Review
Biochemistry & Molecular Biology
Alice Ossoli, Anna Wolska, Alan T. Remaley, Monica Gomaraschi
Summary: High-density lipoproteins (HDL) play a protective role against atherosclerosis and may also impact cancer cell proliferation and tumor progression. Through mechanisms such as reducing cancer cell cholesterol content and decreasing oxidative stress and inflammation, HDL can help inhibit cancer development.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Pharmacology & Pharmacy
Zehui Tan, Tong Li, Hongrui Lei, Xin Zhai
Summary: Histone methylation plays a crucial role in disease development, and current treatments face various challenges. New compounds targeting allosteric sites offer a promising solution, providing new possibilities for epigenetic therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mandy M. T. van Leent, Anu E. Meerwaldt, Alexandre Berchouchi, Yohana C. Toner, Marianne E. Burnett, Emma D. Klein, Anna Vera D. Verschuur, Sheqouia A. Nauta, Jazz Munitz, Geoffrey Prevot, Esther M. van Leeuwen, Farideh Ordikhani, Vera P. Mourits, Claudia Calcagno, Philip M. Robson, George Soultanidis, Thomas Reiner, Rick R. M. Joosten, Heiner Friedrich, Joren C. Madsen, Ewelina Kluza, Roy van der Meel, Leo A. B. Joosten, Mihai G. Netea, Jordi Ochando, Zahi A. Fayad, Carlos Perez-Medina, Willem J. M. Mulder, Abraham J. P. Teunissen
Summary: Immunotherapies focusing on the adaptive immune system have been extensively studied, while research on regulating the innate immune system is still limited. Nanoparticles show promise in engaging the innate immune system through interactions with phagocytic myeloid cells. A modular approach was used to efficiently incorporate various drugs into a nanobiologic platform, leading to prolonged allograft survival in a mouse model through the use of rapamycin-loaded nanobiologics. Additionally, biodistribution and safety of the nanobiologics were evaluated in nonhuman primates, supporting the potential clinical translation of this approach.
Review
Biochemistry & Molecular Biology
Carmelita Abrahams, Nicholas J. Woudberg, Sandrine Lecour
Summary: Doxorubicin is an effective antibiotic used for cancer treatment, but it can also lead to heart failure. Early biomarkers are needed to assess the cardiotoxicity induced by this drug. HDL particles and its components may play a key role in the early development of DOX-induced cardiotoxicity.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Food Science & Technology
Romuald Gaillard, Diane Gagnon, Veronique Perreault, Alice Marciniak, Yves Pouliot, Guillaume Brisson, Alain Doyen
Summary: The impact of ultra-high pressure homogenization (UHPH) on the structure of egg yolk granule proteins was evaluated. UHPH treatment destabilized and modified the structure of egg yolk granules, leading to improved water and oil binding capacities and stability. However, egg yolk granule solubility was not affected. These findings have important implications for the food industry in developing new egg yolk granule-based ingredients.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Immunology
Chaoying Song, Jiqian Xu, Chenggang Gao, Wanying Zhang, Xiangzhi Fang, You Shang
Summary: This article reviews the potential application of nanoparticles in treating sepsis. Macrophages play a significant role in the immune response and pathogenesis of sepsis, and nanoparticles can be used to modulate macrophage function for sepsis treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Hyo-Seon Nam, Dae-Jin Kang, Min-Hee Park, Ju-Hyun Kim
Summary: Long-term alcohol consumption, even in small amounts, causes a significant decrease in serum HDL-C and apoA-I levels in middle-aged women, along with atherogenic changes in LDL and HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sylwia Placzkowska, Katarzyna Solkiewicz, Iwona Bednarz-Misa, Ewa Maria Kratz
Summary: The study aimed to assess the relationship between sdLDL and other metabolic disorder parameters and identify markers of increased sdLDL concentration. The results showed that different lipid parameters and atherogenicity indexes are associated with high sdLDL concentration depending on the age group. Abnormal API and non-HDL-C may indicate cardiovascular disease risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Lisa Maria Mustachio, Anca Chelariu-Raicu, Lorant Szekvolgyi, Jason Roszik
Summary: KRAS, mutated in 25% of human cancers, is crucial for tumorigenesis. Despite difficulties in directly targeting it, success has been found in targeting other proteins in the RAS pathway. Recent findings suggest progress towards developing a direct KRAS inhibitor, highlighting the need for continued research for an optimal treatment for certain tumor types.
