Review
Medicine, General & Internal
Grace Wezi Mzumara, Michael Mambiya, Pui-Ying Iroh Tam
Summary: The increasing antimicrobial resistance in low resource settings necessitates the development of context-specific interventions for antimicrobial stewardship to curb the problem. This systematic review aims to examine antimicrobial stewardship approaches in least developed and low-income countries, with the ultimate goal of supporting the development of AMS protocols for these settings to combat AMR.
Article
Medicine, General & Internal
Ameneh Khatami, David A. Foley, Morgyn S. Warner, Elizabeth H. Barnes, Anton Y. Peleg, Jian Li, Stephen Stick, Nettie Burke, Ruby C. Y. Lin, Julia Warning, Thomas L. Snelling, Steven Y. C. Tong, Jonathan Iredell
Summary: This study proposes a standardized protocol for phage therapy and plans to conduct an open-label, single-arm trial. The objectives are to evaluate safety and feasibility, as well as to assess clinical response, quality of life, pharmacokinetics, immune responses, and microbiome analysis.
Article
Medicine, General & Internal
Dewi Lokida, Helmia Farida, Rina Triasih, Yan Mardian, Herman Kosasih, Adhella Menur Naysilla, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Dwi Wastoro, Mujahidah Mujahidah, Setya Dipayana, Amalia Setyati, Abu Tholib Aman, Nurhayati Lukman, Muhammad Karyana, Ahnika Kline, Aaron Neal, Chuen-Yen Lau, Clifford Lane
Summary: This study identified the main pathogens causing hospitalised childhood community-acquired pneumonia (CAP) among Indonesian children aged 2-59 months old through a comprehensive diagnostic approach. The most frequently identified pathogens were Haemophilus influenzae non-type B and respiratory syncytial virus (RSV). The study highlights the importance of PCR for diagnosis and appropriate use of antimicrobials.
Article
Pediatrics
Marta Aboza Garcia, Walter Goycochea-Valdivia, German Penalva, Lola Falcon Neyra, Marta Moleon Ruiz, Angel Rodriguez-Villodres, Cristina Montero Valladares, Peter Olbrich, Elia Sanchez-Valderrabanos, Francisco Jimenez, Maria Molina, Gloria Moreno Madueno, Raquel Valencia Martin, Maria Victoria Gil Navarro, Jose Molina, Olaf Neth, Jose Miguel Cisneros
Summary: This study evaluated the long-term outcomes of an antimicrobial stewardship program (ASP) in pediatric patients using interrupted time series analysis. The results showed that intensification of educational activities improved the quality of prescriptions and reduced antibiotic consumption to some extent in pediatric patients. However, the decreasing trends in mortality remained unchanged.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Medicine, General & Internal
Changcheng Shi, Jian Ye, Renjie Xu, Weizhong Jin, Shuang Xu, Fei Teng, Nengming Lin
Summary: The study found that MSSA isolates with high vancomycin MICs were associated with higher mortality and a greater likelihood of septic thrombophlebitis compared to isolates with low MICs. Similar results were obtained in Etest detection, but no significant differences were found in broth microdilution detection.
Review
Medicine, General & Internal
Brian Zanoni, Moherndran Archary, Thobekile Sibaya, Tatiana Ramos, Geri Donenberg, Maryam Shahmanesh, Connie Celum, Audrey Pettifor, Linda Gail Bekker, Jessica Haberer
Summary: Compared with adults, adolescents in South Africa have lower levels of viral suppression in each step of the HIV continuum of care. Our study identified interventions such as in-home and HIV self-testing, community-based adherence support, and provision of adolescent-friendly services as the most impactful and scalable approaches to address the adolescent HIV continuum of care in South Africa. Future interventions should be comprehensive and tailored to the specific needs of adolescents.
