Article
Obstetrics & Gynecology
Fisun Vural, Birol Vural, Eyupcan Kardas, Ayse Deniz Erturk Coskun, Irem Yildirim
Summary: This study investigated the utilization of Anti-Mullerian hormone (AMH) alone or replacing polycystic ovarian morphology (PCOM) in the PCOS diagnostic criteria. The results showed that AMH can be used with high diagnostic accuracy instead of PCOM in Rotterdam criteria, especially for phenotype A and D.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Alexandra Dietz de Loos, Martin Hund, Katharina Buck, Cindy Meun, Johanna Sillman, Joop S. E. Laven
Summary: The study aimed to determine a cutoff for the Elecsys AMH Plus immunoassay to aid in PCOM diagnosis. The results showed that a cutoff of 3.2 ng/mL (23 pmol/L) demonstrated high sensitivity and specificity for PCOM diagnosis, with consistent performance across different ages and PCOS phenotypes.
FERTILITY AND STERILITY
(2021)
Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Jiexue Pan, Chengliang Zhou, Zhiyang Zhou, Zuwei Yang, Tiantian Dai, Hefeng Huang, Li Jin
Summary: The ovarian PTX3 level was found to be significantly higher in healthy-weight women with PCOS compared to controls. Positive correlations were observed between ovarian PTX3 level and factors such as PCOS diagnosis, cycle length, basal hormone levels, antral follicle count, and ovarian hormone levels. Elevated ovarian PTX3 level may indicate a low-grade chronic inflammatory state in the follicles of PCOS, which could be related to the presence of PCOS, pituitary dysfunction, and ovarian hyperandrogenism.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Endocrinology & Metabolism
Yu Ran, Qiang Yi, Cong Li
Summary: The study found that AMH levels were higher in PCOS patients compared to controls, with no difference in subgroups of PCOS patients under 30 years old. AMH levels in the PCOM subgroup were significantly higher than those in the HA subgroup, suggesting a strong relationship between AMH and PCOM but not with HA.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yi-cheng Wang, Yong-dan Ma, Huan Liu, Zhi-hui Cui, Dan Zhao, Xue-qin Zhang, Li-xue Zhang, Wen-jing Guo, Yun Long, Sha -sha Tu, Dong-zhi Yuan, Jin-hu Zhang, Bing-kun Wang, Liang-zhi Xu, Qiong-yan Shen, Yan Wang, Li Nie, Li-min Yue
Summary: In this study, it was found that hyperandrogenism in PCOS can induce the expression of ovarian aldose reductase, leading to an increase in the flux of the polyol pathway, and affecting ovarian function through excessive oxidative stress.
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sairish Ashraf, Shayaq Ul Abeer Rasool, Mudasar Nabi, Mohd Ashraf Ganie, Farhat Jabeen, Fouzia Rashid, Shajrul Amin
Summary: The study found no significant difference in allelic and genotypic distribution of CYP17 gene polymorphism between PCOS patients and healthy controls in the Kashmiri population. However, PCOS patients with mutant genotype showed significantly higher levels of total testosterone and clinical features related to hyperandrogenism, indicating an association in this population.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Balkis Zaitoun, Abdullah Al Kubaisi, Noora AlQattan, Yahya Alassouli, Alshaima Mohammad, Huriya Alameeri, Ghada Mohammed
Summary: This study aimed to assess the knowledge and awareness of polycystic ovarian syndrome (PCOS) among females above the age of 18 years in the United Arab Emirates (UAE) and to correlate the level of awareness with women's backgrounds, demographics, and education levels. The study found that the overall level of PCOS awareness was insufficient, with more accurate knowledge observed among females who had received information from medical practitioners. Therefore, raising awareness of PCOS among females in the UAE is necessary for early diagnosis and improved patient outcomes.
Article
Obstetrics & Gynecology
Daniel A. Dumesic, Ayli Tulberg, Karen L. Leung, Samantha C. Fisch, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk
Summary: In vitro differentiation of adipose stem cells into adipocytes in SC abdominal fat may predict insulin sensitivity in vivo in normal-weight women with PCOS, suggesting a potential role for hyperandrogenism in metabolic thrift. PCOS patients exhibited higher androgen levels, adipose-IR, and android fat percentage, while their adipocyte differentiation and gene expression in vitro were negatively correlated with adipose-IR and serum free testosterone but positively correlated with insulin sensitivity.