Review
Biochemistry & Molecular Biology
Wenli Zhao, Yue Liu, Lijuan Xu, Yuan He, Zhenyu Cai, Jianqiang Yu, Wannian Zhang, Chengguo Xing, Chunlin Zhuang, Zhuo Qu
Summary: This article summarizes the potential role of necroptosis in Alzheimer's disease progression and explores the therapeutic capacity of targeting necroptosis for AD patients.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Food Science & Technology
Francine C. Cadona, Rafael Ferreira Dantas, Gabriela Haas de Mello, Floriano Paes Silva-Jr
Summary: Natural products such as caffeine, theobromine, and (+)-catechin have been studied for their potential therapeutic properties against cancer by targeting different hallmarks and enabling characteristics of the disease. These bioactive molecules exhibit antioxidant, anti-inflammatory, and antitumor capacities, offering new insights into combating cancer and developing novel treatments.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cell Biology
Xiude Ren, Tao Li, Wei Zhang, Xuejun Yang
Summary: Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. It plays a role in the malignant behaviors of cancer cells, but currently there are no effective single-agent treatments. Combining HSP90 inhibitors with other anticancer therapies may be a better strategy.
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Jae-Ryong Kim, In-Chul Lee, Hyung-Jun Kwon
Summary: Native HDL exhibits potent antiviral activity against SARS-CoV-2 without cytotoxicity, while glycation of HDL impairs its antiviral activity. These results may explain why patients with diabetes mellitus or hypertension are more sensitive to COVID-19 infection and have a higher risk of mortality.
Review
Chemistry, Medicinal
Sai Kumar Gadidala, Ebin Johny, Christy Thomas, Mounika Nadella, Krishna Undela, Ramu Adela
Summary: A systematic review and meta-analysis found that garlic can significantly improve cardiovascular disease risk factors such as blood lipids, inflammation markers, and coronary artery calcification in CAD patients. Garlic was shown to reduce LDL levels, increase HDL levels, decrease inflammation, and reduce coronary artery calcification. Subgroup analysis indicated that garlic is particularly effective in reducing cardiovascular risk factors in high-risk patients. The study findings provide consistent evidence that garlic intake reduces CVD risk factors and can be considered a safe natural medicine to alleviate inflammation in CAD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Hyo-Seon Nam, Dae-Jin Kang, Seonggeun Zee, Min-Hee Park
Summary: Regular exercise, especially aerobic exercise, is beneficial for increasing serum high-density lipoprotein-cholesterol (HDL-C) levels in the general population. The optimal intensity and frequency of exercise to increase HDL quantity and enhance HDL quality in middle-aged women need to be determined. This study compared the changes in HDL quantity and quality among middle-aged women depending on exercise intensity, frequency, and duration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Noel Peretti, Alexandre Vimont, Emmanuel Mas, Jean Ferrieres, Patrick Tounian, Julie Lemale, Franck Boccara, Mathilde Di Filippo, Sybil Charriere, Philippe Moulin, Pierre Poinsot, Yves Cottin, Pierre-Henri Ducluzeau, Caroline Dourmap, Bertrand Cariou, Michel Farnier, Francois Paillard, Alain Pradignac, Cecile Yelnik, Antonio Gallo, Eric Bruckert, Sophie Beliard
Summary: Childhood and parental factors, including genetic diagnosis and parental vascular disease, are associated with the initiation of statin therapy in children with HeFH. Genetic diagnosis may be useful for cardiovascular prevention in children.
JOURNAL OF PEDIATRICS
(2023)
Article
Biology
Agnes Ribes, Cedric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Senard, Celine Gales, Veronique Pons
Summary: This study investigated the pharmacology of P2Y(1)-R signaling in various cells and platelets and found that P2Y(1)-R is constitutively active in physiological conditions. The study also identified P2Y(1)-R antagonists that can inhibit this constitutive activation. These findings suggest that targeting P2Y(1)-R constitutive activation could be a promising strategy for antiplatelet therapy.
