Article
Cardiac & Cardiovascular Systems
Xianli Wang, Shaokun Yu, Yuting Jian, Hongmin Pan, Jiannan Guo, Jian Wu, Wei Guo
Summary: The study found that hydrogen sulfide (H2S) can prevent oxidative stress injury in extravillous trophoblasts by decreasing ROS concentration, maintaining mitochondrial membrane stability, and promoting apoptosis-inhibiting protein expression in cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nan Chu, Yao Tang, Cheng-Jie Wang, Jiang-Nan Pei, Shou-Ling Luo, Yi Yu, Zhen-Zhen Liu, Hai-Yan Liu, Xue-Min Qiu, Ling Wang, Da-Jin Li, Wei-Rong Gu
Summary: Preeclampsia is associated with a lack of active ANP, and ANP can promote trophoblast invasion by inhibiting autophagy. The study also found that NFYA is one of the transcription factors for PKN3 and ANP can regulate PKN3 expression through NFYA. These findings suggest that ANP can enhance trophoblast invasion by inhibiting autophagy through the AMPK/mTORC1 signaling pathway.
Article
Developmental Biology
Tomoaki Yoshida, Kazuhide Takada, Shihoko Komine-Aizawa, Yoshimasa Kamei, Osamu Ishihara, Satoshi Hayakawa
Summary: Recent studies indicate that Lactobacillus crispatus can promote trophoblast invasion by increasing the activation of MMP-1 and MMP-2, without affecting migration. This suggests that the dominance of Lactobacillus in the endometrium may be beneficial for implantation, but further research is needed to determine if it is favorable for successful placentation at the early stage of pregnancy.
Article
Biochemistry & Molecular Biology
Diana Pintye, Reka Eszter Sziva, Maxim Mastyugin, Marianna Torok, Sonako Jacas, Agnes Lo, Saira Salahuddin, Zsuzsanna K. Zsengeller
Summary: Preeclampsia (PE), a syndrome specific to pregnancy, affects 5-7% of patients and currently has no effective treatment. Early abnormal placental development leads to oxidative stress and release of reactive oxygen species (ROS) in the placenta, resulting in downstream signaling, stabilization of Hypoxia Inducible Factor 1A (HIF1A), and transcription of anti-angiogenic factors sFLT1 and sEng. This study found that the nitroxide-type antioxidant molecule HMP could reduce placental oxidative stress and alleviate PE symptoms in vitro.
Article
Reproductive Biology
Marilin Profita, Elena Fabbri, Enzo Spisni, Paola Valbonesi
Summary: BPA and BPS significantly impact the biological functions of HTR-8/SVneo cells through processes mediated by estrogen receptors and MAPK. BPS induces secretion of interleukins 6 and 8, which can be inhibited by blocking ERK1/2 phosphorylation.
BIOLOGY OF REPRODUCTION
(2021)
Article
Pharmacology & Pharmacy
Dan Qi, Jingyuan Lu, Ziyi Fu, Shanshan Lv, Lili Hou
Summary: In this study, psoralen was found to enhance the proliferation, migration, and invasion abilities of trophoblast cells by upregulating the expression and activity of MMP-2 and MMP-9, and promoting the nuclear translocation of NF-κB p65. Psoralen may serve as a potential repurpose drug candidate for inducing trophoblast cell migration and invasion through the NF-κB pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Developmental Biology
Hongqin Chen, Yanping Zhang, Jin Jia, Jie Ren, Hongbiao Yu, Cairong Zhu, Yanyun Wang, Rong Zhou
Summary: Preeclampsia poses a major challenge for obstetricians, with no effective way to block its development other than terminating the pregnancy. This study found that decreased MSP leads to reduced trophoblast cell invasion, especially in early-onset sPE patients, playing a crucial role in the pathogenesis of PE.
Article
Pharmacology & Pharmacy
Patricia Alves, Cristina Amaral, Natercia Teixeira, Georgina Correia-da-Silva
Summary: In recent years, there has been an increase in cannabis use among pregnant women. The cannabinoids CBD and THC can cross the placenta and may interfere with crucial processes for placental development, compromising pregnancy success.
