Article
Nutrition & Dietetics
Joshua L. Gills, Anthony Campitelli, Megan Jones, Sally Paulson, Jennifer Rae Myers, Erica N. Madero, Jordan M. Glenn, James Komorowski, Michelle Gray
Summary: This study found that acute ASI ingestion can improve overall RBANS and immediate memory scores in young healthy adults, but the effects on other cognitive domains are not significant. Further research is needed to explore the acute effects of ASI on other domains of cognition, in older populations, and its long-term effects on cognition.
Article
Fisheries
Ghasem Rashidian, Mahyar Zare, Hamidreza Tabibi, Vlastimil Stejskal, Caterina Faggio
Summary: This study aimed to investigate the effects of medicinal plants and chelated minerals on fish growth and immunity. The results showed that the addition of chelated minerals and a mixture of medicinal plants can improve the growth and immunity of rainbow trout.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Shoumin Bao, Linying Zhuo, Delin Qi, Haining Tian, Deyun Wang, Bo Zhu, Yuqiong Meng, Rui Ma
Summary: This study compared the fillet nutritional quality of diploid and triploid rainbow trout with the same genetic background, farming condition and body weight. The results showed that diploid trout had higher protein content and amino acid scores, while triploid trout had higher lipid content and fatty acid scores. Both types of trout were suitable for human consumption and had beneficial effects on health. However, triploid trout had higher mineral content and differed in nutritional composition compared to diploid trout. The difference in lipid metabolism may be the reason for these variations.
AQUACULTURE REPORTS
(2023)
Review
Oncology
Chengying Jiang, Fangke Hu, Jiazhen Li, Guangshen Gao, Xiaojing Guo
Summary: The purpose of this meta-analysis was to summarize the diagnostic value of serum alkaline phosphatase (ALP) and bone-specific isoforms (BAP) in metastatic breast cancer (BC), with a focus on bone metastases. High levels of ALP and BAP in serum were found to be associated with a higher detection rate of bone metastatic BC patients. Although not highly reliable, serum ALP and BAP still provide some useful information for early detection of BC metastases, especially bone metastases.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Saravanan Sekaran, Selvaraj Vimalraj, Lakshmi Thangavelu
Summary: TNAP is an essential enzyme involved in skeletal tissue mineralization and dephosphorylation of various physiological substrates. It plays vital roles in neuronal development, detoxification, anti-inflammatory processes, bile pH regulation, and maintaining the blood brain barrier. Understanding the mechanisms mediated by TNAP is crucial for minimizing off targeted effects and improving various pathological scenarios.
Article
Biochemistry & Molecular Biology
Grace Felciya Sekar Jeyakumar, Poornima Velswamy, Deebasuganya Gunasekaran, Nivethitha Panneerselvam Manimegalai, Kiran Manikantan Syamala, Uma Tiruchirappalli Sivagnanam
Summary: The irregular expression of bone matrix proteins during bone regeneration can result in deformities. In this study, a metal-organic composite [TQ-Sr-Fe] was developed to enhance bone mineralization. The composite showed a sheet-like structure and exhibited biocompatibility with cells. It promoted cell adhesion, proliferation, and osteoblastic differentiation, leading to increased calcium deposition and mineralization. Overall, the TQ-Sr-Fe composite has the potential to accelerate bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Imtiaz Ahmed, Ishtiyaq Ahmad, Bashir Ahmad Malla, Basit Amin Shah, Zubair Ahmad Wani, Younis Mohd Khan
Summary: The study evaluated the effects of arginine on various parameters in fingerling Oncorhynchus mykiss and found that a concentration of 17.5 g kg(-1) of arginine showed optimal results for growth, hemato-biochemical variables, intestinal enzymes, and antioxidant ability.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Fisheries
Guro Lokka, Anusha K. S. Dhanasiri, Ashild Krogdahl, Trond M. Kortner
