Article
Allergy
Anna R. Wolfson, Dennis Wong, Elissa M. Abrams, Susan Waserman, Gordon L. Sussman
Summary: This article discusses the side effects of diphenhydramine as an antihistamine medication and alternative options, suggesting a move towards newer second-generation antihistamines.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Immunology
Kanokvalai Kulthanan, Martin K. Church, Eva Maria Grekowitz, Tomasz Hawro, Lea Alice Kiefer, Kanyalak Munprom, Yanisorn Nanchaipruek, Chuda Rujitharanawong, Dorothea Terhorst-Molawi, Marcus Maurer
Summary: The study systematically reviewed a large number of literature and found that histamine plays a key role in the pathogenesis of chronic inducible urticaria, but it is not the sole mediator.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Basma Mahrous El-fatatry, Sahar Mohamed El-Haggar, Osama Mohamed Ibrahim, Khaled Hamed Shalaby
Summary: Fexofenadine may be a promising adjunctive therapy in patients with DKD. Further large-scale trials are needed to confirm our preliminary results.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Surgery
Iris M. Reijmerink, Maarten J. van der Laan, J. K. Goetz Wietasch, Lotty Hooft, Fokie Cnossen
Summary: This systematic review examines the effect of non-muscular fatigue on surgical outcome. The findings indicate that almost half of the simulator studies and one-third of the real-life studies consistently report negative effects of fatigue on surgical outcomes. The difference between simulator studies and real-life studies may be attributed to heightened motivation and effort investment in real-life studies. However, the current published studies on fatigue and surgical performance have limitations in terms of measuring fatigue directly and using crude outcome measures.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Allergy
Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes, Mario Sanchez Borges
Summary: This narrative review provides an update on the current knowledge of urticaria, its treatment options, and the safety and efficacy of fexofenadine hydrochloride (HCl). The exact pathogenesis of urticaria remains unclear, but pharmacological approaches are commonly used to control the symptoms. Second-generation non-sedating H1-antihistamines, such as fexofenadine HCl, are recommended as the preferred treatment worldwide. The occurrence of urticaria in COVID-19 patients is also briefly discussed.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rando Asai, Teruna Takeuchi, Keita Kondo, Toshiyuki Niwa
Summary: A novel dosage form called xerogel pills, with dose-adjusting and swallow-assisting functions, was developed for pediatric or geriatric patients. The pills were double-structured small spheres with an inner drug core and an outer dried-gel layer. Fexofenadine hydrochloride was used as a model drug, and xanthan gum was formulated to achieve a smooth mouth-feeling. The pills were easily swallowed and gelled quickly upon contact with water.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Jinxin Zheng, Yongpeng Shang, Yang Wu, Yuxi Zhao, Zhong Chen, Zhiwei Lin, Peiyu Li, Xiang Sun, Guangjian Xu, Zewen Wen, Junwen Chen, Yu Wang, Zhanwen Wang, Yanpeng Xiong, Qiwen Deng, Di Qu, Zhijian Yu
Summary: Loratadine inhibits biofilm formation and reduces virulence of Staphylococcus aureus, leading to decreased mortality in a pulmonary infection model. It also acts synergistically with statins to further reduce bacterial load and inflammation.
Article
Pharmacology & Pharmacy
Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee
Summary: This study aimed to verify the validity of genetic factors through fexofenadine population pharmacokinetic modeling and explore the correlations affecting the pharmacokinetic variability. OATP1B1 and 2B1 were identified as effective covariates of fexofenadine pharmacokinetic variability. The variations in fexofenadine clearance and steady-state plasma concentration were significantly influenced by OATP1B1 polymorphism. OATP1B1 was confirmed to be relatively more important than 2B1 in terms of its effect on fexofenadine pharmacokinetic variability.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Allergy
Eli O. Meltzer, Nelson Augusto Rosario, Hugo Van Bever, Luiz Lucio
Summary: Allergic rhinitis is a common undiagnosed chronic condition in children with moderate/severe symptoms affecting quality of life. While first-generation antihistamines are affordable but cause sedation and cardiovascular side effects, second-generation antihistamines like fexofenadine offer safety and efficacy for children with AR.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Christine M. Wickens, Madison Wright, Robert E. Mann, Bruna Brands, Patricia Di Ciano, Gina Stoduto, Andrew Fares, Justin Matheson, Tony P. George, Juergen Rehm, Paul A. Shuper, Beth Sproule, Andriy Samohkvalov, Marilyn A. Huestis, Bernard Le Foll
Summary: The co-use of alcohol and cannabis is associated with increased frequency and intensity of use and related problems. This study found that cannabis affects mood and subjective experience, with minimal impact on cognitive performance; while alcohol impairs cognitive and psychomotor performance, with minimal impact on mood and subjective experience. The acute effects of alcohol and cannabis combined were mostly additive.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Engineering, Industrial
Arne Nieuwenhuys, Jonas Dora, Melanie Knufinke-Meyfroyt, Debby Beckers, Gerard Rietjens, Pieter Helmhout
Summary: The study found that submariners experienced suboptimal sleep, cognitive performance, and self-reported recovery status throughout a long military mission, with day-to-day fluctuations gradually leading to overall deterioration in performance.
