Article
Medicine, General & Internal
Valerie Y. Chock, Haresh Kirpalani, Edward F. Bell, Sylvia Tan, Susan R. Hintz, M. Bethany Ball, Emily Smith, Abhik Das, Yvonne C. Loggins, Beena G. Sood, Lina F. Chalak, Myra H. Wyckoff, Stephen D. Kicklighter, Kathleen A. Kennedy, Ravi M. Patel, Waldemar A. Carlo, Karen J. Johnson, Kristi L. Watterberg, Pablo J. Sanchez, Abbot R. Laptook, Ruth B. Seabrook, C. Michael Cotten, Toni Mancini, Gregory M. Sokol, Robin K. Ohls, Anna Maria Hibbs, Brenda B. Poindexter, Anne Marie Reynolds, Sara B. DeMauro, Sanjay Chawla, Mariana Baserga, Michele C. Walsh, Rosemary D. Higgins, Krisa P. Van Meurs
Summary: This study investigates the effects of red blood cell transfusion on cerebral and mesenteric tissue saturation in preterm infants and explores the association with degree of anemia and death or neurodevelopmental impairment. The results show an increase in tissue saturation after transfusion, and lower pretransfusion cerebral saturation may be associated with adverse outcomes.
Article
Pediatrics
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixon, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: The study aimed to investigate the amount of time spent in periodic breathing and its consequences in infants born preterm before and after hospital discharge. The results showed no significant changes in the percentage of sleep time spent in periodic breathing between different time points. Infants who had a high percentage of periodic breathing at 32-36 weeks of gestational age also had a high percentage at 36-40 weeks and 6 months of corrected age.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Willemien S. Kalteren, Arend F. Bos, Willem van Oeveren, Jan B. F. Hulscher, Elisabeth M. W. Kooi
Summary: The study found that urinary I-FABP levels were higher in anemic preterm infants before transfusion compared to non-anemic controls, indicating a link between anemia and intestinal injury. Anemia may result in reduced splanchnic oxygen saturation and intestinal tissue hypoxia, contributing to the development of NEC. Lower hemoglobin levels were associated with higher urinary I-FABP levels in anemic preterm infants, supporting the hypothesis that anemia leads to intestinal cell injury and potentially NEC.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Mona B. Noroozi-Clever, Steve M. Liao, Halana V. Whitehead, Zachary A. Vesoulis
Summary: By using cerebral near-infrared spectroscopy (NIRS), this study aimed to quantify occult cerebral hypoxia in preterm infants across different respiratory support modes. The results showed that premature infants on higher levels of respiratory support had lower cerebral hypoxia than those on lower respiratory support. This raises concerns about unrecognized cerebral hypoxia and its impact on adverse outcomes during lower acuity periods of neonatal intensive care unit hospitalization.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Yuju Mu, Hua Wang, Mengting Tian, Yong Hu, Yi Feng, Ruifeng Lu, Qi He, Shouliang Jiang, Jinglan Huang, Surong Duan, Dezhi Mu
Summary: This study found that an RDW of >= 18% in the first 14 days is associated with rcSO2 of <55% in preterm infants, suggesting that RDW may be a potential indicator for monitoring cerebral tissue oxygen saturation in preterm infants.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Kiran Kumar Balegar, Gary K. K. Low, Ralph K. H. Nanan
Summary: This study aimed to investigate the correlation between low haemoglobin and symptoms of anaemia with cerebral and splanchnic fractional tissue oxygen extraction (FTOE). The results showed no significant correlation between haemoglobin and cerebral or splanchnic FTOE. These findings suggest that pre-transfusion haemoglobin and symptoms of anaemia may not accurately reflect oxygen delivery-consumption imbalances.
Article
Medicine, General & Internal
Mi Jin Kim, Jae Suk Baek, Jung A. Kim, Seul Gi Cha, Jeong Jin Yu
Summary: Preoperative cerebral and abdominal regional oxygen saturations in neonates with critical congenital heart disease vary according to cardiac diagnosis. Severe atrioventricular valvar regurgitation patients have the lowest ScO2 levels. ScO2 tends to decrease gradually over time, suggesting a higher risk of hypoxic brain injury with longer time to surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Minoo Ashoori, John M. O'Toole, Ken D. O'Halloran, Gunnar Naulaers, Liesbeth Thewissen, Jan Miletin, Po-Yin Cheung, Afif EL-Khuffash, David Van Laere, Zbynek Stranak, Eugene M. Dempsey, Fiona B. McDonald
Summary: This study aimed to test the potential utility of applying machine learning methods to detect brain injury in extremely preterm infants using regional cerebral (rcSO(2)) and peripheral oxygen saturation (SpO(2)) signals. The analysis of a subset of infants in a clinical trial showed that data-driven desaturation (PRD) in rcSO(2) could better predict brain injury compared to a threshold-based approach.