Review
Geriatrics & Gerontology
Jaqueline Aragoni da Silva, Yves Rolland, Laurent O. Martinez, Philipe de Souto Barreto
Summary: Mitochondrial dysfunction may contribute to age-related decline in intrinsic capacity across multiple domains. However, the evidence regarding the associations between mitochondrial function and intrinsic capacity domains is still limited. Most studies have been cross-sectional with small sample sizes, primarily investigating skeletal muscle and peripheral blood mononuclear cells. The available evidence suggests that mitochondrial function, particularly mitochondrial DNA copy number, is associated with all intrinsic capacity domains, but more robust evidence is found for locomotion than hearing. Further research is needed to confirm the role of mitochondria in maintaining optimal function and promoting healthy aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Leonardo Bencivenga, Mathilde Strumia, Yves Rolland, Laurent Martinez, Philippe Cestac, Sophie Guyonnet, Sandrine Andrieu, Angelo Parini, Alexandre Lucas, Bruno Vellas, Philipe De Souto Barreto, Laure Rouch
Summary: This study aimed to determine the association between plasma levels of the stress-related mitokine growth/differentiation factor 15 (GDF-15), inflammatory biomarkers interleukin 6 (IL-6) and tumor necrosis factor receptor 1 (TNFR-1), and visit-to-visit blood pressure variability (BPV) in community-dwelling older adults. The results showed that higher levels of GDF-15 were significantly associated with increased systolic blood pressure variability (SBPV), but not diastolic blood pressure variability (DBPV).
Article
Cardiac & Cardiovascular Systems
Miloud Cherbi, Francois Roubille, Nicolas Lamblin, Laurent Bonello, Guillaume Leurent, Bruno Levy, Meyer Elbaz, Sebastien Champion, Pascal Lim, Francis Schneider, Alain Cariou, Hadi Khachab, Jeremy Bourenne, Marie-France Seronde, Guillaume Schurtz, Brahim Harbaoui, Gerald Vanzetto, Charlotte Quentin, Xavier Delabranche, Nadia Aissaoui, Nicolas Combaret, Danka Tomasevic, Benjamin Marchandot, Benoit Lattuca, Patrick Henry, Edouard Gerbaud, Eric Bonnefoy, Etienne Puymirat, Philippe Maury, Clement Delmas
Summary: This study evaluated the 1-year outcomes of cardiogenic shock (CS) triggered by ventricular arrhythmia (VA) compared to non-VA triggers. The results showed that although VA-triggered CS did not have a higher mortality rate compared to other triggers, it resulted in more heart transplantations and ventricular assist device (VAD) use, especially in patients with non-ischemic cardiomyopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria Gauthier, Martin Lafrance, Mael Barthoulot, Louis Rousselet, Michele Montaye, Jean Ferrieres, Samantha Huo Yung Kai, Katia Biasch, Marie Moitry, Philippe Amouyel, Jean Dallongeville, Aline Meirhaeghe
Summary: The study aimed to characterize the long-term risk of first recurrence of ACS among survivors of an incident ACS, based on the STEMI/NSTEMI/UA diagnosis. The risk of recurrence did not depend on the type of the incident ACS, but major complications and impaired LVEF increased the risk. The most frequent forms of recurrence were NSTEMI and UA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Jaqueline Aragoni da Silva, Laurent O. Martinez, Yves Rolland, Souad Najib, Mikael Croyal, Bertrand Perret, Nabila Jabrane-Ferrat, Hicham El Costa, Sophie Guyonnet, Bruno Vellas, Philipe de Souto Barreto, MAPT DSA grp
Summary: This study investigated the association between plasma levels of ATPase inhibitory factor 1 (IF1) and intrinsic capacity (IC) in community-dwelling older adults. The findings showed that plasma IF1 levels were associated with IC composite scores, with both low-intermediate and high-intermediate levels being linked to higher scores. This study is the first to demonstrate the relationship between circulating IF1 levels and IC in older adults, but further research is needed to understand the underlying mechanisms.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Jean Ferrieres, Eric Bruckert, Michel Farnier, Michel Krempf, Jean-Jacques Mourad, Baptiste Roux, Francois Schiele
