Article
Food Science & Technology
Jenni Soukka, Lauri Polari, Marko Kalliomaki, Lotta Saros, Teemu D. Laajala, Tero Vahlberg, Diana M. Toivola, Kirsi Laitinen
Summary: This study evaluated the effects of fish oil and/or probiotics supplementation on the concentration of immune mediators in colostrum, and their associations with perinatal clinical factors. The results showed that the fish oil+probiotics group had higher concentrations of IL-12p70 and FLT-3L compared to the other groups. However, the differences in IFN alpha 2 levels between the fish oil+probiotics group and the fish oil+placebo group were not statistically significant after correction for multiple testing. In conclusion, the fish oil/probiotics intervention had a minor effect on colostrum immune mediators, while medication during the perinatal period had a significant modulating effect on immune mediators.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sergio Serrano-Villar, Alba Talavera-Rodriguez, Maria Jose Gosalbes, Nadia Madrid, Jose A. Perez-Molina, Ryan J. Elliott, Beatriz Navia, Val F. Lanza, Alejandro Vallejo, Majdi Osman, Fernando Dronda, Shrish Budree, Javier Zamora, Carolina Gutierrez, Monica Manzano, Maria Jesus Vivancos, Raquel Ron, Javier Martinez-Sanz, Sabina Herrera, Uxua Ansa, Andres Moya, Santiago Moreno
Summary: This study demonstrates the safety and efficacy of fecal microbiota transplantation in HIV-infected individuals, showing successful engraftment of transplanted microbiota and improvement of HIV-associated dysbiosis.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Oliwia Gawlik-Kotelnicka, Aleksandra Margulska, Anna Skowronska, Dominik Strzelecki
Summary: Finding new treatment options for depression and its comorbidities is crucial. Microbiota interventions, such as probiotics, may be a safe and easy-to-use adjunctive therapy for patients who are partially responsive to pharmacologic treatment. The study discussed the feasibility and pilot findings of a randomized controlled trial on the effect of probiotic supplementation on depressive disorders in patients with metabolic syndrome.
Article
Nutrition & Dietetics
Paolo Orlandoni, Nikolina Jukic Peladic, Angela Amoruso, Marco Pane, Mirko Di Rosa, Jennifer Vedruccio, Franco Santini
Summary: A double-blind, placebo-controlled study on geriatric patients undergoing home enteral nutrition (HEN) showed that Proxian(R) probiotic supplement did not significantly reduce infection incidence or modulate inflammation, but demonstrated potential in safety and ease of administration.
Article
Nutrition & Dietetics
Xue-Jun Kong, Jun Liu, Kevin Liu, Madelyn Koh, Hannah Sherman, Siyu Liu, Ruiyi Tian, Piyawat Sukijthamapan, Jiuju Wang, Michelle Fong, Lei Xu, Cullen Clairmont, Min-Seo Jeong, Alice Li, Maria Lopes, Veronica Hagan, Tess Dutton, Suk-Tak (Phoebe) Chan, Hang Lee, Amy Kendall, Kenneth Kwong, Yiqing Song
Summary: The combination therapy of probiotics PS128 and oxytocin has shown significant therapeutic effects on individuals with ASD, including improvements in social behavior and overall clinical outcomes. Additionally, positive changes in gut microbiome were observed after combination therapy, which may be closely related to the improvement in social cognition in patients.
Article
Gastroenterology & Hepatology
Kati Mokkala, Niklas Paulin, Noora Houttu, Ella Koivuniemi, Outi Pellonpera, Sofia Khan, Sami Pietila, Kristiina Tertti, Laura L. Elo, Kirsi Laitinen
Summary: This study found differences in the composition and function of gut microbiota during pregnancy between women with and without gestational diabetes mellitus (GDM), especially those receiving a combination of fish oil and probiotics. Specific gut microbiota species do not directly contribute to GDM in overweight/obese women, but the status of GDM may affect maternal gut microbiota flexibility.
