Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Article
Chemistry, Medicinal
Jae-Min Kim, Kyung-Sook Chung, Young-Seo Yoon, Seo-Yun Jang, So-Won Heo, Geonha Park, Young-Pyo Jang, Hye-Shin Ahn, Yu-Kyong Shin, Sun-Hee Lee, Kyung-Tae Lee
Summary: The study found that dieckol can inhibit UVB-induced skin photoaging by regulating the TGF-beta/Smad2/3 and MAPKs/AP-1 signaling pathways, thereby suppressing collagen degradation and MMP expression. In addition, dieckol restored the production of hyaluronic acid, reducing transepidermal water loss, epidermal/dermal thickness, and wrinkle formation.
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Sarah S. McCarthy, Michele Karolak, Leif Oxburgh
Summary: Expansion of interstitial cells in adult kidney is a hallmark of chronic disease, while their proliferation during fetal development is necessary for organ formation. Inactivation of TGF beta/Smad response in mouse interstitial cell lineage leads to overproliferation of interstitial cells regionally in the kidney medulla. Smad4 loss primarily reduces TGF beta signaling in the interstitium, while increasing Wnt/beta-catenin signaling.
Article
Medicine, General & Internal
Michael Constantin Kirchberger, Michael Gfesser, Michael Erdmann, Stefan Schliep, Carola Berking, Markus Vincent Heppt
Summary: The study found that tirbanibulin 1% ointment significantly and rapidly reduced the AKASI score in a real-world setting, achieving similar clearance rates as observed in the pivotal trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Zhang Li, Ming Li, Pengcheng Xia, Lili Wang, Zhiming Lu
Summary: This study discovered that p53 exerts anti-oncogenic function on glioma development by suppressing IncRNA PVT1 and subsequently inactivating TGF-beta/Smad pathway.
CANCER BIOLOGY & THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Yufei Qiu, Xudong Song, Yong Liu, Yan Wu, Jiayi Shi, Fan Zhang, Yu Pan, Zhiqin Cao, Keke Zhang, Jingruo Liu, Yanhui Chu, Xiaohuan Yuan, Dan Wu
Summary: Cardiac fibrosis is a remodeling process characterized by abnormal metabolism of the extracellular matrix and excessive accumulation of collagen fibers. Transforming growth factor-beta 1 (TGF-beta 1) plays a crucial role in this process. Studies have shown that interfering with TGF-beta 1 and its signaling pathways using latency-associated peptide (LAP) can attenuate cardiac fibrosis. In this study, recombinant LAP and truncated LAP were found to inhibit activation, inflammation, and fibrosis in isoproterenol-induced cardiac fibroblasts, and also improved cardiac function and alleviated myocardial injury, inflammation, and fibrosis in mice.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hongyong Kim, Qiwen Zheng, Sarang Oh, Shengdao Zheng, Myeongju Kim, Tae-Hoo Yi
Summary: This study demonstrates that Jawoongo can reduce photodamage caused by UVB irradiation in HaCaT cells by regulating signaling pathways such as Nrf2/ARE and TGF-beta/Smad. These findings highlight the potential of Jawoongo as a skincare anti-aging treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Dermatology
Soheila Nasiri, Vahidehsadat Azhari, Farahnaz Bidari-Zerehpoosh, Zahra Asadi-Kani, Atefeh Talebi
Summary: The study demonstrates that p16 and p53 are useful markers in differentiating between AK and BD based on the involvement and sparing of basal keratinocytes.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Jason Thomson, Findlay Bewicke-Copley, Chinedu Anthony Anene, Abha Gulati, Ai Nagano, Karin Purdie, Gareth J. Inman, Charlotte M. Proby, Irene M. Leigh, Catherine A. Harwood, Jun Wang
Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Cell Biology
Zhigang Yi, Tao Ma, Jia Liu, Wenting Tie, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: This study found that LGR4 expression was significantly upregulated in multiple myeloma (MM) tissues and cells. Knockdown of LGR4 inhibited MM cell proliferation, promoted apoptosis and cell cycle arrest in G1, while overexpression showed the opposite effect. Mechanistic studies revealed that LGR4 could interact with TGF-beta 1 and activate the TGF-beta 1/Smad signaling pathway, promoting MM progression. LGR4 may be a potential new target for MM diagnosis and treatment.
CELLULAR SIGNALLING
(2023)
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Cell Biology
Lih-Fhung Hiew, Chi-Him Poon, Heng-Ze You, Lee-Wei Lim
Summary: Research on TGF-beta/Smad signaling has shown its significance in neurogenesis and its potential impact on neuropsychiatric disorders. The relationship between TGF-beta/Smad signaling and neurogenesis in response to stressors suggests a role in stress response regulation and behavioral outcomes of mood disorders. Modifications to these signaling pathways have been found to have diverse effects on neurogenesis, highlighting the complexity of the interactions involved.
Article
Oncology
Sami Shoucair, Joseph R. Habib, Ning Pu, Benedict Kinny-Koster, A. Floortje van Ooston, Ammar A. Javed, Kelly J. Lafaro, Jin He, Christopher L. Wolfgang, Jun Yu
Summary: The study revealed that combinations of mutations in the four driver genes are associated with prognosis in resected PDAC patients. Patients with combined mtKRAS and mtTP53 had a better overall survival and recurrence-free survival when the KRAS p.G12D variant was present.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Honghao Jiang, Xiaoyong Zhou, Liuqing Chen
Summary: Asiaticoside, a compound isolated from Centella asiatica, has been found to improve cell viability and maintain normal morphology in UV-damaged cells. It also inhibits the release of beta-galactosidase and attenuates UV-induced ROS generation and SOD reduction. RNA sequencing revealed that asiaticoside negatively regulates cell cycle and MAPK pathways. Western blotting analysis showed that asiaticoside attenuates the upregulation of TGF-beta 1, Smad2, and Smad3, thus reversing cell senescence.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
