Review
Cell Biology
Pamelika Das, Pappula Mounika, Manoj Limbraj Yellurkar, Vani Sai Prasanna, Sulogna Sarkar, Ravichandiran Velayutham, Somasundaram Arumugam
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by rashes, itching, and pruritus. The pathogenesis of AD is closely related to immunological factors, including the role of the epidermal barrier and abnormal cytokine expressions. Disrupted epidermal barriers and the abnormal release of pro-inflammatory mediators from keratinocytes, as well as the role of immune cells, contribute to the pathophysiology of AD. Specific biomarkers for diagnosis are lacking, highlighting the need for further research in this area.
Review
Immunology
Melanie Humeau, Katia Boniface, Charles Bodet
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dysregulated immune response and increased colonization of Staphylococcus aureus. The interaction between T cells and keratinocytes through cytokine release plays a key role in AD pathogenesis, with potential impact from virulence factors produced by Staphylococcus aureus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
P. Chieosilapatham, C. Kiatsurayanon, Y. Umehara, J. V. Trujillo-Paez, G. Peng, H. Yue, L. T. H. Nguyen, F. Niyonsaba
Summary: The skin serves as a complex immune organ, with keratinocytes playing a crucial role in the pathogenesis of atopic dermatitis. Activation of keratinocytes contributes to immune dysregulation and biological processes that drive the development of atopic dermatitis. Understanding the innate immune functions of keratinocytes can provide insights into the pathophysiological processes of atopic dermatitis and aid in the development of new therapeutic approaches.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tsugunobu Andoh, Yoko Yoshihisa, Mati Ur Rehman, Yoshiaki Tabuchi, Tadamichi Shimizu
Summary: The study found that berberine has a certain ameliorative effect on the AD-like symptoms in mice, acting by inhibiting the expression of inflammatory factors and the recruitment of inflammatory cells.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Immunology
Xun Chen, Yujin Zhang, Junxia Pei, Xin Zeng, Yixi Yang, YaMei Zhang, Fulun Li, Yu Deng
Summary: Phellopterin, a bioactive compound from the root of Angelica dahurica, has anti-atopic dermatitis effects by inhibiting the activation of STAT3 and reducing the expression of TSLP and IL-33 in epidermal keratinocytes. It shows potential as a candidate for topical therapy of AD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Allergy
Pelin Sahlen, Rapolas Spalinskas, Samina Asad, Kunal Das Mahapatra, Pontus Hojer, Anandashankar Anil, Jesper Eisfeldt, Ankit Srivastava, Pernilla Nikamo, Anaya Mukherjee, Kyu-Han Kim, Otto Bergman, Mona Stahle, Eniko Sonkoly, Andor Pivarcsi, Carl-Fredrik Wahlgren, Magnus Nordenskjold, Fulya Taylan, Maria Bradley, Isabel Tapia-Paez
Summary: This study identified target genes of AD and psoriasis GWAS variants and found differential expression of some genes in AD or psoriasis lesions. Genes like AFG1L, CLINT1 were highlighted as having potential roles in AD and psoriasis. This work provides a catalogue of candidate genes for modulating the risk of AD and psoriasis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Mab P. Correa, Libnah L. Areias, Rebeca D. Correia-Silva, Solange C. G. P. D'Avila, Andreia M. Leopoldino, Karin V. Greco, Cristiane D. Gil
Summary: The study found that the levels of Gal-9 significantly increased in patients with atopic dermatitis and in a mouse experimental model, and it has an immunomodulatory effect on keratinocytes, controlling inflammatory response and cell proliferation process.
Article
Dermatology
Astrid H. Lossius, Teresa L. Berents, Frank Saetre, Hogne R. Nilsen, Maria Bradley, Samina Asad, Guttorm Haraldsen, Olav Sundnes, Jan-oivind Holm
Summary: The early molecular responses to nb-UVB treatment in AD skin showed significant modulation of gene expression related to inflammatory response, melanin synthesis, and other functions. Interestingly, there was a noted decrease in pro-inflammatory cytokine IL-36 gamma and an increase in anti-inflammatory cytokine IL-37 after treatment with nb-UVB. This study provides important insights into the molecular mechanisms behind the treatment response and indicates potential new treatment targets.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Hye-Min Kim, Bo-Ram Jin, Jin-Sil Lee, Eun Heui Jo, Min Cheol Park, Hyo-Jin An
Summary: Fish collagen has anti-atopic dermatitis effects by reducing inflammation and restoring skin barrier protein. It can be administered through multiple routes to alleviate AD symptoms.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Sanggon Lee, Hyun-Jong Ahn, Yong Seek Park, Ji-Hyun Kim, Yoon-Seong Kim, Jeong-Je Cho, Cheung-Seog Park
Summary: The study found that NXP081 has anti-inflammatory effects on AD and can improve its symptoms, indicating its potential therapeutic value.
