Review
Oncology
Qiliang Yin, Xiumin Shi, Shijie Lan, Haofan Jin, Di Wu
Summary: Melanoma stem cells (MSCs) play a crucial role in tumor angiogenesis and metastasis, exhibiting multidrug resistance and immune evasion capabilities. Specific biomarkers such as CD133, CD271, etc., are key players in melanoma stem cells.
Article
Oncology
Martina Anselmi, Fabrizio Fontana, Monica Marzagalli, Nicoletta Gagliano, Michele Sommariva, Patrizia Limonta
Summary: In melanoma patients, poor prognosis often correlates with high presence of cancer-associated neutrophils, indicating that tumors can recruit these immune cells to specifically sustain their own development and progression. However, the role of cancer stem cells (CSCs) in this dialogue has not been elucidated yet. Our results revealed that melanoma SCs can reshape the immune microenvironment by triggering a pro-tumor N2 phenotype in neutrophils, which in turn are able to confer stemness properties to melanoma cells.
Article
Cell & Tissue Engineering
Mengqi Chu, Haitao Wan, Xiaobo Zhang
Summary: The study revealed that hnRNP A2B1 is significantly upregulated in melanoma stem cells, playing an important role in promoting the expression of anti-apoptosis genes and suppressing pro-apoptosis genes by regulating their splicing. This ultimately leads to cell cycle arrest in G2 phase and apoptosis of melanoma stem cells, highlighting the crucial requirement of hnRNP A2B1 in tumorigenesis and providing novel insights into the role of hnRNPs in cancer stem cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Alessandra Loda, Stefano Calza, Arianna Giacomini, Cosetta Ravelli, Adwaid Manu Krishna Chandran, Chiara Tobia, Giovanna Tabellini, Silvia Parolini, Francesco Semeraro, Roberto Ronca, Sara Rezzola
Summary: This study reveals that FGF and FGFR play a crucial role in regulating the development and survival of CSCs in primary UM tumors. Furthermore, a strong correlation between FGFs/FGFRs and stemness-related genes was found at the clinical level.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Cynthia M. Simbulan-Rosenthal, Yogameenakshi Haribabu, Sahar Vakili, Li-Wei Kuo, Havens Clark, Ryan Dougherty, Ryyan Alobaidi, Bonnie Carney, Peter Sykora, Dean S. Rosenthal
Summary: This study investigates the underlying mechanisms of CD133's anti-apoptotic activity in malignant melanoma, revealing that CD133 activates a survival pathway and contributes to drug resistance. Targeting the CD133, AKT, or BCL-2 survival pathways shows potential for more effective treatments for high-risk melanoma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Prakrit R. Kumar, Mona Saad, Charlotte Hellmich, Jayna J. Mistry, Jamie A. Moore, Shannon Conway, Christopher J. Morris, Kristian M. Bowles, Marc D. Moncrieff, Stuart A. Rushworth
Summary: Melanoma cells stimulate mitochondrial biogenesis in bone marrow-derived stromal cells, which leads to the transfer of mitochondria to melanoma cells. This study reveals metabolic interactions between melanoma and its microenvironment and provides new therapeutic approaches for melanoma treatment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Yao Chen, Xiaoqin Lu, Ling Gao, Douglas C. Dean, Yongqing Liu
Summary: The mechanism underlying cancer heterogeneity and plasticity in uveal melanoma (UM) remains unknown. This study aimed to investigate the involvement of cancer stem cells and the role of ZEB1 in cancer cell plasticity in UM. Results showed that cancer stem cells and ZEB1 may contribute to the heterogeneity and plasticity of UM.
Article
Biology
Xiaoshuang Li, Doudou Liu, Hao Chen, Bin Zeng, Qiting Zhao, Yuhan Zhang, Yuting Chen, Jianyu Wang, H. Rosie Xing
Summary: Our study shows that non-CSC melanoma cells can acquire the metastatic ability from CSC cells by utilizing exosomes to deliver functional miRNAs, such as miR-1268a. The exosomal miR-1268a promotes metastatic colonization by inactivating the autophagy pathway in the targeted cells.
BIOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Zhiwei Sun, Doudou Liu, Bin Zeng, Qiting Zhao, Xiaoshuang Li, Hao Chen, Jianyu Wang, H. Rosie Xing
Summary: This study has revealed a new mechanism through which Sec23a inhibits the self-renewal of melanoma CSCs by inactivating ER-phagy, providing new insights into the regulatory network of CSC self-renewal.
CELL COMMUNICATION AND SIGNALING
(2022)
Correction
Biochemistry & Molecular Biology
Jingfeng Zhou, Shenglan Liu, Yun Wang, Wei Dai, Hailin Zou, Shubo Wang, Jing Zhang, Jingxuan Pan
Summary: An amendment to the paper has been published and can be accessed through the original article.
Article
Multidisciplinary Sciences
Ji Eun Lee, Sungjin Ahn, Haengdueng Jeong, Seungchan An, Cheol Hwan Myung, Jeong Ah Lee, Sung Chan Hong, Youn Jin Kim, Jin Young Kim, Jong Hyuk Ryu, Minsoo Noh, Ki Taek Nam, Jae Sung Hwang
Summary: Olig2 plays a crucial role in promoting apoptosis, migration, and invasion of melanoma cells by regulating key signaling pathways involved in cancer progression.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Marta Cecchi, Antonella Mannini, Andrea Lapucci, Angela Silvano, Matteo Lulli, Cristina Luceri, Mario D'Ambrosio, Alberto Chiarugi, Ali H. Eid, Astrid Parenti
Summary: In addition to its immunosuppressive actions, the enzyme tryptophan 2,3-dioxygenase (TDO) also has direct effects on tumor cell function. This study shows that the drug dexamethasone (dex), which is commonly used in the treatment of advanced melanoma, upregulates TDO and promotes melanoma cell function and tumor-supporting properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Silvia Tyciakova, Valeria Valova, Barbora Svitkova, Miroslava Matuskova
Summary: The study reveals that TNF alpha has different effects on malignant tumor cells of different origins, potentially influencing cellular biological processes such as autophagy, apoptosis, and mitochondrial function through regulation of proinflammatory cytokines and pro-apoptotic ligand genes.
Article
Chemistry, Analytical
Francesca Pagliari, Elisa Sogne, Davide Panella, Gerardo Perozziello, Carlo Liberale, Gobind Das, Alice Turdo, Simone Di Franco, Joao Seco, Andrea Falqui, Santo Gratteri, Arturo Pujia, Enzo Di Fabrizio, Patrizio Candeloro, Luca Tirinato
Summary: Melanoma is a type of tumor with a high percentage of cancer stem cells. Researchers have identified lipid droplets as one of the markers for these cells. They have used various techniques, such as mass spectrometry and imaging techniques, to characterize the droplets and developed a new experimental approach to study them.
Article
Multidisciplinary Sciences
Masayoshi Suda, Ippei Shimizu, Goro Katsuumi, Chieh Lun Hsiao, Yohko Yoshida, Naomi Matsumoto, Yutaka Yoshida, Akihiro Katayama, Jun Wada, Masahide Seki, Yutaka Suzuki, Shujiro Okuda, Kazuyuki Ozaki, Mayumi Nakanishi-Matsui, Tohru Minamino
Summary: Accumulation of senescent cells in various tissues is associated with age-related diseases. Recent studies have shown that elimination of senescent cells can reverse pathological aging without increasing cancer risk. This study investigated the role of glycoprotein nonmetastatic melanoma protein B (GPNMB) in senescent cells. It was found that GPNMB acts as a survival factor in senescent cells and targeting seno-antigens like GPNMB may be a novel strategy for senolytic treatments.
SCIENTIFIC REPORTS
(2022)
