Article
Pediatrics
Bithi Roy, Annabel Webb, Karen Walker, Catherine Morgan, Nadia Badawi, Iona Novak
Summary: This study aimed to confirm the risk factors and identify any previously unknown variables of perinatal stroke. The results showed that perinatal stroke is associated with multiple risk factors including smoking, low Apgar scores at 1 and 10 minutes, neonatal infection, and hypoglycemia. Emergency caesarean section, resuscitation at birth, and abnormal cord blood gas were additional risk factors.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Clinical Neurology
Stefania Nannoni, Ali Scherz-Moussa Youma, Michael Amiguet, Ashraf Eskandari, Davide Strambo, Patrik Michel
Summary: In this study, 2% of AIS patients were found to have no established vascular risk factors (EVRFs), who were typically younger with more multiterritorial strokes, and had strong associations with PFO and contraceptive use. These patients showed worse long-term outcomes in terms of adjusted functional outcome, recurrence, and death.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Alexander Humberg, Lisa Neuenburg, Hannah Boeckel, Mats Ingmar Fortmann, Christoph Haertel, Egbert Herting, Heilwig Hinrichs, Franziska Rademacher, Juergen Harder
Summary: This study examined the expression of antimicrobial peptides (AMPs) in the skin of preterm infants and found that the expression of AMPs was decreased in preterm infants compared to term infants. Preterm infants with infections or inflammation had higher concentrations of AMPs. These findings are significant for understanding the susceptibility to infection in preterm infants and developing new prevention strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Jing Yang, Shouling Wu, Anxin Wang, Shuohua Chen, Chenlu Yang, Qi Zhang
Summary: The study investigates sex-specific risk factors for early-onset ischaemic stroke in the Chinese population. The top three risk factors for women were hypertension, diabetes mellitus, and adverse pregnancy outcomes, while for men they were hypertension, increased hs-CRP, and diabetes mellitus. The effects of diabetes mellitus and systolic blood pressure varied by sex.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Tao You, Yi Li, Xiaoguang Wu, Siyi Wu, Yanlin Zhang, Xiang Zhou
Summary: The study found that preferences for fruits and soy products are negatively associated with the risk of IS, while lower life satisfaction is positively associated with the risk of IS. Adding these factors to a basic CVD risk model can improve the discriminative ability and reclassification for IS.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Pediatrics
Amira M. Saber, Shereen P. Aziz, Al Zahraa E. Almasry, Ramadan A. Mahmoud
Summary: Neonatal thrombocytopenia is common in the NICU, with severe cases requiring more platelet transfusions and having higher mortality rates, primarily due to neonatal sepsis and postoperative states.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Peter B. Sporns, Heather J. Fullerton, Sarah Lee, Adam Kirton, Moritz Wildgruber
Summary: Paediatric arterial ischaemic stroke is a significant cause of neurological morbidity in children, with challenges including delays in diagnosis and treatment. Current research focuses on epidemiology, etiology, rehabilitation, secondary prevention, and advances in hyperacute therapies to improve outcomes for affected children and their families.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Babak B. Navi, Cenai Zhang, Jed H. Kaiser, Vanessa Liao, Mary Cushman, Scott E. Kasner, Mitchell S. Elkind, Scott T. Tagawa, Saketh R. Guntupalli, Mario F. L. Gaudino, Agnes Y. Y. Lee, Alok A. Khorana, Hooman Kamel
Summary: Cancer is an independent risk factor for perioperative arterial ischemic events.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Medicine, General & Internal
M. N. Gynnild, R. Aakery, O. Spigset, T. Askim, M. K. Beyer, H. Ihle-Hansen, R. Munthe-Kaas, A. B. Knapskog, S. Lydersen, H. Nss, T. G. Rsstad, Y. M. Seljeseth, P. Thingstad, I Saltvedt, H. Ellekjaer
Summary: The study reported medication adherence and risk factor control following ischemic stroke. While medication persistence and adherence were high, risk factor control was suboptimal, indicating the need for a better understanding of the complex clinical setting to optimize secondary prevention strategies.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Alan T. N. Tita, Lindsay Doherty, William A. Grobman, Uma M. Reddy, Robert M. Silver, Gail Mallett, Madeline Murguia Rice, Yasser Y. El-Sayed, Ronald J. Wapner, Dwight J. Rouse, George R. Saade, John M. Thorp, Suneet P. Chauhan, Maged M. Costantine, Edward K. Chien, Brian M. Casey, Sindhu K. Srinivas, Geeta K. Swamy, Hyagriv N. Simhan, George A. Macones
Summary: The study found that expectant management from 39 to 42 weeks of gestation in low-risk nulliparous patients increased the frequency of medically indicated induction of labor, significantly increased the rate of cesarean delivery, and led to a slightly increased risk of perinatal composite outcomes in pregnancies beyond 40 weeks.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Pediatrics
Anna-Lisa Sorg, Rudiger von Kries, Mathias Klemme, Lucia Gerstl, Ursula Felderhoff-Mueser, Mark Dzietko
Summary: Valid incidence estimates of perinatal arterial ischemic stroke (PAIS) are lacking. This study in Germany found that the incidence of PAIS in preterm-born infants is as common as in term-born infants, but their symptoms are often unspecific. Risk factor patterns were similar between the two groups, although preterm babies had more risk factors on average and were diagnosed at an older age.