Article
Cell Biology
Matthew G. Brewer, Stephanie R. Monticelli, Mary C. Moran, Benjamin L. Miller, Lisa A. Beck, Brian M. Ward
Summary: Individuals with atopic dermatitis (AD) are more susceptible to viral infections, but little is known about how the inflammatory environment affects the susceptibility of skin cells to viruses. This study found that under conditions simulating AD, keratinocytes become more susceptible to vaccinia virus (the causative agent of eczema vaccinatum), and this susceptibility can be reduced by inhibiting JAK.
Article
Biochemistry & Molecular Biology
En-Cheng Lin, Chien-Hui Hong
Summary: This study reveals that IL-33 enhances ACE2 expression on keratinocytes via ERK in patients with atopic dermatitis (AD), which may have important implications for the transmission of SARS-CoV-2 in AD patients.
Article
Endocrinology & Metabolism
Odelia Cooper, Vivien S. Bonert, Jeremy Rudnick, Barry D. Pressman, Janet Lo, Roberto Salvatori, Kevin C. J. Yuen, Maria Fleseriu, Shlomo Melmed
Summary: This study evaluated the effect of lapatinib, a tyrosine kinase inhibitor, on aggressive prolactinomas that are resistant to dopamine agonist therapy. While none of the participants achieved the primary endpoint, three showed stable disease and lapatinib was generally well tolerated with reversible side effects.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Yun-Mi Kang, Minho Lee, Hyo-Jin An
Summary: RXA treatment effectively alleviated Dfb-induced AD skin symptoms and clinical severity in mice by reducing IgE, histamine, and inflammatory cytokines levels. RXA inhibited adhesive molecules expression, restored filaggrin expression, upregulated aryl hydrocarbon receptor and sirtuin1, and suppressed nuclear factor kappa cascade in AD models, indicating its potential as an anti-AD candidate.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Allergy
Alain Lefevre-Utile, Melissa Saichi, Peter Olah, Marc Delord, Bernhard Homey, Vassili Soumelis
Summary: The study identified 4 endotypes of AD and discovered key gene sets associated with specific biological pathways. There were significant differences in disease severity and S. aureus colonization between different clusters. These findings could potentially provide new insights into personalized treatment strategies.
Article
Multidisciplinary Sciences
Kristina Lagerstedt-Robinson, Izabella Baranowska Korberg, Stefanos Tsiaprazis, Erik Bjorck, Emma Tham, Anna Poluha, Maritta Hellstrom Pigg, Ylva Paulsson-Karlsson, Magnus Nordenskjold, Maria Johansson-Soller, Christos Aravidis
Summary: Birt-Hogg-Dubé syndrome is a rare autosomal dominant disorder characterized by fibrofolliculomas, pneumothorax, and kidney tumors. The most common pathogenic variant in the Swedish population is c.779+1G>T, and the carrier frequency may be higher than previously estimated.
Article
Dermatology
H. O. Dikmen, K. Yilmaz, S. Benoit, P. Bernard, K. Drenovska, S. Gerdes, R. Glaeser, C. Guenther, B. Homey, O. N. Horvath, L. Huilaja, P. Joly, D. Kiritsi, S. Meller, A. Patsatsi, M. Sardy, F. Schauer, M. Shahid, M. Sticherling, K. Tasanen, S. Vassileva, M. Worm, D. Zillikens, C. D. Sadik, N. van Beek, I. R. Koenig, E. Schmidt
Summary: This study aimed to determine the associations between autoantibody reactivities, comorbidities, and concomitant medication in patients with bullous pemphigoid. The findings suggest a link between autoantibody reactivities and neuropsychiatric comorbidities as well as specific medications.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephan A. Braun, Alexander T. Bauer, Csongor Nemeth, Annamaria Rozsa, Louisa Rusch, Luise Erpenbeck, Sebastian Schloer, Steffi Silling, Dieter Metze, Peter A. Gerber, Stefan W. Schneider, Rolland Gyulai, Bernhard Homey
Summary: Research has found that Ingenol mebutate (IM) is highly effective in treating anogenital warts (AGW) caused by human papillomavirus (HPV), leading to fast ablation of the warts. The study identified that IM induces a prothrombotic environment by activating endothelial cells and promoting neutrophil extracellular traps (NETosis), leading to immunothrombosis and rapid ablation of the warts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Sarah Janssen, Bernhard Homey, Stephan Meller
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oliver H. Weiergraeber, Dusan Petrovic, Andreas Kislat, Martin Pattky, Judith Fabig, Renu Batra-Safferling, Jan Schulte Am Esch, Karen Haenel, Carolin Huhn, Birgit Strodel, Bernhard Homey, Dieter Willbold
Summary: CCL16 is primarily synthesized by hepatocytes, circulates in the blood as a full-length protein, and the C-terminal extension may impair its biological activity modulation.
