Salivary cortisol and frailty syndrome in elderly residents of long-stay institutions: A cross-sectional study

Analyze the relationship between frailty and cortisol in elderly residents of long-stay institutions. A cross-sectional study was conducted in the city of Joao Pessoa-PB-Brazil, on a sample of residents of long-stay institutions. Data were collected on frailty phenotype (weight loss, fatigue, slowness, weakness and low physical activity) and salivary cortisol (first measurement between 6 and 7 a. m.; second measurement between 11 and 12 a. m.; third measurement between 4 and 5 p. m.). Statistical analysis applied Pearson's correlation test, Chi-square test, ANOVA and linear regression. The sample was composed of 69 elderly subjects, 37.7% men and 62.3% women, with a mean age of 77.5 (+/- 7.8) years. The percentage of frail elderly was 45.8%. Frail aged subjects achieved higher cortisol values on the third measurement (p = 0.04) and frailty load was significantly associated to the first measurement (r = 0.25, p = 0.04). Simple linear regression analysis showed a rate of determination (R-2 = 0.05) between frailty load and the first cortisol measurement. Greater cortisol values in the morning and before bed among frail aged individuals suggest a positive correlation may exist between cortisol levels and frailty in elderly residents of long-stay institutions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.