Article
Cell Biology
Hong-Qing Cai, Min-Jie Zhang, Zhi-Jian Cheng, Jing Yu, Qing Yuan, Jin Zhang, Yan Cai, Li-Yan Yang, Yu Zhang, Jia-Jie Hao, Ming-Rong Wang, Jing-Hai Wan
Summary: FKBP10 is highly expressed in glioma and promotes cell proliferation by interacting with Hsp47 and activating the AKT-CREB-PCNA signaling pathways. Inhibition of FKBP10 related signaling may offer a potential therapeutic option for glioma patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Cell Biology
Caroline M. Li, Pouya Haratipour, Robert G. Lingeman, J. Jefferson P. Perry, Long Gu, Robert J. Hickey, Linda H. Malkas
Summary: Peptides are increasingly being used as therapeutics for various diseases, including cancer, due to their target specificity and low toxicity. They can induce cell death through multiple mechanisms, but face challenges such as degradation by proteases and poor absorption. Recent strategies have been developed to overcome these obstacles and improve peptide delivery and bioavailability for cancer treatment.
Article
Fisheries
Jian-Fei Lu, Tian-Cheng Jin, Ting Zhou, Xin-Jiang Lu, Jian-Ping Chen, Jiong Chen
Summary: Virus-encoded tumor necrosis factor receptors help viruses evade the host immune response; a novel TNFR homolog named ORF4 in Cyprinid Herpesvirus-2 was identified and characterized in this study; the expression of ORF4 affects viral propagation and host cell proliferation and apoptosis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ismael Hernandez-Nunez, Ana Quelle-Regaldie, Laura Sanchez, Fatima Adrio, Eva Candal, Anton Barreiro-Iglesias
Summary: Despite the common assumption of teleost retina showing continuous proliferative activity throughout life, a systematic study on zebrafish revealed a decline in cell proliferation with aging, with a wave of secondary proliferation during sexual maturation. This contrasts with previous studies and highlights the importance of understanding the changes in proliferative activity in the fish retina as they age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Wan Fatin Amira Wan Mohd Zawawi, M. H. Hibma, M. Salim, K. Jemon
Summary: Near infrared radiation heat therapy can effectively slow down the progression of breast tumors, enhance activation and infiltration of immune cells, and increase the median survival of mice with tumors.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Majid Mufaqam Syed-Abdul, Priska Stahel, Alyssa Zembroski, Lili Tian, Changting Xiao, Avital Nahmias, Ian Bookman, Kimberly K. Buhman, Gary F. Lewis
Summary: GLP-2 increases CM secretion without mobilizing CLDs in the intestine. Proteomic analysis identified potential proteins involved in GLP-2-mediated CM secretion. This suggests that GLP-2 enhances CM secretion through a different mechanism than glucose.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Min Chen, Yanke Lin, Yongkang Dang, Yifei Xiao, Fugui Zhang, Guanghui Sun, Xuejun Jiang, Li Zhang, Jianhao Du, Shuyi Duan, Xiaojian Zhang, Zifei Qin, Jing Yang, Kaisheng Liu, Baojian Wu
Summary: This study reveals that the intestinal clock plays a crucial role in regulating liver rhythmicity and metabolism. The loss of the intestinal clock leads to a large-scale reprogramming of the liver transcriptome and alters hepatic metabolism. The intestinal clock controls the rhythmicity of the hepatic transcription factor SREBP-1c, which further affects hepatic lipogenesis and gluconeogenesis. These findings suggest that targeting intestinal rhythms may be a new approach for improving metabolic health.
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Margaux Nawrot, Simon Peschard, Sophie Lestavel, Bart Staels
Summary: Type 2 diabetes and Non-Alcoholic Fatty Liver Disease are influenced by the interaction between the intestine and the liver, particularly through changes in gut microbiota and intestinal permeability. Targeting intestinal functions may be a promising therapeutic approach for these metabolic diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Biochemistry & Molecular Biology
Ryan Bruellman, Cristina Llorente
Summary: Understanding the complex interactions between the gut microbiome and the host immune system has revealed new possibilities for treating alcohol-associated liver disease. Research has shown that the breakdown of protective gut barriers and the immune response to gut microbes play key roles in the development of this condition, opening up avenues for alternative therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Aimee J. Horsfall, Theresa Chav, John B. Bruning, Andrew D. Abell
Summary: The study showed that peptides containing 4-DAPA were more effective as fluorescent sensors for PCNA and have the potential to be used as cell proliferation sensors for diseases such as cancer.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Rulan Jiang, Jamie Lo, Christine Prell, Bo Loennerdal
Summary: This study found that oral intake of milk containing OPN can promote intestinal development in early life by increasing cell proliferation and activating cellular signaling pathways.
