Article
Biochemistry & Molecular Biology
Louise N. Lindback, Yuzhao Hu, Amanda Ackermann, Oliver Artz, Ullas Pedmale
Summary: Light is a crucial signal sensed by CRY receptors to regulate growth and circadian clock. This study uncovers the role of UBP12/13 deubiquitinases in negatively regulating CRY2 and modulating hypocotyl growth. UBP12/13 interacts with COP1 to stabilize it, leading to degradation of CRY2 under blue light. The findings provide insight into the regulation of deubiquitinase activity and its role in controlling plant growth.
Article
Multidisciplinary Sciences
Simon Miller, Manish Kesherwani, Priscilla Chan, Yoshiko Nagai, Moeri Yagi, Jamie Cope, Florence Tama, Steve A. Kay, Tsuyoshi Hirota
Summary: This study elucidated the selectivity of SHP656 for CRY2 and identified the R form of SHP656 as the active isomer. The findings suggest a direct role of CRY2 in glioblastoma antitumorigenesis and provide a rationale for the selective modulation of CRY isoforms in the therapeutic treatment of glioblastoma and other circadian clock-related diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yadi Chen, Xiaohua Hu, Siyuan Liu, Tiantian Su, Hsiaochi Huang, Huibo Ren, Zhensheng Gao, Xu Wang, Deshu Lin, James A. Wohlschlegel, Qin Wang, Chentao Lin
Summary: The degradation of the plant blue light receptor CRY2 is determined by two distinct E3 ubiquitin ligases, Cul4(COP1/SPAs) and Cul3(LRBs), regulating the function of CRY2 under different light conditions.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Jie Fan, Feng Gao, Xiang Wang, Qian Liu, Jie Xia, Yan Han, Jinyao Yi, Changlian Tan, Xiongzhao Zhu
Summary: This study examined the impact of childhood trauma (CT) on amygdala and hippocampus functional connectivity (FC) and its association with major depressive disorder (MDD). The results showed that individuals with moderate-to-severe CT had decreased right amygdala-right precuneus connectivity irrespective of MDD diagnosis. This connectivity was significantly correlated with physical and social trait anhedonia in MDD. The findings highlight the role of CT in the FC between right amygdala and right precuneus, suggesting a potential mechanism linking CT and depression through trait anhedonia.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Zhiwei Zhao, Craig Dent, Huafeng Liang, Junqing Lv, Guandong Shang, Yawen Liu, Fan Feng, Fei Wang, Junhong Pang, Xu Li, Libang Ma, Bing Li, Sridevi Sureshkumar, Jia-Wei Wang, Sureshkumar Balasubramanian, Hongtao Liu
Summary: Blue light and CRY2 play critical roles in regulating thermosensory flowering in Arabidopsis by modulating RNA alternative splicing. CRY2 interacts with the splicing factor CIS1 in a blue light-dependent manner to promote thermosensory flowering. These findings uncover the molecular mechanism of blue light in temperature-sensitive flowering.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Chengcheng Zhang, Peiyan Ni, Sugai Liang, Xiaojing Li, Yang Tian, Xiangdong Du, Wei Wei, Yajing Meng, Jinxue Wei, Xiaohong Ma, Wei Deng, Wanjun Guo, Mingli Li, Hua Yu, Liansheng Zhao, Qiang Wang, Sham C. Pak, Tao Li
Summary: Patients with bipolar depression or unipolar depression shared gray matter volume abnormalities in the right thalamus. The PER3 and CRY2 genes may play critical roles in right hippocampal dysfunction in bipolar depression and right thalamic dysfunction in unipolar depression, respectively. These findings provide potential molecular targets for the treatment of mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Arti Gandhi, Jasmine Mote, Daniel Fulford
Summary: The research found that individuals with Major Depressive Disorder (MDD) and Schizophrenia Spectrum Disorder (SSDs) experience higher levels of physical and social anhedonia compared to controls. Depressive symptom severity influences the differences in physical anhedonia, while age moderates the differences between social and physical anhedonia in the SSD group.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Wei Zheng, Li-Mei Gu, Chen-Hui Sun, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Yu-Ping Ning
Summary: This study found that repeated ketamine infusions appeared to be effective at rapidly ameliorating anhedonia in Chinese individuals suffering from MDD and BD, with similar efficacy between the two groups.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Spencer D. Balay, Tobias Hochstoeger, Alexandra Vilceanu, E. Pascal Malkemper, William Snider, Gerhard Duernberger, Karl Mechtler, Stefan Schuechner, Egon Ogris, Gregory C. Nordmann, Lyubov Ushakova, Simon Nimpf, David A. Keays
Summary: Research on the pigeon retina revealed two distinct transcript variants of clCRY2, with clCRY2a distributed throughout all retinal layers and clCRY2b enriched in the inner and outer nuclear layers. Proteomic analysis showed that clCRY2a/b interacts with typical circadian molecules, cell junction proteins, and components associated with the microtubule motor dynein.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Wenjiao Min, Xueli Sun, Nie Tang, Yaoyin Zhang, Fang Luo, Min Zhu, Wei Xia, Bo Zhou
Summary: This study aimed to explore a new treatment model for type 2 diabetes mellitus (DM) based on rhythm regulation under the framework of psychosomatic medicine. By using psychotropics as rhythm regulators, 178 patients with DM were divided into three groups and treated for 16 weeks. After the treatment, blood glucose and glycosylated hemoglobin levels in all three groups decreased, and the incidence of abnormal hypothalamic-pituitary-adrenal axis and somatic symptom scores significantly decreased in the psychotropic treatment group and combined treatment group. These findings suggest that blood glucose control plus rhythm regulation can be considered as optimized treatment goals for DM, and psychotropics have potential value for clinical application as biorhythm regulators.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Brian D. Kangas, Annabel K. Short, Oanh T. Luc, Hal S. Stern, Tallie Z. Baram, Diego A. Pizzagalli