Article
Medicine, General & Internal
Iryna Rybak, Kelly N. Haas, Simran K. Dhaliwal, Waqas A. Burney, Aunna Pourang, Simran S. Sandhu, Jessica Maloh, John W. Newman, Robert Crawford, Raja K. Sivamani
Summary: This study aimed to investigate the effects of oral spore-based probiotic ingestion on the gut microbiome, plasma short-chain fatty acids (SCFAs), and skin biophysical properties. The results showed that probiotic supplementation led to a decrease in facial sebum excretion rate and an overall increase in transepidermal water loss (TEWL). Participants with acne showed improvements in lesion counts and markers of gut permeability. The gut microbiome of the nonacne population had an increase in Akkermansia, while those with acne had an increase in Lachnospiraceae and Ruminococcus gnavus. Preliminary evidence suggests the potential use of spore-based probiotic supplementation for modulating the gut microbiome and increasing SCFAs in both acne and nonacne populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Food Science & Technology
Parisa Janmohammadi, Zeinab Nourmohammadi, Siavash Fazelian, Atieh Mirzababaei, Shahab Alizadeh, Mahtab Zarei, Elnaz Daneshzad, Kurosh Djafarian
Summary: Several studies have suggested that formulas containing synbiotics (composed of prebiotics and probiotics) may have a positive effect on anthropometric indices. However, the results of these studies are inconsistent. This meta-analysis found that the consumption of formulas containing synbiotics did not significantly affect the growth of healthy infants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Dooheon Son, Youn Jung Choi, Min Young Son, Won Moon, Seun Ja Park, Sanghyun Lim, Jae Hyun Kim
Summary: The study aimed to evaluate the effects of probiotic pretreatment on gut microbiota alteration and recovery after bowel preparation and its correlation with minor complications. In a randomized, double-blind, placebo-controlled pilot trial with participants aged 40-65, probiotics or placebo were given for 1 month before colonoscopy. The results showed that probiotic pretreatment had beneficial effects on gut microbiota alteration and recovery, as well as a significant reduction in the duration of minor complications.
Article
Microbiology
Masaki Terahara, Yoshitaka Nakamura, Misato Tsuboi, Shinji Jinno, Takamitsu Tsukahara, Takao Miyake, Naoki Shimojo
Summary: The study found that providing non-live OLB6378 to full-term infants can enhance the production of secretory IgA, especially at four weeks after birth.
BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
(2021)
Article
Pediatrics
Jacob A. F. Westaway, Roger Huerlimann, Yoga Kandasamy, Catherine M. Miller, Robert Norton, David Watson, Sandra Infante-Vilamil, Donna Rudd
Summary: Probiotic prophylaxis can reduce the risk of acute diseases in preterm infants by modulating the gut microbiome. However, the effects of probiotic species and modulation do not seem to persist beyond discharge.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Richard A. Forsgard, Julia Rode, Karin Lobenius-Palmer, Annalena Kamm, Snehal Patil, Mirriam G. J. Tacken, Marleen A. H. Lentjes, Jakob Axelsson, Gianfranco Grompone, Scott Montgomery, Robert J. Brummer
Summary: Studies have shown that probiotics can decrease symptoms of respiratory tract infections and enhance antibody responses. This study examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses after infection and COVID-19 vaccination. The results suggest that supplementation with specific probiotics may improve the long-term efficacy of mRNA-based COVID-19 vaccines through enhanced IgA response.
Article
Immunology
Seyed Mehran Marashian, Mohammadreza Hashemian, Mihan Pourabdollah, Mansour Nasseri, Saeed Mahmoudian, Florian Reinhart, Alireza Eslaminejad
Summary: This study suggests that photobiomodulation (PBM) therapy may be effective in inhibiting the release of pro-inflammatory cytokines in COVID-19 patients, reducing organ damage and preventing severe disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Mahtab Matin, Aziz Homayouni-Rad, Manizheh Mostafa-Gharehbaghi, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh-Charandabi
Summary: Oral probiotic administration of Lacticaseibacillus paracasei to breastfeeding mothers of VLBW infants or to the infants can reduce infant TSB level but has no significant effect on weight gain.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Clinical Neurology
Gustavo C. Leal, Breno Souza-Marques, Rodrigo P. Mello, Igor D. Bandeira, Ana Teresa Caliman-Fontes, Beatriz A. Carneiro, Daniela Faria-Guimaraes, Livia N. F. Guerreiro-Costa, Ana Paula Jesus-Nunes, Samantha S. Silva, Daniel H. Lins-Silva, Mariana A. Fontes, Raiza Alves-Pereira, Vivian Cordeiro, Sidelcina Rugieri-Pacheco, Cassio Santos-Lima, Fernanda S. Correia-Melo, Flavia Vieira, Gerard Sanacora, Acioly L. T. Lacerda, Lucas C. Quarantini
Summary: This study aimed to explore the feasibility of using (R)-ketamine (arketamine) for treatment-resistant depression (TRD) and assess its efficacy and safety compared to placebo. The results showed that arketamine was not significantly different from placebo in treating depression. The findings highlight the importance of conducting further clinical trials.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Gal Tsaban, Anat Yaskolka Meir, Ehud Rinott, Hila Zelicha, Alon Kaplan, Aryeh Shalev, Amos Katz, Assaf Rudich, Amir Tirosh, Ilan Shelef, Ilan Youngster, Sharon Lebovitz, Noa Israeli, May Shabat, Dov Brikner, Efrat Pupkin, Michael Stumvoll, Joachim Thiery, Uta Ceglarek, John T. Heiker, Antje Koerner, Kathrin Landgraf, Martin von Bergen, Matthias Blueher, Meir J. Stampfer, Iris Shai
Summary: The study suggests that the green Mediterranean diet has a positive impact on cardiometabolic risk, resulting in reduced waist circumference, cholesterol levels, blood pressure, and improved insulin resistance. Compared to the traditional Mediterranean diet, the green Mediterranean diet shows more significant effects.
Article
Health Care Sciences & Services
Hilla Bahat, Adi Hasidov-Gafni, Ilan Youngster, Michael Goldman, Osnat Levtzion-Korach
Summary: This study found that needlestick and sharps injuries (NSIs) and underreporting are common among hospital workers, including those who do not use needles. Higher prevalence of NSIs were noted among physicians and workers in emergency and surgical departments. Underreporting was significantly more common among physicians, seniors, workers without training about NSIs, older age groups, and males. Recommendations include improving preventive measures, encouraging reporting, reducing bedside procedures, and assigning two workers to high-risk procedures to increase reporting rates.
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2021)
Article
Multidisciplinary Sciences
Erez N. Baruch, Ilan Youngster, Guy Ben-Betzalel, Rona Ortenberg, Adi Lahat, Lior Katz, Katerina Adler, Daniela Dick-Necula, Stephen Raskin, Naamah Bloch, Daniil Rotin, Liat Anafi, Camila Avivi, Jenny Melnichenko, Yael Steinberg-Silman, Ronac Mamtani, Hagit Harati, Nethanel Asher, Ronnie Shapira-Frommer, Tal Brosh-Nissimov, Yael Eshet, Shira Ben-Simon, Oren Ziv, Md Abdul Wadud Khan, Moran Amit, Nadim J. Ajami, Iris Barshack, Jacob Schachter, Jennifer A. Wargo, Omry Koren, Gal Markel, Ben Boursi
Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.
Article
Public, Environmental & Occupational Health
Eran Kozer, Ehud Rinott, Guy Kozer, Adina Bar-Haim, Patricia Benveniste-Levkovitz, Hodaya Klainer, Sivan Perl, Ilan Youngster
Summary: This study aimed to assess the presence of SARS-CoV-2 in environmental samples collected at public playgrounds and water fountains in a country with high disease prevalence. The results showed that a small percentage of samples tested positive for the virus, highlighting the importance of maintaining environmental and personal hygiene in urban settings.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Ehud Rinott, Ilan Youngster, Anat Yaskolka Meir, Gal Tsaban, Alon Kaplan, Hila Zelicha, Elad Rubin, Omry Koren, Iris Shai
Summary: The study found that during autologous fecal microbiota transplantation treatment, patients were able to maintain metabolic benefits achieved during the weight loss phase, including stability in weight, blood sugar, and blood lipids.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Netanel Agajany, Eran Kozer, Netta Agajany, Daniel Trotzky, Ibrahim Abu Kishk, Ilan Youngster
Summary: The clinical presentation of snakebites from D. palaestinae can vary depending on the season, with victims in the spring and early summer showing more severe symptoms. It is important for hospitals to be prepared to treat critically ill patients during these seasons.