Article
Clinical Neurology
Andre Rego, Stefania Nannoni, Ali Scherz, Ashraf Eskandari, Alexander Salerno, Miguel Pereira, Davide Strambo, Patrik Michel
Summary: This retrospective study analyzed clinical data from patients with acute ischemic stroke and previously undiagnosed major vascular risk factors (UMRFs). Among these patients, 25.8% were newly diagnosed with at least one major risk factor, with the most common being hypertension, dyslipidemia, and atrial fibrillation. Compared to patients with previously diagnosed risk factors (DMRFs), UMRF patients were younger, more likely to smoke, and had more patent-foramen-ovale-related strokes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Qianqian Xia, Fa Guo, Xinlin Hou, Zezhong Tang, Lili Liu
Summary: This study assessed the clinical characteristics, long-term outcomes, and prognostic factors of perinatal stroke. The results showed that hemorrhagic stroke was more common than ischemic stroke, and convulsions were the first symptom of perinatal stroke. The most common lesion site for ischemic stroke was the left middle cerebral artery, while for hemorrhagic stroke it was the temporal lobe. There was no association between different risk factors and adverse outcomes after perinatal stroke.
PEDIATRIC NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Chen Chen, Xiaoyuan Qiao, Jianyong Guo, Ting Yang, Min Wang, Yipeng Ma, Shuhe Zhao, Ling Ding, Hong Liu, Jintao Wang
Summary: This study aimed to identify potential biomarkers associated with minor ischaemic stroke. The results showed that increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population. Additionally, high blood pressure, a lack of physical activity, smoking, and increased TMAO level were identified as influencing factors for the occurrence of minor ischaemic stroke.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Alice Barsch Bergqvist, Eleni Simatou, Beatrice Skiold, Ayoub Mitha, Jenny Bolk
Summary: The prevalence of seizures in term-born infants with perinatal stroke in Swedish neonatal wards was investigated. Anti-seizure medication was prescribed for 97% of infants with a stroke, and 52% were discharged with anti-seizure medication, contrary to Swedish recommendations.
Review
Pediatrics
Burcu Cebeci, Thomas Alderliesten, Jannie P. Wijnen, Niek E. van der Aa, Manon J. N. L. Benders, Linda S. de Vries, Agnes van den Hoogen, Floris Groenendaal
Summary: This review assessed the associations between cerebral H-1-MRS and neurodevelopment after preterm birth, finding that NAA/Cho is the most common metabolite ratio associated with motor, language, and cognitive outcomes.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Corline E. J. Parmentier, Sylke J. Steggerda, Lauren C. Weeke, Monique Rijken, Linda S. De Vries, Floris Groenendaal
Summary: In a retrospective cohort study, all infants with perinatal asphyxia and early seizure onset who did not receive therapeutic hypothermia had MRI abnormalities and half died or had poor neurodevelopmental outcome.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Corline E. J. Parmentier, Linda S. de Vries, Niek E. van der Aa, Maria J. C. Eijsermans, Johanneke C. Harteman, Maarten H. Lequin, Henriette F. N. Swanenburg de Veye, Corine Koopman-Esseboom, Floris Groenendaal
Summary: This single-center retrospective cohort study aimed to determine the incidence of hypoglycemia in infants with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia, and its association with brain injury and neurodevelopmental outcomes. The results showed that over one-third of infants with HIE experienced hypoglycemia, which was correlated with higher levels of brain injury on MRI and lower cognitive function during the preschool age. Therefore, strategies to prevent hypoglycemia should be optimized in this population.
JOURNAL OF PEDIATRICS
(2022)
Letter
Obstetrics & Gynecology
L. S. de Vries, S. J. Steggerda, F. Groenendaal, F. M. Cowan
JOURNAL OF PERINATOLOGY
(2022)
Review
Clinical Neurology
K. M. E. Meys, L. S. de Vries, F. Groenendaal, S. D. Vann, M. H. Lequin
Summary: Despite their small size, mammillary bodies play a crucial role in supporting recollective memory. However, their significance is often overlooked in assessing memory-related neurological disorders, especially in infants and children. This literature review indicates that mammillary body pathology is present in pediatric populations with various conditions, as shown by signal change and atrophy on brain MR imaging. The main causes of pathology are thiamine deficiency, hypoxia-ischemia, direct damage, or deafferentation within the Papez circuit. Given their importance in memory processes, it is critical to optimize scanning protocols and include assessment of mammillary body status as a standard procedure.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Editorial Material
Pediatrics
Floris Groenendaal, Peter G. J. Nikkels
JORNAL DE PEDIATRIA
(2022)
Article
Medicine, General & Internal
Corline E. J. Parmentier, Linda S. de Vries, Floris Groenendaal
Summary: Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-)term newborns. Neuroimaging, including cranial ultrasonography and magnetic resonance imaging (MRI), plays a crucial role in assessing brain injury and predicting outcomes. Advanced imaging techniques such as diffusion tensor imaging and arterial spin labeling provide valuable information about the etiology and prognosis of brain injury.