Article
Medicine, General & Internal
Asma Sadruddin Pethani, Zaubina Kazi, Ujala Nayyar, Muhammad Shafiq-ur-Rehman, Muhammad Tahir Yousafzai, Mach Ondrej, Ali Faisal Saleem
Summary: This study aims to establish a pilot surveillance system to identify and monitor VDPV excretion in children with PID and evaluate the use of Jeffrey Modell PID warning signs as a screening tool for PID in Pakistan.
Article
Medicine, General & Internal
Amanda J. Driscoll, Fadima Cheick Haidara, Milagritos D. Tapia, Emily L. Deichsel, Ousmane S. Samake, Tiecoura Bocoum, Jason A. Bailey, Meagan C. Fitzpatrick, Robert L. Goldenberg, Mamoudou Kodio, Lawrence H. Moulton, Dilruba Nasrin, Uma Onwuchekwa, Allison M. Shaffer, Samba O. Sow, Karen L. Kotloff
Summary: This study aims to evaluate the effectiveness of azithromycin in preventing stillbirths and infant mortality in high mortality settings, and to determine the optimal strategy for the delivery of azithromycin to pregnant women and their infants.
Article
Medicine, General & Internal
Jan Yvan Jos Verbakel, Tine De Burghgraeve, Ann Van den Bruel, Samuel Coenen, Sibyl Anthierens, Louise Joly, Annouschka Laenen, Jeroen Luyten, An De Sutter
Summary: The study aims to evaluate the clinical and cost effectiveness of a diagnostic algorithm in acutely ill children aged 6 months to 12 years in ambulatory care. The primary outcome is antibiotic prescribing, with secondary outcomes including clinical recovery, reconsultation, referral/admission to hospital, additional testing, mortality and patient satisfaction. If the intervention proves to be successful, it may lead to an implementation strategy for educating physicians about the algorithm in their daily practice.
Review
Medicine, General & Internal
Tsz Yuen Au, Chanika Assavarittirong
Summary: Antimicrobial resistance (AMR) poses a significant challenge in various fields. Bacteriophage therapy, which involves infecting bacteria with a virus, has shown promise in treating AMR. However, limited clinical trials have been conducted, and further research is needed to determine the efficacy and dosage of specific bacteriophage strains.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Shunsuke Yasuo, Maki Murata, Natsuki Nakagawa, Takeshi Kawasaki, Takuo Yoshida, Koichi Ando, Satoshi Okamori, Yohei Okada
Summary: This study provides an updated understanding of the diagnostic accuracy of urinary antigen tests for diagnosing Streptococcus pneumoniae infection in patients with pneumonia. The results suggest that urinary antigen tests are useful for achieving a definitive diagnosis of S. pneumoniae infection in patients with pneumonia.
Article
Medicine, General & Internal
Thel Khin Hla, Joshua Osowicki, Sam Salman, Kevin T. Batty, Julie A. Marsh, Joseph Kado, Renae Barr, Stephanie L. Enkel, Thomas L. Snelling, James McCarthy, Andrew C. Steer, Jonathan Carapetis, Laurens Manning
Summary: Regular intramuscular benzathine penicillin G injections have been used for RHD secondary prophylaxis, but the minimum effective penicillin exposure required for prevention is still unknown. The CHIPS trial aims to determine the minimum effective steady-state plasma penicillin concentration required to prevent experimental pharyngitis and explore other related factors.
Article
Medicine, General & Internal
Sara Grillo, Guillermo Cuervo, Jordi Carratala, Rafael San-Juan, Jose M. Aguado, Laura Morata, Silvia Gomez-Zorrilla, Joaquin Lopez-Contreras, Oriol Gasch, Aina Gomila-Grange, Simona Iftimie, Graciano Garcia-Pardo, Esther Calbo, Lucia Boix-Palop, Isabel Orio, Alfredo Jover-Saenz, Luis Eduardo Lopez-Cortes, Gorane Euba, Malen Aguirregabiria, Maria Jose Garcia-pais, Francesca Gioia, Jose Ramon Pano, Maria Luisa Pedro-Botet, Rosa Maria Benitez, Maria Teresa Perez-Rodriguez, Yolanda Meije, Maria Belen Loeches-Yague, Gertrudis Horna, Damaris Berbel, Maria Angeles Dominguez, Ariadna Padulles, Sara Cobo, Pilar Hereu, Sebastian Videla, Cristian Tebe, Natalia Pallares, Josep M. Miro, Miquel Pujol
Summary: This study aims to test whether the combination of cloxacillin and fosfomycin is more effective in treating MSSA bacteremia compared to cloxacillin alone.