FERTILITY AND STERILITY
(2021)
Article
Reproductive Biology
Zaixin Guo, Xiaohan Chen, Penghui Feng, Qi Yu
Summary: In DHEA-induced PCOS mice, rapamycin exacerbated reproductive imbalance characterized by elevated testosterone levels and suppressed steroid synthesis.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Obstetrics & Gynecology
Sofia Persson, Evangelia Elenis, Sahruh Turkmen, Michael S. Kramer, Eu-Leong Yong, Inger Sundstrom Poromaa
Summary: This study found that polycystic ovary syndrome is an independent risk factor for type 2 diabetes, regardless of BMI adjustment. Women with the hyperandrogenic PCOS phenotype face a higher risk of type 2 diabetes than those with the normoandrogenic PCOS phenotype.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Christos Damaskos, Nikolaos Garmpis, Kleio Vrettou, Anna Garmpi, Efstathios A. Antoniou, Athanasios Chionis, Konstantinos Nikolettos, Konstantinos Kontzoglou, Dimitrios Dimitroulis
Summary: Polycystic ovary syndrome (PCOS) is strongly associated with ovarian torsion, which is a significant risk in patients with enlarged ovaries. The most common symptom is acute lower abdominal pain, and diagnosis usually involves ultrasound and CT or MRI scans. Emergency laparoscopy with ovarian or adnexal detorsion is the standard treatment, while ovariopexy or ovariectomy/adnexectomy may be considered for recurrent torsions.
Article
Endocrinology & Metabolism
Carlos Moran, Monica Arriaga, Fabian Arechavaleta-Velasco, Segundo Moran
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2015)
Article
Nutrition & Dietetics
Segundo Moran, Aline Mina, Ximena Duque, Andres Henao, Judith Flores, Rita Gomez-Diaz, Homero Martinez
TOPICS IN CLINICAL NUTRITION
(2017)
Article
Medicine, Research & Experimental
Segundo Moran, Aline Mina, Ximena Duque, Salome Anaya, Uritzimar San-Martin, Patricia Yanez, Gustavo Rodriguez-Leal
ARCHIVES OF MEDICAL RESEARCH
(2013)
Article
Gastroenterology & Hepatology
Eugenia Mendoza, Margarita Camorlinga-Ponce, Guillermo Perez-Perez, Robertino Mera, Jenny Vilchis, Segundo Moran, Octavio Rivera, Rafael Coria, Javier Torres, Pelayo Correa, Ximena Duque
Article
Gastroenterology & Hepatology
Aline Mina, Segundo Moran, Nayeli Ortiz-Olvera, Robertino Mera, Misael Uribe
HEPATOLOGY RESEARCH
(2014)
Article
Endocrinology & Metabolism
Guadalupe Ramirez-Lopez, Segundo Moran-Villota, Francisco Mendoza-Carrera, Eliseo Portilla-de Buen, Victoria Valles-Sanchez, Xochitl H. Castro-Martinez, Jose Sanchez-Corona, Jorge Salmeron
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2018)
Article
Gastroenterology & Hepatology
Ximena Duque, Jenny Vilchis, Robertino Mera, Belem Trejo-Valdivia, Karen J. Goodman, Maria-Eugenia Mendoza, Fabiola Navarro, Victoria Roque, Segundo Moran, Javier Torres, Pelayo Correa
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2012)
Article
Nutrition & Dietetics
Ximena Duque, Homero Martinez, Jenny Vilchis-Gil, Eugenia Mendoza, Sergio Flores-Hernandez, Segundo Moran, Fabiola Navarro, Victoria Roque-Evangelista, Anayeli Serrano, Robertino M. Mera
Article
Nutrition & Dietetics
Eugenia Mendoza, Ximena Duque, Jordan I. Hernandez Franco, Elba Reyes Maldonado, Segundo Moran, Gloria Martinez, Aaron Salinas Rodriguez, Homero Martinez
Review
Nutrition & Dietetics
Renata Rivera-Flores, Segundo Moran-Villota, Luisa Cervantes-Barragan, Constantino Lopez-Macias, Misael Uribe
Article
Hematology
Eugenia Mendoza, Ximena Duque, Segundo Moran, Gloria Martinez-Andrade, Elba Reyes-Maldonado, Samuel Flores-Huerta, Homero Martinez
Summary: This study aimed to describe changes in iron status indicators in infants at 6 and 12 months of age, controlling for inflammation by measuring AGP. Results showed that hemoglobin and sTfR/ferritin ratio increased with age, while ferritin and TBI decreased. Hepcidin levels were higher in infants with inflammation and showed significant positive correlations with ferritin and TBI stores, indicating a functional hepcidin response to changes in iron stores.
ANNALS OF HEMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yazmin Karel Melchor-Mendoza, Braulio Martinez-Benitez, Aline Mina-Hawat, Gustavo Rodriguez-Leal, Ximena Duque, Segundo Moran-Villota
ANNALS OF HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
O. Ortiz-Garrido, N. X. Ortiz-Olvera, M. Gonzalez-Martinez, S. Moran-Villota, G. Vargas-Lopez, M. Dehesa-Violante, A. Ruiz-de Leon
REVISTA DE GASTROENTEROLOGIA DE MEXICO
(2015)
Article
Gastroenterology & Hepatology
Santiago Henao-Moran, Edgar Denova-Gutierrez, Segundo Moran, Ximena Duque, Katia Gallegos-Carrillo, Nayeli Macias, Jorge Salmeron
ANNALS OF HEPATOLOGY
(2014)
Article
Gastroenterology & Hepatology
Gustavo A. Rodriguez-Leal, Segundo Moran, Roberto Corona-Cedillo, Rocio Brom-Valladares
WORLD JOURNAL OF HEPATOLOGY
(2014)