Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This meta-analysis revealed that the circulating level of interleukin-18 is significantly higher in systemic lupus erythematosus (SLE) patients compared to healthy controls. Patients with higher SLEDAI scores, Asian, White, Arab, or mixed ethnicity tend to have elevated levels of IL-18, indicating the potential role of IL-18 in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Yantong Zhu, Xiaojun Tang, Yang Xu, Si Wu, Weilin Liu, Linyu Geng, Xiaolei Ma, Betty P. Tsao, Xuebing Feng, Lingyun Sun
Summary: Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies. This study found that Ribonuclease A family member 2 (RNase2) is highly expressed in SLE patients and is associated with the increase of autoreactive B cells known as age-associated B cells (ABCs). Reduction of RNASE2 expression led to a decrease in ABCs, accompanied by a reduction in total IgG and IL-10 levels. It was also found that both RNASE2 and IL-10 in SLE patients were mainly derived from monocytes. The study concluded that RNASE2 might induce the production of ABCs via IL-10 secreted from monocytes, contributing to the pathogenesis of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zhihui Liu, Ruijuan Cheng, Yi Liu
Summary: This study evaluated the safety of anifrolumab in patients with moderate to severe systemic lupus erythematosus (SLE). The results showed that serious adverse events were less common in the anifrolumab group compared to the placebo group. The most common adverse events included upper respiratory tract infection, nasopharyngitis, bronchitis, and herpes zoster. Anifrolumab is considered a well-tolerated option for the treatment of SLE patients with good safety.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Viktoryia Laurynenka, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yongfei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Ken Yamaji, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Leah C. Kottyan, Matthew T. Weirauch, Sreeja Parameswaran, Shruti Eswar, Hanan Salim, Xiaoting Chen, Kazuhiko Yamamoto, John B. Harley, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: This study conducted the largest genome-wide meta-analysis for SLE in East Asian populations, identifying 46 novel loci and prioritizing putative causal variants using Bayesian statistical approach. The findings highlight the power of large-scale genetic discovery in shedding light on the genetic and biological understandings of SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Zhenrui Shi, Yu-ping Zhang, Dan Hong, Xiaonan Qiu, Lin Zheng, Lijuan Bian, Fengqiu Hu, Liuyu Chen, Hui Xiong, Qiongqiong Yang, Shanping Jiang, Guozhen Tan, Liangchun Wang
Summary: Vascular inflammation can occur in various organs and tissues in patients with systematic lupus erythematosus (SLE), with the skin being the most common site. Anti-galectin-3 (Gal3) antibodies are identified as an important mediator of lupus cutaneous vasculopathy. The dys-regulation of vascular endothelial cells by anti-Gal3 antibodies leads to increased production of IL-10, which is dependent on NLRP3 inflammasome. Injection of anti-Gal3 antibodies in mice induces local inflammation with immune cell infiltration, which can be inhibited by blocking IL-10. Induction of anti-Gal3 antibodies in circulation not only causes skin histopathologic changes but also systemic autoimmune phenotypes and kidney damage. IL-10 overexpression is primarily associated with skin lesions in mice. The serum levels of IL-10 are comparable between SLE patients and healthy donors, but there is higher IL-10 expression in the local area of lupus skin lesions. These results suggest the important role of IL-10 in mediating anti-Gal3 antibody-induced skin vascular inflammation and the potential use of IL-10 blocking therapies in treating lupus cutaneous damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Qian Wu, Yang Liu, Wei Wang, Yu Zhang, Kui Liu, Song-Hua Chen, Bin Chen
Summary: This meta-analysis investigates the incidence and prevalence of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). The results show that both the incidence and prevalence of TB are high among SLE patients. Subgroup analyses also reveal that the incidence is higher in Africa and countries with a high TB burden, while the prevalence is elevated in Asia, patients taking a high daily dose of glucocorticoids, studies with small sample sizes and those conducted before 2001.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Rou Wu, Chung-Hsi Hsing, Chiao-Juno Chiu, Hsin-Yi Huang, Yu-Hsiang Hsu
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown etiology that affects multiple organ systems. Dysregulation of cytokines, particularly IL-1 and IL-10 families, plays a vital role in immune activation and self-tolerance in the pathogenesis of SLE. These cytokines could be potential targets for therapeutic intervention in SLE.