Article
Genetics & Heredity
Ehud Rinott, Anat Yaskolka Meir, Gal Tsaban, Hila Zelicha, Alon Kaplan, Dan Knights, Kieran Tuohy, Matthias Uwe Scholz, Omry Koren, Meir J. Stampfer, Dong D. Wang, Iris Shai, Ilan Youngster
Summary: The study found that the Mediterranean diet has significant effects on gut microbiota and cardiometabolic health, particularly the Green-MED diet. The Green-MED diet induces beneficial changes in gut microbiota composition and enzymatic functions, which are associated with improvements in body weight and cardiometabolic biomarkers.
Correction
Pediatrics
Iren Zargari, Adi Adar, Iris Morag, Orit Pinhas-Hamiel, Ori Eyal, Rimona Keidar, Neta Loewenthal, Milana Levy, Orna Dally-Gottfried, Zohar Landau, Floris Levy-Khademi, Smadar Eventov-Friedman, David Zangen, Ilan Youngster, Marianna Rachmiel
PEDIATRIC RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Ilan Youngster
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Pediatrics
Dana Danino, Liat Ashkenazi-Hoffnung, Alejandro Diaz, Amir Dov Erps, Noa Eliakim-Raz, Yonat Shemer Avni, David Greenberg, Noga Givon-Lavi, Ilan Youngster
Summary: This retrospective study assessed the clinical effectiveness of the BNT162b2 vaccine during pregnancy in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalizations in infants under 6 months of age. The results showed that the effectiveness of fully vaccinated mothers was 61.6%, while the effectiveness of partially vaccinated mothers was not significant.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Ilan Youngster, Renana Gelernter, Hodaya Klainer, Hadas Paz, Eran Kozer, Michael Goldman
Summary: This study aimed to evaluate adherence to short-term antibiotic treatment in children. The results showed that overall adherence was 62%, and timing adherence was 21%. The study also found that being a single parent was significantly associated with nonadherence.
Article
Medicine, General & Internal
Mark Loeb, Amy Bartholomew, Madiha Hashmi, Wadea Tarhuni, Mohamed Hassany, Ilan Youngster, Ranjani Somayaji, Oscar Larios, Joseph Kim, Bayan Missaghi, Joseph V. Vayalumkal, Dominik Mertz, Zain Chagla, Maureen Cividino, Karim Ali, Sarah Mansour, Lana A. Castellucci, Charles Frenette, Leighanne Parkes, Mark Downing, Matthew Muller, Verne Glavin, Jennifer Newton, Ravi Hookoom, Jerome A. Leis, James Kinross, Stephanie Smith, Sayem Borhan, Pardeep Singh, Eleanor Pullenayegum, John Conly
Summary: This study aimed to determine the noninferiority of medical masks compared to N95 respirators in preventing COVID-19 among healthcare workers. The results showed that there was little difference in the occurrence of RT-PCR-confirmed COVID-19 between the medical mask group and the N95 respirator group. The subgroup analysis by country yielded varied results.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Pediatrics
Roni Cohen Shavit, Najib Nasrallah, Oshra Levi, Ilan Youngster, Itai Shavit
Summary: A study found that the type of face mask worn by nurses in a pediatric emergency department during the pandemic influenced children's reports of pain. Wearing a surgical face mask was associated with a lower likelihood of reporting pain compared to wearing a clear face mask. This study provides preliminary evidence that the type of face mask used by healthcare providers might have a negative impact on the child's report of pain.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Infectious Diseases
Michal Paret, Rebecca Trillo, Jennifer Lighter, Ilan Youngster, Adam J. Ratner, Rebecca Pellett Madan
Summary: Large outbreaks of measles occurred in Israel and New York City during 2018-2019, mainly due to travel of unimmunized children between the two communities. The majority of measles cases occurred in eligible but unvaccinated children. Moreover, over 25% of children in both measles-positive and -negative groups remained unimmunized for measles, mumps, and rubella (MMR) vaccine one year after the outbreak.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Hematology
Adi Eshel, Itai Sharon, Arnon Nagler, David Bomze, Ivetta Danylesko, Joshua A. Fein, Mika Geva, Israel Henig, Avichai Shimoni, Tsila Zuckerman, Ilan Youngster, Omry Koren, Roni Shouval
Summary: In this study, high rates of bloodstream infections were observed following fecal microbiota transplantation (FMT) for graft-versus-host-disease. Through metagenomic screening, the origin of these infections was determined to not be from the FMT donations. The findings support the safety of FMT in immunocompromised patients but do not rule out the possibility of bacterial translocation caused by FMT.