Article
Immunology
Mallikarjun Gundappa, Vijaya Anand Arumugam, Hsi-Lung Hsieh, Balamuralikrishnan Balasubramanian, Shanmugam Velayuthaprabhu
Summary: Placenta is an important source of Tissue Factor (TF) for initiating coagulation, and aberrant expression of TF has been implicated in thrombosis, inflammation, cancer metastasis, and atherosclerosis. This study aims to investigate the role of TF in placental functions and found that TF-FVIIa interaction modulates TF-dependent integrin signal transduction in trophoblasts, affecting cell invasion.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Environmental Sciences
Ying Liao, Jiayuan Zhao, Shiqin Peng, Lei He, Yu Wang, Yang Li, Danwei Ma, Yanan Wang, Liang Sun, Hong Zheng, Wenke Yang, Fengyan Dai, Jiayuan Zhao
Summary: This study demonstrated the cytotoxicity of MeHg on HTR-8/SVneo cells, inducing apoptosis and impacting cell migration and invasion capabilities through increased oxidative stress and altered gene expression. The findings contribute to understanding the potential adverse effects and mechanisms of MeHg exposure during pregnancy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Obstetrics & Gynecology
Tingting Li, Sumei Wei, Conghong Fan, Dongmei Tang, Dan Luo
Summary: This study demonstrated that Nesfatin-1 promotes trophoblast cell proliferation, migration, invasion, and EMT while suppressing oxidative stress by activating the PI3K/AKT/mTOR and AKT/GSK3 beta signaling pathways, suggesting a potential therapeutic target for preeclampsia.
REPRODUCTIVE SCIENCES
(2021)
Article
Environmental Sciences
Ying Liao, Hong Zheng, Langbo Wu, Lei He, Yu Wang, Yangsong Ou, Hongjun Yang, Shiqin Peng, Fengwang Chen, Xiaoyan Wang, Jiayuan Zhao
Summary: This study reveals that the accumulation of cadmium in the human body through food chain can lead to adverse pregnancy outcomes. The cytotoxic effects of Cd on HTR-8/SVneo cells include disruption of cellular submicrostructure, promotion of oxidative stress and apoptosis, and reduction of migration and invasion capabilities. Cd can also upregulate genes related to oxidative stress, inflammatory response, cell cycle, apoptosis, migration and invasion, impacting cell functions.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Toxicology
Qingfang Deng, Qiyou Wan, Juan Liao, Derong Fang, Linglu Wang, Shimin Xiong, Pei Xu, Xubo Shen, Quan Li, Yuanzhong Zhou
Summary: Nickel nanoparticles (Ni NPs) inhibit the migration and invasion functions of extravillous trophoblast cells by downregulating the PI3K/AKT/MMP2 signaling pathway. This study is important for the development of safety evaluation criteria for Ni NPs.
TOXICOLOGY IN VITRO
(2022)
Article
Reproductive Biology
Feng Dong, Pan Xiao, Xiangyang Li, Pengxiang Chang, Wenyi Zhang, Lan Wang
Summary: The study found that CdCl2 induced oxidative stress and mitochondrial damage in trophoblast cells, leading to apoptosis. Apoptosis was mediated by regulating the Bax/Bcl-2 ratios and activating the apoptotic molecule caspase-3. NAC could alleviate the damage and apoptosis caused by CdCl2. In the mouse experiment, CdCl2 only induced apoptosis in trophoblast cells.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rosario Macchi, Agustina D. Sotelo, Andrea C. Parrado, Luciana S. Salaverry, Guillermo A. Blanco, Marisa S. Castro, Estela B. Rey-Roldan, Andrea M. Canellada
Summary: During implantation in humans, there is a deep interaction between the endometrium and the invading trophoblast. The AT1 receptor is involved in the reciprocal dialogue occurring between endometrial stroma and trophoblast cells. Angiotensin II (Ang II) can promote endometrial decidualization and secretion of CXCL8 and MMP-2 in human endometrial stromal cells. Treatment with losartan, an AT1 receptor blocker, can inhibit the effects of Ang II on T-HESC and trophoblast migration.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Developmental Biology
Milica Jovanovic Krivokuca, Aleksandra Vilotic, Ivana Stefanoska, Zanka Bojic-Trbojevic, Ljiljana Vicovac
Summary: Macrophage migration inhibitory factor (MIF) is a versatile cytokine that plays an important role in early pregnancy events and is associated with several placental pathological conditions, including infection, preeclampsia, gestational diabetes mellitus, and choriocarcinoma.
