Journal
ARCHIV DER PHARMAZIE
Volume 346, Issue 11, Pages 805-811Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201300240
Keywords
Antioxidant activity; Pyrimidones; Xanthine oxidase inhibitory activity
Funding
- Vision Group on Science and Technology, Department of Information Technology, Biotechnology and Science & Technology, Government of Karnataka, Bangalore, under the scheme CISEE-programme
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The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate-lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds 5a-j and also their antioxidant activities. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. On the other hand, compounds 5g and 5j exhibited moderate antioxidant activity.
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