Article
Endocrinology & Metabolism
Huiyuan Zheng, Lorena Lopez-Ferreras, Jean-Phillipe Krieger, Stephen Fasul, Valentina Cea Salazar, Natalia Valderrama Pena, Karolina P. Skibicka, Linda Rinaman
Summary: The study presented a novel Gcg-Cre rat model for studying the development, anatomy, and function of Gcg-expressing cells in the brain and periphery. The homozygous Gcg-Cre rats showed lower plasma glucose levels and exhibited cell expression in brain regions that do not match Gcg expression. Stimulation of specific brain regions' GLP1 neurons reduced food intake in male rats but not in female rats.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Yun Yang, Yuanyuan Li, Jialong Fu, Yanfeng Li, Shuang Li, Rui Ni, Qifen Yang, Lingfei Luo
Summary: During the development of neighboring organs from the same germ layer, it is important for the precursors of one organ to resist the inductive signals of the other organ to avoid being misinduced to a wrong cell fate. This study identified a zebrafish mutant with a unique hepatized intestine phenotype, where liver cells replace anterior intestinal cells. The study revealed that the Cdx1b-Sfrp5 cascade plays a crucial role in conferring intestinal precursor cells resistance to liver-inductive signals, shedding light on the general question of how precursor cells resist incorrect inductive signals during embryonic development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Jin Yan, Yang Wang, Xiao Li, Dongnan Guo, Zhengjun Zhou, Ge Bai, Jianhui Li, Na Huang, Jiajie Diao, Yong Li, Wangxiao He, Wenjia Liu, Kaishan Tao
Summary: Self-assembling peptide hydrogels present a promising approach for treating liver bleeding, with a nano-band-aid (NBA) developed through a three-stage self-assembly process of two functionalized peptides demonstrating rapid and effective control of bleeding in animal experiments.
Article
Microbiology
Yuqing Cui, Lu Zhang, Chunyu Lu, Mengmeng Dou, Yulan Jiao, Yongzhan Bao, Wanyu Shi
Summary: The study aimed to explore the improvement effect of compound small peptide of Chinese medicine (CSPCM) on intestinal immunity and microflora. It was found that cyclophosphamide has a strong destructive effect on the intestine and significantly negative impact on the development of the small intestine, intestinal immune system, and intestinal flora. However, the addition of CSPCM can improve these negative effects.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Fisheries
Maciej Wozny, Stefan Dobosz, Piotr Hliwa, Piotr Gomulka, Jaroslaw Krol, Kazimierz Obremski, Jana Blahova, Zdenka Svobodova, Oliwia Michalik, Konrad Ocalewicz, Pawel Brzuzan
Review
Biochemistry & Molecular Biology
Sylwia Judycka, Joanna Nynca, Piotr Hliwa, Andrzej Ciereszko
Summary: This article presents recent knowledge regarding sex-reversed females (SRFs) of salmonid fish, including sex reversal methods, effects on reproductive tract morphology and semen quality factors, as well as methods for short-term and cryopreservation semen storage. The need for artificial maturation of SRF sperm and recent progress in efficient cryopreservation procedures and use of cryopreserved semen in hatchery practice are discussed. Additionally, proteomic investigations of salmonid sperm, primarily comparing normal male and SRF testicular semen, and changes in SRF rainbow trout sperm proteome after in vitro incubation in artificial seminal plasma are addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Krystyna Demska-Zakes, Piotr Gomulka, Maciej Rozynski, Zdzislaw Zakes
Summary: The study showed that immersing pikeperch in a sodium chloride solution did not cause significant stress, but led to short-term biochemical and hematological changes. Exposure to high concentrations of NaCl resulted in significant alterations in biochemical and blood parameters, however, these changes were temporary and the fish showed significant recovery abilities.
AQUACULTURE REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
D. Zarski, J. Krol, Y. Ledore, B. Sarosiek, K. Dryl, P. Gomulka, K. Palinska-Zarska, L. Toomey, P. Fontaine, S. Milla
Summary: This study assessed the effect of constant darkness on reproductive traits in domesticated females of Eurasian perch and found that constant darkness negatively affected hormonal dose application, disrupted ovulation, and reduced ovulation rates.
Article
Fisheries
Jaroslaw Krol, Piotr Hliwa, Malgorzata Wozniak, Agnieszka Stabinska-Ulas, Slawomir Krejszeff, Robert Stabinski, Sergiusz J. Czesny
Summary: The study investigated the effects of three commercial diets on growth, cannibalism, and survival in Eurasian perch post-larvae. It was found that the diet with the highest fat content and lowest protein content resulted in significantly higher weight and body length in the perch. Survival rates were higher in groups fed with certain diets, and cannibalism was lower in perch fed with specific diets.
