Article
Environmental Sciences
M. Konschak, J. P. Zubrod, P. Baudy, P. Fink, K. G. J. Kenngott, D. Englert, N. Roeder, C. Ogbeide, R. Schulz, M. Bundschuh
Summary: The study found that the strobilurin fungicide azoxystrobin had negative effects on crustacean leaf shredders in waterborne exposure, while no effects were observed via dietary pathway. Furthermore, it was suggested that waterborne exposure at higher concentrations had more pronounced effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Claudia Cosio, Davide Degli-Esposti, Christine Almunia, Veronique Gaillet, Herve Sartelet, Jean Armengaud, Arnaud Chaumot, Olivier Geffard, Alain Geffard
Summary: The study found that invertebrates fed with methyl-Hg (MeHg) from cell walls of plants had higher concentrations of Hg, potentially triggering different threshold of proteomic response.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Ophelia Gestin, Thomas Lacoue-Labarthe, Nicolas Delorme, Laura Garnero, Olivier Geffard, Christelle Lopes
Summary: This study aimed to investigate the effects of Cd concentration on organotropism, toxico-kinetics, and fate of Cd in gammarids. The results showed that Cd concentration did not significantly modulate the bioconcentration capacity and Cd distribution in different organs. However, Cd accumulation rates in organs (except intestines) were dependent on the exposure concentration. The in vivo management of Cd among organs remained qualitatively unchanged according to exposure concentration. This study highlights the importance of implementing toxico-kinetic approaches to enhance the understanding of the toxicity risk of contaminants in invertebrates.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Marie V. Brasseur, Arne J. Beermann, Vasco Elbrecht, Daniel Grabner, Bianca Peinert-Voss, Romana Salis, Martina Weiss, Christoph Mayer, Florian Leese
Summary: This study used transcriptome-wide sequencing data to quantify the effects of multiple anthropogenic stressors on gene expression in the freshwater amphipod Gammarus fossarum. The results showed that stressor exposure led to the suppression of genes involved in metabolic and energy consuming cellular processes. The strongest transcriptional response was induced by increased salinity, which contradicted the observed abundance patterns. The interactions between stressors were mainly antagonistic.
Article
Chemistry, Analytical
Julien Faugere, Thomas Alexandre Brunet, Yohann Clement, Anabelle Espeyte, Olivier Geffard, Jerome Lemoine, Arnaud Chaumot, Davide Degli-Esposti, Sophie Ayciriex, Arnaud Salvador
Summary: Omics study, including proteomics, lipidomics, and metabolomics, allows us to understand the molecular modifications in living organisms in response to contaminants or in different physiological conditions. However, individual omics only provides a partial image of the biological complexity. To obtain comprehensive omics information from a single sample, a specific sample preparation method needs to be optimized. This study developed a biphasic extraction procedure using a MTBE/Methanol mixture to simultaneously extract polar (proteins, metabolites) and apolar compounds (lipids) for multi-omics analyses. The method was applied to study the reproductive cycle of female amphipod Gammarus fossarum, and multivariate data analyses were used to integrate the multi-omics datasets and identify molecular signatures specific to different stages.
Article
Environmental Sciences
Maxime Lepretre, Arnaud Chaumot, Rayan Aboud, Nicolas Delorme, Anabelle Espeyte, Arnaud Salvador, Sophie Ayciriex, Jean Armengaud, Marina Coquery, Olivier Geffard, Davide Degli-Esposti
Summary: Mass spectrometry in multiple reaction monitoring (MRM) mode enables selective and multiplexed quantification of peptides derived from proteins. This study evaluates the feasibility of using dynamic MRM (dMRM) tools to investigate proteomes in sentinel species and demonstrates their potential for discovering new protein biomarkers. A dMRM assay was developed to capture the functional proteome of a freshwater crustacean and assess the effects of metal exposure. Metal-specific signatures were identified as potential biomarkers for tracking metal levels in freshwater ecosystems. This study highlights the potential of dMRM for identifying and developing biomarkers in sentinel species.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Yaping Shao, Zhenfa Fu, Yanfeng Wang, Zhaofei Yang, Yushan Lin, Song Li, Cheng Cheng, Min Wei, Zheyi Liu, Guowang Xu, Weidong Le
Summary: By using metabolomics and lipidomics analysis, this study investigated the effects of fasting on brain metabolism in mice. The results showed that fasting induced triacylglycerol degradation and lipolysis to meet energy demands, and led to changes in amino acid profiles that may play crucial roles in energy metabolism, neurotransmitter signaling, and anti-inflammatory and antioxidant responses. Additionally, the study reported a significant elevation of neuroprotective lipids called N-acylethanolamines in the brain and liver during fasting. These findings provide novel insights into the molecular basis and mechanisms of calorie restriction and offer a comprehensive resource for further investigation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Marine & Freshwater Biology
Natacha Koenig, Christine Almunia, Aurore Bonnal-Conduzorgues, Jean Armengaud, Arnaud Chaumot, Olivier Geffard, Davide Degli Esposti
Summary: Omics approaches are shedding light on the mechanisms of action of contaminants in environmentally relevant species, contributing to the development of molecular ecotoxicology. Co-expression network analysis proved effective in identifying key pathways and proteins associated with testicular toxicity in Gammarus fossarum exposed to endocrine disruptors. The study revealed distinct modules correlated with exposure to different contaminants, with specific functions identified for each module.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Maxime Lepretre, Olivier Geffard, Anabelle Espeyte, Julien Faugere, Sophie Ayciriex, Arnaud Salvador, Nicolas Delorme, Arnaud Chaumot, Davide Degli-Esposti
Summary: This study utilized multiple reaction monitoring mass spectrometry to measure customized molecular markers in freshwater sentinel species and proposed a breakthrough approach to screen and identify potential proteins.