Article
Obstetrics & Gynecology
R. A. Thomas, M-R Ballard, N. Aladangady, J. Banerjee
Summary: This study assessed the reliability of using near-infrared spectroscopy (NIRS) to monitor gut oxygenation. The results showed that gut perfusion improved in infants who received blood transfusion, as measured by NIRS, while no changes were seen in the control group. Therefore, NIRS is a reliable method to measure splanchnic tissue oxygenation.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Willemien S. Kalteren, Arend F. Bos, Klasien A. Bergman, Willem van Oeveren, Jan B. F. Hulscher, Elisabeth M. W. Kooi
Summary: Transfusions of red blood cells (RBC) in preterm infants are associated with oxidative stress and intestinal injury, along with decreased variability in splanchnic oxygenation. This may represent the early pathogenesis of transfusion-associated necrotizing enterocolitis (NEC).
PEDIATRIC RESEARCH
(2023)
Article
Critical Care Medicine
Ilia Bresesti, Alexander Avian, Marlies Bruckner, Corinna Binder-Heschl, Bernhard Schwaberger, Nariae Baik-Schneditz, Georg Schmoelzer, Gerhard Pichler, Berndt Urlesberger
Summary: The study found that the degree of bradycardia only significantly impacted the course of SpO(2), but when combined with hypoxemia, it also had a significant impact on cerebral oxygenation parameters. Additionally, the presence of hypoxemia had a significant impact on the delivered FiO(2). The study highlights the importance of heart rate and oxygen saturation during neonatal resuscitation, emphasizing the relevance of hypoxemia in the early transitional phase.
Review
Anesthesiology
L. Meng, Y. Sun, X. Zhao, D. M. Meng, Z. Liu, D. C. Adams, D. L. Mcdonagh, M. Rasmussen
Summary: A systematic review was conducted on the effects of phenylephrine on blood pressure, cardiac output, cerebral blood flow, and cerebral tissue oxygen saturation. The results showed that phenylephrine increases blood pressure while decreasing cardiac output. Although it increases cerebral blood flow, it decreases cerebral tissue oxygen saturation. The effects of the drug on cardiac output, cerebral blood flow, and cerebral tissue oxygen saturation are closely related to the magnitude of the changes in blood pressure induced by phenylephrine. There is no significant difference in the effects of phenylephrine between awake and anesthetized humans.
Article
Pediatrics
Sarah E. Kolnik, Rebecca Marquard, Olivia Brandon, Mihai Puia-Dumitrescu, Gregory Valentine, Janessa B. Law, Niranjana Natarajan, Manjiri Dighe, Pierre D. Mourad, Thomas R. Wood, Ulrike Mietzsch
Summary: This study analyzed the cerebral tissue oxygenation levels in preterm neonates and found that head circumference and brain regions measured have an impact on the readings.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Zeinab Rabbani Mohamammadie, Monir Ramezani, Mohammad Heidarzadeh, Majid Sezavar, Azadeh Saki
Summary: This study aims to determine the effect of head positioning on brain tissue oxygenation in preterm infants. The findings suggest that head positioning significantly affects brain tissue oxygen saturation in preterm infants.
JOURNAL OF PERINATOLOGY
(2022)
Article
Pediatrics
Valerie Y. Chock, Emily Smith, Sylvia Tan, M. Bethany Ball, Abhik Das, Susan R. Hintz, Haresh Kirpalani, Edward F. Bell, Lina F. Chalak, Waldemar A. Carlo, C. Michael Cotten, John A. Widness, Kathleen A. Kennedy, Robin K. Ohls, Ruth B. Seabrook, Ravi M. Patel, Abbot R. Laptook, Toni Mancini, Gregory M. Sokol, Michele C. Walsh, Bradley A. Yoder, Brenda B. Poindexter, Sanjay Chawla, Carl T. D'Angio, Rosemary D. Higgins, Krisa P. Van Meurs
Summary: This study aimed to analyze the changes in cerebral and mesenteric oxygen saturation in extremely low birth weight (ELBW) infants and explore their relationship with perinatal variables. The results showed that the oxygen saturation of the brain and gut decreased while oxygen extraction increased over the first week after birth. The increase in oxygen extraction was greater in the brain compared to the gut in infants with lower gestational age, lower birth weight, and 5-minute Apgar score ≤ 5. Infants managed with a lower hemoglobin transfusion threshold and receiving ≥ 2 transfusions in the first week had the lowest cerebral saturation and highest cerebral oxygen extraction.
PEDIATRIC RESEARCH
(2022)