Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study demonstrated that in women with PCOS, lifestyle modifications combined with synbiotic supplementation can significantly decrease body weight, waist circumference, hip circumference, and thigh circumference, as well as lead to a significant reduction in serum testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study found that synbiotic supplementation can enhance the effects of lifestyle modifications on weight and testosterone levels in patients with PCOS, leading to significant improvements.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Klara Beitl, Didier Dewailly, Rudolf Seemann, Marlene Hager, Jakob Buenker, Daniel Mayrhofer, Iris Holzer, Johannes Ott
Summary: Polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea (FHA) are the two most frequent causes of secondary amenorrhea, and distinguishing between them remains challenging. A retrospective case-control study found significant differences in hormone levels and protein binding globulin between PCOS-D patients and FHA-PCOM patients. The authors proposed a model including serological parameters as a reliable tool to distinguish between the two conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Wenhua Liu, Songyi Li, Xiaoming Lou, Dingheng Li, Fang Wang, Zhifen Zhang
Summary: This study found that levels of NLR, hs-CRP, and MPV are increased in patients with obese PCOS. The obese PCOS group had higher levels of NLR, hs-CRP, and MPV compared to the controls, and higher levels compared to the nonobese PCOS group.
Article
Biochemistry & Molecular Biology
Robert Tarszabo, Balint Banyai, Eva Ruisanchez, Borbala Peterffy, Agnes Korsos-Novak, Krisztina Lajtai, Reka Eszter Sziva, Dora Gerszi, Adam Hosszu, Rita Benko, Zoltan Benyo, Eszter Maria Horvath, Gabriella Masszi, Szabolcs Varbiro
Summary: In a rat model, vitamin D deficiency was found to impair the vasoactive effect of estradiol, while short-term chronic hyperandrogenism did not have this effect. Additionally, vitamin D deficiency also affected the immunostaining of estrogen receptor and nitric oxide synthase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Evolutionary Biology
Natalie L. Dinsdale, Bernard J. Crespi
Summary: Evolutionary and comparative approaches can provide new insights into human adaptation and disease. The study proposes the diametric disorder hypothesis between endometriosis and PCOS, with support from diverse fields of research. Findings suggest that PCOS and endometriosis represent maladaptive extremes of female life-history variation and expression of sexually dimorphic female reproductive traits.
EVOLUTIONARY APPLICATIONS
(2021)
Review
Medicine, Research & Experimental
Li Li, Jianxiu Yu, Zhongwei Zhou
Summary: This meta-analysis reveals that women with polycystic ovary syndrome (PCOS) have a significantly increased mean platelet volume (MPV) compared to women without PCOS, which may be associated with insulin resistance.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Lijun Chen, Wang Xu, Juanxia Chen, Huifang Zhang, Xiaobo Huang, Liting Ma, Genggeng Yu, Yanjun Zhou, Bin Ma, Chao Chen, Yanhong Liu, Xiaoyong Ma
Summary: This study aimed to evaluate the differences in coagulation indicators between the stable phase and acute exacerbation of COPD. The results showed that during acute exacerbation, the levels of white blood cell count, neutrophil count, fibrinogen, and D-dimer were significantly increased, while mean platelet volume, activated partial thromboplastin time, and prothrombin time were significantly decreased. Furthermore, mean platelet volume was negatively correlated with white blood cell count and neutrophil count, and forced expiratory volume in one second was negatively correlated with D-dimer and fibrinogen.
Article
Endocrinology & Metabolism
Xiang Hong, Pengfei Qin, Jiechen Yin, Yong Shi, Yan Xuan, Zhengqi Chen, Xu Zhou, Hong Yu, Danhong Peng, Bei Wang
Summary: The vaginal microbiome of PCOS patients is associated with specific clinical manifestations, such as acanthosis nigricans, intermenstrual bleeding, pregnancy history, testosterone level, and anti-mullerian hormone level. The abundance of certain bacterial species, such as Lactobacillus crispatus, was found to be higher among PCOS patients with elevated testosterone levels. Further studies are needed to explore the microbiota and molecular mechanisms underlying this relationship.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kristen J. Polinski, Sonia L. Robinson, Diane L. Putnick, Rajeshwari Sundaram, Erin Bell, Paule V. Joseph, James Segars, Weihua Guan, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford, Edwina H. Yeung
Summary: Research suggests that newborns exposed to PCOS, particularly those born to mothers with hirsutism, have differential DNA methylation at certain CpG sites. Additionally, newborns of women with higher preconception testosterone levels also show differential DNA methylation. These differences may be under fetal genetic control.
