Article
Immunology
Hemanta Kumar Mondal, Usha Jyoti Maji, Sriprakash Mohanty, Pramoda Kumar Sahoo, Nikhil Kumar Maiti
Summary: The study found that Argulus infection significantly affects the diversity and richness of intestinal microbiota in rohu fish, with an enrichment of Actinobacteria and Patescibacteria. Infected fish showed a higher number of unique genera compared to healthy fish, with significant increases in certain genera like Stenotrophomonas and Pirellula, and a decrease in Reyranella. The composition and function of the gut microbiota were positively associated, and the predicted function in infected fish suggested an enrichment in the synthesis of chitinases, chitin binding proteins, osmoprotectant proteins, and sulfatases enzymes.
MICROBIAL PATHOGENESIS
(2022)
Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zhineng Wang, Ying Sun, Wenbo Yao, Qian Ba, Hui Wang
Summary: Cadmium, a biologically non-essential heavy metal, widely present in the environment and foods, is mainly known for its immunotoxicity, which includes modulation of immune cell activity, induction of immune responses, and alteration of antibody production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Sonali Parida, Amruta Mohapatra, Sweta Das, Pramoda Kumar Sahoo
Summary: This study focused on the role of linker histone H1 (LHH1) in the ontogeny and innate immunity of the Indian major carp species rohu. The expression of LHH1 was found to be significantly increased during early development and varied in response to different infection models. However, a synthetic peptide derived from LHH1 did not possess antibacterial activity.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Immunology
Xiaowu Bai, Weixin Liu, Hongxia Chen, Tao Zuo, Xiaojian Wu
Summary: By analyzing RNA-seq data from patients with IBD (including CD and UC) and healthy individuals, this study revealed increased numbers of immune cells in different intestinal regions and disease-specific immune features in CD and UC. These findings provide important insights into the pathogenesis of IBD and serve as a valuable resource for future targeted studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Entomology
Mark S. Bulmer, Bruno A. Franco, Aditi Biswas, Samantha F. Greenbaum
Summary: We investigated whether two closely related termite species differ in their reliance on social or individual immunity against two species of pathogenic fungi, which were all collected from the same location. Our results indicate that mutual grooming (allogrooming) is highly effective at limiting fatal infections to the extent that it can compensate for relatively weak individual immune defenses. After pathogens are encountered, termites use an alternate strategy for social distancing and limiting the spread of contagious disease and instead come together to clean each other.
Article
Virology
Andrew T. Abad, Pranav Danthi
Summary: Viruses infect host cells to replicate, but hosts can activate defenses to limit replication. This study provides new insights into how host cells detect the genomes of invading reovirus particles and the factors that determine the magnitude of the immune response triggered during infection.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Priyanka Das, Mohan R. Badhe, Pramoda Kumar Sahoo, Raudu Rajendra Kumar Reddy, Amol R. Suryawanshi, Jyotirmaya Mohanty
Summary: An immunoproteomic approach was used to identify immunoreactive antigens of the fish ectoparasite, Argulus siamensis. Three proteins identified could serve as potential vaccine candidates against argulosis in carps.
PARASITE IMMUNOLOGY
(2021)
Review
Immunology
Elisa Jentho, Sebastian Weis
Summary: The ability to remember previous encounters with pathogens was considered a key feature of the adaptive immune system for a long time, but recent evidence shows that the innate immune system also possesses memory features. This memory is mediated by reorganization of chromatin landscape and adaptations of myelopoiesis. Damage-associated molecular patterns can also induce innate immune memory, potentially through the same receptors and pathways responsible for pathogen-associated innate immune training.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Sahar Farahnak Roudsari, Houman Rajabi Islami, Seyed Abdolmajid Mousavi, Mehdi Shamsaie Mehrgan
Summary: The study showed that dietary FA-coated nanochitosan significantly improved the growth performance, feed utilization, antioxidant status, and immune responses of rainbow trout. The antioxidant responses were highest in fish fed with 0.50 mg/kg FA-coated nanochitosan, and immune responses showed a linear increase with increasing dietary FA-coated nanochitosan levels.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Immunology
Jia-Rui Zheng, Zi-Long Wang, Bo Feng
Summary: Hepatitis B virus infection causes indirect damage to hepatocytes through the immune system. The exhaustion of virus-specific immune cells and immune suppression by virus antigens contribute to the chronicity of the infection. Functional cure can be achieved by restoring the specific immune function, providing a theoretical basis for complete cure of hepatitis B.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Giacomo Della Camera, Mariusz Madej, Anna Maria Ferretti, Rita La Spina, Yang Li, Annunziata Corteggio, Tommaso Heinzl, Benjamin J. Swartzwelter, Gergo Sipos, Sabrina Gioria, Alessandro Ponti, Diana Boraschi, Paola Italiani
Summary: This study found that nanoparticles used for diagnostic imaging, such as gold and iron oxide nanoparticles, can induce or modulate innate memory in human primary monocytes. The effects on innate memory were found to be donor-dependent, suggesting personalized profiling would be needed to predict the impact of imaging nanoparticles on patients' innate immune reactivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Ronan Talty, Kelly Olino
Summary: Both cancer cells and immune cells rely on specific metabolic programs for survival and function, with immune cells having the capability to either enhance or suppress the antitumor immune response based on metabolic changes. The shared microenvironment within tumors affects the metabolism of immune cells and can impact the efficacy of immunotherapies, highlighting the importance of understanding the interplay between metabolism, immune response, and cancer progression.
Review
Immunology
Wen Cao, Dongsheng Fan
Summary: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by motor neuron loss. Dysregulated peripheral immunity, particularly the role of neutrophils, has been implicated in ALS pathogenesis. Understanding the functions of neutrophils in ALS and their potential as therapeutic targets could provide insights into slowing disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
