Comparative Toxicokinetics, Absolute Oral Bioavailability, and Biotransformation of Zearalenone in Different Poultry Species

After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (T-max = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% = 6.87-10,28%). Next, also a rapid elimination of the mycotoxin in all poultry species was observed (T-1/2el = 0.29-0.46 h). Both alpha- and beta-zearalenone (ZEL) were formed equally after IV administration in all species studied, Whereas an increased biotransformation to beta-ZEL was demonstrated after PO administration, indicating presystemic biotransformation mainly in broiler chickens and laying hens. In comparison to the latter, turkey poults demonstrated a more extensive biotransformation of ZEN to alpha-ZEL after PO administration which could, in combination with the observed higher volume of distribution of ZEN, indicate a higher sensitivity of this species to the effects of ZEN in comparison to other poultry species.