Review
Dermatology
Anthony Bewley, Bernard Homey, Andrew Pink
Summary: Prurigo nodularis is a rare but often underdiagnosed and underrecognized disease for which there are currently no approved drugs to effectively relieve symptoms. Research on the neuroimmune pathways involved in the disease has led to the discovery of promising emerging treatments.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
Summary: TREATgermany is a disease registry that investigates the severity, symptoms, treatment, and quality of life in patients with moderate to severe atopic dermatitis. The results show that 97.2% of patients experienced itch, and the severity of itch is correlated with the patient's self-reported disease severity.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Longlong Luo, Lorenzo Pasquali, Ankit Srivastava, Jan C. Freisenhausen, Andor Pivarcsi, Eniko Sonkoly
Summary: This study identified LINC00958 as an overexpressed long noncoding RNA in keratinocytes from psoriasis skin lesions. IL-17A induced LINC00958 expression in keratinocytes through C/EBP-b and the p38 pathway. Inhibiting LINC00958 led to decreased cell proliferation and altered expression of cell cycle-related genes in keratinocytes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Surgery
Peter Arne Gerber, Bettina A. Buhren, Edwin Boelke, Wolfgang G. Philipp-Dormston, Bernhard Homey, Holger Schrumpf
Summary: This study found that almost all hyaluronic acid fillers can be dissolved by hyaluronidase in a dose- and time-dependent manner. The technology and degree of cross-linking of the fillers seem to have a stronger effect on degradability by hyaluronidase compared to the concentration of hyaluronic acid.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Medicine, Research & Experimental
Alessio Mylonas, Heike C. Hawerkamp, Yichen Wang, Jiaqi Chen, Francesco Messina, Olivier Demaria, Stephan Meller, Bernhard Homey, Jeremy Di Domizio, Lucia Mazzolai, Alain Hovnanian, Michel Gilliet, Curdin Conrad
Summary: Rosacea is a chronic inflammatory skin disease characterized by excessive inflammation and neovascularization. Bacillus oleronius and kallikrein 5 have been identified as key triggers in the development of rosacea. This study reveals that plasmacytoid dendritic cells produce type I interferons, linking microbial dysbiosis, immune response abnormalities, and neovascularization. The excessive expression of type I interferons leads to neoangiogenesis through IL-22 induction and upregulation of the IL-22 receptor on endothelial cells.
Article
Biochemistry & Molecular Biology
Andreas Kislat, Peter Olah, Marcus Kuchner, Peter Arne Gerber, Juergen Schrader, Stephan Meller, Bernhard Homey
Summary: Alitretinoin, a dual RAR and RXR agonist, targets skin dysregulation and exerts strong immunomodulatory effects on antigen presenting cells, leading to the treatment of chronic hand eczema with remarkable efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Kim Thrane, Marten C. G. Winge, Hongyu Wang, Larry Chen, Margaret G. Guo, Alma Andersson, Xesus M. Abalo, Xue Yang, Daniel S. Kim, Sophia K. Longo, Brian Y. Soong, Jordan M. Meyers, David L. Reynolds, Aaron McGeever, Deniz Demircioglu, Dan Hasson, Reza Mirzazadeh, Adam J. Rubin, Gordon H. Bae, Jim Karkanias, Kerri Rieger, Joakim Lundeberg, Andrew L. Ji
Summary: This study integrates human and mouse skin data to explore the relationship between epidermal homeostasis, skin diseases, and cellular subpopulations, and identifies potential therapeutic targets.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Oncology
Marten C. G. Winge, Laura N. Kellman, Konnie Guo, Jean Y. Tang, Susan M. Swetter, Sumaira Z. Aasi, Kavita Y. Sarin, Anne Lynn S. Chang, Paul A. Khavari
Summary: This Review provides an overview of risk factors and prevention strategies for cSCC, and highlights recent advances in understanding the impact of molecular and cellular intra-tumour heterogeneity in new therapeutic strategies. Despite clinical benefits associated with prevention and therapeutic management, the prognosis for advanced cSCC remains poor. Understanding the interaction between genetic mechanisms driving cSCC and the tumour microenvironment is a current focus in cSCC research.
NATURE REVIEWS CANCER
(2023)
Article
Medicine, Research & Experimental
Danny Jazmati, Balint Tamaskovics, Norman-Philipp Hoff, Bernhard Homey, Edwin Boelke, Belebenie Boyomo, Waseem Garabet, Jan Haussmann, Wilfried Budach, Judith Neuwahl, Hubert Schelzig, Stefanie Corradini, Martijn van Griensven, Johannes Fischer, Wolfram Trudo Knoefel, John Pegani, Alessia Pedoto, Gerald Antoch, Julian Kirchner, Tom Luedde, Noemi F. Freise, Torsten Feldt, Bjoern-Erik Ole Jensen, Verena Keitel, Christiane Matuschek
Summary: Low-dose irradiation is an effective treatment option for persistent lymphatic fistulas after inguinal vascular surgery, preventing infection, sepsis, bleeding, and possible leg amputation. The recommended dose ranges from 0.3-0.5 to 1-12 Gy. In this study, every patient experienced resolution of the lymphatic fistula without major complications.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)