Article
Cell Biology
Liying Han, Jinpeng Zhou, Leiyang Li, Xun Wu, Yingwu Shi, Wenxing Cui, Shenghao Zhang, Qing Hu, Jin Wang, Hao Bai, Haixiao Liu, Chengxuan Guo, Haiyan Cao, Min Chao, Yaqin Hu, Yueyang Mou, Yang Jiao, Dayun Feng, Liang Wang, Yan Qu
Summary: In this study, we developed a novel prognostic model for glioma based on seven ferroptosis-related genes (FRGs), which could predict the prognosis and immune status of glioma patients. Among the model, solute carrier family 1 member 5 (SLC1A5) was identified as a potential new target for glioma treatment. The expression of SLC1A5 was upregulated in high-grade glioblastoma tissues, and SLC1A5 knockdown inhibited glioma cell proliferation and invasion, as well as reduced the sensitivity to ferroptosis. Moreover, SLC1A5 was associated with immune response, and SLC1A5 knockdown decreased the infiltration and polarization of tumor-associated macrophages.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Shusuke Uekusa, Mayu Onozato, Tatsuya Sakamoto, Maho Umino, Hideaki Ichiba, Kenji Okoshi, Takeshi Fukushima
Summary: A derivatization reagent was designed to selectively analyze taurine and other amino acids in Japanese littleneck clams, enabling the detection of 18 amino acids with high selectivity and sensitivity. This method allowed for highly selective quantification using UHPLC-HRMS/MS.
Article
Fisheries
Jiahuan Liu, Mingzhu Pan, Yue Liu, Dong Huang, Kai Luo, Zhenhua Wu, Wenbing Zhang, Kangsen Mai
Summary: This study evaluated the effects of taurine on endoplasmic reticulum stress, inflammatory cytokine expression, and mitochondrial oxidative stress induced by high glucose. Taurine was found to alleviate these negative effects and provide cellular protection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wonsuk Choi, Mohammad Moniruzzaman, Ali Hamidoghli, Jinho Bae, Seunghyung Lee, Seunghan Lee, Taesun Min, Sungchul C. Bai
Summary: An 8-week feeding trial was conducted on juvenile olive flounder to assess the effectiveness of four functional feed additives in replacing antibiotics in a low-fish-meal diet. The results showed that the diets containing GRO, GROMW, GROPT, and GROTW significantly improved weight gain, growth rate, and protein efficiency ratio compared to the control diet. Furthermore, these diets also had positive effects on enzyme activities, gene expressions, and intestinal histology. Overall, the study suggests that GRO, GROMW, GROPT, and GROTW diets can be beneficial alternatives to antibiotics in juvenile olive flounder fed low-fish-meal diets.
Article
Environmental Sciences
Ping Han, Yingjie Qiao, Jiayi He, Xubo Wang
Summary: This study investigated the effects of temperature rise on the liver of Japanese flounder. The results showed that heat stress can cause tissue damage, inflammation, oxidative stress, and endoplasmic reticulum stress. These findings contribute to understanding the adaptive mechanisms of economic fish in the face of increasing water temperature caused by global warming.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Nutrition & Dietetics
Chenming Li, Lidong Gao, Chunxiao Lv, Ziqiang Li, Shanshan Fan, Xinyue Liu, Xinyi Rong, Yuhong Huang, Jia Liu
Summary: Diabetic Kidney Disease (DKD) is a significant microvascular complication of type 2 diabetes mellitus with a complex etiology and protracted course. In the early stages, most patients have few clinical symptoms, but are prone to develop life-threatening end-stage renal disease later on. Abnormal amino acid metabolism is closely associated with the development of DKD, involving various pathological processes such as oxidative stress, inflammatory response, and immune response, as well as autophagy, mitochondrial dysfunction, and iron death.
FRONTIERS IN NUTRITION
(2023)
Article
Genetics & Heredity
Fan Yang, Saisai Liu, Jiangbo Qu, Quanqi Zhang
Summary: The Pomstna gene in Japanese flounder has been identified as a negative regulator of muscle growth and differentiation, and it operates through a different regulatory mechanism than Pomstnb. This study suggests that muscle proliferation and differentiation are not only regulated through the TGF-beta signaling pathway, but also through other unknown mechanisms.