AQUACULTURE REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Piotr Hliwa, Ligia Panasiak, Elzbieta Ziomek, Rafal Rozynski, Lukasz Leonowicz, Joanna Grudniewska, Stefan Dobosz, Konrad Ocalewicz
Summary: The use of parental individuals from allochthonous lineages for stocking specimens of European grayling has led to genetic contamination in local populations. This study aimed to triploidize the grayling and examine the gonads of triploid individuals. The results showed that triploid grayling exhibited sterile gonads, indicating their inability to reproduce.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Fisheries
Tatyana Gebauer, Radek Gebauer, Katarzyna Palinska-Zarska, Petr Cisar, Oleksandr Movchan, Ondrej Tomasek, Marketa Prokesova, Jan Matousek, Piotr Hliwa, Jaroslaw Krol, Daniel Zarski, Alexander Rebl, Vlastimil Stejskal
Summary: Monitoring the physiological and behavioral characteristics of European perch stocks from different aquaculture systems can assess their potential as breeding candidates. The perch stock from Denmark showed the most active behavior and higher tolerance to environmental challenges compared to stocks from France and Hungary.
Article
Fisheries
S. Judycka, D. Zarski, M. A. Dietrich, H. Karol, P. Hliwa, M. Blazejewski, A. Ciereszko
Summary: The study focuses on an improved semen cryopreservation protocol for commercial fertilization in European perch, showing high sperm motility with a new extender and KCl supplementation. The enhanced procedure allows for handling prediluted semen and maintaining high fertilization rates for cryopreserved and fresh semen, enabling large-scale fertilization applications.
Article
Environmental Sciences
Magdalena Surma, Piotr Hliwa, Katarzyna Sznajder-Katarzynska, Wieslaw Wiczkowski, Joanna Topolska, Henryk Zielinski
Summary: The study analyzed the presence of PFAS in tissues of pike and roach from two lakes in the Masurian Lake District in Poland, finding four PFAS substances above quantification limits and higher concentrations in kidneys. The findings provide insights into PFAS distribution and accumulation in biota.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Environmental Sciences
Malgorzata Dmitryjuk, Magdalena Szczotko, Katarzyna Kubiak, Janina Dziekonska-Rynko, Joanna Cichocka, Piotr Hliwa, Katarzyna Mierzejewska
Summary: The molecular identification of Cystidicola farionis, a swim bladder nematode found in the Vistula Lagoon in Poland, was conducted. The study showed that the trehalose level was higher in adult nematodes compared to larvae, but the activity of enzymes involved in trehalose synthesis was higher in larvae under optimal conditions. The research provides insights into the metabolic adaptation of parasites and its potential impact on aquacultures and public health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Fisheries
Karol Korzekwa, Piotr Gomulka, Joanna Nowosad, Daria J. Kucharczyk, Katarzyna Targonska, Tomasz K. Czarkowski, Daniel Zarski, Laszlo Horvath, Tamas Muller, Roman Kujawa, Marek J. Luczynski, Joanna Luczynska, Hany M. R. Abdel-Latif, Dariusz Kucharczyk
Summary: Controlled indoor reproduction of European eel is considered a promising method to prevent the extinction of this fish species. Limited information is available on the diversity of bacterial microflora in European eel during long maturation under changing temperature and salinity conditions. Changes in the bacterial microflora during indoor reproduction may increase the risk of bacterial infection, especially during the freshwater phase of female maturation.
AQUACULTURE REPORTS
(2022)
Article
Fisheries
Zdzislaw Zakes, Krystyna Demska-Zakes, Maciej Rozynski, Piotr Gomulka, Rafal Rozynski
Summary: The influence of implanting 12 mm PIT tags on juvenile brown trout was analyzed for 28 days. The study found that the implantation wounds fully healed and the PIT retention rate was 97.5% after 28 days. Furthermore, the tags did not affect growth performance, feeding effectiveness, or survival. However, significant changes were observed in cortisol levels, white blood cell counts, hemoglobin levels, and cidal ability after tagging, although these indicators returned to normal after 28 days.
FISHERIES RESEARCH
(2022)
Article
Veterinary Sciences
Mariola A. Dietrich, Mikolaj Adamek, Verena Jung-Schroers, Krzysztof Rakus, Magdalena Chadzinska, Anna Hejmej, Piotr Hliwa, Barbara Bilinska, Halina Karol, Andrzej Ciereszko
VETERINARY RESEARCH
(2020)
Article
Limnology
Maciej Blazejewski, Jaroslaw Krol, Tomasz Kakareko, Katarzyna Mierzejewska, Piotr Hliwa
Summary: The study examined the daily and seasonal dynamics of changes in fish communities in two environmentally different littoral zones of the Wloclawek Reservoir. Results showed the domination of native fish species in catches and the varying presence of alien invasive gobies throughout the season.
JOURNAL OF LIMNOLOGY
(2022)
