Article
Environmental Sciences
Rosario Planello, Roberto Rosal, Monica Aquilino, Oscar Herrero
Summary: The study assessed the toxicity of PAMAM dendrimers using a model insect, showing that G3-NH2 dendrimers induced more significant transcriptional alterations compared to G3-OH dendrimers, with both dendrimers producing persistent transcriptional changes even after compound withdrawal, with the lowest concentration being the most toxic. Additionally, both dendrimers demonstrated genotoxic effects on DNA.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Laura Passatore, Fabrizio Pietrini, Serena Carloni, Lorenzo Massimi, Chiara Giusto, Massimo Zacchini, Valentina Iannilli
Summary: This study investigated the toxicity effects of bismuth (Bi) on garden cress plants. The results showed that low concentrations of Bi had no significant effects, but higher concentrations caused toxicity in terms of germination index and root length reduction. Bi exposure also induced genotoxicity and metal accumulation in the plants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Chemical
Carlo A. Tamanaha-Vegas, Jacquelyne Y. Zarria-Romero, Jean-Marc Greneche, Edson C. Passamani, Juan A. Ramos-Guivar
Summary: A ternary magnetic nanohybrid composed of maghemite, titanium dioxide, and graphene oxide was synthesized and its magnetic properties were systematically studied. Acute toxicity tests on Daphnia Magna water fleas showed toxic effects of the nanohybrid.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Environmental Sciences
Beatriz Salesa, Javier Torres-Gavila, Encarnacion Sancho, Maria Dolores Ferrando
Summary: In this study, the ecotoxicological effects of Pyriproxifen, an insecticide, on the crustacean Daphnia magna were evaluated. Acute toxicity tests, feeding behavior tests, and chronic toxicity tests were conducted on the parental daphnid generation (F0). The results showed that exposure to Pyriproxifen led to a decrease in reproductive parameters and population growth rate in the F0 generation, while the survival rate remained unaffected. Offspring from the F0 generation also exhibited abnormalities in morphology and a decrease in reproductive parameters. Additionally, the appearance of males among the F0 offspring was observed.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Sylwia Charazinska, Pawel Lochynski, Marta Markiewicz, Stefan Stolte, Ewa Burszta-Adamiak
Summary: The amount of industrial pollution in the environment and its impact on living organisms is a concern. This study investigated the influence of metal ions in industrial wastewater on Daphnia magna. It was found that the organic content in the wastewater had a positive impact on the survival of D. magna and the range of heavy metal concentrations tolerated by them. The two-stage process of Ca(OH)2 neutralisation followed by sorption with peat effectively removed almost 100% of metal ions from the wastewater.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Williams Nascimento de Siqueira, Elvis Joacir de Franca, Dewson Rocha Pereira, Maira de Vasconcelos Lima, Hianna Arely Milca Fagundes Silva, Jose Luis Ferreira Sa, Hallysson Douglas Andrade de Araujo, Ana Maria Mendonca de Albuquerque Melo
Summary: The study investigated the genotoxic and cytotoxic effects of domestic sewage sludge on the mollusk Biomphalaria glabrata. The results showed deleterious effects on mollusk cells, confirming genotoxicity and cytotoxicity caused by domestic sewage sludge. The mollusk B. glabrata can be a cost-effective alternative for biomonitoring freshwater environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Sardar Khan, Zahir Qamar, Ajmal Khan, Muhammad Waqas, Javed Nawab, Muhmmmad Khisroon, Ajmal Khan
Summary: This study investigated the genotoxic effects of polycyclic aromatic hydrocarbons (PAHs) present in vehicle-wash wastewater (VWW) on fish and freshwater mussels. The results showed that the genotoxicity of VWW on both fish and mussels increased with the duration of exposure, indicating the high genotoxicity of VWW and the need for treatment before discharge into aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Felipe de Araujo Nascimento, Daniela de Melo e Silva, Thays Millena Alves Pedroso, Jheneffer Sonara Aguiar Ramos, Michelle Rocha Parise
Summary: Occupational exposure to pesticides in farmers results in significant DNA damage, showing a notable impact and variability in the studies. Smokers who are occupationally exposed to pesticides have slightly reduced DNA damage compared to non-smokers, indicating some genetic toxicity. The study demonstrates a higher risk of occupationally exposed rural workers developing related diseases due to the genotoxic effect of pesticides.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Sergey Petrovich Kukla, Victor Pavlovich Chelomin, Andrey Alexandrovich Mazur, Valentina Vladimirovna Slobodskova
Summary: This study compared the effects of zinc ions and zinc oxide nanoparticles on the sperm of marine organisms. The results showed that both pollutants caused an increase in DNA damage, and the increase in DNA damage varied with the concentration of pollutants in different experimental groups.
