Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease

Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin

(2013) C. Buerger et al.   BRITISH JOURNAL OF DERMATOLOGY

Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma

(2013) Qishan Tang et al.   CANCER LETTERS

Peracetylated (−)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34 + skin stem cells and skin tumors

(2013) Yi-Shiou Chiou et al.   CARCINOGENESIS

Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase

(2013) Agustín España et al.   EXPERIMENTAL DERMATOLOGY

1α,25-Dihydroxyvitamin-D3-3-Bromoacetate Regulates AKT/mTOR Signaling Cascades: A Therapeutic Agent for Psoriasis

(2013) Ananya Datta Mitra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides

(2013) Georgia Levidou et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Effect of Gartanin, a Naturally Occurring Xanthone in Mangosteen Juice, on the mTOR Pathway, Autophagy, Apoptosis, and the Growth of Human Urinary Bladder Cancer Cell Lines

(2013) Zhongbo Liu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo

(2013) Daisy Machado et al.   PLoS One

Inhibition of mTOR Suppresses UVB-Induced Keratinocyte Proliferation and Survival

(2012) T. D. Carr et al.   Cancer Prevention Research

Functional Protein Pathway Activation Mapping of the Progression of Normal Skin to Squamous Cell Carcinoma

(2012) J. G. Einspahr et al.   Cancer Prevention Research

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Activation of PI3K Signaling in Merkel Cell Carcinoma

(2012) Valentina Nardi et al.   CLINICAL CANCER RESEARCH

mTOR Inhibitors in Tuberous Sclerosis Complex

(2012) Paolo Curatolo et al.   Current Neuropharmacology

Immunohistochemical Analysis of the Akt/mTOR/4E-BP1 Signalling Pathway in Canine Haemangiomas and Haemangiosarcomas

(2012) A. Murai et al.   JOURNAL OF COMPARATIVE PATHOLOGY

mTORC2-PKBα/Akt1 Serine 473 Phosphorylation Axis Is Essential for Regulation of FOXP3 Stability by Chemokine CCL3 in Psoriasis

(2012) Ling Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

(2012) Y Romeo et al.   ONCOGENE

Differential Activation of Signaling Pathways by UVA and UVB Radiation in Normal Human Epidermal Keratinocytes†

(2012) Deeba N. Syed et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin

(2012) Mohd Askandar Iqbal et al.   PLoS One

Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis

(2012) Mei-Ling Tsai et al.   Food & Function

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

(2011) Glenn S. Van Aller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing

(2011) L. Feldmeyer et al.   BRITISH JOURNAL OF DERMATOLOGY

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

The integral role of mTOR in lipid metabolism

(2011) Ghada A. Soliman   CELL CYCLE

Caffeine Promotes Ultraviolet B-induced Apoptosis in Human Keratinocytes without Complete DNA Repair

(2011) Weinong Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB

(2011) Saswati Bhattacharya et al.   MELANOMA RESEARCH

Curcumin Inhibits Skin Squamous Cell Carcinoma Tumor Growth In Vivo

(2011) Jeffrey M. Phillips et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

(2011) Xiaoxia Zhu et al.   PLoS One

Angiosarcoma

(2010) Guy Lahat et al.   ANNALS OF SURGERY

Quercetin Potentiates UVB-Induced c-Fos Expression: Implications for Its Use as a Chemopreventive Agent

(2010) E. R. Olson et al.   Cancer Prevention Research

Mammalian Target of Rapamycin Activator RHEB Is Frequently Overexpressed in Human Carcinomas and Is Critical and Sufficient for Skin Epithelial Carcinogenesis

(2010) Z. H. Lu et al.   CANCER RESEARCH

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models

(2010) Cristiane H. Squarize et al.   PLoS One

Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2

(2009) S-J. Chen et al.   BRITISH JOURNAL OF DERMATOLOGY

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris

(2009) Maider Pretel et al.   EXPERIMENTAL DERMATOLOGY

The role of the Birt–Hogg–Dubé protein in mTOR activation and renal tumorigenesis

(2009) T R Hartman et al.   ONCOGENE

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Kaposi's Sarcoma-Associated Herpesvirus Confers a Survival Advantage to Endothelial Cells

(2008) L. Wang et al.   CANCER RESEARCH

Dynamic frequency of CD4+CD25+Foxp3+ Treg cells in Psoriasis vulgaris

(2008) Ling Chen et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Reactive Oxygen Species in Tumor Necrosis Factor-α-Activated Primary Human Keratinocytes: Implications for Psoriasis and Inflammatory Skin Disease

(2008) Chen N. Young et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IGF-1 Induces SREBP-1 Expression and Lipogenesis in SEB-1 Sebocytes via Activation of the Phosphoinositide 3-Kinase/Akt Pathway

(2007) Terry M. Smith et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

mTOR Is Activated in the Majority of Malignant Melanomas

(2007) Magdalena Karbowniczek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY