Journal
ARCHIV DER PHARMAZIE
Volume 342, Issue 5, Pages 281-290Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200800149
Keywords
Anti-HIV activity; 4-Hydroxycoumarin; NNRTIs; s-Triazines
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Novel 2-(coumarin-4-yloxy)-4,6-(substituted)-s-triazine derivatives i.e., diaryltriazine (DATA) are reported as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs), were synthesized and their activities against human immunodeficiency virus HIV-1 (III-B), HIV-2 (ROD), and the double RT Mutant HIV-1 (K103N and Y181C) were assessed. Modifications at positions 4 and 6 of the coumarinyl-triazine scaffold generated interesting derivatives displaying good to moderate anti-HIV activity against selected HIV strains as compared to nevirapine and efavirenz. The synthesized compounds were characterized by FTIR, H-1-NMR, and mass spectral data together with elemental analysis.
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