Article
Cardiac & Cardiovascular Systems
Jeffrey J. Chapa, Onyedika J. Ilonze, Maya E. Guglin, Roopa A. Rao
Summary: Cardiac involvement in Systemic Lupus Erythematosus can be successfully treated with orthotopic heart transplantation, and it can be considered in select patients after careful evaluation.
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study found that circulating IL-33 levels were significantly higher in patients with SLE, suggesting a relationship between IL-33 and SLE. Additionally, the research identified an association between the IL-33 rs1891385 polymorphism and SLE susceptibility.
Review
Obstetrics & Gynecology
Joao Pedro Ferrari-Souza, Mirela Tschiedel Pedrotti, Enrico Emerim Moretto, Laura Penso Farenzena, Luis Guilherme Crippa, Joao Sabino Cunha-Filho
Summary: This study found an association between endometriosis and systemic lupus erythematosus (SLE) through a systematic review and meta-analysis. Although the included studies had limited quality, the results suggest a link between endometriosis and SLE.
REPRODUCTIVE SCIENCES
(2023)
Article
Rheumatology
E. Rzeszotarska, A. Sowinska, B. Stypinska, A. Lutkowska, A. Felis-Giemza, M. Olesinska, M. Puszczewicz, D. Majewski, P. P. Jagodzinski, E. Haladyj, A. Paradowska-Gorycka
Summary: Our study revealed that IL-1#-511, IL-1# +3953, IL-10-592, IL-10-1082, and TNF-alpha-308 polymorphisms may affect SLE risk and phenotype. Specifically, certain genotypes were found to be associated with the SLE phenotype and serum concentrations of TNF-alpha, IL-1#, and IL-10.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Luana Andreea Macovei, Ioana Ruxandra Mihai, Anca Cardoneanu, Maria Alexandra Burlui, Elena Rezus
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder in which cytokines, such as TNF-alpha and IL-17, play crucial roles. The modulation of these cytokines may impact disease progression and serve as potential biomarkers. Elevated levels of TNF-alpha and IL-17 are associated with high disease activity in SLE patients, although their inhibition as a treatment option is still under discussion. Further studies are needed to explore the therapeutic potential of targeting these cytokines in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Yiwei Huang, Danni Guan, Yijin Li, Jiahao Li, Yirong Zeng
Summary: This study reviewed the current evidence on complications and postoperative function in systemic lupus erythematosus (SLE) patients undergoing total hip arthroplasty (THA). The meta-analysis results showed that SLE patients have an increased risk of deep vein thrombosis, wound infection, dislocation, periprosthetic fracture, and revision after THA compared to non-SLE patients.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Julie Sarrand, Muhammad Soyfoo
Summary: IL-33 is a newly discovered cytokine that acts as an alarmin to alert the innate immune system following cell death or necrosis. It has been found to be significantly upregulated in patients with SLE and lupus nephritis, suggesting its involvement in the pathology of SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Rheumatology
Jiangwei Xia, Lin Xu, Ke-Qi Liu, Zhi-Min Ying, Shu-Yang Xie, Hou-Feng Zheng
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Jie Huang, Zhi-Sheng Liang, Stefano Pallotti, Janice M. Ranson, David J. Llewellyn, Zhi-Jie Zheng, Daniel A. King, Qiang Zhou, Houfeng Zheng, Valerio Napolioni
Summary: Despite the identification of numerous genetic variants associated with various diseases through GWASs, the interpretation of these results is not widely accessible to the public. PAGEANT is a web-based genetic analysis tool that provides quality assurance of genetic data, quantitative assessment of health risk susceptibility, query of third-party variant databases, and quick response codes for genetic variants of interest.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Genetics & Heredity
Yu Qian, Zhixing He, Sizheng Steven Zhao, Bin Liu, Ying Chen, Xiaohui Sun, Ding Ye, Xia Jiang, Hui Zheng, Chengping Wen, Houfeng Zheng, Yingying Mao
Summary: This study using Mendelian randomization (MR) analysis found that genetically determined elevated circulating levels of MIP-1b may be associated with a lower risk of rheumatoid arthritis (RA).