ENVIRONMENTAL POLLUTION
(2022)
Article
Nutrition & Dietetics
Johanna Sigaux, Alice Bellicha, Camille Buscail, Chantal Julia, Rene-Marc Flipo, Alain Cantagrel, Francois Laporte, Caroline Beal, Marie-Christophe Boissier, Luca Semerano
Summary: This study aimed to investigate the relationship between serum lipid profiles and disease activity in patients with early rheumatoid arthritis (RA). The study found that a serum lipid profile rich in n-3 fatty acids was independently associated with persistently reduced disease activity, while a profile rich in n-6 fatty acids was associated with lower disease activity.
Article
Biochemistry & Molecular Biology
Davide Degli Esposti, Aureline Lalouette, Karen Gaget, Louveline Lepeule, Zineb Chaabi, Maxime Lepretre, Anabelle Espeyte, Nicolas Delorme, Herve Queau, Laura Garnero, Federica Calevro, Arnaud Chaumot, Olivier Geffard
Summary: Metal pollution has significant effects on aquatic environments, and metallothioneins play important roles in maintaining metal homeostasis and detoxification. This study identified two metallothionein-coding transcripts in Gammarus fossarum and investigated their organ-specific expression patterns. The results showed that mt1 was more strongly induced after cadmium exposure, and mt1 was more highly induced in the caeca compared to the gills for any metal exposure. Additionally, mt2 was more inducible in the gills than in the caeca for cadmium and zinc exposure at the individual level.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Environmental Sciences
Kahina Mehennaoui, Sebastien Cambier, Laetitia Minguez, Tommaso Serchi, Francois Guerold, Arno C. Gutleb, Laure Giamberini
Summary: The study aimed to evaluate the sub-chronic effects of silver (AgNPs) and gold nanoparticles (AuNPs) of 40 nm on the freshwater invertebrate Gammarus fossarum. The exposure led to significant uptake of Ag and Au in the animals but below toxic levels, while causing up-regulation of specific gene expressions and a more developed lysosomal system in response to stress. The nanoparticles also significantly affected locomotor activity of G. fossarum without impacting haemolymphatic ions and ventilation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Geriatrics & Gerontology
Adam Oesterle, Petra Buzkova, Cara N. Pellegrini, Calvin Hirsch, Russell P. Tracy, David S. Siscovick, Luc Djousse, Ken J. Mukamal, Jorge R. Kizer
Summary: Glucose, both fasting and post-load, is associated with incident heart failure, while non-esterified fatty acids (NEFA) are not. The association is particularly strong for post-load glucose, suggesting potential targets for HF prevention.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Environmental Sciences
Jeremie D. Lebrun, Sabry El Kouch, Angeline Guenne, Julien Tournebize
Summary: This study aimed to evaluate the potential toxicity of currently used herbicides in Gammarus fossarum using multi-level biomarkers. The results showed that these herbicides caused increased locomotion and respiration in the crustaceans, as well as disruptions in moulting, antioxidant responses and cell integrity. Statistical analyses identified herbicide clusters likely to trigger common sets of biological responses. These findings demonstrate unexpected toxicological effects of currently used herbicides in non-target wild animals.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Sander Kersten
Summary: Fasting and starvation have been significant environmental factors that have shaped human energy metabolism. Humans adapt to fasting through time-dependent changes in energy metabolism, including the breakdown of liver glycogen, muscle protein, and fat stores. This paper provides an overview of the effects of fasting on adipose tissue metabolism, including the inhibition of lipoprotein lipase activity and activation of adipose triglyceride lipase.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Entomology
Stefanie M. Colombo, Kruti Shukla, Lesley G. Campbell, Alina Tsimbaliouk, Michael T. Arts
PHYSIOLOGICAL ENTOMOLOGY
(2020)
Article
Ecology
Franziska Guenter, Michael Beaulieu, Kasimir F. Freiberg, Ines Welzel, Nia Toshkova, Anamarija Zagar, Tatjana Simcic, Klaus Fischer
JOURNAL OF EVOLUTIONARY BIOLOGY
(2020)
Article
Environmental Sciences
Craig E. Hebert, D. V. Chip Weseloh, Michael T. Arts, Shane R. de Solla, David J. Moore, Gordon Paterson, Cynthia Pekarik
JOURNAL OF GREAT LAKES RESEARCH
(2020)
Article
Environmental Sciences
Ursula Strandberg, Satyendra P. Bhavsar, Michael T. Arts
JOURNAL OF GREAT LAKES RESEARCH
(2020)
Review
Environmental Sciences
Tjasa Matjasic, Tatjana Simcic, Neja Medvescek, Oliver Bajt, Tanja Dreo, Natasa Mori
Summary: This study conducted a systematic literature review on bacterial biodegradation of synthetic plastics, identifying common bacteria and suggesting future research directions. The importance of standardized reporting protocols and comprehensive information for replication by other research groups was emphasized.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Geology
Tatjana Simcic, Boris Sket
Summary: The study compared the effects of exposure to hypoxia, followed by reoxygenation, and increased temperature on oxygen consumption, potential metabolic activity, and antioxidant activities in closely related epigean and hypogean Niphargus species. Results showed differences in respiratory and antioxidant responses between the two species, indicating potential adaptations to different environmental conditions. Hypogean species exhibited characteristics suitable for temperature stable subterranean environments, while epigean species were more adapted to specific surface habitats.
