4.5 Article

Synthesis, Molecular Modelling and Biological Evaluation of 4-Amino-2(1H)-quinazolinone and 2,4(1H,3H)-Quinazolidone Derivatives as Antitumor Agents

Journal

ARCHIV DER PHARMAZIE
Volume 344, Issue 12, Pages 810-820

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201000312

Keywords

4-Amino-2(1H)-quinazolinone; Antitumor activity; 2; 4(1H; 3H)-Quinazolidone

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A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)-quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines.

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