Article
Biochemistry & Molecular Biology
Eloy Bejarano, Elizabeth A. Whitcomb, Rebecca L. Pfeiffer, Kristie L. Rose, Maria Jose Asensio, Jose Antonio Rodriguez-Navarro, Alejandro Ponce-Mora, Antolin Canto, Inma Almansa, Kevin L. Schey, Bryan W. Jones, Allen Taylor, Sheldon Rowan
Summary: The lens proteome undergoes major changes during development and maturation, and abnormal development can lead to congenital cataracts. To better understand cataractogenesis, researchers used a transgenic mouse model and found that metabolic pathways were altered in cataractous lenses. The findings provide insights into the molecular mechanisms behind early-onset cataracts.
Article
Environmental Sciences
Zhengrui Zhang, Yuezhong Liu, Wei Zhang, Xinxin Du, Jinxiang Liu
Summary: The study focuses on the diversity of opsins and their expression patterns in flatfishes, particularly in Japanese flounder. The research reveals that the visual system of Japanese flounder is adapted to a benthic environment through fine-tuning paralogous opsins and regulated expression. The study suggests that opsin repertoires optimize visual function under variable light environments through gene family duplications, differential expressions, and variations in maximum absorption wavelength (lambda max).
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Immunology
Wenrui Li, Xiaolu Guan, Bin Sun, Li Sun
Summary: A novel miRNA-CSF3 regulatory system was discovered in flounder, shedding light on the role and mechanism of fish miRNA and CSF3 in antimicrobial immunity. The study found that pol-miR-novel_642 targeted a flounder gene encoding a protein similar to murine CSF3, and its expression was regulated by bacterial and viral pathogens. Modulating the expression of pol-miR-novel_642 and its target gene affected bacterial and viral infections in flounder, as well as the activation of autophagy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Michael O. Wellington, Tetske G. Hulshof, Kristi Ernst, Anke Balemans, Greg Page, Hubert M. J. Van Hees
Summary: Adding arginine and glutamine to the diet of weanling pigs can improve their growth performance, but the results are inconsistent during enteric Escherichia coli challenge. This study investigated the effects of independent or combined arginine and glutamine supplementation on performance and immune response under an E. coli F4 challenge. The results showed no improvements in performance, but there was an improvement in the acute phase response and immune response status.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Hisayo Yokoyama, Daiki Imai, Yuta Suzuki, Akira Ogita, Hitoshi Watanabe, Haruka Kawabata, Takaaki Miyake, Izumi Yoshii, Shinji Tsubouchi, Yoshimasa Matsuura, Kazunobu Okazaki
Summary: This study evaluated the current state of health literacy (HL) among college students and explored the factors influencing HL, as well as the relationship between HL and health conditions. The majority of participants had problematic or unsatisfactory HL levels. Those with healthy lifestyles scored higher on HL, and higher HL levels were associated with better subjective health. Educational intervention programs for college students should be established to improve their HL levels.
Article
Oncology
Haowen Jiang, Clifford Jiajun He, Albert Li, Bo He, Yang Li, Meng-Ning Zhou, Jiangbin Ye
Summary: This study demonstrates that mitochondrial uncoupling effectively inhibits the reductive carboxylation in cancer cells. By activating the electron transport chain and increasing the NAD(+)/NADH ratio, mitochondrial uncoupling accelerates the oxidative tricarboxylic acid cycle and blocks reductive carboxylation. Inhibiting reductive carboxylation could be a key mechanism by which mitochondrial uncouplers inhibit tumor growth.
MOLECULAR CANCER RESEARCH
(2023)
Article
Fisheries
Peng Zhang, Boguang Sun
Summary: This study investigates the involvement of PoCry1 in the immune response during bacterial infection in Japanese flounder. The results show that PoCry1 is involved in anti-infection immunity and exhibits circadian oscillation in transcription upon rhythmic light stimulation. These findings suggest that light condition can be exploited to strengthen fish immune system and benefit disease control in aquaculture.
Article
Fisheries
Xuangang Wang, Xiangfu Kong, Xiaobing Liu, Xubo Wang, Zhigang Wang, Jinxiang Liu, Quanqi Zhang, Haiyang Yu
Summary: Pyroptosis is a caspase-1-dependent form of programmed cell death characterized by cell lysis and inflammatory cytokine release. This study demonstrates that E. tarda infection triggers pyroptosis in macrophages of Japanese flounder, playing a vital role in the immune response. Treatment with a caspase-1 inhibitor significantly reduces pyroptosis, indicating the association of caspase-1 with pyroptosis.
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.