Article
Environmental Sciences
Jian-sheng Huang, Rong-xin Li, Rui-tao Xie, You-ming Chen, Jian-dong Zhang, Eric Amenyogbe, Gang Chen
Summary: This study investigates the amino acid and fatty acid profiles of cobia during different stages of development. The results reveal significant variations in crude protein composition and highlight the importance of consuming large amounts of n3PUFA for the survival rate of cobia larvae.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Agronomy
Ekaterina Anokhina, Svetlana Obraztsova, Anna Tolkacheva, Dmitrii Cherenkov, Tatyana Sviridova, Olga Korneeva
Summary: The use of amaranth green mass as an alternative source of protein and fiber for canned feed for ruminants is very promising. A developed silage starter from lactic acid bacteria significantly improves the quality of amaranth silage by promoting rapid fermentation and increasing crude protein retention.
Article
Medicine, General & Internal
Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher, Jian-Gao Fan
Summary: This study used Mendelian randomization analysis to uncover a causal relationship between higher alanine and lower glutamine levels and an increased risk of developing MAFLD, providing potential targets for MAFLD prevention or treatment.
Article
Endocrinology & Metabolism
Tie Li, Hui-Huan Luo, Xiao-Fei Feng, Yu Bai, Zhong-Ze Fang, Gui-Gang Wu, Jian-Lin Wu
Summary: This study found that elevated factor 3 composed of glutamate and tryptophan in plasma free amino acids was associated with increased risk of cardiovascular disease, especially stroke, in Chinese with Type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Arnaud Germain, Ludovic Giloteaux, Geoffrey E. Moore, Susan M. Levine, John K. Chia, Betsy A. Keller, Jared Stevens, Carl J. Franconi, Xiangling Mao, Dikoma C. Shungu, Andrew Grimson, Maureen R. Hanson
Summary: Post-exertional malaise (PEM) is a prominent symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). By monitoring plasma metabolites, this study found significant differences in metabolic response and recovery pattern between ME/CFS patients and healthy control participants after two maximal exercise tests. Glutamate metabolism was identified as a crucial factor in the metabolic disruptions that lead to PEM.
Article
Cell Biology
Guo-Bang Li, Hong-Rong Hu, Wen-Feng Pan, Bo Li, Zhi-Ying Ou, Hui-Ying Liang, Cong Li
Summary: The study used metabolomic profiling to identify specific metabolic alterations in pediatric sepsis patients, constructed diagnostic models, and revealed metabolites that can distinguish between case and control subjects. Furthermore, significantly altered metabolites were found in sepsis survivors compared to non-survivors, and fatty acid metabolism may play a crucial role in the pathogenesis of sepsis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Cristina Galarregui, Irene Cantero, Bertha Araceli Marin-Alejandre, J. Ignacio Monreal, Mariana Elorz, Alberto Benito-Boillos, Jose Ignacio Herrero, de la O. Victor, Miguel Ruiz-Canela, Helen Hermana M. Hermsdorff, Josefina Bressan, Josep A. Tur, J. Alfredo Martinez, M. Angeles Zulet, Itziar Abete
Summary: The study found that higher consumption of specific dietary amino acids was associated with poorer liver health, as indicated by liver fat content, liver iron concentration, and ferritin levels. The intake of these amino acids was positively correlated with markers of glucose metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Chemistry, Organic
Mingming Mao, Jia Li, Kang Dong, Rui-Peng Li, Xi Chen, Jian Liu, Shouchu Tang
Summary: We present a metal-free late-stage reductive C2 alkylation method for the synthesis of structurally complex peptides, utilizing readily available 1,3-dithianes. This protocol shows a broad substrate scope and excellent tolerance toward reactive functional groups.
Article
Agronomy
Siran Wang, Junfeng Li, Jie Zhao, Zhihao Dong, Tao Shao
Summary: This study investigated the silage quality, bacterial community, and predicted functional profiles during the ensiling of whole-crop maize. The results showed that after 60 days of ensiling, the maize silages had high levels of lactic acid, low pH, butyric acid, and ammonia N. Lactobacillus was the dominant genus during fermentation. The metabolism of amino acid, energy, cofactors and vitamins was inhibited, while the metabolism of nucleotide and carbohydrate was enhanced. Overall, this approach provided comprehensive insights into bacterial community and functional profiles to improve silage quality.
Article
Nutrition & Dietetics
Mohamad Tarik, Lakshmy Ramakrishnan, Nidhi Bhatia, Ravindra Goswami, Devasenathipathy Kandasamy, Atanu Roy, Dinu S. Chandran, Archna Singh, Ashish Datt Upadhyay, Mani Kalaivani, Jayanthi Neelamraju, Ratna Sudha Madempudi, Reena Rajan
Summary: The effect of Bacillus coagulans Unique IS-2 supplementation on protein absorption and utilization in resistance-trained males was assessed in this study. The results showed that Bacillus coagulans Unique IS-2 supplementation significantly increased protein absorption and intake of branched chain amino acids (BCAA), while also improving lower body muscle strength.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Nikkie van der Wielen, Sonja de Vries, Walter J. Gerrits, Kim Lammers-Jannink, Paul J. Moughan, Marco Mensink, Wouter Hendriks
Summary: This study demonstrates the presence of unabsorbed free amino acids (AAs) in the terminal ileum, which can impact the nutritional value of food proteins, especially for poorly digestible protein sources.
JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
David M. Whalley, Jayasree Seayad, Michael F. Greaney
Summary: The ring-opening of 3-aminocyclobutanone oximes leads to the formation of primary alkyl radicals, enabling a novel strain-release, desulfonylative radical Truce-Smiles rearrangement process, which allows for the divergent synthesis of valuable 1,3 diamines and unnatural beta-amino acids. The protocol is characterized by mild conditions and a wide range of migrating species, facilitating the modular assembly of sp(3)-aryls under transition metal-free, room-temperature conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Linchen He, Xinyan Hu, Drew B. Day, Meilin Yan, Yanbo Teng, Xing (Lucy) Liu, Erik Yan, Jianbang Xiang, Xinghua Qiu, Jinhan Mo, Yinping Zhang, Junfeng (Jim) Zhang, Jicheng Gong
Summary: Exposure to certain nitro-PAHs may affect glucose homeostasis, partly resulting from the depletion of insulin-stimulating amino acids.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemical Research Methods
Yaniv Shlosberg, Yair Farber, Salah Hasson, Valery Bulatov, Israel Schechter
Summary: Rapid identification of pathogenic bacteria is crucial for patient diagnosis in hospitals and environmental monitoring. A new method using synchronous fluorescence has been developed to quantify the concentrations of three amino acids and differentiate six pathogenic bacterial species, showing potential for broad applicability in rapid cell identification.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Veterinary Sciences
Yiyan Cui, Zhimei Tian, Miao Yu, Dun Deng, Huijie Lu, Min Song, Xianyong Ma, Limin Wang
Summary: The study found that GAA did not affect pig growth performance, but it did alter the profiles of free amino acids and related metabolites in plasma and tissues in a tissue-dependent manner.
PORCINE HEALTH MANAGEMENT
(2022)