Immunology of metal allergies

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity

(2014) Gina M. Clayton et al.   CELL

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response

(2014) Nikhil Dhingra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis

(2014) Juan Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

(2014) Yohei Natsuaki et al.   NATURE IMMUNOLOGY

Accumulation of Metal-Specific T Cells in Inflamed Skin in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis

(2014) Hiroaki Shigematsu et al.   PLoS One

An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells

(2014) Shinsuke Yasukawa et al.   Nature Communications

Why does allergic contact dermatitis exist?

(2013) J.P. McFadden et al.   BRITISH JOURNAL OF DERMATOLOGY

Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles

(2013) Pushya A. Potnis et al.   CELLULAR IMMUNOLOGY

Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits

(2013) Matthias Peiser   Clinical & Developmental Immunology

Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators

(2013) Dessy Rachmawati et al.   CONTACT DERMATITIS

Ni(ii) binding to the 429–460 peptide fragment from human Toll like receptor (hTLR4): a crucial role for nickel-induced contact allergy?

(2013) Maria Antonietta Zoroddu et al.   DALTON TRANSACTIONS

Nickel Induces Interleukin-1β Secretion via the NLRP3–ASC–Caspase-1 Pathway

(2013) Xiujin Li et al.   INFLAMMATION

Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

(2013) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures

(2013) Eun-Hee Kim et al.   Immune Network

Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

(2012) Badrinarayanan Raghavan et al.   EMBO REPORTS

Structural basis of metal hypersensitivity

(2012) Yang Wang et al.   IMMUNOLOGIC RESEARCH

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

(2012) Mercedes Gomez de Agüero et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-1 Receptor Signaling Is Required at Multiple Stages of Sensitization and Elicitation of the Contact Hypersensitivity Response

(2012) D. D. Kish et al.   JOURNAL OF IMMUNOLOGY

Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis

(2012) Tetsuya Honda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy

(2012) L. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis

(2011) S. F. Martin et al.   ALLERGY

Palladium allergy prevalence is underestimated because of an inadequate test allergen

(2011) Joris Muris et al.   CONTACT DERMATITIS

Metal allergen of the 21st century-a review on exposure, epidemiology and clinical manifestations of palladium allergy

(2011) Annesofie Faurschou et al.   CONTACT DERMATITIS

Nickel allergies: paying the Toll for innate immunity

(2011) Marc Schmidt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Divergent Effect of Cobalt and Beryllium Salts on the Fate of Peripheral Blood Monocytes and T Lymphocytes

(2010) F. Paladini et al.   TOXICOLOGICAL SCIENCES

Effector pathways during eczematous dermatitis: where inflammation meets cell death

(2009) Andreas Kerstan et al.   EXPERIMENTAL DERMATOLOGY

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

(2008) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH