Article
Microbiology
Dominik Schuster, Katharina Axtmann, Niklas Holstein, Carsten Felder, Alex Voigt, Harald Faerber, Patrick Ciorba, Christiane Szekat, Anna Schallenberg, Matthias Boeckmann, Christiane Zarfl, Claudio Neidhoefer, Kornelia Smalla, Martin Exner, Gabriele Bierbaum
Summary: Antibiotic concentrations in hospital wastewater fluctuate, with meropenem consistently exceeding the minimal selective concentrations for resistant strains and ciprofloxacin being within the lowest minimal selective concentration range for about half of the time.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Immunology
Ning Yang, Xiao Jin, Chenghua Zhu, Fenglin Gao, Zheqi Weng, Xingran Du, Ganzhu Feng
Summary: Acinetobacter baumannii is a gram-negative bacterium and an important opportunistic pathogen in hospitals. Its increasing multidrug-resistant strains and global prevalence have made A. baumannii infection a challenging problem in clinical practice. Vaccines, specifically subunit vaccines, are being researched as effective tools to prevent and control A. baumannii infection. However, the lack of clinical trials may be due to the degradation and weak immunogenicity of subunit vaccines. Using adjuvants or delivery vehicles to prepare subunit vaccines can improve their stability and efficacy. Selecting the appropriate adjuvant and immunization method is essential for subunit vaccine research. This review aims to guide current and future research on A. baumannii subunit vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sean Jeffreys, James P. Chambers, Jieh-Juen Yu, Chiung-Yu Hung, Thomas Forsthuber, Bernard P. Arulanandam
Summary: Acinetobacter baumannii is a drug-resistant bacteria that causes hospital-acquired infections, which have contributed to increased costs and mortality during the COVID-19 pandemic. Immune-based therapy, including vaccines and monoclonal antibodies, is a promising strategy to combat this pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Microbiology
Santiago Castillo-Ramirez
Summary: A recent study published in mBio sequenced the genomes of 313 carbapenem-resistant A. baumannii isolates from over 100 hospitals in almost 50 countries, providing an updated view of the global distribution of major international clones and their carbapenemase genes. Future global genomic epidemiology studies can be enhanced by considering both human and non-human isolates and their antibiotic resistance profiles.
Article
Biochemistry & Molecular Biology
Abebe Mekuria Shenkutie, Jiaying Zhang, Mianzhi Yao, Daniel Asrat, Franklin W. N. Chow, Polly H. M. Leung
Summary: Suboptimal doses of antibiotics can promote biofilm formation and antibiotic resistance by regulating gene expression. Specifically, sub-MIC doses of imipenem and colistin upregulate genes associated with matrix synthesis, multidrug efflux pump, and fimbrial proteins, leading to increased biofilm production and antibiotic tolerance. Meanwhile, these antibiotics downregulate genes involved in protein synthesis, resulting in slowed cell metabolism and enhanced antibiotic tolerance in biofilm cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Stephen J. Dollery, Daniel Zurawski, Elena K. Gaidamakova, Vera Y. Matrosova, John K. Tobin, Taralyn J. Wiggins, Ruth Bushnell, David A. MacLeod, Yonas A. Alamneh, Rania Abu-Taleb, Mariel G. Escatte, Heather N. Meeks, Michael J. Daly, Gregory J. Tobin
Summary: The study successfully produced new vaccines by utilizing A. baumannii cells cultured using various methods, and then treated with radiation and antioxidants, which significantly improved protection in mice.
Article
Biochemistry & Molecular Biology
Nina Vesel, Christian Iseli, Nicolas Guex, Alexandre Lemopoulos, Melanie Blokesch
Summary: A. baumannii is a dangerous nosocomial pathogen that can rapidly acquire antibiotic resistance genes. This study investigates the role of epigenetic DNA modification in horizontal gene transfer, finding that diverse A. baumannii strains have different methylome patterns that influence DNA exchange.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Gathoni Kamuyu, Giuseppe Ercoli, Elisa Ramos-Sevillano, Sam Willcocks, Chidchamai Kewcharoenwong, Pattarachai Kiratisin, Peter W. Taylor, Brendan W. Wren, Ganjana Lertmemongkolchai, Richard A. Stabler, Jeremy S. Brown
Summary: The complement system plays an important role in the defense against bacterial infections, but different strains of A. baumannii show variations in their sensitivity to the complement system. These differences are partially independent of capsule composition or size, and variations in serum resistance among strains are not solely determined by MAC formation on bacterial surfaces.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Julius K. Demmer, Ben P. Phillips, O. Lisa Uhrig, Alain Filloux, Luke P. Allsopp, Maike Bublitz, Thomas Meier
Summary: This research elucidates the structure of F1Fo-ATP synthase in A. baumannii and reveals specific self-inhibition mechanism and structural adaptations in the proton-conducting pathway. These features may serve as attractive targets for the development of next-generation therapeutics.
Article
Chemistry, Multidisciplinary
Julinton Sianturi, Patricia Priegue, Jing Hu, Jian Yin, Peter H. Seeberger
Summary: Acinetobacter baumannii is a bacteria that is increasingly resistant to antibiotics and causes dangerous infections. The polysaccharides that cover A. baumannii are important in its pathogenesis and can be used for typing and vaccine development. By printing synthetic oligosaccharides resembling the polysaccharides onto microarray slides, the researchers were able to screen sera from infected patients and antibodies, leading to the identification of a potential vaccine candidate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Microbiology
Greater Kayode Oyejobi, Sunday Olabode Olaniyan, Nana-Aishat Yusuf, Deborah Adepeju Ojewande, Mobolaji Johnson Awopetu, Goodness Opeyemi Oyeniran, Fazal Mehmood Khan, Peter Alabi Dare, Maryam Kikelomo Adegbite-Badmus
Summary: Acinetobacter baumannii is an important nosocomial and opportunistic pathogen with high antibiotic resistance. New treatment approaches like the use of bacteriophage, phage-antibiotic combinations, and resistance-driven fitness losses are crucial for controlling its infections.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Review
Immunology
Chunli Sun, Yunsong Yu, Xiaoting Hua
Summary: Acinetobacter baumannii is a common pathogen causing various infectious diseases and has a high drug resistance rate, severely limiting antibiotic treatment options. Tigecycline and polymyxins are considered the last line of defense against multidrug resistant A. baumannii. This review focuses on the mechanisms of tigecycline resistance in A. baumannii and highlights the need for further investigation and development of new antibiotics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Wesley D. Kufel, Yasmeen Abouelhassan, Jeffrey M. Steele, Ramiro L. Gutierrez, Talha Perwez, George Bourdages, David P. Nicolau
Summary: The study investigated the pharmacokinetics of cefiderocol in cerebrospinal fluid (CSF) and plasma during the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB) meningitis using two different dosing regimens. Results showed that cefiderocol achieved CSF concentrations surpassing the organism-specific MIC and the CLSI susceptible breakpoint for 100% of the dosing interval, leading to microbiological and clinical cure without any adverse effects.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Valeria Mateo-Estrada, Jose Luis Fernandez-Vazquez, Julia Moreno-Manjon, Ismael L. Hernandez-Gonzalez, Eduardo Rodriguez-Noriega, Rayo Morfin-Otero, Maria Dolores Alcantar-Curiel, Santiago Castillo-Ramirez
Summary: This study used whole-genome sequencing to uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital over a decade, showing that accessory genome variation can be a powerful tool for conducting genomic epidemiology.
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.