APPLIED ERGONOMICS
(2021)
Editorial Material
Dermatology
Torsten Zuberbier, Sabine Altrichter, Sabine Bauer, Randolf Brehler, Knut Brockow, Corinna Dressler, Joachim Fluhr, Matthew Gaskins, Eckard Hamelmann, Kathrin Kuehne, Hans Merk, Norbert K. Muelleneisen, Alexander Nast, Heidi Olze, Hagen Ott, Marc Pleimes, Franziska Rueff, Petra Staubach-Renz, Bettina Wedi, Marcus Maurer
Summary: This article is the first section of the Urticaria Guideline, focusing on the classification and diagnosis of urticaria, as well as strategies for efficient diagnosis. Urticaria is a severe allergic disease with a lifetime prevalence of almost 20%, which significantly impacts the quality of life and performance of those affected.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Review
Allergy
Carla Carnovale, Vera Battini, Michele Gringeri, Marina Volonte, Maria Chiara Uboldi, Andrea Chiarenza, Giovanni Passalacqua
Summary: This study evaluated the safety of fexofenadine after its switch to over-the-counter (OTC) status in Italy and compared it to other European countries. The results showed that the switch to OTC did not affect the safety of fexofenadine in Italy. The study also found that OTC use of oral antihistamines is acceptable in Europe and larger pack sizes are feasible in Italy.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Multidisciplinary Sciences
Helen A. Banwell, Ryan S. Causby, Alyson J. Crozier, Brendan Nettle, Carolyn Murray
Summary: The use of 3D printed foot models can increase podiatry students' self-confidence and self-efficacy, reduce anxiety, particularly in higher risk situations. Students perceive learning scalpel skills with 3D foot models as 'authentic' and 'lifelike'.
Article
Engineering, Aerospace
Xueting Pan, Honghao Yue, Shufeng Liu, Fei Yang, Yifan Lu, Gang Chen
Summary: This paper proposes a morphing aircraft with a deployable flared skirt and studies the influence of the flared skirt on the static stability of the aircraft. By establishing a theoretical model and using numerical simulation methods, the influence of the flared skirt on the pressure distribution and pressure center position of the aircraft is analyzed. The results show that the static stability of the aircraft with the same forebody is significantly improved by using a flared skirt with a deployment angle of 30 degrees under different flight Mach numbers.
Article
Biochemistry & Molecular Biology
Bolati Wulaer, Kazuo Kunisawa, Kazuhiro Hada, Willy Jaya Suento, Hisayoshi Kubota, Tsubasa Iida, Aika Kosuge, Taku Nagai, Kiyofumi Yamada, Atsumi Nitta, Yasuko Yamamoto, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima
Summary: Deficiency of Shati/Nat8l affects neurogenesis and attentional behavior in mice, possibly through modulation of dopaminergic transmission.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Oncology
Tetsunari Hase, Masayuki Miyazaki, Kazuya Ichikawa, Naoyuki Yogo, Naoya Ozawa, Takahiro Hatta, Masahiko Ando, Mitsuo Sato, Masashi Kondo, Kiyofumi Yamada, Yoshinori Hasegawa
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Psychiatry
Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata, Kazuhiro Hada, Ryosuke Ikeda, Mio Shinno, Chikara Mizukoshi, Keita Tsujimura, Akira Yoshimi, Kanako Ishizuka, Yuto Takasaki, Hiroki Kimura, Jingrui Xing, Yanjie Yu, Maeri Yamamoto, Takashi Okada, Emiko Shishido, Toshiya Inada, Masahiro Nakatochi, Tetsuya Takano, Keisuke Kuroda, Mutsuki Amano, Branko Aleksic, Takashi Yamomoto, Tetsushi Sakuma, Tomomi Aida, Kohichi Tanaka, Ryota Hashimoto, Makoto Arai, Masashi Ikeda, Nakao Iwata, Teppei Shimamura, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada, Daisuke Mori, Norio Ozaki
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Neurosciences
Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
Summary: A study showed that mutations in the Arhgap10 gene associated with schizophrenia may lead to neuronal morphological abnormalities in specific brain regions, which could be related to vulnerability of cognition to methamphetamine treatment.