Article
Medicine, General & Internal
Naina McCann, Katherine Emary, Nisha Singh, Florence Mclean, Susana Camara, Elizabeth Jones, Young Chan Kim, Xinxue Liu, Melanie Greenland, Kerry Conlin, Jennifer Hill, Marije Verheul, Hannah Robinson, Brian Angus, Maheshi N. Ramasamy, Myron M. Levine, Andrew J. Pollard
Summary: This is the first efficacy study of an oral live attenuated vaccine against Salmonella Paratyphi A using a human challenge model. S. Paratyphi A causes 3.3 million cases of enteric fever annually, resulting in over 19,000 deaths. Vaccination offers a cost-effective, medium-term solution to reduce the burden of this condition. Human challenge models provide a unique and cost-effective solution to test the efficacy of such vaccines.
Article
Infectious Diseases
Tal Zilberman, Ili Margalit, Dafna Yahav, Noam Tau
Summary: This study examined the rate and characteristics of retracted articles in infectious diseases and clinical microbiology. The findings revealed an increasing trend in retraction, with common reasons including errors, plagiarism, and falsification/fabrication. Despite being retracted, these publications continue to be frequently cited.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Editorial Material
Immunology
Maria Angeles Melendez-Carmona, Raul Recio, Jaime Lora-Tamayo, Fernando Chaves, M. Angeles Orellana
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
J. Origuen, L. Corbella, M. A. Orellana, M. Fernandez-Ruiz, F. Lopez-Medrano, R. San Juan, M. Lizasoain, T. Ruiz-Merlo, A. Morales-Cartagena, G. Maestro, P. Parra, J. Villa, R. Delgado, J. M. Aguado
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Article
Infectious Diseases
Patricia Branas, Marta Gil, Jennifer Villa, Maria Angeles Orellana, Fernando Chaves
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2018)
Article
Infectious Diseases
Raul Recio, Jennifer Villa, Esther Viedma, Maria Angeles Orellana, Jaime Lora-Tamayo, Fernando Chaves
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Infectious Diseases
Patricia Munoz, Antonio Vena, Marina Machado, Francesca Gioia, Maria Carmen Martinez-Jimenez, Elia Gomez, Julia Origuen, Maria Angeles Orellana, Francisco Lopez-Medrano, Mario Fernandez-Ruiz, Paloma Merino, Fernando Gonzalez-Romo, Isabel Frias, Maria-Jesus Perez-Granda, Jose Maria Aguado, Jesus Fortun, Emilio Bouza
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Infectious Diseases
Patricia Munoz, Antonio Vena, Marina Machado, Maria Carmen Martinez-Jimenez, Francesca Gioia, Elia Gomez, Julia Origuen, Maria Angeles Orellana, Francisco Lopez-Medrano, Maria-Jesus Perez-Granda, Jose Prime Maria Aguado, Jesus Fortun, Emilio Bouza
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Letter
Infectious Diseases
Emilio Bouza, Antonio Vena, Patricia Munoz, Emilio Bouza, Marina Machado, Carmen Martinez-Jimenez, Patricia Munoz, Raquel Navarro, Maria-Jesus Perez-Granda, Carlos Sanchez, Antonio Vena, Jesus Fortun, Francesca Gioia, Elia Gomez, Cruz Soriano, David Pestana, Fernando Gonzalez-Romo, Paloma Merino, Jose Maria Aguado, Mario Fernandez-Ruiz, Francisco Lopez-Medrano, Maria Angeles Orellana, Julia Origuen