Review
Biochemistry & Molecular Biology
Maja Kosanovic, Alicia Llorente, Sofija Glamoclija, Jose M. Valdivielso, Milica Bozic
Summary: Renal fibrosis is a complex disorder without cure, in which extracellular vesicles (EVs) play a crucial role in transferring signaling messengers between different renal compartments. EVs have shown renoprotective effects and potential therapeutic applications in renal fibrosis. The advantages and future perspectives of using EVs as therapeutic agents in renal diseases have also been highlighted in recent studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Transplantation
Milica Bozic, Juan M. Diaz-Tocados, Marcelino Bermudez-Lopez, Carles Forne, Cristina Martinez, Elvira Fernandez, Jose M. Valdivielso
Summary: The study found that SHPT and hyperphosphatemia are independently associated with CKD progression and cardiovascular event incidence in CKD patients, while hypercalcemia does not act as an effect modifier for SHPT.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Milica Jovanovic Krivokuca, Aleksandra Vilotic, Mirjana Nacka-Aleksic, Andrea Pirkovic, Danica Cujic, Janko Legner, Dragana Dekanski, Zanka Bojic-Trbojevic
Summary: Galectins play important roles in pregnancy, affecting placental development, immune regulation, angiogenesis, and are associated with some pregnancy-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maja Kosanovic, Bojana Milutinovic, Sofija Glamoclija, Ingrid Mena Morlans, Alberto Ortiz, Milica Bozic
Summary: Acute kidney injury (AKI) is a sudden decline of renal function for which there are currently no treatments. Extracellular vesicles (EVs) are nanoparticles that mediate intercellular communication in the kidney and have potential diagnostic and therapeutic applications in AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Abrar Ul Haq Khan, Hamideh Salehi, Catherine Alexia, Jose M. Valdivielso, Milica Bozic, Isabel C. Lopez-Mejia, Lluis Fajas, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Delphine Gitenay, Martin Villalba
Summary: This study shows that glucose starvation or sustained pyruvate dehydrogenase activation can induce genetic remodeling to enhance fatty acid oxidation in cells. The signaling pathway MEK5/ERK5 plays a key role in this process, regulating lipid transport, activation of acyl-CoA synthetase long-chain family members, and induction of acyl-CoA dehydrogenases.
Article
Cardiac & Cardiovascular Systems
Kunihiro Matsushita, Stephen Kaptoge, Steven H. J. Hageman, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J. Brunskill, Alex R. Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T. Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H. Jafar, Simerjot K. Jassal, Takamasa Kayama, Csaba P. Kovesdy, Gijs W. Landman, Andrew S. Levey, Donald M. Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N. Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J. Pena, Kevan R. Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P. Schneider, Varda Shalev, Michael G. Shlipak, Marit D. Solbu, Nikita Stempniewicz, James Tollitt, Jose M. Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick A. N. Dorresteijn, Emanuele Di Angelantonio, Frank L. J. Visseren, Lisa Pennells, Josef Coresh
Summary: This study developed an "Add-on" method to incorporate chronic kidney disease (CKD) measures into cardiovascular disease (CVD) risk prediction algorithms, which improved the predictive accuracy. This approach will assist clinicians and patients in more precise risk assessment and personalized preventive therapies for CKD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Vilotic, Mirjana Nacka-Aleksic, Andrea Pirkovic, Zanka Bojic-Trbojevic, Dragana Dekanski, Milica Jovanovic Krivokuca
Summary: This review summarizes the role of interleukin-6 (IL-6) and interleukin-8 (IL-8) in healthy and pathological pregnancies. The authors provide an overview of the expression of these cytokines during pregnancy and discuss their involvement in pregnancy establishment, parturition, and various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Juan F. Navarro-Gonzalez, Carmen Mora-Fernandez, Juan Miguel Diaz-Tocados, Milica Bozic, Marcelino Bermudez-Lopez, Marisa Martin, Jose Manuel Valdivielso
Summary: This study found that elevated serum phosphate and intact FGF23 levels were closely associated with an increased risk of anemia in patients with chronic kidney disease. Low phosphate levels amplified the effect of intact FGF23 concentration on anemia.