Article
Biochemistry & Molecular Biology
You-Hsin Lin, Yukie Yamahashi, Keisuke Kuroda, Omar Faruk, Xinjian Zhang, Kiyofumi Yamada, Akihiro Yamanaka, Taku Nagai, Kozo Kaibuchi
Summary: The study revealed that accumbal D2R-MSNs regulate negative reinforcement through the A2aR-PKA-Rap1-MEK pathway. Inhibition of this pathway has been shown to attenuate aversive responses.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yumi Tsuneura, Masahito Sawahata, Norimichi Itoh, Ryoya Miyajima, Daisuke Mori, Takao Kohno, Mitsuharu Hattori, Akira Sobue, Taku Nagai, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
Summary: Reelin, a crucial extracellular matrix protein secreted by Cajal-Retzius cells, plays important roles in brain development and neuronal functions. Reductions in Reelin are associated with brain dysfunctions in mental disorders like schizophrenia. A recent study identified a novel deletion in RELN encoding Reelin in Japanese schizophrenia patients, leading to abnormalities in brain structures and social behavior.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Tsuyoshi Nakai, Kiyofumi Yamada, Hiroyuki Mizoguchi
Summary: Alzheimer's disease is an age-related and progressive neurodegenerative disorder mainly caused by the accumulation of Aβ and tau. Despite various AD mouse models developed, none fully replicate all pathologies present in human AD. APP knock-in mice may offer a better evaluation of candidate therapeutics in early-stage AD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Taku Nagai, Kiyofumi Yamada, Hiroshi Arima
Summary: This study investigated the role of glucocorticoid receptor signaling in the reward system on the rewarding value of a high-fat diet under restricted caloric stress. Results showed that mice lacking functional GRs in dopaminergic neurons did not exhibit a preference for HFD, in contrast to corticostriatal neuron knockout mice and wild-type mice.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Jingzhu Liao, Geyao Dong, Bolati Wulaer, Masahito Sawahata, Hiroyuki Mizoguchi, Daisuke Mori, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada
Summary: The study found that Reln-del mice exhibited delayed learning in visual discrimination and reversal learning tasks, but their behavioral flexibility remained unaffected.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yumi Tsuneura, Tsuyoshi Nakai, Hiroyuki Mizoguchi, Kiyofumi Yamada
Summary: Reelin, an important protein for brain development and function, is found to be associated with neuropsychiatric disorders. Supplementing Reelin could improve learning and neuronal dysfunctions in animal models. Therefore, studying the role of Reelin in neuropsychiatric disorders and potential therapeutic approaches is of great significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Md Omar Faruk, Daisuke Tsuboi, Yukie Yamahashi, Yasuhiro Funahashi, You-Hsin Lin, Rijwan Uddin Ahammad, Emran Hossen, Mutsuki Amano, Tomoki Nishioka, Anastasios Tzingounis, Kiyofumi Yamada, Taku Nagai, Kozo Kaibuchi
Summary: The nucleus accumbens (NAc) plays crucial roles in emotional behaviors, and muscarinic signaling induces the phosphorylation of KCNQ2 at T217 via PKC activation for aversive learning. Electric foot shock and donepezil can induce this phosphorylation, while an M1R antagonist can suppress this process.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Tetsuo Matsuzaki, Yoshiaki Kato, Hiroyuki Mizoguchi, Kiyofumi Yamada
Summary: This study developed a predictive model for initial vancomycin dosing using machine learning, and compared its performance with experts, another machine learning model, and commonly used dosing software. The results showed that our model had a comparable target attainment rate to experts, and it could assist in decision making for initial dosing in the absence of dose planning consultations.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mizuki Uchida, Yukihiro Noda, Sho Hasegawa, Hirotake Hida, Masayuki Taniguchi, Akihiro Mouri, Akira Yoshimi, Toshitaka Nabeshima, Kiyofumi Yamada, Tomomi Aida, Kohichi Tanaka, Norio Ozaki
Summary: The study found that GLAST plays an important role in regulating cognitive and emotional behaviors in mice during neurodevelopment. Dysfunction of early postnatal glutamatergic facilitation by GLAST leads to cognitive and emotional abnormalities, primarily manifested as neurotransmission dysfunction and morphological changes.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Masahito Sawahata, Hiroki Asano, Taku Nagai, Norimichi Ito, Takao Kohno, Toshitaka Nabeshima, Mitsuharu Hattori, Kiyofumi Yamada
Summary: The study showed that microinjection of recombinant Reelin into the medial prefrontal cortex prevented recognition memory impairment induced by MK-801, highlighting the potential therapeutic effects of Reelin on cognitive deficits associated with schizophrenia. Despite this positive effect, Reelin treatment did not ameliorate deficits in sensory-motor gating and short-term memory in the animal model of schizophrenia. The results suggest that Reelin acts on its receptors to suppress neural activity in the mPFC, thereby preventing cognitive deficits induced by MK-801.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Rijwan Uddin Ahammad, Tomoki Nishioka, Junichiro Yoshimoto, Takayuki Kannon, Mutsuki Amano, Yasuhiro Funahashi, Daisuke Tsuboi, Md. Omar Faruk, Yukie Yamahashi, Kiyofumi Yamada, Taku Nagai, Kozo Kaibuchi
Summary: Protein phosphorylation plays a critical role in intracellular signaling pathways and physiological functions in the brain. Dysregulation of these pathways is associated with neurodevelopmental disorders. This study developed an online database to provide information on phosphorylation signals and analyzed related pathways.