Summary: Exposure to early-life adversity leads to blunted response biases in the Probabilistic Reward Task (PRT) and decreased sucrose preference, indicating anhedonic-like phenotypes. The unpredictability of maternal care during early life is identified as a key driver of reward sensitivity deficits, highlighting the importance of maternal signals in shaping reward circuitry. The PRT is established as a powerful tool to assess the impact of early-life adversity on reward circuitry across different species.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Reproductive Biology
Guoli Zhou, Thu Duong, Eric P. Kasten, Hanne M. Hoffmann
Summary: This study examined the association of 10 core circadian transcripts in maternal blood with preterm birth, finding that CLOCK and CRY2 transcripts were significantly lower in preterm birth cases in the 2nd trimester. Changes in PER3 mRNA from trimesters 2-3 were also associated with preterm birth, with identified pathways related to neuron death, parturition, and uterine excitability during pregnancy.
BIOLOGY OF REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Simon Miller, Ashutosh Srivastava, Yoshiko Nagai, Yoshiki Aikawa, Florence Tama, Tsuyoshi Hirota
Summary: Intrinsic structural differences between CRY1 and CRY2, particularly in the FAD pocket and lid loop, can be targeted for isoform-selective regulation using compounds like KL101 and TH301.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Juanjuan Ren, Zhiguo Wu, Daihui Peng, Jia Huang, Weiping Xia, Jingjing Xu, Chenglei Wang, Lvchun Cui, Yiru Fang, Chen Zhang
Summary: This study investigated the differences in anhedonia and its cognitive correlates between first episode of depression (FED) and recurrent depression (RD). The results showed that RD patients had more severe symptoms of anhedonia and cognitive impairment compared to FED patients. There was a significant correlation between cognitive symptoms and anhedonia, and different medications had different effects on cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biology
Vijay K. Jidigam, Onkar B. Sawant, Rebecca D. Fuller, Kenya Wilcots, Rupesh Singh, Richard A. Lang, Sujata Rao
Summary: Research has shown that clock genes are expressed in the mouse embryonic retina, and this expression requires light cues. Deletion of Bmal1 and Per2 from retinal neurons leads to retinal angiogenic defects, indicating that a dysregulated circadian clock primarily drives neovascularization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Timo Partonen, Jari Haukka, Liisa Kuula, Anu-Katriina Pesonen
Summary: The interaction between the main circadian clock and the homeostatic sleep process forms a time-sensitive window for easy falling asleep in the evening, which is influenced by thermoregulation. Changes in skin and core body temperatures before sleep onset may directly affect sleep regulation. A study found that wrist skin temperatures increased by an average of 0.6 degrees Celsius in the 10 minutes before sleep onset and could be tracked reliably over time.
BIOLOGICAL RHYTHM RESEARCH
(2022)
Letter
Dermatology
Annina Raita, Iina-Maria Haggqvist, Heli Joronen, Veera Nikkola, Riitta Huotari-Orava, Lasse Ylianttila, Hannu Kautiainen, Erna Snellman, Rafael Pasternack, Timo Partonen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Neurosciences
Eunsoo Moon, Timo Partonen, Serge Beaulieu, Outi Linnaranta
Summary: This systematic review and meta-analysis examines the effects of melatonin supplements and agonists on sleep-wake cycle and melatonin circadian rhythm. It found that these agents can advance the sleep-wake cycle in both healthy participants and patients with psychiatric disorders, indicating their potential value in regulating circadian rhythms.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Oskari Heikinheimo, Elena Toffol, Timo Partonen, Anna But, Antti Latvala, Jari Haukka
Summary: This study aimed to assess the associations between the patterns of use of different hormonal contraceptives and the risk of venous thromboembolism. The results showed that ethinylestradiol-containing combined preparations were associated with increased risk, while estradiol-containing combined preparations only had a slightly increased risk, and progestin-only contraception was not associated with venous thromboembolism risk.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Psychiatry
Raimo Palmu, Seppo Koskinen, Timo Partonen
Summary: Limited evidence suggests a significant association between seasonal variations in mood and behavior and suicidality and worthlessness. This study analyzed nationwide data from Finland and found that seasonal variations in mood and behavior were significantly associated with both suicidality and worthlessness.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Immunology
Zsofia Hevesi, Daniela Anna Gerges, Sebastian Kapps, Raimundo Freire, Sophie Schmidt, Daniela D. Pollak, Klaus Schmetterer, Tobias Frey, Rita Lang, Wolfgang Winnicki, Alice Schmidt, Tibor Harkany, Ludwig Wagner
Summary: Researchers engineered a divalent gene construct combining the receptor-binding domain (RBD) of the spike protein and the immunodominant region of the viral nucleocapsid. They demonstrated that this approach can effectively generate antibody response and stimulate T cell immune response.