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Mingyu Han, Marie Woottum, Remi Mascarau, Zoi Vahlas, Christel Verollet, Serge Benichou
Summary: In addition to CD4+ T lymphocytes, cells of the myeloid lineage such as macrophages, dendritic cells, and osteoclasts are also important target cells for HIV-1. These cells likely participate in all steps of pathogenesis and can constitute persistent virus reservoirs. In vitro, these myeloid cells are poorly infected by cell-free viral particles, but can be productively infected through direct cell-to-cell contacts. The different mechanisms reported for cell-to-cell transfer and spreading of HIV-1 in myeloid cells lead to efficient spreading in these poorly susceptible cell types.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Pei-Kuan Cong, Wei-Yang Bai, Jin-Chen Li, Meng-Yuan Yang, Saber Khederzadeh, Si-Rui Gai, Nan Li, Yu-Heng Liu, Shi-Hui Yu, Wei-Wei Zhao, Jun-Quan Liu, Yi Sun, Xiao-Wei Zhu, Pian-Pian Zhao, Jiang-Wei Xia, Peng-Lin Guan, Yu Qian, Jian-Guo Tao, Lin Xu, Geng Tian, Ping-Yu Wang, Shu-Yang Xie, Mo-Chang Qiu, Ke-Qi Liu, Bei-Sha Tang, Hou-Feng Zheng
Summary: Through the WBBC pilot project, we conducted large-scale genome sequencing and genotyping on Chinese individuals and established a population-specific reference panel and an online imputation server. By analyzing the data, we discovered the geographical boundary and genetic differences among the Han Chinese, providing important insights into the genetic characteristics and evolution of the Chinese population.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Mingyu Han, Vincent Cantaloube-Ferrieu, Maorong Xie, Marie Armani-Tourret, Marie R. Woottum, Jean-Christophe Pages, Philippe R. Colin, Bernard Lagane, Serge R. Benichou
Summary: The study shows that HIV-1 can effectively infect macrophages through cell-to-cell transfer, even with virus isolates initially defined as non-macrophage tropic in cell-free infection. This intercellular viral transfer is facilitated by enhanced interactions between the HIV-1 envelope glycoproteins and cellular entry receptors.
Article
Oncology
Pei-Kuan Cong, Saber Khederzadeh, Cheng-Da Yuan, Rui-Jie Ma, Yi-Yao Zhang, Jun-Quan Liu, Shi-Hui Yu, Lin Xu, Jian-Hua Gao, Hong-Xu Pan, Jin-Chen Li, Shu-Yang Xie, Ke-Qi Liu, Bei-Sha Tang, Hou-Feng Zheng
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xiao-Wei Zhu, Ke-Qi Liu, Cheng-Da Yuan, Jiang-Wei Xia, Yu Qian, Lin Xu, Jian-Hua Gao, Xiao-Li Rong, Guo-Bo Chen, David Karasik, Shu-Yang Xie, Hou-Feng Zheng
Summary: A prospective study was conducted to investigate the relationship between obesity and fracture, as well as the difference between general and abdominal obesity. The results showed that maintaining a moderate-high BMI can reduce the risk of fracture, while abdominal adiposity may increase the risk of fracture.
Article
Cell Biology
Yuan-Rong Liu, Dan-Dan Song, Dong-Min Liang, You-Jie Li, Yun-Fei Yan, Hong-Fang Sun, Mei-Ling Zhang, Jin-Xia Hu, Yu-Long Zhao, Yan Liang, Yan-Mei Li, Zhen Yang, Ran-Ran Wang, Hou-Feng Zheng, Pingyu Wang, Shu-Yang Xie
Summary: This study demonstrates that TRIB2 can directly phosphorylate PKM2 in cancer cells and promote its nuclear translocation, leading to increased expression of aerobic glycolysis-related genes. This enhances cancer cell proliferation and migration while reducing cellular ATP content.
CELL DEATH DISCOVERY
(2022)
Article
Medicine, General & Internal
Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen, Hou-Feng Zheng
Summary: This study explores the relationship between birth weight and adult bone mass, indicating that higher birth weight is associated with increased bone area and decreased bone mineral density in adults.