Summary: The increased cultivation of fish and decreased supply of marine ingredients has led to a higher demand for new nutrient sources. This study investigates the effects of adding bile salts, specifically taurocholate, to the culture media of fish gut epithelial cells. The results show that bile salts play important roles in the metabolism, barrier function, and immune response of intestinal epithelial cells.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Konstantinos Makris, Chagigia Mousa, Etienne Cavalier
Summary: Alkaline phosphatases are isoenzymes that catalyze the hydrolysis of organic phosphate esters in the extracellular space. Zinc and magnesium are important co-factors for their biological activity. They are found in various tissues, but most are derived from the liver and bone in the bloodstream. However, their exact physiological function remains largely unknown.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Freja Pontan, Helena Hauta-alus, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Sture Andersson, Outi Makitie, Elisa Holmlund-Suila
Summary: This study investigated the concentrations of alkaline phosphatase (ALP) and the prevalence of hyperphosphatasemia in healthy children, and their association with vitamin D, growth, infections, and bone parameters. It was found that boys had higher ALP levels than girls, and hyperphosphatasemia was more common at 12 months. Hyperphosphatasemia was associated with body size, growth rate, and bone mineralization, but not with infections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Giuseppe Cannalire, Simone Pilloni, Susanna Esposito, Giacomo Biasucci, Anna Di Franco, Maria Elisabeth Street
Summary: Serum alkaline phosphatase (ALP) and its isoenzymes play a crucial role in reflecting bone metabolism. ALP increases mineralization and reduces the concentration of an inhibitor of mineral formation. Different isoenzymes of ALP are expressed in different tissues and the bone isoenzyme (B-ALP) is involved in bone turnover. ALP measurements are important in the diagnosis, differentiation, and follow-up of rickets.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Ji-hoon Jung, Chae-Moon Hong, Il Jo, Shin-Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Summary: This study aimed to evaluate whether serum alkaline phosphatase (ALP) can differentiate flare phenomenon from disease progression on bone scintigraphy in breast or prostate cancer patients with bone metastasis. The results suggest that ALP is a useful serologic marker to differentiate flare phenomenon from disease progression on bone scintigraphy in patients with bone metastasis.
Article
Environmental Sciences
Gilles Tinant, Ineke Neefs, Krishna Das, Jean-Francois Rees, Yvan Larondelle, Cathy Debier
Summary: The study found that MeHg affects lipid metabolism in rainbow trout adipocytes, leading to intracellular accumulation of neutral lipids and up-regulation of adipocyte-specific and lipid-related genes.
Article
Fisheries
Lianqun Sun, Carole R. Engle, Ganesh Kumar, Jonathan van Senten
Summary: This study examines the retail sales of farm-raised trout in the United States from 2016 to 2021. The results show that sales increased steadily during this period, with the fastest growth observed in the West North Central region. The top market regions for trout sales were Seattle/Tacoma and Portland Oregon.
AQUACULTURE REPORTS
(2023)
Review
Nutrition & Dietetics
Mathias Haarhaus, Giuseppe Cianciolo, Simona Barbuto, Gaetano La Manna, Lorenzo Gasperoni, Giovanni Tripepi, Mario Plebani, Maria Fusaro, Per Magnusson
Summary: This narrative review summarizes recent clinical investigations and mechanisms linking alkaline phosphatase (ALP) and bone alkaline phosphatase (BALP) to inflammation, metabolic syndrome, vascular calcification, cardiovascular disease, and mortality. Further discussions include the association between ALP, vitamin K, bone metabolism, and fracture risk in patients with chronic kidney disease (CKD), as well as advancements in pharmacological strategies to modulate ALP expression in CKD-mineral and bone disorder (CKD-MBD).