INTERNATIONAL JOURNAL OF SPELEOLOGY
(2021)
Article
Fisheries
Angelisa T. Y. Osmond, Michael T. Arts, Richard P. Bazinet, Johnathan A. Napier, Lihua Han, Stefanie M. Colombo
Summary: The genetically engineered Camelina sativa oil, designed to produce EPA and DHA at levels similar to fish oil, improved growth performance and EPA content in rainbow trout muscle tissue. Additionally, rainbow trout fed with HCO diet had firmer texture and higher orange intensity in fillets compared to the FO group.
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2021)
Article
Biology
Matthias Pilecky, Libor Zavorka, Michael T. Arts, Martin J. Kainz
Summary: This review discusses the role of Ω-3 PUFA, especially EPA and DHA, in neuronal cell membranes and their relationship with GPCRs, as well as the potential impact of deficiencies in dietary DHA supply on cognition, vision, and behavior. Additionally, the implications of changes in access to dietary Ω-3 PUFA on trophic interactions and ecosystem functioning are explored.
BIOLOGICAL REVIEWS
(2021)
Article
Engineering, Environmental
Tjasa Matjasic, Tatjana Simcic, Tjasa Kanduc, Zoran Samardzija, Natasa Mori
Summary: The presence of PET fibers in riverbed sediments was found to impact microbial metabolic functioning in rivers, suppressing overall microbial activity while enhancing the utilization of complex synthetic polymer substrates. However, PET fibers also slightly suppressed microbial biomass and respiratory activity.
Article
Limnology
Tatjana Simcic, Polona Pengal, Tina Elersek, Blaz Cokan, Natasa Mori
Summary: This study aimed to identify the anthropogenic drivers that significantly impact the ecological processes in the Moste reservoir. The results showed that temperature regime and increased nutrient concentrations have substantial effects on the processes in the reservoir.
FUNDAMENTAL AND APPLIED LIMNOLOGY
(2022)
Article
Ecology
Teo Delic, Peter Trontelj, Valerija Zaksek, Anton Brancelj, Tatjana Simcic, Fabio Stoch, Cene Fiser
Summary: The study in the north-western part of the Balkan Peninsula focused on the evolutionary history and distribution of a subterranean amphipod, revealing four independently evolving tentative species dating back to the Pleistocene with no evidence of extinction events. Speciation events mainly occurred in allopatry, leading to differences in climatic niche envelopes and physiological responses to unfavourable temperatures among lineages, indicating low recent dispersal.
JOURNAL OF BIOGEOGRAPHY
(2022)
Article
Multidisciplinary Sciences
Andreea Oarga-Mulec, Sara Skok, Tatjana Simcic, Janez Mulec
Summary: The mixture of coal bottom ash, slag, and fly ash placed in the cave may have harmful effects on the ecological environment and biota in the cave ecosystem. Thorough investigation should be carried out when removing these mixtures.
SCIENTIFIC REPORTS
(2021)
Article
Biodiversity Conservation
Veronica Gomes, Anamarija Zagar, Guillem Perez i de Lanuza, Tatjana Simcic, Miguel A. Carretero
Summary: Colour polymorphism in the European wall lizard is accompanied by variations in phenotypic traits related to fitness. This study examines the interrelationships between colour, morphology, performance, and physiology in different morphs of the lizard. The results suggest existing and non-existing relationships that can have short- and long-term effects on selection.
Article
Biochemistry & Molecular Biology
Anamarija Zagar, Tatjana Simcic, Urban Dajcman, Rodrigo Megia-Palma
Summary: This study reveals the relationships between physiological, biotic, and environmental traits by investigating the metabolism in two sympatric lizard species across an elevational gradient.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Fisheries
Mehis Rohtla, Francoise Daverat, Michael T. Arts, Howard I. Browman, Camilla Parzanini, Berit Skiftesvik, Eva B. Thorstad, Terje van der Meeren, Leif Asbjorn Vollestad, Caroline M. F. Durif
Summary: Many anguillid eel species display facultative catadromy, and northern European shallow marine habitats may serve as important yellow eel growth habitats and may be critical to the population's survival.
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2023)