Review
Endocrinology & Metabolism
Vahid Maleki, Ehsaneh Taheri, Parisa Varshosaz, Fatemeh Pourteymour Fard Tabrizi, Jalal Moludi, Hamed Jafari-Vayghan, Mahdi Shadnoush, Seyed Hossein Yahyazadeh Jabbari, Mehri Seifoleslami, Mohammad Alizadeh
Summary: Green tea extract (GTE) may have therapeutic effects on polycystic ovary syndrome (PCOS), mainly reflected in weight loss and improvement of glycemic levels. Current research results show that GTE can reduce testosterone and luteinizing hormone levels, and increase follicle-stimulating hormone and progesterone levels in animal models. Additional studies are needed to determine the effects and mechanisms of GTE in PCOS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hao-Ran Shen, Xiao Xu, Xue-Lian Li
Summary: This study found that berberine (BBR) can reduce insulin resistance and testosterone levels in PCOS rats by inhibiting cell apoptosis and regulating the expression levels of various genes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Rheumatology
Aslihan Avanoglu Guler, Tuba Yuce Inel, Timucin Kasifoglu, Cansu Coskun, Hazan Karadeniz, Derya Yildirim, Reyhan Bilici, Hasan Satis, Hamit Kucuk, Seminur Haznedaroglu, Berna Goker, Mehmet Akif Ozturk, Ismail Sari, Abdurrahman Tufan
Summary: The features of familial Mediterranean fever (FMF) do not have a negative impact on the prognosis of COVID-19. Non-adherence to colchicine treatment is a risk factor for requiring hospitalization for respiratory support. The rate of FMF attacks increases significantly after COVID-19, with some of them being prolonged and destructive.
MODERN RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Tuba Demirci Yildirim, Turhan Mammadov, Ali Osman Saatci, Ismail Sari
Article
Rheumatology
Ali Karakas, Semih Gulle, Gercek Can, Ediz Dalkilic, Servet Akar, Suleyman Serdar Koca, Yavuz Pehlivan, Soner Senel, Abdurrahman Tufan, Mehmet Akif Ozturk, Sema Yilmaz, Ayten Yazici, Ayse Cefle, Tuba Yuce Inel, Yesim Erez, Ismail Sari, Merih Birlik, Haner Direskeneli, Nurullah Akkoc, Fatos Onen
Summary: This study aimed to evaluate the impact of obesity on the treatment response to secukinumab and drug retention in patients with ankylosing spondylitis. The results of the observational cohort study showed that obesity did not affect the treatment response and drug retention in AS patients.
MODERN RHEUMATOLOGY
(2023)
Article
Rehabilitation
Fatih Ozden, Mehmet Ozkeskin, Ozge Ocaker Aktan, Tuba Demirci Yildirim, Ismail Sari
Summary: The present study aimed to translate, culturally adapt, and assess the psychometric properties of the Turkish version of FLARE-RA. A cross-sectional psychometric analysis was conducted with 80 patients, and the results demonstrated the good comprehensibility, feasibility, and reliability of the Turkish FLARE-RA, supporting its use in assessing disease flares in rheumatoid arthritis patients.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Integrative & Complementary Medicine
Yasemin Acar, Nursen Ilcin, Ismail Sari
Summary: This randomized controlled trial examined the effects of tele-yoga on various aspects of physical and psychological well-being in patients with ankylosing spondylitis. The results showed that tele-yoga practice improved physical function, disease activity, flexibility, balance, sleep quality, stress, depression, and quality of life in these patients.
JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
(2023)
Article
Rheumatology
Sinakhanim Huseynzada, Tuba Yuce Inel, Farid Hajiyev, Aydan Koken Avsar, Ali Balci, Hale Akpinar, Fatos Onen, Ismail Sari
Summary: This study aimed to investigate the effect of vedolizumab on rheumatological symptoms and the clinical course of patients with spondyloarthritis. The results showed that vedolizumab treatment had no effect on the occurrence and course of rheumatological manifestations in patients with inflammatory bowel disease. Further studies are needed to replicate these findings.
EUROPEAN JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Tuba Yuce Inel, Aydan Koken Avsar, Pelin Teke Kisa, Erdener Ozer, Ismail Sari
Summary: Pompe disease is a rare metabolic disorder characterized by deficiency of acid alpha-glucosidase, leading to glycogen accumulation in various tissues. Late-onset Pompe disease (LOPD) poses challenges for clinicians due to its milder phenotype and slower progression. Differential diagnosis of LOPD includes inflammatory myositis, as both diseases share similar clinical and laboratory characteristics. We presented a case of a 30-year-old female initially diagnosed with polymyositis and treated with immunosuppressive therapy, but later found to have LOPD.
EUROPEAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Tuba Demirci Yildirim, Asli Kahraman, Aydan Koken Avsar, Fatos Onen, Servet Akar, Ismail Sari
Summary: This study investigated the involvement of the JAK/STAT signaling pathway in the pathogenesis of inflammatory skin diseases (ISDs). The results showed that multiple components of the JAK/STAT pathway were overexpressed in the skin of ISDs patients. These findings suggest that targeting the JAK/STAT pathway could be a potential therapeutic strategy for treating ISDs.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Rheumatology
Tuba Demirci Yildirim, Ismail Sari
Summary: SAPHO is a rare autoinflammatory disease that primarily affects bones, skin, and joints. The pathogenesis and diagnosis of SAPHO are currently unclear, but treatment options include medication and biological therapies.
RHEUMATOLOGY INTERNATIONAL
(2023)
Meeting Abstract
Rheumatology
Semih Gulle, Ali Karakas, Gercek Can, Soner Senel, Sedat Capar, Huseyin Ediz Dalkilic, Servet Akar, Suleyman Serdar Koca, Abdurrahman Tufan, Ayten Yazici, Sema Yilmaz, Nevsun Inanc, Merih Birlik, Dilek Solmaz, Ayse Cefle, Berna Goker, Servet Yolbas, Niels Steen Krough, Neslihan Yilmaz, Sukran Erten, Cemal Bes, Ozgul Soysal, Mehmet Akif Ozturk, Seminur Haznedaroglu, Sule Yavuz, Haner Direskeneli, Fatos Onen, Ismail Sari
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Sadettin Uslu, Semih Gulle, Gercek Can, Soner Senel, Sedat Capar, Huseyin Ediz Dalkilic, Servet Akar, Suleyman Serdar Koca, Abdurrahman Tufan, Ayten Yazici, Sema Yilmaz, Nevsun Inanc, Merih Birlik, Dilek Solmaz, Ayse Cefle, Berna Goker, Servet Yolbas, Niels Steen Krough, Neslihan Yilmaz, Sukran Erten, Cemal Bes, Ozgul Soysal, Mehmet Akif Ozturk, Seminur Haznedaroglu, Sule Yavuz, Haner Direskeneli, Fatos Onen, Ismail Sari
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Mehmet Ozkeskin, Fatih Ozden, Ozge Ocaker Aktan, Tuba Demirci Yildirim, Ismail Sari
Summary: The Turkish version of the RLDQ was found to be valid and reliable for assessing patients with AS. The questionnaire is unique and valuable, focusing separately on neck, posture, or other mobility parameters.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Rheumatology
Fatos Onen, Gercek Can, Sedat Capar, Ediz Dalkilic, Yavuz Pehlivan, Soner Senel, Servet Akar, Suleyman Serdar Koca, Abdurrahman Tufan, Ayten Yazici, Sema Yilmaz, Nevsun Inanc, Ismail Sari, Merih Birlik, Dilek Solmaz, Ayse Cefle, Mehmet Akif Ozturk, Servet Yolbas, Niels Steen Krogh, Neslihan Yilmaz, Sukran Erten, Cemal Bes, Ozgul Soysal Gunduz, Berna Goker, Seminur Haznedaroglu, Sule Yavuz, Gozde Yildirim Cetin, Fatih Yildiz, Haner Direskeneli, Nurullah Akkoc
Summary: TURKBIO registry, the first nationwide biological database in Turkey, provides valuable real-life experience with the use of biologics in rheumatic diseases. The study showed significant improvements in disease activity and health assessment parameters following biological treatments, but also identified risks of adverse events.
EUROPEAN JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui, Robert D. Inman
Summary: This study finds that male HLA-B27-positive radiographic-axial spondyloarthritis (r-axSpA) patients are the most susceptible to severe ankylosis, and Lipocalin 2 (LCN2) and LCN2-MMP9 (LM) can serve as biomarkers for both sacroiliac joint and spinal inflammation.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Ali Karakas, Tuba Yuce Inel, Fatos Onen, Ismail Sari
Summary: Patients with Takayasu arteritis (TAK) faced challenges such as delayed patient care and disease flares during the COVID-19 pandemic. The risk of TAK flares may outweigh the risk of COVID-19 infection.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)