Editorial Material
Multidisciplinary Sciences
Yanan Cao, Lingling Chen, Hua Chen, Yupeng Cun, Xiaofeng Dai, Hongli Du, Feng Gao, Fengbiao Guo, Yalong Guo, Pei Hao, Shunmin He, Shunping He, XiongLei He, Zheng Hu, Boon-Peng Hoh, Xin Jin, Qian Jiang, Qinghua Jiang, Asifullah Khan, Hong-Zhi Kong, Jinchen Li, Shuai Cheng Li, Ying Li, Qiang Lin, Jianquan Liu, Qi Liu, Jian Lu, Xuemei Lu, Shujin Luo, Qinghua Nie, Zilong Qiu, Tieliu Shi, Xiaofeng Song, Jianzhong Su, Sheng-ce Tao, Chaolong Wang, Chuan-Chao Wang, Guo-Dong Wang, Jiguang Wang, Qi Wu, Shaoyuan Wu, Shuhua Xu, Yu Xue, Wenjun Yang, Zhaohui Yang, Kai Ye, Yuan-Nong Ye, Li Yu, Fangqing Zhao, Yiqiang Zhao, Weiwei Zhai, Dandan Zhang, Liye Zhang, Houfeng Zheng, Qi Zhou, Tianqi Zhu, Ya-ping Zhang
NATIONAL SCIENCE REVIEW
(2023)
Article
Medicine, General & Internal
Zhangxin Wen, Jiaxuan Gu, Rong Chen, Qinyi Wang, Na Ding, Lingqiong Meng, Xiangbing Wang, Hong Liu, Zhifeng Sheng, Houfeng Zheng
Summary: This study analyzed the relationship between handgrip strength and appendicular lean mass index with age, anthropometry, and body composition in a sample of US participants. The results showed that handgrip strength and appendicular lean mass index decrease with advancing age and are influenced by the fat mass index. The conclusion is that handgrip strength and appendicular lean mass index change with age and are affected by anthropometry, nutrition, physical activity, and body composition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Hongxu Pan, Zhenhua Liu, Jinghong Ma, Yuanyuan Li, Yuwen Zhao, Xiaoxia Zhou, Yaqin Xiang, Yige Wang, Xun Zhou, Runcheng He, Yali Xie, Qiao Zhou, Kai Yuan, Qian Xu, Qiying Sun, Junling Wang, Xinxiang Yan, Hainan Zhang, Chunyu Wang, Lifang Lei, Weiguo Liu, Xuejing Wang, Xuebing Ding, Tao Wang, Zheng Xue, Zhentao Zhang, Ling Chen, Qing Wang, Yonghong Liu, Jiayu Tang, Xuewei Zhang, Shifang Peng, Chaodong Wang, Jianqing Ding, Chunfeng Liu, Lijuan Wang, Haibo Chen, Lu Shen, Hong Jiang, Xinyin Wu, Hongzhuan Tan, Dan Luo, Shuiyuan Xiao, Xiang Chen, Jieqiong Tan, Zhengmao Hu, Chao Chen, Kun Xia, Zhuohua Zhang, Jia Nee Foo, Cornelis Blauwendraat, Mike Nalls, Andrew Singleton, Jun Liu, Piu Chan, Houfeng Zheng, Jinchen Li, Jifeng Guo, Jian Yang, Beisha Tang
Summary: Through GWAS and WGS, genetic variants associated with Parkinson's disease were identified in the Chinese population, revealing both genetic homogeneity and heterogeneity of the disease across different ethnic groups. These findings highlight the importance of WGS in improving our understanding of the genetic architecture of Parkinson's disease.
NPJ PARKINSONS DISEASE
(2023)
Article
Cell Biology
Chao Zheng, He Liu, Pianpian Zhao, Weiguang Lu, Shiju Song, Ting He, Jing Fan, Di Wang, Pengfei Yang, Qiang Jie, Hou-Feng Zheng, Zhuojing Luo, Liu Yang
Summary: This study identifies the deficiency of sulfate transporter SLC26A2 as a causative factor for osteoporosis and reveals the mechanoreciprocity between sulfation, matrix, and osteoblasts during development.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Letter
Rheumatology
Ke-Qi Liu, Jiangwei Xia, Qiu-Ping Chen, Jian-Qiang Yang, Hou-Feng Zheng
ANNALS OF THE RHEUMATIC DISEASES
(2023)