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Microbiology
Julia Origuen, Marfa Angeles Orellana, Mario Fernandez-Ruiz, Laura Corbella, Rafael San Juan, Marfa Ruiz-Ruigomez, Francisco Lopez-Medrano, Manuel Lizasoain, Tamara Ruiz-Merlo, Guillermo Maestro-de la Calle, Patricia Parra, Jennifer Villa, Rafael Delgado, Jose Maria Aguado
JOURNAL OF CLINICAL MICROBIOLOGY
(2019)
Article
Infectious Diseases
Rafael San-Juan, Ivan Martinez-Redondo, Mario Fernandez-Ruiz, Maria Ruiz-Ruigomez, Laura Corbella, Pilar Hernandez-Jimenez, Jose Tiago Silva, Francisco Lopez-Medrano, Raul Recio, Maria Angeles Orellana, Jose Maria Aguado
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Article
Immunology
Juan J. Picazo, Jesus Ruiz-Contreras, Juan Casado-Flores, Sagrario Negreira, Fernando Baquero-Artigao, Teresa Hernandez-Sampelayo, Enrique Otheo, Maria del Amo, Cristina Mendez, J. T. Ramos, C. Betriu, E. Culebras, F. Gonzalez, I Rodriguez-Avial, J. Ruiz-Contreras, S. Negreira, M. A. Orellana, A. Delgado-Iribarren, M. Bueno, A. Alhambra, M. T. Garcia, M. J. Gonzalez, J. Cobos, F. Baquero, A. Garcia, J. Casado, B. Hernandez, M. Zafra, J. Jaqueti, C. Calvo, I Wilhelmi, C. Serrano, E. Garcia-Penuela, E. Cercenado, T. Hernandez-Sampelayo, E. Otheo, P. Ruiz, N. Dominguez, I Gadea, I Romero, J. L. Gomez-Garces, M. A. Roa, M. Ruiz, J. Cacho, M. L. Garcia-Picazo, S. Gallego, M. J. Cilleruelo, M. Sanchez, M. Penin, P. Gomez, S. Salso, M. Corcino, A. Rodriguez, J. Clemente, J. L. Ruibal, B. Agundez, A. Canete, C. Garcia-Vao, A. Sanchez, J. C. Sanz, C. Mendez, M. del Amo, C. Balseiro, M. L. Samaniego
Article
Microbiology
M. Angeles Orellana, Fernando Chaves, Rafael Delgado
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2020)
Article
Microbiology
Octavio Carretero, Gonzalo Rivas, Cristina Loras, M. Angeles Orellana
JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Infectious Diseases
Marta Rolo, Maria Carmen Martin-Higuera, Esther Viedma, Jennifer Villa, Mikel Mancheno-Losa, Jaime Lora-Tamayo, Fernando Chaves, Maria Angeles Orellana, Raul Recio
Summary: This study found that a short time-to-positivity of blood cultures (<= 16 hours) is independently associated with increased 30-day mortality in patients with Pseudomonas aeruginosa bacteremia, along with other clinical factors.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Ana Arias-Felipe, Jesus Ramirez-Berrios, Raul Recio-Martinez, Maria Angeles Orellana-Miguel, Diego Fontiveros-Escalona, Elena Bergon-Sendin, Concepcion de Alba-Romero
Summary: We conducted a study on the time required for bacterial growth in blood cultures from newborns in our NICU, aiming to reduce antibiotic dosage. The time to positivity of blood cultures can determine the need for empirical antibiotic treatment.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Nursing
Ignacio Zaragoza-Garcia, Santiago Perez-Garcia, Maria de los Angeles Orellana-Miguel, Clotilde Pose-Becerra, Maria Andion Goni-Olangua
REVISTA DA ESCOLA DE ENFERMAGEM DA USP
(2019)