Article
Biochemistry & Molecular Biology
Betul Demir, Demet Cicek, Cemal Orhan, Besir Er, Fusun Erten, Mehmet Tuzcu, Ibrahim Hanifi Ozercan, Nurhan Sahin, James Komorowski, Sara Perez Ojalvo, Sarah Sylla, Kazim Sahin
Summary: The combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) can promote hair growth by regulating various signaling pathways, while having no effect on nail growth.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pinar Oner, Besir Er, Cemal Orhan, Kazim Sahin
Summary: Sepsis is associated with systemic inflammation and oxidative stress, leading to organ dysfunction. This study investigated the therapeutic effects of ZnSePO on LPS-GalN-induced septic lung injury, showing that ZnSePO can reduce inflammation and improve survival rates.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Physical
Ibtissem Kadi, Güldeniz Sekerci, Houssem Boulebd, Zineddine Zebbiche, Suat Tekin, Hasan Kucukbay, Fatümetüzzehra Kucukbay, Taoues Boumoud
Summary: In this study, a series of novel poly-heterocyclic compounds containing pyridine and furan moieties were synthesized and characterized. The electronic properties, reactivity, cytotoxicity, and pharmacokinetic properties of these compounds were evaluated using experimental and computational methods. The results showed that some of the compounds exhibited potent cytotoxicity and displayed excellent affinity for the active site of the human topoisomerase II ss enzyme.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Kazim Sahin, Cemal Orhan, Oguzhan Ozdemir, Mehmet Tuzcu, Nurhan Sahin, Sara Perez Ojalvo, James R. Komorowski
Summary: This study aimed to examine the impact of different doses of whey protein and amylopectin/chromium complex on muscle protein synthesis, amino acid and insulin levels, and the mTOR signaling pathway in exercised rats. The results showed that rats that received 3.1 g/kg of whey protein combined with chromium complex exhibited a significant increase in muscle protein synthesis. Additionally, the combination of whey protein and chromium complex had beneficial effects on insulin levels and the mTOR signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Nutrition & Dietetics
Oguzhan Ozdemir, Fusun Erten, Besir Er, Cemal Orhan, James R. Komorowski, Sarah Sylla, Sara Perez Ojalvo, Kazim Sahin
Summary: A combination of amylopectin/chromium complex and pea/rice protein can significantly enhance muscle protein synthesis, increase insulin and musclin levels, and activate the mTOR pathway. These findings suggest that the combination of amylopectin/chromium complex and pea/rice protein can be an alternative for muscle remodeling and repair after exercise.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
T. Bayril, F. Akdemir, S. Gurgoze, C. Orhan
Summary: The aim of this study was to investigate the effects of supplemental stevia and ginger extracts on laying performance, fertility, hatchability, and serum biochemical parameters in laying Japanese quails under heat stress. The results showed that the quails supplemented with stevia and ginger extracts had higher feed intake, egg production, and egg weight compared to the control group. The fertility index and hatching egg weight were also higher in the experimental groups. Furthermore, the supplementation improved selected serum biochemical parameters and mitigated the negative effects of heat stress.
JOURNAL OF ANIMAL AND FEED SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Kazim Sahin, Emre Sahin, Patrick B. D. Deeh, Veysi Kayri, Cemal Orhan, Nurhan Sahin
Summary: The main stress factors that disrupt homoeostasis in poultry are environmental, nutritional, microbiological, and managing. Among these factors, high ambient temperatures have a significant impact on poultry production and health. High temperatures lead to oxidative stress and damage the antioxidant capacity of poultry. Nutrients such as vitamins E and C, selenium, and curcumin play a crucial role in enhancing the antioxidant defence system and mitigating the detrimental effects of heat stress.
WORLDS POULTRY SCIENCE JOURNAL
(2023)
Article
Food Science & Technology
Emrah Yazici, Emre Sahin, Nurhan Sahin, Mehmet Tuzcu, Kazim Sahin, Cemal Orhan
Summary: Mango ginger extract has potential antidiabetic effects by reducing serum glucose, insulin, free fatty acid, cholesterol, and triglyceride levels, increasing total antioxidant capacity, and decreasing malondialdehyde levels. It can also alleviate hepatocellular fat accumulation and promote the upregulation of heme oxygenase 1 in the liver through the regulation of GSK-3 beta/Fyn/Nrf2 signaling pathway.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Cemal Orhan, Emre Sahin, Mehmet Tuzcu, Nurhan Sahin, Abdullah Celik, Sara Perez Ojalvo, Sarah Sylla, James R. Komorowski, Kazim Sahin
Summary: The combination of NR and PC can improve inflammatory and antioxidant status in rats under chronic stress conditions by enhancing antioxidant enzyme activities and NAD+ levels.
Article
Medicine, General & Internal
Emre Sahin, Cemal Orhan, Fusun Erten, Fikrettin Sahin, Nurhan Sahin, Kazim Sahin
Summary: This study aimed to investigate the effects of different boron derivatives on nutrient digestibility, intestinal nutrient transporters, and lipid metabolism in rats. The results showed that supplementation of boric acid and sodium pentaborate pentahydrate improved nutrient digestibility, increased the expression levels of intestinal glucose transporters and fatty acid transport proteins, and modulated liver lipid metabolism. These findings are important for promoting intestinal health and maintaining a healthy lifestyle.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dilsad Sezgin, Gulnur Aslan, Kazim Sahin, Mehmet Tuzcu, Necip Ilhan, Engin Sahna
Summary: The aim of this study was to investigate the effects of melatonin on endothelial function and inflammation in hypercholesterolemic rats. The results showed that melatonin could restore the abnormal expressions caused by hypercholesterolemia, thus having protective and therapeutic effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
