Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 495, Issue 1, Pages 49-55Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2009.12.015
Keywords
RRR-alpha-tocopherol; Gene expression; Synthetic alpha-tocopherol; T-cell
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Funding
- NIDDK NIH HHS [P30 DK040561-14, P30 DK040561] Funding Source: Medline
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Mice were supplemented with low and high doses of natural and synthetic vitamin E, T cells from the spleen isolated and stimulated with plate-bound anti-CD3 and soluble anti-CD28, and gene expression changes assessed by gene array experiments. The data obtained indicate significant qualitative and quantitative differences between the two vitamin forms in regulating gene expression in response to T-cell stimulation. Marker genes have been found whose expression can be considered significant in establishing the level of, and response to vitamin E for both natural and synthetic vitamin E supplementation; unique markers for synthetic vitamin E supplementation and unique markers for natural vitamin E supplementation have been identified. (C) 2009 Elsevier Inc. All rights reserved.
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