Design, Synthesis, and Evaluation of Non-ATP-Competitive Small-Molecule Polo-Like Kinase 1 (Plk1) Inhibitors

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1

(2013) Ravichandran N. Murugan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay

(2013) Jing Lu et al.   PLoS One

Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic

(2012) Zhou Yin et al.   ACS Chemical Biology

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

(2012) Fa Liu et al.   ACS Chemical Biology

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)

(2012) Wen-Jian Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1

(2012) Fa Liu et al.   CHEMBIOCHEM

Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

(2011) Juping Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

PLK1 as an oncology target: current status and future potential

(2011) Campbell McInnes et al.   DRUG DISCOVERY TODAY

Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity

(2011) Ravichandran N. Murugan et al.   MOLECULES AND CELLS

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

(2011) Fa Liu et al.   Nature Chemical Biology

Identification and Validation of a Potent Type II Inhibitor of Inactive Polo-like Kinase 1

(2009) Sarah Keppner et al.   ChemMedChem

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

(2009) Sang-Moon Yun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY