Article
Toxicology
S. G. Rudyak, L. A. Usakin, E. A. Tverye, E. D. Robertson, A. A. Panteleyev
Summary: Aryl hydrocarbon receptor (AhR) expression and stability are influenced by AhR ligands. Treatment with TCDD, FICZ, and I3C caused a decrease in AhR expression. AhR degradation is regulated by proteasomal degradation and the presence of AhR antagonists, and requires the involvement of AhR dimerization partner ARNT. In addition, HDAC inhibition enhances AhR expression.
TOXICOLOGY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
A. Katharina Ceranski, Martha J. J. Carreno-Gonzalez, Anna C. C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Gruenewald
Summary: Hypoxia develops in solid tumors and Ewing sarcoma (EwS) due to low oxygen tension. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) and EWSR1::FLI1 have been identified as key molecules in the hypoxic response and oncogenesis of EwS. This review summarizes recent findings on the role of hypoxia and HIFs in EwS, suggesting their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment.
Article
Gastroenterology & Hepatology
Peter A. C. Wing, Peter Jianrui Liu, James M. Harris, Andrea Magri, Thomas Michler, Xiaodong Zhuang, Helene Borrmann, Rosalba Minisini, Nicholas R. Frampton, Jochen M. Wettengel, Laurent Mailly, Valentina D'Arienzo, Tobias Riedl, Luis Nobre, Michael P. Weekes, Mario Pirisi, Mathias Heikenwalder, Thomas F. Baumert, Ester M. Hammond, David R. Mole, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Summary: HIFs play a crucial role in regulating HBV replication, revealing an evolutionary mechanism by which HBV exploits the HIF signaling pathway to persist in the low oxygen environment of the liver.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marta Vuerich, Rasika Harshe, Luiza Abrahao Frank, Samiran Mukherjee, Barbora Gromova, Eva Csizmadia, Imad A. M. Nasser, Yun Ma, Alan Bonder, Vilas Patwardhan, Simon C. Robson, Maria Serena Longhi
Summary: In patients with autoimmune hepatitis, dysfunction of the aryl hydrocarbon receptor pathway, resulting from aberrant inhibition or non-canonical activation, impairs Treg- and Th17 cell-induced upregulation of CD39, a key ectoenzyme for immuno-regulation. Blockade of excessive inhibition or non-canonical activation of the aryl hydrocarbon receptor pathway might represent a novel therapeutic strategy to control inflammation while restoring immune balance in autoimmune hepatitis.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cell Biology
Tu Nguyen, Mei Zheng, Maura Knapp, Nikola Sladojevic, Qin Zhang, Lizhuo Ai, Devin Harrison, Anna Chen, Albert Sitikov, Le Shen, Frank J. Gonzalez, Qiong Zhao, Yun Fang, James J. K. Liao, Rongxue Wu
Summary: The decline in endothelial ARNT expression contributes to the suppressed angiogenic phenotype in diabetic mice. The cytoprotective effect of ARNT in endothelial cells is partially mediated by declines in ROS production.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kiichi Hirota
Summary: Oxygen is essential for the body, with the hypoxia-inducible factor playing a key role in hypoxic environments. HIF-prolyl hydroxylases serve as oxygen sensors, detecting decreases in oxygen partial pressure. Inhibiting HIF-PH can activate HIF artificially for medical intervention purposes.
Review
Pharmacology & Pharmacy
Colleen S. Curran, Jeffrey B. Kopp
Summary: The aryl hydrocarbon receptor (AHR) plays an important role in the development of chronic kidney disease (CKD) by binding various endogenous and xenobiotic ligands and regulating kidney stability, transcriptional activity, and cell signaling. AHR activity is closely associated with kidney damage and protection, with its cross-talk with estrogen, peroxisome proliferator-activated receptor-gamma, and NF-kappa B pathways contributing to the diversity of AHR responses in different forms and stages of CKD. Understanding the roles of AHR in kidney fibrosis, metabolism, and the renin-angiotensin system can provide insights into the pathogenesis and therapies of CKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Claudia M. Rejano-Gordillo, Beatriz Marin-Diaz, Ana Ordiales-Talavero, Jaime M. Merino, Francisco J. Gonzalez-Rico, Pedro M. Fernandez-Salguero
Summary: The aryl hydrocarbon receptor (AHR) plays a crucial role in regulating cellular and molecular processes. It is involved in transcriptional regulation, chromatin architecture modifications, and key signaling pathways, ultimately impacting organ and tissue homeostasis. This review covers the diverse roles of AHR, from classical embryonic development to modern epigenetics and immune system research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yujing Bi, Qiuli Yang, Zhengchao Li, Yuexin Wang, Yufei Wang, Anna Jia, Zhiyuan Pan, Ruifu Yang, Guangwei Liu
Summary: The lack of aryl hydrocarbon receptor nuclear translocator (ARNT) promotes neutrophil recruitment, neutrophil extracellular trap (NET) development, inflammatory cytokine secretion, and suppressive activities, thereby promoting colorectal cancer growth. The gut microbiota plays a crucial role in the functional alterations of Arnt(-/-) neutrophils. These findings have important implications for the combination of gut microbiota and immunotherapy approaches in colorectal cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, Research & Experimental
Colleen S. Curran, Jeffrey B. Kopp
Summary: Early detection of CKD is crucial. CKD from different causes share similar histological patterns. Tissue ischemia promotes HIF activation and NAD depletion, while NAD metabolic pathways and gap junctions regulate NAD biosynthesis and cellular retention. Dysregulated NAD metabolism leads to various complications, and nanoparticles can be used for CKD diagnosis and treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Physiology
Ainash Childebayeva, Taylor Harman, Julien Weinstein, Trevor Day, Tom D. Brutsaert, Abigail W. Bigham
Summary: The physiological response to high-altitude hypoxia involves genetic and non-genetic factors, including epigenetic modifications. Epigenetic changes in HIF and RAS pathways were significant at high altitudes. The study identified numerous differentially methylated positions and regions associated with altitude ascent, as well as an association between ACE gene polymorphism and oxygen saturation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Ji Yoon Kim, Hayoung Cho, Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee, So Hee Kwon
Summary: Melanoma is a deadly skin cancer that causes over 55,000 deaths annually. Regional melanoma can be surgically removed, but once it metastasizes, the survival rate drops dramatically. Current treatment options are not highly effective, leading to the search for novel therapeutic targets.