Article
Pharmacology & Pharmacy
Giselle S. Meireles, Rafaela Aires, Larissa Z. Coco, Edgar H. Kampke, Maria E. S. Barroso, Elisardo C. Vasquez, Thiago M. C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro
Summary: This study found that renovascular hypertension can cause oxidative damage and impaired DNA repair in bone marrow cells, leading to compromised hematopoiesis. It provides new insights into the influence of hypertension on bone marrow homeostasis.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Chemistry, Medicinal
Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hegarat, Haifa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valerie Fessard
Summary: In this study, the in vivo genotoxic effects of C17-sphinganine analog mycotoxin (C17-SAMT) were evaluated using comet assays and micronucleus assay. The results showed that C17-SAMT induced DNA damage in the duodenum and spleen, but had no significant effect on chromosome and genome damage in the bone marrow. Microscopic observations of the liver revealed increased mitosis and hepatocytes' cytoplasm clarification.
Article
Environmental Sciences
Kerstin Hund-Rinke, Dirk Brossell, Sebastian Eilebrecht, Karsten Schlich, Ruben Schlinkert, Tim Steska, Carmen Wolf, Dana Kuehnel
Summary: This study provides ecotoxicity data for various nano- and microparticles and identifies chemical identity and agglomeration behavior as important factors affecting their toxicities. Fibrous particles have stronger impacts on algae, while only materials releasing toxic ions are toxic to Daphnia magna.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Environmental Sciences
Claudia Castro, Ana Carvalho, Isabel Gaivao, Jose Lima-Brito
Summary: The study evaluated the tolerance of four wine-producing varieties to different concentrations of Cu by treating V. vinifera cuttings with Cu-rich hydroponic solutions. It was found that 50μM Cu treatment increased DNA damage, with 'Tinto Cao' being the most sensitive variety. Comet-FISH analysis revealed partial damage on rDNA and telomeric DNA in response to Cu treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Nasrin Ghassemi-Barghi, Zeynab Ehsanfar, Omid Mohammadrezakhani, Sorour Ashari, Shamim Ghiabi, Zahra Bayrami
Summary: ARA290 has been found to exert a protective effect against cisplatin-induced nephrotoxicity by anti-apoptotic, anti-inflammatory, and antioxidant mechanisms, suggesting its potential as a new therapeutic approach for acute kidney injury patients.
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Valerio Pellegri, Gessica Gorbi, Annamaria Buschini
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Food Science & Technology
Laura Arru, Francesca Mussi, Luca Forti, Annamaria Buschini
Summary: The research found that spinach extracts and the components of the phytocomplex have certain regulatory effects on the proliferation, antioxidant defense, and genotoxicity of human colorectal cells, with a certain dose-dependent and extraction method-related correlation. In the presence of oxidative stress, their effects vary depending on the specific oxidizing agent involved.
Article
Biochemistry & Molecular Biology
Serena Montalbano, Francesca Degola, Jennifer Bartoli, Franco Bisceglie, Annamaria Buschini, Mauro Carcelli, Donatella Feretti, Serena Galati, Laura Marchi, Nicolo Orsoni, Giorgio Pelosi, Marianna Pioli, Francesco M. Restivo, Dominga Rogolino, Mirco Scaccaglia, Olga Serra, Giorgio Spadola, Gaia C. V. Viola, Ilaria Zerbini, Claudia Zani
Summary: Controlling fungal contamination on crops is a priority for many countries' health authorities, and developing new drugs from natural sources to reduce aflatoxin contamination is seen as a successful strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sofia Beghi, Francesca Cavaliere, Matteo Manfredini, Sandro Ferrarese, Claudio Corazzari, Cesare Beghi, Annamaria Buschini
Summary: Cardiovascular diseases are the leading cause of death globally, with a complex etiology involving various factors. A study investigated the SNP rs7214723 within the CAMKK1 gene and found a potential association with CVD susceptibility.
BIOSCIENCE REPORTS
(2021)
Article
Food Science & Technology
Francesca Mussi, Serena Montalbano, Belsem Marzouk, Laura Arru, Meher Refifa, Zohra Marzouk, Jamil Kraiem, Francesca Degola, Annamaria Buschini
Summary: Plant extracts and natural compounds are considered promising alternatives to chemical preservatives against microbial contamination in food and feed commodities. These species have been studied for decades to explore their antimicrobial and antioxidant properties, validating their ethnobotanical use and suitability as food preservatives.
JOURNAL OF FOOD QUALITY
(2021)
Article
Environmental Sciences
Claudia Zani, Elisabetta Ceretti, Donatella Feretti, Milena Villarini, Massimo Moretti, Marco Verani, Antonella De Donno, Sara Bonetta, Annamaria Buschini, Alberto Bonetti, Silvia Bonizzoni, Umberto Gelatti
Summary: The study aimed to assess DNA damage in buccal cells of children living in an area with high air pollution, using micronuclei (MN) and comet tests. Despite high levels of DNA damage, especially in the first winter, no significant association was found between air pollutant levels and DNA damage in the repeated measures study.