Review
Nutrition & Dietetics
Mirjana Nacka-Aleksic, Andrea Pirkovic, Aleksandra Vilotic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Francesca Giampieri, Maurizio Battino, Dragana Dekanski
Summary: This narrative review focuses on the role of polyphenols in both healthy and pathological pregnancy, including early-pregnancy events and common pregnancy-associated pathological conditions. It also discusses the potential risk of polyphenol consumption on pregnancy outcomes and emphasizes the need for further research.
Article
Biochemistry & Molecular Biology
Andrea Pirkovic, Aleksandra Vilotic, Suncica Borozan, Mirjana Nacka-Aleksic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Maurizio Battino, Francesca Giampieri, Dragana Dekanski
Summary: The bioactive compound oleuropein derived from olives was evaluated for its effects on damage induced by hydrogen peroxide in human trophoblast cells in vitro. The study found that oleuropein had cytoprotective effects by improving antioxidant status, preventing protein and lipid damage, and reducing iNOS levels.
Article
Hematology
Maite Caus, Cristina Alonso-Montes, Jose Luis Fernandez-Martin, Manuel Marti-Antonio, Milica Bozic, Jose M. Valdivielso
Summary: This study investigated the role of local vitamin D signaling in vascular smooth muscle cells (VSMCs) during chronic kidney disease (CKD)-induced vascular calcification (VC). The results showed that CKD-affected patients and mice with CKD exhibited increased VC and arterial expression of vitamin D receptor (VDR). Conditional gene silencing of VDR in VSMCs led to a significant decrease in VC in the mouse model of CKD. In addition, miR-145a was found to be involved in VC, and its expression was recovered in animals with deletion of VDR in VSMCs.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maja Kosanovic, Bojana Milutinovic, Tanja J. Kutzner, Yanis Mouloud, Milica Bozic
Summary: Kidney disease is a growing public health problem worldwide, and current therapies only slow down the progression of the disease. One promising approach for treatment is mesenchymal stromal/stem cell (MSC) therapy, which has shown beneficial effects in preclinical studies. Another potential therapy option is the use of extracellular vesicles (EVs) released by MSCs, which have regenerative, anti-inflammatory, and immunomodulatory properties. However, there is limited clinical data available regarding the use of MSC-EVs in kidney pathologies. This review article provides an overview of the renoprotective effects of MSC-EVs in different preclinical models of kidney disease and emphasizes the need for standardized methods for characterizing EV-based products and investigating dosing, safety, efficacy, and potency assays for MSC-EVs.
Meeting Abstract
Cardiac & Cardiovascular Systems
K. Matsushita, S. Kaptoge, S. H. J. Hageman, F. L. J. Visseren, L. Pennells, J. Coresh
EUROPEAN HEART JOURNAL
(2022)
Article
Biology
Natasa Ilic, Zanka Bojic-Trbojevic, Britta Lundstroem-Stadelmann, Danica Cujic, Ivana Mitic, Alisa Gruden-Movsesijan
Summary: This study demonstrates the immunomodulatory potential of Trichinella spiralis muscle larvae excretory-secretory products and suggests their possible use as a treatment for inflammatory disorders. The isolated proteins possess galectin-1 properties and induce tolerogenic dendritic cells and regulatory T cells.
