Article
Microbiology
Blanca Bravo-Queipo-de-Llano, Laura Sanchez Garcia, Inmaculada Casas, Francisco Pozo, Leticia La Banda, Sonia Alcolea, Jorge Atucha, Rocio Sanchez-Leon, Adelina Pellicer, Cristina Calvo
Summary: This study reports on viral respiratory infections (VRIs) in very low birthweight infants during NICU admission and compares data collected before and after the COVID-19 pandemic. The results showed a significant decrease in the incidence of VRI during the pandemic, possibly due to increased infection prevention measures globally.
Article
Medicine, General & Internal
Jayanta Banerjee, Edward Mullins, Julia Townson, Rebecca Playle, Caroline Shaw, Nigel Kirby, Kim Munnery, Tom Bourne, Tg Teoh, Mandish Dhanjal, Liona Poon, Alison Wright, Christoph Lees
Summary: The PAN-COVID registry is an observational study collecting data on pregnant women with suspected COVID-19 or confirmed SARS-CoV-2 infection and their newborns. It aims to evaluate outcomes such as miscarriage, fetal growth restriction, preterm delivery, vertical transmission, and early onset neonatal SARS-CoV-2 infection. The study has received research ethics approval in the UK and will disseminate findings to participants through various channels.
Article
Pediatrics
Laura Sanchez Garcia, Adelina Pellicer, Clara Lopez-Martinez, Maria L. Garcia-Garcia, Inmaculada Casas, Francisco Pozo, Cristina Calvo
Summary: This study found that very low birth weight infants who suffered from symptomatic VRI during NICU admission had a significantly higher frequency of wheezing episodes and respiratory impairment-related hospital admissions in the first 2 years of life. Early surveillance of VRI during NICU admission is important for prognostic counseling and monitoring after discharge. Routine instruction on asthma-related risk factors and early prescription of antiasthmatic treatments should be considered.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nicolas Severino, Soledad Urzua, Mauricio Ibacache, Claudio Paulos, Luis Cortinez, Alberto Toso, Liliana Leguizamon, Rocio Inojosa, Andrea Maccioni, Sebastian Meza, Andres Garcia, Marcelo Ramirez, Catalina Von Mentlen, Javiera Ceballos, Noemi Paredes
Summary: This study aimed to characterize the pharmacokinetic parameters of intravenous amikacin in newborns and assess the impact of sepsis on amikacin exposure. Data from 329 drug assay samples obtained from 116 newborn patients showed that weight, postmenstrual age (PMA), and renal function were key factors influencing amikacin pharmacokinetics in newborns. Additionally, it was found that pathophysiological states such as sepsis and shock had opposite effects on amikacin clearance and should be considered in dose adjustments.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pediatrics
Siren Rettedal, Amalie Kibsgaard, Jan Terje Kvaloy, Joar Eilevstjonn, Hege Langli Ersdal
Summary: This study aimed to determine the prevalence of bradycardia in newborns in the first minute after birth and its association with positive pressure ventilation (PPV). The study found that 16.3% of newborns had a heart rate lower than 100 beats/minute in the first minute, but most cases resolved on their own. Only 4% of newborns remained bradycardic at 60 seconds, and only 20% of them received PPV.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Marlies Bruckner, Seung Yeon Kim, Gyu Hong Shim, Mattias Neset, Catalina Garcia-Hidalgo, Tze-Fun Lee, Megan O'Reilly, Po-Yin Cheung, Georg M. Schmolzer
Summary: The study found that a 40% anterior-posterior chest depth is optimal for reducing time to return of spontaneous circulation and improving survival during chest compressions, with further improvement in hemodynamic and respiratory parameters observed at depths ranging from 25% to 40%.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Alon Keller, Amit Boukai, Oren Feldman, Raz Diamand, Itai Shavit
Summary: A study compared the success rates and ease of use of three intraosseous access devices on a neonatal bone model, finding that the EZ-IO drill had lower success rates but was easier to use compared to the NIO-I and Jamshidi needles.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Brenda Hiu Yan Law, Georg M. Schmoelzer
Summary: In neonatal simulation, VTV-PPV reduces mask leak and ensures consistent VT delivery compared to T-piece with and without RFM guidance.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Marlies Bruckner, Mattias Neset, Megan O'Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. Schmoelzer
Summary: The study found that incremental increases in the rate of chest compressions up to 180/min improved cardiac output in asphyxiated piglets receiving cardiopulmonary resuscitation with sustained inflations.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Review
Pediatrics
Colm Patrick Finbarr O'Donnell, Janneke Dekker, Mario Ruediger, Arjan B. Te Pas
Summary: Despite an increase in research, most of the evidence supporting treatment of newborns in the delivery room is of low quality due to a lack of clinical trial evidence. Challenges such as obtaining consent, enrolling participants, limiting bias, and identifying appropriate outcome measures make delivery room trials difficult. Suggestions for more pragmatic future trials could improve the design of large studies necessary for clinical practice evolution.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Review
Pediatrics
Joyce E. O'Shea, Alexandra Scrivens, Gemma Edwards, Charles Christoph Roehr
Summary: This review examines the challenges encountered with neonatal airway management, discusses the potential of using supraglottic airway as an alternative tool, and examines strategies to optimize intubation success.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Ju Lee Oei, Vishal Kapadia, Yacov Rabi, Ola Didrik Saugstad, Denise Rook, Marijn J. Vermeulen, Nuria Boronat, Valerie Thamrin, William Tarnow-Mordi, John Smyth, Ian M. Wright, Kei Lui, Johannes B. van Goudoever, Val Gebski, Maximo Vento
Summary: In this study, resuscitation with lower or higher initial FiO2 was not associated with the risk of death or disability at 2 years in infants under 32 weeks gestation. However, the wide confidence intervals indicate that conclusive evidence is lacking, and larger randomized studies are urgently needed to further investigate the potential benefits or harms of different initial FiO2 levels on infant outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Vincent D. Gaertner, Christoph Martin Ruegger, Eoin O'Currain, C. Omar Farouk Kamlin, Stuart B. Hooper, Peter G. Davis, Laila Springer
Summary: The application of a face mask during neonatal stabilisation in term and late-preterm infants can lead to apnoea and bradycardia, with a higher incidence after the first application compared to subsequent ones. Healthcare providers need to be aware of these effects and be vigilant when using a face mask on newborn infants.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Article
Pediatrics
Madeleine C. Murphy, Allan Jenkinson, John Coveney, Lisa K. McCarthy, Colm Patrick Finbarr Donnell
Summary: The study aimed to compare the speed of heart rate display at birth between IntelliVue ECG and Nellcor pulse oximeter in preterm infants. The study was terminated after enrolling 39 infants due to the COVID-19 pandemic, with no significant differences found between the two groups in heart rate display speed.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Review
Pediatrics
Vix Monnelly, Justin B. Josephsen, Tetsuya Isayama, Maria Fernanda B. de Almeida, Ruth Guinsburg, Georg M. Schmolzer, Yacov Rabi, Myra H. Wyckoff, Gary Weiner, Helen G. Liley, Anne Lee Solevag
Summary: Objective measurement of exhaled carbon dioxide (ECO2) during non-invasive ventilation at birth may provide information about lung aeration, but the evidence supporting the use of an ECO2 monitor is lacking. The International Liaison Committee on Resuscitation (ILCOR) has prioritized the need to evaluate the effectiveness of ECO2 measurement in guiding non-invasive ventilation of newborn infants. More research is needed to determine whether the use of an ECO2 monitor can improve outcomes in delivery room resuscitation.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