Article
Psychiatry
Kaisla Komulainen, Christian Hakulinen, Jari Lipsanen, Timo Partonen, Laura Pulkki-Raback, Mika Kahonen, Marianna Virtanen, Reija Ruuhela, Olli Raitakari, Marko Elovainio
Summary: Evidence suggests that solar insolation may contribute to symptom-specific differences in depression, with higher levels of solar insolation associated with lower likelihood of reporting suicidal thought and higher likelihoods of reporting changes in appetite, sleep, and feelings of worthlessness/guilt.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Raimo Palmu, Seppo Koskinen, Timo Partonen
Summary: Higher scores on the GHQ-12 are associated with an increased likelihood of suicidal ideation and suicide attempts. Specifically, item 6 and item 11 are associated with both suicidal ideation and suicide attempts, while item 7 is only associated with suicide attempts.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Genetics & Heredity
Michael N. Weedon, Samuel E. Jones, Jacqueline M. Lane, Jiwon Lee, Hanna M. Ollila, Amy Dawes, Jess Tyrrell, Robin N. Beaumont, Timo Partonen, Ilona Merikanto, Stephen S. Rich, Jerome Rotter, Timothy M. Frayling, Martin K. Rutter, Susan Redline, Tamar Sofer, Richa Saxena, Andrew R. Wood
Summary: The effects of previously reported rare genetic variants on extreme sleep conditions and circadian phenotypes are generally less penetrant in the general population, with few highly penetrant associations observed.
Article
Public, Environmental & Occupational Health
Soili Tormalehto, Tanja Svirskis, Timo Partonen, Erkki Isometsa, Sami Pirkola, Marianna Virtanen, Reijo Sund
Summary: This study examines the seasonal patterns of hospital admissions in patients with mood and psychotic disorders and investigates whether the admission rates vary according to the seasonal daylength. The findings indicate that manic episodes peak in summer and have the lowest rates in winter. Unipolar depressive episodes peak in autumn and spring and have lower rates in summer. There is a similar seasonal pattern between schizophrenia and manic episodes, as well as between unipolar depressive, bipolar depressive, and mixed episodes.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Psychiatry
Spyros Sideromenos, Maria Nikou, Barbara Czuczu, Nikolas Thalheimer, Anna Gundacker, Orsolya Horvath, Laura Cuenca Rico, Peter Stoehrmann, Marco Niello, Timo Partonen, Daniela D. Pollak
Summary: Based on a genetic model study, it was found that the absence of the neural regulator USF-1 can alleviate depression and anxiety behaviors in mice. This modulation of mood states is unrelated to USF-1-dependent brown fat tissue activation but is associated with structural changes in hippocampal neurons.
TRANSLATIONAL PSYCHIATRY
(2022)
Editorial Material
Clinical Neurology
Timo Partonen
Article
Psychiatry
Raimo Palmu, Timo Partonen
Summary: Suicide prevention requires measures and understanding the role of adverse childhood experiences can help elucidate the suicide process and identify suicide risk.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Timo Partonen, Elena Toffol, Antti Latvala, Oskari Heikinheimo, Jari Haukka
Summary: Limited evidence suggests that the use of hormonal contraception may be associated with insomnia. A nationwide study of women aged 15-49 found significant associations between hormonal contraception use and insomnia. Specific products, such as drospirenone and ethinylestradiol, were associated with decreased odds of insomnia, while levonorgestrel-releasing intrauterine devices and vaginal rings with etonogestrel and ethinylestradiol were associated with increased odds of insomnia.
Article
Public, Environmental & Occupational Health
Raimo Palmu, Timo Partonen
Summary: This study found that cynical hostility and sense of coherence are related to suicidal thoughts. Cynical hostility increases the occurrence of suicidal thoughts, while sense of coherence can protect individuals from such thoughts.
HEALTH SCIENCE REPORTS
(2023)