Article
Chemistry, Medicinal
Carmen Lammi, Enrico M. A. Fassi, Marco Manenti, Marta Brambilla, Maria Conti, Jianqiang Li, Gabriella Roda, Marina Camera, Alessandra Silvani, Giovanni Grazioso
Summary: Proprotein convertase subtilisin/kexin 9 (PCSK9) is a key target for the treatment of hypercholesterolemia and cardiovascular diseases. In this study, we discovered Rim13, a polyimidazole derivative that inhibits the interaction between PCSK9 and LDLR. Through computational design, we optimized the shape of PCSK9/ligand complementarity and identified potent diimidazole derivatives. Compound Dim16 showed improved PCSK9 inhibitory activity and some compounds in this series also showed hypocholesterolemic activity by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Je-Wen Liou, Hemalatha Mani, Jui-Hung Yen
Summary: Hepatitis is an inflammatory disease of the liver caused by viral infections, most commonly hepatitis B and hepatitis C. Host lipid metabolism, particularly cholesterol metabolism, is crucial for hepatitis viral infection and life cycle. Manipulating host cholesterol metabolism-related genes and proteins, such as using cholesterol-lowering drugs, has shown promising results in the treatment of viral hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hasi Hays, Zhixiang Gu, Kangsen Mai, Wenbing Zhang
Summary: This study investigated the effects of dietary taurine on transcriptomics and gene regulation in turbot muscle. The results showed that 1.2% dietary taurine supplementation significantly increased the expression of muscle growth stimulatory genes and enriched metabolic pathways. These findings highlight the positive impacts of taurine on muscle growth and metabolic processes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2023)
Article
Fisheries
Danni Liu, Yue Zhang, Mingzhu Pan, Mengxi Yang, Xinxin Li, Yonghao Fu, Weihua Gao, Wenbing Zhang, Kangsen Mai
Summary: Juvenile turbots fed with diets containing 16% carbohydrate and 1.5 mg/kg biotin exhibited the best growth performance and glucose metabolism. Biotin decreased postprandial plasma glucose levels regardless of carbohydrate levels, indicating its potential in improving glucose regulation in juvenile turbot.
Article
Agriculture, Multidisciplinary
Bingbing Ma, Lin Zhang, Jiaolong Li, Tong Xing, Yun Jiang, Feng Gao
Summary: The study demonstrates that supplemental taurine can effectively mitigate heat stress-induced breast muscle loss by reducing apoptosis and suppressing protein catabolism.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Review
Plant Sciences
Nourhan Hisham Shady, Ahmed Zayed, Rania Alaaeldin, Mohamed Hisham, Mohamed Gawesh, Randa Mohammed, Mahmoud A. Elrehany, Usama Ramadan Abdelmohsen
Summary: This article focuses on the pathogenesis and pathways involved in hyperlipidemia and summarizes potential drugs derived from natural products. The pharmacological activities and mechanisms of action of phytochemicals extracted from terrestrial plants and their endophytes are discussed based on previous in vivo studies.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Fisheries
Yuanyuan Zhou, Juyun He, Ningning Su, Karthik Masagounder, Minglei Xu, Leling Chen, Qingying Liu, Huaqun Ye, Zhenzhu Sun, Chaoxia Ye
Summary: This study showed that dietary supplementation of DL-Met or MHACa can significantly improve the growth performance and feed utilization of common carp, increase the concentration of free essential amino acids in serum, enhance taurine synthesis and protein synthesis. Furthermore, DL-Met significantly increased the expression of CDO and CSD, and the research also found that the bioavailability of MHA-Ca in common carp is lower compared to DL-Met.
Article
Fisheries
Xiangkai Li, Peng Li, Qicun Zhou, Yuhang Yang, Shichao Xie, Chen Guo, Zheng Yang, Jiaxiang Luo, Tingting Zhu, Chaokai Huang, Lefei Jiao, Min Jin
Summary: The study investigated the effects of replacing fish meal with spray-dried egg meal on various aspects in juvenile Portunus trituberculatus. Results showed that the replacement affected growth performance, anti-oxidative capacity, mTOR pathway, and cholesterol metabolism. The optimal replacement level of fish meal with SEM for juvenile swimming crab was estimated to be 15.94%.
AQUACULTURE REPORTS
(2023)
Article
Fisheries
Fakai Bai, Xingjian Niu, Xuexi Wang, Jidan Ye
Summary: The study showed that diets with higher lipid content led to increased lipid accumulation in the body of grouper fish, while dietary taurine supplementation improved growth rates and lipid metabolism. Taurine also influenced plasma lipid levels and liver gene expression related to lipid metabolism in groupers.
AQUACULTURE NUTRITION
(2021)
Article
Physiology
Jichang Zheng, Wencong Zhang, Zhijie Dan, Yanwen Zhuang, Yongtao Liu, Kangsen Mai, Qinghui Ai
Summary: This study found that Clostridium autoethanogenum meal (CAM) can replace up to 45% of dietary fish meal protein without significant adverse effects on growth performance in juvenile turbot. However, excessive intake of CAM may result in growth reduction and lipid deposition.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiang Ma, Houguo Xu, Yuliang Wei, Mengqing Liang
Summary: The study systematically elucidated the metabolic and physiological changes in turbot under acute hypoxia, revealing the effects of acute hypoxia on fish. The findings provide important guidance for improving hypoxia tolerance in fish.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane
Summary: HMG-CoA reductase is a key enzyme in cholesterol biosynthesis, and statins are commonly used inhibitors for treating hyperlipidemia. In this study, we identified a highly potent HMG-CoA reductase degrader, SRP3042, through a structure-activity relationship study. We found that mono-fluorination of tert-butyl groups on the molecule increased degradation activity while reducing lipophilicity, demonstrating the effectiveness of this strategy in balancing potency and physicochemical properties of lead compounds.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Fisheries
Jichang Zheng, Wencong Zhang, Zhijie Dan, Xiufei Cao, Kun Cui, Si Zhu, Yanwen Zhuang, Kangsen Mai, Qinghui Ai
Summary: MBM can replace up to 30% dietary FM without significantly adverse effects on growth performance and health of turbot juveniles, but excessive substitution levels (80% and 100%) would compromise antioxidant capacity, liver health, and protein metabolism.
Article
Biochemistry & Molecular Biology
Ryoma Tagawa, Masaki Kobayashi, Misako Sakurai, Maho Yoshida, Hiroki Kaneko, Yuhei Mizunoe, Yuka Nozaki, Naoyuki Okita, Yuka Sudo, Yoshikazu Higami
Summary: Long-term feeding of taurine lowers plasma cholesterol and bile acids by suppressing the FGF21/ERK pathway and upregulating Cyp7a1 expression, promoting cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Paulo J. da Costa, Malika Hamdane, Luc Buee, Franck Martin
Summary: Tau proteins play a crucial role in regulating microtubule dynamics and are also involved in various functions in neurons. Abnormal tau mRNA metabolism, expression, and post-translational modifications are critical steps in the pathogenicity of tau proteins. Recent research has highlighted the relevance of tau function to general mRNA metabolism.
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.