Rukset Attar, Ulku Ozbey, Mirna Azalea Romero, Ishmuratova Margarita Yulaevna, Jelena Purenovic
Summary: The diversity of highly bioactive and pharmacologically active natural products provides a valuable resource for drug discovery. Nobiletin has shown chemopreventive effects and potential molecular targets in cancer treatment.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Imran Sohail, Naila Malkani, Nimra Tahir, Ateeb Khalil, Rukset Attar, Sidra Mumtaz
Summary: This study evaluated the anti-cholestatic effect of silymarin against ANIT-induced cholestasis. The results showed that silymarin could alleviate hepatic injury by modulating the expression of genes involved in bile acid homeostasis.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ammad Ahmad Farooqi, Fatima Tahir, Maham Fakhar, Ghazala Butt, Tatiana Colombo Pimentel, Ning Wu, Ishmuratova Margarita Yulaevna, Rukset Attar
Summary: Research on metastasis has advanced significantly, uncovering the important role of bioactive chemicals from citrus fruits in cancer chemoprevention, as well as the potential value of citrus-derived bioactive components in inhibiting metastasis.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aima Adylova, Auyezova Ardak Mukhanbetzhanovna, Rukset Attar, Ishmuratova Margarita Yulaevna, Ammad Ahmad Farooqi
Summary: The multi-layered regulation of TGF beta/SMAD signaling in cancer cells involves complex interactions with oncogenic and tumor suppressor long non-coding RNAs (LncRNAs). These LncRNAs can either positively or negatively modulate the TGF beta/SMAD pathway in different types of cancer, making it a double-edged sword in molecular oncology. This review summarizes recent breakthroughs in understanding how LncRNAs regulate TGF beta/SMAD signaling, filling in missing pieces of the puzzle in the LncRNA-interactome.
NON-CODING RNA RESEARCH
(2021)