Article
Pediatrics
Elif Keles, Pia Wintermark, Floris Groenendaal, Noor Borloo, Anne Smits, Annouschka Laenen, Djalila Mekahli, Pieter Annaert, Suzan Sahin, Mehmet Yekta Oncel, Valerie Chock, Didem Armangil, Esin Koc, Malcolm R. Battin, Adam Frymoyer, Karel Allegaert
Summary: There is a large variability in kidney function and injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia. Using serum creatinine centiles over postnatal age may provide more valuable information in these neonates. Understanding postnatal age-related patterns enables clinicians to better assess kidney function and tailor treatment.
Letter
Pediatrics
Karel Allegaert, Djalila Mekahli, Pia Wintermark, Floris Groenendaal, Noor Borloo, Annouschka Laenen, Pieter Annaert, Suzan Sahin, Mehmet Yekta Oncel, Valerie Y. Chock, Didem Armangil, Esin Koc, Malcolm R. Battin, Adam Frymoyer, Elif Keles, Anne Smits
Article
Pediatrics
Corline E. J. Parmentier, Maarten H. Lequin, Thomas Alderliesten, Henriette F. N. Swanenburg de Veye, Niek E. van der Aa, Jeroen Dudink, Manon J. N. L. Benders, Johanna C. Harteman, Corine Koopman-Esseboom, Floris Groenendaal, Linda S. de Vries
Summary: This study evaluated the evolution of brain injury observed on magnetic resonance imaging (MRI) in neonatal encephalopathy (NE) following perinatal asphyxia. A scoring system was developed to assess brain injury on 3-month MRI and its association with neurodevelopmental outcome. The study found that abnormalities in deep gray matter (DGM) on 3-month MRI, preceded by DGM abnormalities on neonatal MRI, were associated with 18- to 24-month outcome, indicating the potential usefulness of 3-month MRI in evaluating treatment efficacy.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Juliette Langeslag, Wes Onland, Douwe Visser, Floris Groenendaal, Linda de Vries, Anton H. van Kaam, T. R. de Haan
Summary: The study aimed to evaluate the predictive ability of multiple organ dysfunction (MOD) in asphyxiated neonates undergoing therapeutic hypothermia (TH) on mortality or neurodevelopmental impairment (NDI) at 24 months, and to identify peripartum variables associated with the onset of MOD. The results showed that MOD has low accuracy in predicting the 24-month outcome or its components, and may not be useful for prognostication. Signs of acid-base disturbance at birth and the use of epinephrine are associated with the development of MOD.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Obstetrics & Gynecology
C. E. Tacke, W. Onland, P. C. A. M. Bakker, F. Groenendaal, A. N. Rosman, L. Broeders, J. V. Been, A. C. J. Ravelli
Summary: The risk of low 5-minute Apgar scores in singleton births has increased in the Netherlands over the past decade, with instrumental vaginal delivery and emergency cesarean section showing the highest relative increase.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Angret de Boer, Paulin van Beek, Peter Andriessen, Floris Groenendaal, Marije Hogeveen, Julia Meijer, Sylvia Obermann-Borst, Wes Onland, Liesbeth Scheepers, Marijn Vermeulen, E. J. T. (Joanne) Verweij, Lien De Proost, Rosa Geurtzen
Summary: Predicting the outcomes of extremely preterm infants is challenging, and multivariable prognostic models can provide accurate estimates for clinicians, parents, and policymakers. These models can support the development of treatment guidelines at a population level and improve prenatal counselling conversations at an individual level. Considerations for developing these models include predictor and outcome measure selection, clinical impact assessment, and generalizability.
Article
Pediatrics
Laura A. Warmerdam, Gerda van Wezel-Meijler, Linda S. de Vries, Floris Groenendaal, Sylke J. Steggerda
Summary: This study compared cerebellar growth in premature infants who received dexamethasone or hydrocortisone to premature infants who did not receive postnatal corticosteroids. The results showed that both types of corticosteroid had a negative association with cerebellar growth, but had no evident negative associations with cerebral growth.
Article
Pediatrics
Juliette F. Langeslag, Floris Groenendaal, Stefan D. Roosendaal, Linda S. de Vries, Wes Onland, Mariska M. G. Leeflang, Paul F. C. Groot, Anton H. van Kaam, Timo R. de Haan
Summary: This study aimed to determine which MRI scoring system best predicts adverse outcomes in term infants with perinatal asphyxia at 24 months of age, and has the highest inter-rater reliability. The results showed that all four MRI scoring systems had good predictive accuracy for adverse outcomes, with the Weeke and Trivedi scores demonstrating the highest inter-rater reliability. Using high-quality MRI scans further improved prediction.