Summary: This online survey studied French cardiologists' lipid-lowering approaches in patients with hypercholesterolemia and high cardiovascular risk. The results showed that most physicians underestimated the cardiovascular risk and selected higher-than-recommended LDL-C targets and less intensive treatment.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Medicine, General & Internal
Thibault Lhermusier, Pascal Motreff, Vincent Bataille, Guillaume Cayla, Bruno Farah, Jerome Roncalli, Meyer Elbaz, Nicolas Boudou, Fransisco Campello-Parada, Frederic Bouisset, Geraud Souteyrand, Emilie Berard, Vanina Bongard, Didier Carrie
Summary: The aim of this trial was to compare the efficacy of ticagrelor and clopidogrel in reducing post-rotational atherectomy troponin release. The results showed no significant difference in troponin release between the ticagrelor and clopidogrel groups. In conclusion, more potent antiplatelet drugs did not affect periprocedural myocardial necrosis in the setting of rotational atherectomy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Jules Merian, Lamia Ghezali, Charlotte Trenteseaux, Thibaut Duparc, Diane Beuzelin, Vanessa Bouguetoch, Guillaume Combes, Nabil Sioufi, Laurent O. Martinez, Souad Najib
Summary: Intermittent fasting interventions can improve insulin sensitivity, lipid metabolism, and prevent atherosclerosis. However, the effects may vary based on sex and dietary composition.
Article
Cardiac & Cardiovascular Systems
Anthony Matta, Laszlo Levai, Jerome Roncalli, Meyer Elbaz, Frederic Bouisset, Vanessa Nader, Stephanie Blanco, Francisco Campelo Parada, Didier Carrie, Thibault Lhermusier
Summary: This study compared the efficacy, safety, and long-term survival outcomes of VIV-TAVR and NV-TAVR. The results showed that there were no significant differences in TAVR success rate, in-hospital complications, and survival outcomes between the two procedures. VIV-TAVR had better early outcomes but a higher non-significant long-term mortality rate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Anthony Matta, Laszlo Levai, Meyer Elbaz, Vanessa Nader, Francisco Campelo Parada, Didier Carrie, Jerome Roncalli
Summary: Spontaneous coronary artery dissection (SCAD) is a condition characterized by sudden rupture of the coronary artery wall, leading to the formation of a false lumen and intramural hematoma. It primarily affects young and middle-aged women without typical cardiovascular risk factors. Fibromuscular dysplasia and pregnancy are strongly associated with SCAD. Two hypotheses, the inside-out and outside-in, have been proposed to explain the pathogenesis of SCAD. Coronary angiography is the gold standard diagnostic test, and intracoronary imaging modalities may be used in cases with ambiguous diagnosis or to guide treatment. Treatment options for SCAD include conservative management, coronary revascularization strategies (such as percutaneous coronary intervention and coronary artery bypass graft), and long-term follow-up. The prognosis for SCAD patients is generally favorable, with spontaneous healing observed in a significant proportion of cases.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Laetitia Lengele, Yves Rolland, Laurent O. Martinez, Sophie Guyonnet, Angelo Parini, Alexandre Lucas, Bruno Vellas, Philipe de Souto Barreto, MAPT DSA Grp
Summary: Plasma levels of GDF-15 are associated with key malnutrition criteria.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Manoj Kumar Honaryar, Rodrigue Allodji, Gaelle Jimenez, Mathieu Lapeyre, Loic Panh, Jeremy Camilleri, David Broggio, Jean Ferrieres, Florent De Vathaire, Sophie Jacob
Summary: This study aimed to evaluate the development of atherosclerotic plaques over 2 years after breast cancer radiotherapy (RT) and their associations with cardiac exposure. The results showed that the risk of overall plaque development was significantly associated with doses to the coronary arteries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Geriatrics & Gerontology
Wan-Hsuan Lu, Sophie Guyonnet, Laurent O. Martinez, Alexandre Lucas, Angelo Parini, Bruno Vellas, Philipe de Souto Barreto
Summary: This study investigated the association between longitudinal intrinsic capacity trajectories and plasma biomarkers of chronic inflammation and mitochondrial dysfunction in older adults. The findings showed that elevated levels of IL-6, TNFR-1, and GDF-15 were associated with a higher risk of multi-impaired intrinsic capacity trajectories.