Article
Chemistry, Inorganic & Nuclear
M. Carcelli, S. Montalbano, D. Rogolino, V Gandin, F. Miglioli, G. Pelosi, A. Buschini
Summary: Complexes of nickel(II), palladium(II), and zinc(II) with thiosemicarbazone ligands were synthesized and evaluated for their antiproliferative and genotoxic activities. The nickel complexes showed the most promising results, particularly the nickel dimer [NiL](2), which exhibited both antiproliferative and genotoxic activities.
INORGANICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Mattia Di Nunzio, Cecilia Loffi, Serena Montalbano, Elena Chiarello, Luca Dellafiora, Gianfranco Picone, Giorgia Antonelli, Tullia Tedeschi, Annamaria Buschini, Francesco Capozzi, Gianni Galaverna, Alessandra Bordoni
Summary: Replacing synthetic nitrates/nitrites with natural additives can be a promising strategy to develop clean label salamis without negatively affecting their nutritional value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Belsem Marzouk, Meher Refifa, Serena Montalbano, Annamaria Buschini, Stefano Negri, Mauro Commisso, Francesca Degola
Summary: Cucurbitacins, bioactive compounds found in Cucurbitaceae plants, have immense pharmacological potential. Citrullus colocynthis has been widely used in folk medicine due to its high content of cucurbitacins. However, the cultivation conditions and seed germination of C. colocynthis limit the exploitation of its phytochemical potential. This study evaluated axenic sprouted plantlets cultivated under laboratory conditions and found that they contain cucurbitacins and other bioactive compounds, exhibit antioxidant potential, and show activity against pathogenic fungi. These findings support the feasibility of scaling up the cultivation of C. colocynthis as a valuable natural resource for pharmaceutical compounds.
Review
Biochemistry & Molecular Biology
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
Summary: Cardiovascular disease remains a major cause of death worldwide, despite advancements in medication and preventive measures. Calcium plays a vital role in the cardiovascular system, regulating events from action potentials to muscle contraction. Calcium calmodulin pathways are involved in the regulation of cardiac functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nicolo Riboni, Antonio Suppa, Annamaria Buschini, Federica Bianchi, Valeria Rossi, Gessica Gorbi, Maria Careri
Summary: This study developed a reliable method to analyze the release of methyl farnesoate (MF) by daphnids into the growth medium in response to stress. The results showed a significant decrease in MF release under crowding conditions and in the presence of MK801. These findings strengthen the link between environmental stimuli and the regulation of the MF signaling pathway.
Article
Oncology
Serena Montalbano, Samanta Raboni, Simone Sidoli, Andrea Mozzarelli, Stefano Bettati, Annamaria Buschini
Summary: Cancer cells have a higher requirement for methionine compared to healthy cells, but the mechanism behind their higher sensitivity to methionine depletion is still unclear. Methionine plays a crucial role in the epigenetic reprogramming of cells and the modification of histone variants. Mass-spectrometry analysis was used to characterize the post-translational modifications of histone variants in normal and cancer cells in the presence and absence of methionine gamma-lyase (MGL). The results revealed a complex pattern of modifications and significant differences between normal and cancer cells, providing insight into the molecular mechanisms triggered by methionine depletion and its potential therapeutic application with MGL.
Article
Pharmacology & Pharmacy
Serena Montalbano, Franco Bisceglie, Giorgio Pelosi, Mirca Lazzaretti, Annamaria Buschini
Summary: Since the discovery of cisplatin, the search for metal-based compounds with therapeutic potential has been a challenge for the scientific community. Thiosemicarbazones and their metal derivatives, such as the three metal thiosemicarbazones [Ni(tcitr)(2)], [Pt(tcitr)(2)], and [Cu(tcitr)(2)] investigated in this study, show promise as anticancer agents with high selectivity and low toxicity. The study deepened the understanding of the molecular action mechanism of these compounds and demonstrated their potential as candidate antiproliferative thiosemicarbazones, although the overall molecular mechanism is still to be understood.
Article
Ecology
Antonio Suppa, Gessica Gorbi, Silvia Markova, Annamaria Buschini, Valeria Rossi
Summary: Environmental sex determination is influenced by factors such as temperature, photoperiod, food availability, and population density. Different clones of Daphnia pulex showed varying responses to juvenile hormone methyl farnesoate (MF), with differences in male and ephippia production, as well as sensitivity to stimuli triggering the switch to sexual reproduction.
FRESHWATER BIOLOGY
(2021)