Article
Multidisciplinary Sciences
Shuyan Dai, Lingzhi Qu, Jun Li, Ye Zhang, Longying Jiang, Hudie Wei, Ming Guo, Xiaojuan Chen, Yongheng Chen
Summary: The aryl hydrocarbon receptor (AHR), an important transcription factor, plays significant roles in regulating xenobiotic metabolism, cellular differentiation, and immunity. This study provides multiple crystal structures of the Drosophila AHR PAS-B domain, which sheds light on the mechanism of AHR ligand binding. These findings have implications for the development of AHR-targeted therapeutics.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yong Zhang, Li Jiang, Nianqun Qin, Mi Cao, Xiujuan Liang, Rensheng Wang
Summary: This study reveals that under hypoxic conditions, hCINAP regulates the migration and EMT of cervical cancer cells through the Akt-mTOR signaling pathway, while also inhibiting hypoxia-induced p53-dependent apoptosis. This suggests that hCINAP may play essential roles in cervical cancer metastasis and could be a potential target for the treatment of cervical cancer.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Evolutionary Biology
Allie M. Graham, Felipe S. Barreto
Summary: In aerobic organisms, the hypoxia-inducible factor pathway and mitochondrial genomes regulate oxygen homeostasis. Recent research suggests that these mechanisms vary across species, prompting further investigation into the conditions that lead to the loss of such genes. This study examines the presence of oxygen-sensing genes in different cnidarian species, particularly those that are obligate endoparasites and frequently encounter hypoxic environments. The results reveal variations in the HIF pathway and genes associated with mitochondria, hypoxia, and stress response, suggesting flexibility and adaptation in these regulatory mechanisms.
GENOME BIOLOGY AND EVOLUTION
(2023)
Editorial Material
Marine & Freshwater Biology
Mikko Nikinmaa, Ron Tjeerdema, Malin Celander, Alex Ford, Deirdre Dunne
AQUATIC TOXICOLOGY
(2015)
Article
Marine & Freshwater Biology
Jenni M. Prokkola, Mikko Nikinmaa, Pedro Lubiana, Mirella Kanerva, R. J. Scott McCairns, Miriam Goetting
AQUATIC TOXICOLOGY
(2015)
Article
Biology
Katja Anttila, Mario Lewis, Jenni M. Prokkola, Mirella Kanerva, Eila Seppanen, Irma Kolari, Mikko Nikinmaa
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Article
Ecology
K. A. Vuori, K. K. Lehtonen, M. Kanerva, H. Peltonen, M. Nikinmaa, N. A. Berezina, E. Boikova
MARINE ECOLOGY PROGRESS SERIES
(2015)
Article
Ecology
K. A. Vuori, K. K. Lehtonen, M. Kanerva, H. Peltonen, M. Nikinmaa, N. A. Berezina, E. Boikova
MARINE ECOLOGY PROGRESS SERIES
(2015)
Editorial Material
Physiology
M. Nikinmaa
Article
Physiology
K. Anttila, T. Streng, J. Pispa, M. Vainio, M. Nikinmaa
Editorial Material
Marine & Freshwater Biology
Mikko Nikinmaa, Ron Tjeerdema, Alex T. Ford, Malin C. Celander
AQUATIC TOXICOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Pedro Lubiana, Jenni M. Prokkola, Mikko Nikinmaa, Thorsten Burmester, Mirella Kanerva, Miriam Goetting
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2016)
Article
Environmental Sciences
Jenni M. Prokkola, Ioanna Katsiadaki, Marion Sebire, Jessica Elphinstone-Davis, Sanna Pausio, Mikko Nikinmaa, Erica H. Leder
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2016)
Article
Genetics & Heredity
Victoria L. Pritchard, Heidi M. Viitaniemi, R. J. Scott McCairns, Juha Merila, Mikko Nikinmaa, Craig R. Primmer, Erica H. Leder
G3-GENES GENOMES GENETICS
(2017)
Article
Biology
Jenni M. Prokkola, Mikko Nikinmaa
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Review
Physiology
Mikko Nikinmaa, Michael Berenbrink, Colin J. Brauner
Editorial Material
Physiology
Mikko Nikinmaa
Article
Environmental Sciences
Mirella Kanerva, Mikko Kiljunen, Jyrki Torniainen, Mikko Nikinmaa, Joerg Dutz, Kristiina A. Vuori
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)